Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm angiotensinamide cas 53-73-6 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo angiotensinamide cas 53-73-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Angiotensinamideyog ib qho tshuaj antihypertensive uas feem ntau yog siv los kho cov hlab ntsha siab thiab lub plawv tsis ua haujlwm. Nws yog ib qho zoo vasoconstrictor, derivative ntawm arterenol, thiab tuaj yeem siv los ua lub plawv dhia. Nws cov txheej txheem ntawm kev txiav txim yog tsuas yog ua kom tau cov nyhuv antihypertensive los ntawm dilating peripheral hlab ntsha thiab txo qis plawv tom qab load. Tshwj xeeb tshaj yog, angiotensiinamide tuaj yeem ua rau adrenergic receptors kom ua rau muaj kev cuam tshuam rau cov ntshav siab.
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Angiotensin Amide COA
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| Certificate of Analysis | ||
| Compound npe | Angiotensin Amide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 53-73-6 | |
| Ntau | Customized | |
| Ntim txheem | Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090013 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -15 degree | |
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| Tshuaj Formula | C49H70N14O11 | |
| Exact Mass | 1030.53 | |
| Molecular Luj | 1031.19 | |
| m/z | 1030.53 (100.0%), 1031.54 (53.0%), 1032.54 (13.8%), 1031.53 (5.2%), 1032.54 (2.7%), 1033.54 (2.3%), 1032.54 (2.3%), 1033.54 (1.2%) | |
| Elemental Analysis | C, 57.07; H, 6.84; N, 19.02; O, 17.07 | |
Qhov kev txiav txim ntawmangiotensinamideNyob rau hauv tib neeg lub cev yog tsuas yog paub los ntawm nws cov pharmacological mechanism, uas yog mas manifested nyob rau hauv cov nram qab no yam:
Dilation ntawm peripheral hlab ntsha
Angiotensineamide relaxes cov leeg du ntawm cov hlab ntsha me thiab cov hlab ntsha, uas ua rau txo qis ntawm cov ntaub so ntswg ib puag ncig thiab ua tiav cov txiaj ntsig ntawm dilating peripheral hlab ntsha.
Txo cov ntshav qab zib
Angiotensineamide txo cov hlab plawv tom qab los ntawm kev nce ventricular kawg - diastolic ntim thiab txo qis atrial.
Thiab pulmonary venous pressures, yog li txhim kho cov tsos mob ntawm cov neeg mob uas muaj lub plawv tsis ua hauj lwm ntev thiab txo qhov tshwm sim ntawm mob plawv tsis ua hauj lwm decompensated.
Anti-inflammatory & Txhawb cov zis tso zis
Ntxiv nrog rau qhov cuam tshuam ncaj qha rau cov hlab plawv cov hlab ntsha tau piav qhia saum toj no, angiotensiinamide tau pom tias muaj cov tshuaj tiv thaiv -cov tshuaj tiv thaiv kab mob uas inhibit inflammatory teb. Nws kuj txhawb kev tso zis tawm, uas pab txo cov tsos mob xws li edema los ntawm lub raum kab mob.
Txawm tias cov txiaj ntsig no,angiotensinamidemuaj qee yam kev mob tshwm sim xws li xeev siab thiab ntuav, mob taub hau thiab kiv taub hau, nrog rau khaus tawv nqaij. Yog li ntawd, thaum siv angiotensineamide, cov neeg mob yuav tsum nruj me ntsis raws li tus kws kho mob cov lus qhia, tsis txhob ua qhov muag tsis pom kev siv tshuaj ntawm lawv tus kheej lossis nce lossis txo cov koob tshuaj kom ntseeg tau tias kev siv tshuaj muaj kev nyab xeeb thiab zoo.
Angiotensinamide yog ib qho tshuaj tiv thaiv hypertensive uas ua haujlwm kom txo qis ntshav siab los ntawm dilating me me peripheral hlab ntsha thiab txo qis peripheral tsis kam. Nws yog tsuas yog siv nyob rau hauv kev kho mob ntawm hypertonia thiab lub plawv tsis ua hauj lwm.
Mechanism ntawm kev ua
Arterenol yog ib yam tshuaj uas tso tawm los ntawm cov qog adrenal, uas yog tsim los ntawm ob lub raum thiab tso rau hauv cov ntshav. Nws tuaj yeem txhawb kev tso tawm ntawm norepinephrine los ntawm sympathetic paj endings thiab qhib AT2 receptors ntawm endothelial hlwb, yog li ua rau cov leeg nqaij contraction thiab sodium retention, ua rau generalized edema thiab sab laug ventricular hypertrophy lossis o, thiab lwm yam. Yog li ntawd, inhibition ntawm arterenol tuaj yeem txo cov tsos mob saum toj no.
Cov lus qhia
Nws yog tsim rau cov neeg mob uas muaj ntau hom thawj thiab theem nrab hypertonia, nrog rau cov neeg laus hypertonia, yooj yim systolic hypertonia, mob me thiab hnyav hypertonia, refractory hypertonia, hypertensive syndrome ntawm cev xeeb tub, hypertonia tshwm sim los ntawm pheochromocytoma, thiab lwm yam. Nws kuj tseem zoo dua rau cov neeg mob hypertonia nrog rau cov kab mob plawv.
daim ntawv thov teb
Cov kev siv tseem ceeb ntawm qhov no yog raws li hauv qab no:
Kev kho mob ntshav siab
Metric Roller Chain Sprocket txo cov zawv zawg kev sib txhuam ntawm cov saw thiab cov sprocket, txo lub zog poob, thiab tseem txhim kho kev sib kis tau zoo.angiotensiinamide yog ib hom tshuaj tiv thaiv hypertensive uas feem ntau yog siv los txo qis ntshav siab. Nws yog qhia rau cov neeg mob uas muaj ntau hom thawj thiab theem nrab hypertonia, suav nrog cov neeg laus hypertonia, yooj yim systolic hypertonia, mob me thiab hnyav hypertonia, refractory hypertonia, thiab hypertensive syndrome ntawm cev xeeb tub.
Nws kuj tseem siv tau rau cov neeg mob ntshav siab nrog cov kab mob plawv, xws li kab mob plawv atherosclerotic, mob myocardial infarction, mob plawv tsis ua hauj lwm, thiab aortic stenosis.
Kev kho mob plawv
Angiotensineamide tuaj yeem siv los kho lub plawv tsis ua haujlwm thiab txo qhov tsis xis nyob ntawm cov neeg mob. Nws tuaj yeem txhim kho cov tsos mob hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev los ntawm kev txo qis ntshav qab zib thiab txo qhov tshwm sim ntawm mob plawv decompensated tsis ua haujlwm.
Lwm Cov Kab Mob Ntshav Qab Zib
Angiotennsinamide kuj tseem ua lub luag haujlwm hauv kev kho mob ntawm lwm cov kab mob plawv,
Xws li mob nephritic syndrome. Txij li thaum lub pathogenesis ntawm tus kab mob no muaj feem xyuam rau kev tuav ntawm sodium thiab dej nyob rau hauv lub cev txoj kev, angiotensiinamide txo urinary protein thiab tswj qhov pib thiab kev loj hlob ntawm edema.Lub synthesis kauj ruam ntawm angiotensiinamide feem ntau koom nrog complex tshuaj tiv thaiv thiab purification txheej txheem. Lub synthesis ntawm nws los yog nws cov analogues koom nrog cov txheej txheem synthesis, nrog rau kev sib xyaw ua ke ntawm cov amino acids, kev taw qhia thiab tshem tawm cov pab pawg tiv thaiv, thiab cov kauj ruam ua kom huv. Cov kauj ruam no yuav tsum tau ua raws li kev tswj hwm nruj kom ntseeg tau tias cov khoom tsim thiab kev ua haujlwm.
analogues ntawm angiotensinamine
Cov analogues tseem ceeb ntawm angiotensinamine muaj xws li angiotensin -hloov enzyme inhibitors (ACE inhibitors) thiab angiotensin receptor blockers (ARBs).
Angiotensin -hloov enzyme inhibitors (ACE inhibitors)
ACE inhibitors yog ib hom tshuaj uas inhibit qhov kev ua ntawm angiotensin -hloov enzyme, yog li thaiv kev tsim cov arterenol. Cov tshuaj no tau siv dav hauv kev kho mob hypertonia thiab lub plawv tsis ua haujlwm. Feem ntau ACE inhibitors suav nrog captopril, enalapril thiab ramipril. Lawv dilates cov hlab ntsha, txo cov ntshav siab, thiab txhim kho lub plawv ua haujlwm los ntawm kev txo qis cov qib arterenol.
Angiotensin receptor blockers (ARBs)
ARBs yog ib chav kawm ntawm cov tshuaj uas xaiv los thaiv kev khi ntawm arterenol rau nws cov receptor.
Lawv siv cov tshuaj tiv thaiv kab mob plawv thiab cov hlab plawv tiv thaiv los ntawm kev thaiv qhov kev txiav txim ntawm arterenol.Cov ARBs muaj xws li chlorosartan, valsartan, irbesartan, thiab lwm yam. ARBs tau siv dav hauv kev kho mob hypertonia, plawv tsis ua haujlwm, thiab kab mob raum.Cov analogs no qhia qee qhov zoo sib xws nrog cov tshuaj angiotensiinulating exacerbation ntawm ob qho tib si hauv lawv cov kev ua haujlwm. angiotensin system. Txawm li cas los xij, lawv tuaj yeem sib txawv hauv cov khoom siv tshuaj lom neeg, cov khoom siv tshuaj pharmacodynamic thiab cov lus qhia. Yog li ntawd, kev xaiv ntawm kev siv cov tshuaj no yuav tsum yog raws li cov kev mob tshwj xeeb ntawm tus neeg mob thiab cov lus qhia ntawm tus kws kho mob.
Kev phiv tshuaj
Angiotensinamide, uas yog ib qho analog ntawm arterenol, plays lub luag haujlwm tseem ceeb hauv tib neeg lub cev kev tswj hwm. Nws tsuas yog ua rau cov receptors hauv vascular du nqaij, adrenal cortex zona glomerulosa hlwb, thiab lwm qhov chaw, ua rau lub cev muaj zog xws li vascular constriction thiab nce aldosterone secretion, yog li tswj cov txheej txheem tseem ceeb hauv lub cev xws li cov hlab ntsha siab thiab dej ntsev sib npaug. Hauv kev kho mob, angiotensinaemide tau siv rau kev kho mob ntawm cov kab mob ntsig txog kev tswj ntshav siab thiab ua cov tshuaj vasopressor thaum muaj xwm txheej ceev xws li kev poob siab.Nws kuj tseem siv rau hauv kev sim ntawm lub cev los tshawb txog kev ua haujlwm ntawm angiotensin system.
Txawm li cas los xij, zoo li lwm yam tshuaj, Angiotransinamide kuj tseem tuaj yeem ua rau muaj kev cuam tshuam tsis zoo thaum siv, uas tsis tsuas yog cuam tshuam rau kev kho mob tab sis kuj ua rau muaj kev hem thawj rau tus neeg mob. Cov tshuaj yuav ua rau lub plab hnyuv mucosa, ua rau cov leeg nqaij du thiab ua rau xeev siab. Nyob rau tib lub sijhawm, tshuaj -induced arterial pressure elevation thiab sympathetic nervous system excitation tuaj yeem cuam tshuam rau kev tswj hwm ntawm lub plab zom mov, ua rau lub plab tsis zoo, ua rau cov tsos mob xeev siab, thiab ua rau ntuav.
Core Efficiency Enhancement Mechanism
Angiotransinamide tsim cov kev mob zoo rau cov tshuaj khomob kom ua rau lawv cov teebmeem los ntawm ntau theem los ntawm kev tsom mus rau vascular system ntawm cov qog nqaij hlav, tshwm sim hauv ob yam hauv qab no:
Xaiv constriction ntawm peripheral hlab ntsha nyob rau hauv cov qog kom optimize cov ntshav muab faib nyob rau hauv lub zos:
Angiotenanamide tuaj yeem ua tshwj xeeb ua rau cov hlab ntsha tsis zoo nyob ib puag ncig cov qog nqaij hlav, ua rau muaj kev nruj me ntsis thiab txo qis cov tshuaj siv tshuaj khomob hauv thaj tsam ntawm cov ntaub so ntswg. Nyob rau tib lub sijhawm, nws qhia cov kws khomob cov tshuaj kom sib sau ua ke hauv qhov chaw tseem ceeb ntawm cov qog, kom tsis txhob muaj kev faib tawm tsis sib xws los ntawm cov hlab ntsha thiab ua kom ntseeg tau tias txhua qhov chaw ntawm cov qog nqaij hlav tuaj yeem sib cuag nrog cov tshuaj muaj txiaj ntsig zoo.
Txhim kho cov qog nqaij hlav cov ntshav khiav thiab ua kom cov khoom sib xyaw hauv zos ntawm cov tshuaj chemotherapy:
Nws cov nyhuv vasoconstrictive tuaj yeem tswj hwm cov hemodynamics ntawm cov qog nqaij hlav, ua kom cov ntshav ntws ntawm cov qog nqaij hlav tsis muaj kev cuam tshuam cov ntaub so ntswg cov ntshav, tso cai rau ntau cov tshuaj kho mob mus txog qhov chaw qog los ntawm cov ntshav ncig thiab nyob twj ywm, ua rau muaj kev nce siab ntawm cov tshuaj khomob hauv cov qog nqaij hlav thiab txhim kho kev tua cov tshuaj ntawm cov qog hlwb.
Muaj feem xyuam rau hom qog nqaij hlav thiab kev siv tshuaj khomob ua ke
Cov nyhuv synergistic ntawm angiotensiinamide feem ntau yog siv rau ntau yam qog nqaij hlav, sawv cev los ntawm kev mob plab hnyuv. Thaum ua ke nrog cov tshuaj siv tshuaj khomob feem ntau, nws tuaj yeem txhim kho kev kho mob zoo. Cov kev faib tshwj xeeb yog raws li nram no:
Gastric mob cancer:
Raws li qhov kev siv tshuaj kho mob ntau tshaj plaws, angiotensineamide feem ntau yog siv ua ke nrog thawj - cov tshuaj siv tshuaj kho mob xws li doxorubicin thiab fluorouracil, tshwj xeeb tshaj yog rau cov neeg mob qog noj ntshav siab. Nws tuaj yeem txhim kho cov permeability ntawm cov tshuaj chemotherapy nyob rau hauv cov ntaub so ntswg mob qog noj ntshav, txo cov qog ua haujlwm, thiab txhim kho cov qog nqaij hlav thiab cov nqi kho mob.
Lwm cov qog nqaij hlav:
Ntxiv nrog rau kev mob qog noj ntshav, nws tseem tuaj yeem siv rau kev kho mob ntxiv rau kev kho mob qog noj ntshav, mob qog nqaij hlav pancreatic thiab lwm yam qog nqaij hlav. Nrog rau cov kev siv tshuaj khomob sib xws (xws li mob qog noj ntshav hauv plab ua ke nrog oxaliplatin + fluorouracil), nws tuaj yeem txhim kho kev tiv thaiv - qog cov nyhuv ntawm kws khomob los ntawm kev txhim kho cov tshuaj hauv zos ntawm cov qog.
Cov ntaub ntawv
Paiva TB, Paiva AC. Qee cov tshuaj pharmacological ntawm hluavtaws analogues ntawm Angiotensinemide. Br J Pharmacol Chemother. 1960;15(4):557-560. doi: 10.1111/j.1476-5381.1960.tb00281.x.
Khairallah PA, Page IH. Angiotensinemide tachyphylaxis thiab nws qhov thim rov qab. Phau Ntawv Qhia . 1965; 17(3): 249-255. doi: 10.1161/01.RES.17.3.249.
Chipens GI, Klusha VE, Kimenis AA. Angiotensinemide - Lub siab - tus neeg ua haujlwm pressor. Pharm Chem J. 1976;10(8):1127-1129. doi: 10.1007/BF00757445.
Saleem A, Ward PE. Lub luag haujlwm ntawm aminopeptidase kev ua haujlwm hauv kev tswj hwm ntawm cov haujlwm pressor ntawm circulating Angiotensinemide. J Pharmacol Exp Ther. 1989;252(2:526-531. PIB: 29144233.
Belmonte C, Nichols J, et al. TFOS DEWS II qhov mob thiab kev xav. Ocul Surf. 2017;15(3):435-474. doi: 10.1016/j.jtos.2017.05.002 (cited for Angiotensinemide-related vasoactive mechanisms in ocular tissues).
FAQ
Angiotensinemide qhia tau hais tias zoo solubility nyob rau hauv aqueous tov thiab polar solvents, nrog ruaj khov zog nyob rau hauv qis kub thiab qhuav ib puag ncig. Nws yog rhiab heev rau qhov kub thiab txias, lub teeb muaj zog thiab pH huab cua, uas yuav yooj yim ua rau cov txheej txheem denaturation thiab poob ntawm lom lom. Nws yuav tsum tau muab khaws cia rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm qhov kub thiab txias kom lav tau ntev - lub sijhawm ruaj khov thiab muaj zog lom.
Angiotensinemide yog siv dav hauv kev tshawb fawb tshuaj, kev tshawb fawb txog kev mob plawv, thiab kev tshuaj ntsuam xyuas tshuaj. Nws tuaj yeem siv los cawm thiab pab kho cov kev poob siab hypotensive, thiab tseem ua haujlwm raws li cov qauv siv tshuaj rau kev tshawb nrhiav cov kev cai lij choj ntawm cov hlab ntsha siab thiab cov hlab ntshav. Tsis tas li ntawd, nws yog feem ntau siv hauv kev sim ua qauv rau hypertonia thiab vascular kev tshawb fawb ntawm lub cev.
Angiotensinemide feem ntau ua rau vascular du leeg thiab cov ntaub so ntswg adrenal. Nws tuaj yeem cuam tshuam vasoconstriction, nce peripheral vascular tsis kam, thiab nce cov hlab ntsha siab. Lub caij no, nws tswj kev tso tawm ntawm aldosterone, tswj dej thiab electrolyte tshuav nyiaj li cas hauv lub cev, thiab koom nrog kev hloov kho ntawm renin-angiotensin system kom ruaj khov circulatory homeostasis.
Angiotensinemide yog ib qho tshuaj lom neeg muaj zog polypeptide compound nrog cov tshuaj lom neeg ruaj khov thiab cov khoom siv tshuaj ntshiab. Raws li ib tug hluavtaws analogue ntawm angiotensin, nws nta ib tug tshwj xeeb amino acid ib theem zuj zus thiab belongs rau cov chav kawm tseem ceeb ntawm cov hlab plawv modulating. Nws yog feem ntau muab los ua kws tshuaj - qib dawb hmoov rau kev tshawb fawb thiab kev siv tshuaj raw khoom, nrog rau cov qauv molecular muaj pes tsawg leeg thiab siab purity.
Cim npe nrov: angiotensinamide cas 53-73-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom