4-Iodophenylboronic acidyog ib qho organic compound nrog CAS 5122-99-6 thiab molecular mis C6H6BINO2. Nws feem ntau tshwm raws li cov khoom dawb mus rau lub teeb daj. Nws cov xim yuav txawv nyob ntawm seb purity los yog qauv batch. Nws muaj cov dej solubility zoo thiab tuaj yeem yaj hauv cov kuab tshuaj organic feem ntau, xws li methanol, ethanol, acetone, thiab lwm yam. Txawm li cas los xij, hauv cov kuab tshuaj polar xws li acetonitrile lossis DMF, lawv cov solubility yuav siab dua. Cov qauv molecular muaj iodine atom, ib lub nplhaib benzene, thiab ib pawg boronic acid.
Ntawm lawv, pawg boronic acid yog ib pawg polar uas muaj boron atoms, uas muab cov compound ib qho polarity. Lub iodine atom, raws li ib tug tsis yog - pawg polar, txuas nrog nws lub nplhaib benzene, muab tag nrho cov molecule ib asymmetric tis ntawm electron huab. Nws yog nkig thiab yooj yim crushes rau hauv hmoov. Thaum sib tsoo los yog txiav nws, ua tib zoo tuav yog tsim nyog kom tsis txhob ua rau tus qauv puas. Nws yog ib qho reactive compound. Piv txwv li, nws tuaj yeem cuam tshuam nrog ntau yam hlau ions lossis pab pawg ua haujlwm. Cov kev cuam tshuam no feem ntau cuam tshuam nrog kev tsim kev sib koom tes lossis cov ntawv cog lus cog lus thiab tsim cov hlau sib txuas lossis cov khoom sib txuas.
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C.F |
C6H6BIO 2 |
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E.M |
248 |
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M.W |
248 |
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m/z |
248 (100.0%), 247 (24.8%), 249 (6.5%), 248 (1.6%) |
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Elemental Analysis |
C, 29.08; H, 2.44; B, 4.36; I, 51.21; O, 12.91 |
4-Iodophenylboronic acidtuaj yeem siv rau kev hloov kho deg functionalization los txhim kho qhov chaw thiab cov khoom sib txuas ntawm cov khoom. Piv txwv li, nws tuaj yeem siv los ua tus neeg sawv cev sib txuas rau kev hloov kho ntawm iav, silicon- cov ntaub ntawv raws li, thiab cov hlau nto los txhim kho lawv cov dej ntub dej, tiv thaiv corrosion, thiab biocompatibility.
Nws tau pom tias muaj peev xwm siv tau zoo hauv kev hloov kho qhov chaw ua haujlwm, nqa cov kev hloov tshiab tseem ceeb rau cov khoom siv science thiab engineering.
Raws li kev hloov kho saum npoo zoo, nws tuaj yeem txhim kho qhov chaw thiab cov khoom sib txuas ntawm cov khoom, muab cov yam ntxwv ua haujlwm tshiab rau ntau yam substrates xws li iav, silicon- cov khoom siv, hlau, thiab lwm yam.
Tshwj xeeb, nws tuaj yeem siv los ua tus neeg sawv cev sib txuas kom nruj nrog rau qhov chaw ntawm cov substrates los ntawm kev sib txuas tshuaj, yog li muab lawv nrog cov haujlwm tshiab ntog yam tsis hloov cov khoom ntawm cov khoom nws tus kheej. Piv txwv li, nws tuaj yeem txhim kho qhov ntub dej ntawm cov ntaub ntawv, ua kom cov kua ntau sib npaug ntawm cov khoom siv, uas yog ib qho tseem ceeb rau kev siv xws li coatings, inks, adhesives, thiab lwm yam.
Nyob rau tib lub sijhawm, nws tuaj yeem txhim kho qhov kev tiv thaiv corrosion ntawm cov ntaub ntawv los ntawm kev tsim cov yeeb yaj kiab tiv thaiv ntawm cov khoom siv, tiv thaiv corrosive media los ntawm corroding cov khoom thiab txuas nws lub neej kev pab cuam.
Rau nyias zaj duab xis npaj: Los ntawm txoj kev Langmuir Blodgett, kom Langmuir monolayers thiab Langmuir Blodgett multilayer films tuaj yeem npaj siv p-Iodophenylboromic Acid. Cov yeeb yaj kiab nyias no muaj cov qauv tshwj xeeb thiab cov khoom siv optoelectronic, thiab muaj peev xwm siv tau cov nqi hauv cov teb xws li optoelectronic li, sensors, thiab lub zog hloov dua siab tshiab.
Siv los npaj cov organic nyias zaj duab xis hnub ci hlwb
Organic nyias zaj duab xis hnub ci hlwb yog ib hom tshiab ntawm lub hnub ci cell nrog qhov zoo xws li tus nqi qis, kev tsim khoom yooj yim, thiab kev daws teeb meem. P-Iodophenylboromic acid, ua cov khoom siv hluav taws xob zoo heev, yog siv dav hauv kev npaj cov organic nyias zaj duab xis hnub ci hlwb. Thaum lub sij hawm kev npaj, p-Iodophenylboromic acid tuaj yeem tsim cov molecular aggregates nrog cov khoom siv hluav taws xob uas muaj ntxhiab los ntawm π - π kev sib cuam tshuam thiab Lewis acid- hauv paus kev cuam tshuam.
Hom molecular aggregate no muaj kev hloov pauv hluav taws xob zoo heev thiab cov khoom siv optoelectronic tunable, uas pab txhim kho cov kev hloov pauv photoelectric efficiency thiab ruaj khov ntawm lub hnub ci hlwb.
Tsis tas li ntawd, p-Iodophenylboromic acid kuj tuaj yeem qhia lwm pab pawg ua haujlwm xws li alkyl thiab alkoxy pawg los ntawm kev tsim qauv molecular los ua kom zoo dua cov qauv hluav taws xob thiab cov khoom ntawm cov khoom. Qhov kev ua tau zoo no ua rau p-Iodophenylboromic acid yog cov khoom siv zoo tshaj plaws hauv kev ua haujlwm ntawm cov organic nyias zaj duab xis hnub ci hlwb.
Siv los npaj optoelectronic haumxeeb films
Photoelectric functional nyias zaj duab xis yog cov khoom siv zaj duab xis nyias nrog photoelectric hloov dua siab tshiab muaj nuj nqi thiab ruaj khov photoelectric kev ua tau zoo. P-Iodophenylboromic acid, raws li ib hom ntawm optoelectronic functional khoom, yog dav siv nyob rau hauv kev npaj ntawm optoelectronic functional films.
Thaum lub sij hawm kev npaj, p-Iodophenylboromic acid tuaj yeem cuam tshuam nrog cov khoom siv xws li cov khoom siv hluav taws xob thauj khoom thiab cov khoom siv semiconductor los tsim cov complexes ruaj khov lossis tsis muaj kev sib raug zoo sib raug zoo, yog li ua tiav cov kev cai thiab kev ua kom zoo ntawm optoelectronic functions.
Cov khoom siv zaj duab xis nyias no muaj kev ua haujlwm siab photoelectric hloov dua siab tshiab thiab ruaj khov, thiab tuaj yeem siv rau hauv thaj chaw xws li hnub ci hlwb, photodetectors, thiab photodiodes. Tsis tas li ntawd, los ntawm kev sib txuas thiab ua kom zoo nrog lwm cov khoom siv, kev ua haujlwm thiab kev siv ntau yam ntawm optoelectronic haumxeeb yeeb yaj kiab tuaj yeem txhim kho ntxiv. Piv txwv li, kev sib txuas ntawm p-Iodophenylboromic acid nrog rau lwm cov organic me me molecules los yog cov ntaub ntawv polymer tuaj yeem tsim cov duab hluav taws xob sensors thiab cov keyboards nrog cov rhiab heev thiab cov lus teb ceev. Cov khoom siv optoelectronic cov ntaub ntawv nyias nyias muaj cov ntawv thov dav dav hauv thaj chaw xws li kev sib txuas lus kho qhov muag, kev ua cov ntaub ntawv, thiab biomedical engineering.
Siv los npaj cov yeeb yaj kiab biocompatible
Biocompatible zaj duab xis yog cov ntaub ntawv nyias nyias siv hauv cov ntaub so ntswg engineering thiab biomedical engineering, nrog rau biocompatibility zoo heev thiab tshuaj lom neeg ruaj khov. P-Iodophenylboromic acid, ua cov khoom siv nrog biocompatibility zoo, yog siv dav hauv kev npaj cov yeeb yaj kiab biocompatible.
Thaum lub sij hawm kev npaj, p-Iodophenylboromic acid tuaj yeem hloov kho thiab molecular tsim los qhia lwm pawg ua haujlwm, xws li amino thiab carboxyl pawg, txhawm rau txhim kho nws cov kev sib cuam tshuam thiab biocompatibility nrog cov ntaub so ntswg lom. Cov khoom siv zaj duab xis nyias no tuaj yeem ua lub substrate rau kev loj hlob ntawm tes thiab txuas rau hauv cov ntaub so ntswg engineering, txhawb nqa cell proliferation thiab sib txawv. Lub caij no, vim nws cov tshuaj lom neeg ruaj khov thiab kev tiv thaiv corrosion, nws kuj tuaj yeem siv rau hauv kev tsim cov khoom siv kho mob thiab cov nqa tshuaj.
Laboratory synthesis txoj kev ntawm4-Iodophenylboronic acidfeem ntau suav nrog cov kauj ruam hauv qab no:
C6H5B (OH)2 + NaI + NaOH → C6H5B (OH)2-Na + I-Na
C6H5B (OH)2-Na + I-Na → C6H5B (OH)2 + NaOH + NaCl
C6H5B (OH)2 + H2O → C6H5B (OH)2 · H2O + NaOH
C6H5B (OH)2 · H2O + H2O → C6H5B (OH)2 + H2O2
Ua ntej ua cov synthesis, nws yog ib qhov tsim nyog los npaj cov reagents thiab khoom siv. Cov reagents yuav tsum muaj xws li sodium iodide, phenylboronic acid, sodium hydroxide, methanol, thiab lwm yam. Cov khoom siv muaj xws li stirrer, condenser, drip device, thiab rotary evaporator.
Dissolve phenylboronic acid hauv methanol los npaj cov tshuaj benzylboronic acid methanol.
Dissolve sodium iodide hauv dej los npaj cov tshuaj aqueous ntawm sodium iodide.
Sib tov cov npaj benzylboronic acid methanol tov thiab sodium iodide aqueous tov ua ke, ntxiv ib qho tsim nyog ntawm sodium hydroxide, thiab do sib npaug.
Tshav kub qhov sib tov rau lub xeev reflux, tswj qhov kub ntawm ib ncig ntawm 100 ° C, thiab hnov mob rau lub sijhawm (xws li 1-2 teev) kom txog rau thaum cov phenylboronic acid reacts tag nrho.
Txias cov tshuaj tiv thaiv rau hauv chav tsev kub, ncuav qhov sib tov rau hauv ib lub beaker, thiab siv cov evaporator rotary evaporate cov kuab tshuaj kom tau cov khoom crude.
Recrystallize cov khoom nyoos nrog methanol kom tau txais cov ntshiab 4 Iodophenylboronic acid crystals
(1) Lim cov khoom nyoos kom tshem tawm cov tsis muaj phenylboronic acid thiab lwm yam impurities.
(2) Recrystallize cov khoom lim nrog methanol kom tau cov ntshiab 4 Iodophenylboronic acid crystals.
(3) Qhuav cov khoom crystallized kom tau qhuav4-Iodophenylboronic acidhmoov los yog siv lead ua.
Quantitative nuclear magnetic resonance (qnmr)
Quantitative nuclear magnetic resonance (qNMR) yog ib txoj kev tsom xam kom muaj nuj nqis raws li lub hauv paus ntsiab lus ntawm nuclear magnetic resonance. Nws muaj qhov zoo ntawm qhov tsis xav tau cov qauv tshuaj, kev ua haujlwm yooj yim thiab cov txiaj ntsig raug, thiab yog qhov tsim nyog rau kev kuaj xyuas purity ntawm 4-iodobenzoboric acid.
Detection Principple
NMR ua tiav qhov kev ntsuam xyuas ntau los ntawm kev sib piv qhov sib txawv ntawm qhov sib txawv ntawm qhov nqus ntawm qhov sib nqus hauv nuclear magnetic resonance spectra. Rau qhov tseeb proton, nws qhov chaw ib feem yog proportional rau molar concentration. Thaum kuaj pom qhov purity ntawm 4-iodobenoboric acid, nws yog ib qho tsim nyog yuav tsum tau ua ntej txiav txim siab qhov tseem ceeb ntawm nws cov yam ntxwv ncov, tus naj npawb ntawm cov protons sib xws rau lub ncov no, cov qauv loj, molar mass thiab purity thiab lwm yam tsis.
Nyob rau tib lub sijhawm, xaiv cov txheej txheem sab hauv uas tsim nyog thiab txiav txim siab nws cov kev coj ua. Lub purity ntawm 4-iodobenzoboric acid tuaj yeem tau los ntawm kev suav qhov sib piv ntawm qhov sib piv ntawm thaj tsam ntawm cov yam ntxwv ntawm cov qauv thiab cov qauv sab hauv, qhov piv ntawm tus lej ntawm cov protons, qhov sib piv ntawm qhov loj thiab qhov piv ntawm molar pawg, thiab lwm yam.
Kev tshuaj xyuas
Kev npaj ua qauv
Siv qhov sib npaug ntawm ultramicro kom raug qhov hnyav ntawm 4-iodobenzoboric acid qauv thiab cov qauv tshuaj (cov qauv sab hauv) rau qNMR, kom ntseeg tau tias qhov hnyav hnyav dua li qhov hnyav tshaj qhov hnyav. Ua kom tiav cov qauv thiab cov txheej txheem sab hauv hauv qhov tsim nyog deuterated hnyav, xws li deuterated chloroform, thiab yuav tsum ceev faj kom tsis txhob sib tshooj ntawm cov teeb liab ntawm deuterated reagent nrog cov khoom raug soj ntsuam.
NMR nrhiav
Hloov cov qauv kev daws teeb meem rau lub raj sib nqus hlau nplaum, teeb tsa NMR kom pom cov xwm txheej, xws li 1-teev resonance zaus saum 400MHz, digital daws teeb meem hauv qab 0.25Hz, pulse Angle ntawm 90 degree, thiab ncua sij hawm ntau dua 60 vib nas this, thiab lwm yam, ua NMR nrhiav thiab sau cov spectrum.
Cov ntaub ntawv tsom xam
Ua cov theem kho, kev kho lub hauv paus thiab lwm yam kev ua haujlwm ntawm lub spectrum, thiab xaiv cov protons nrog kev cuam tshuam tsawg dua, zoo dua cov duab ncov thiab cov hauv paus ruaj khov rau kev sib koom ua ke. Raws li qNMR cov mis laij lej, ua ke nrog cov tsis muaj feem cuam tshuam ntawm cov qauv thiab cov qauv sab hauv, suav nrog purity ntawm 4-iodobenzoboric acid.
I. Early Foundation of Organoboron Compounds (Ib nrab - mus rau -Late 19th Century)
Kev tshawb fawb ntawm organoboron tebchaw pib nyob rau hauv 1860. British chemist Edward Frankland thawj synthesized thiab cais ib tug alkylboronic acid derivative - ethylboronic acid, pioneering kev tshawb fawb ntawm organoboron chemistry.
Xyoo 1880, A. Michaelis thiab P. Becker tau ua tiav kev tsim cov phenylboronic acid, txuas ntxiv kev tshawb fawb boronic acid rau hauv cov tshuaj tsw qab thiab tso lub hauv paus tseem ceeb rau kev tsim cov phenylboronic acids hloov.
Thaum lub sij hawm no, organoboron tebchaw tsuas yog suav hais tias yog tshuaj lom neeg xav paub, featuring hnyav synthesis tej yam kev mob, yields tsawg, thiab untapped daim ntawv thov nqi.
II. Synthesis thiab Emergence (Mid-20th Century)
Nyob rau hauv nruab nrab-20th caug xyoo, breakthroughs nyob rau hauv hluavtaws technologies xws li Grignard reagents thiab organolithium reagents zoo heev txhim kho cov synthesis efficiency ntawm hloov phenylboronic acids.
Raws li ib qho tseem ceeb ntawm haloarylboronic acid,4-Iodophenylboronic acidtau ua tiav synthesized nyob rau hauv 1950s-1960s. Nws txoj kev siv hluavtaws classic siv 1,4-diiodobenzene raws li cov khoom siv raw, uas dhau mus lithiation nrog n-butyllithium, reacts nrog triisopropyl borate, thiab thaum kawg tau los ntawm hydrolysis.
Txoj kev no tseem yog qhov tseem ceeb hauv chav kuaj npaj raws li niaj hnub no. Thaum lub sijhawm ntawd, nws tau siv los ua cov organic synthesis nruab nrab rau kev tsim boron -muaj cov khoom siv ua haujlwm, tsis muaj daim ntawv thov loj -.
III. Sawv ntawm daim ntawv thov thiab tsim kom muaj nuj nqis (Late 20th Century to Tam sim no)
Tom qab xyoo 1990, kev tshawb fawb ntawm nws tau mus txog qhov cuam tshuam. Xyoo 1996, nws tau tshawb pom los ua lub zog txhawb zog rau horseradish peroxidase (HRP) -catalyzed luminol chemiluminescence system, zoo heev txhim kho luminescence siv thiab kev tshawb nrhiav rhiab heev, thiab txhawb nws txoj kev siv dav hauv kev kho mob thiab biosensing teb.
Xyoo 2010, Suzuki-Miyaura coupling cov tshuaj tiv thaiv tau txais qhov khoom plig Nobel hauv Chemistry. Raws li cov monomer difunctional uas muaj ob qho tib si iodine atom thiab boronic acid pawg, nws tau dhau los ua lub tsev tseem ceeb rau kev tsim cov polymers (piv txwv li, poly (phenylene)), cov tshuaj molecules complex thiab cov khoom siv organic.
Nws cov txheej txheem hluavtaws tau ua kom zoo tsis tu ncua, thiab kev tsim khoom lag luam tau maj mam matured. Txij thaum ntawd los, nws tau hloov zuj zus los ntawm lub niche nruab nrab mus rau hauv cov tshuaj tseem ceeb hauv cov organic synthesis, cov ntaub ntawv science, biomedicine thiab lwm yam kev lag luam.
FAQ
1. Dab tsi yog qhov tshwj xeeb cuam tshuam ntawm spatial steric hindrance ntawm iodine atom ntawm metalation kauj ruam hauv Suzuki coupling cov tshuaj tiv thaiv?
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Piv nrog rau lwm cov halogens, iodine atom muaj qhov ntim loj dua, uas yuav ua rau muaj kev hloov pauv me ntsis ntawm lub hom phiaj ntawm lub nplhaib benzene, yog li cuam tshuam rau kev sib koom tes nrog palladium catalyst thiab tom qab tus nqi tsim ntawm aryl{0}}palladium daim ntawv cog lus. Hauv qee qhov substrates, qhov no yuav ua rau muaj kev hloov pauv hauv kev sib txuas ua haujlwm.
2. Cov ester pauv cov tshuaj tiv thaiv ntawm cov tshuaj no ruaj khov npaum li cas nrog cov ortho-diphenolic pawg nyob rau hauv ib puag ncig uas tsis yog-catalytic (xws li cov tshuaj physiological pH tsis haum)?
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Cov hluav taws xob muaj zog- rho tawm cov cuab yeej ntawm iodine txhim kho cov kua qaub ntawm boronic acid, ua rau nws muaj peev xwm tsim cov esters thim rov qab nrog diols nyob ze - tej yam kev mob nruab nrab. Txawm li cas los xij, daim ntawv cog lus no kuj tseem ceeb heev rau hydrolysis, thiab hauv kev siv tshuaj lom neeg (xws li cov suab thaj sensors), dynamic equilibrium yuav tsum xav txog.
3. Puas muaj cov qauv ntim tshwj xeeb uas muaj nyob hauv lub xeev uas tau tsav los ntawm kev sib cuam tshuam ntawm iodine atoms lossis kev cuam tshuam ntawm iodine thiab π bonds?
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Ib leeg siv lead ua diffraction qhia tau hais tias cov molecules yuav tsim tshwj xeeb supramolecular sib dhos los ntawm cov iodine tsis muaj zog -Iodine kev sib cuam tshuam los yog kev cuam tshuam ntawm iodine atoms thiab π electron huab ntawm benzene rings uas nyob ib sab. Qhov no yuav cuam tshuam rau nws daim ntawv crystalline thiab solubility.
4. Nyob rau hauv lub teeb, cov pa roj carbon-iodine daim ntawv cog lus puas tuaj yeem raug tshem tawm thiab ua rau muaj kev cuam tshuam dawb radical?
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Lub zog ntawm daim ntawv cog lus ntawm carbon-iodine daim ntawv cog lus kuj tsawg. Nyob rau hauv muaj zog ultraviolet lub teeb irradiation los yog muaj cov dawb radical pib, nws yuav undergo cleavage los tsim phenyl radicals, uas nyob rau hauv lem yuav ua rau tsis tsim nyog polymerization los yog reacts nrog cov kuab tshuaj, yog li cuam tshuam nws stability nyob rau hauv photochemical synthesis.
Cim npe nrov: 4-iodophenylboronic acid CAS 5122-99-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom