Vapreotide CAS 10322-11-3

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm Vapreotide CAS 10322-11-3 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale tej siab zoo vapreotide CAS 103222-11-3 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Vapreotide, tshuaj lom neeg npe D - Phenyylalanyl - l {}} l {{4 4 4 4 phenylalany l - d {}}} tryptophl {} l} l {{l {10 10} {peb Acetate Lev Hydrate (C57H70n12N12O9S2HS2HS2KO), CAS 10322-11-3. Nws muaj ntau amino acid seem thiab ib qho acetate molecule, thiab tej zaum yuav muaj nyob rau hauv daim ntawv ntawm hydrates. Nws tus txheeb ze lub cev hnyav yog 1257.5 da. Nws yog dawb lossis yuav luag dawb cov hmoov zoo, qee zaum kuj tseem nyob hauv lub teeb xim daj xim. Tus nqi pH muaj qhov cuam tshuam tseem ceeb ntawm nws cov tshuaj lom neeg thiab kev ua haujlwm biological. Nws muaj cov solubility siab hauv dej, methanol, thiab ethanol, thiab solubility yog tsawg hauv cov kuab tshuaj organic xws li chloroform, benzene, thiab dichhloromethane. Nws yog ruaj khov nyob rau hauv acidic tej yam kev mob (ph<3), but slowly decomposes under alkaline conditions (pH>10). Nws yog ib somatostatin analogue siv los kho cov qog neuroendocrine thiab lwm yam endocrine cuam tshuam.

Cov qauv no cuam tshuam rau txoj kev npajVapreotideteej tug rau ntawm thaj teb ntawm tshuaj schthesis. Vasropril yog ib lub phuatiologically nquag pentapeide compound uas tuaj yeem siv los kho cov mob hnyuv kuj xws li crohn's kab mob. Kab lus no muab txoj kev rau kev npaj cov tshuaj tiv thaiv, uas yooj yim rau kev ua haujlwm, muaj cov roj raw yooj yim, thiab muaj txiaj ntsig zoo, thiab muaj txiaj ntsig zoo thiab muaj nuj nqis zoo thiab muaj nuj nqis.

Ib txoj kev rau kev npaj cov tshuaj tiv thaiv, suav nrog cov kauj ruam hauv qab no:

(1) Rink Andide resin nrog HMpta kom tau HMpta kho Rink Andide Resin;

(2) Ua rau cov HMPTA kho Rink Andide Resin tau txais hauv Kauj Ruam (1) nrog rau cov khoom siv Tetrafuorobore kom tau txais cov khoom- theem synthes;

(3) Ua cov tshuaj tiv thaiv oxidation ntawm cov tawv -}}}}}}}} theem synthemes;

(4) Ua cov tshuaj tiv thaiv ntawm oxidized cov khoom {}}}}}}}}}}} kom tau cov khoom lag luam uas muaj valproide;

(5) Ua tsis txaus siab, kev cia siab, thiab kev kho kom zoo nkauj ntawm cov khoom lag luam nyoos tau nyob hauv kauj ruam (4) kom tau txais cov khoom lag luamVapreotide.

Hauv kauj ruam (1), cov tshuaj tiv thaiv ntawm Rink Andide Resin thiab HMTa yog raws li hauv qab no: kho nrog piperidine hauv aqueous DMF kev daws teeb meem. Los ntawm kev txiav txim ntawm piperidine, cov tertiary amine pawg ntawm rink

Hauv kauj ruam (2), cov tshuaj tiv thaiv ntawm Tetrafruoroborore kev daws teeb meem yog raws li hauv qab no, cov tshuaj tiv thaiv yog ua kom haum ntawm methanol, acetoniturile, thiab dej. Nyob rau theem no, Tetrafuoroborate ntawm Aminophlenylacetylene yog condensed nrog cov carboxyl pawg ntawm rinin amide resin mus rau lub cob, sib sau} theem synthemes.

Hauv kauj ruam (3), cov tshuaj tiv thaiv oxidation muaj raws li hauv qab no: Cov tshuaj tiv thaiv yog nqa tawm hauv kev sib xyaw ntawm methanol, acetoniturile, thiab dej. Hauv cov kauj ruam no, cov pab pawg iine hauv cov khoom {2} ecase oxidized synroctiate yog oxidized rau cov pa oxidized {}} theem synthemes. Kev tshuaj lom neeg tshwj xeeb yog raws li hauv qab no:

Rink - nh - l ch - CO^- + I₂+ Naoh → rink - nh -}} npib + nai + h₂O

Hauv kauj ruam (4), cov tshuaj tiv thaiv kab tawg tau raws li hauv qab no: Cov tshuaj tiv thaiv yog nqa tawm hauv kev sib xyaw ntawm methanol, acetoniturile, thiab dej. Nyob rau theem no, oxidized cov khoom-} theem synthes synlingiate yog siv tshuaj tua me me los ntawm kev siv cov khoom lag luam ntawm Valproide. Kev tshuaj lom neeg tshwj xeeb yog raws li hauv qab no:

Rink - nh-}}}}}}- COoh

Hauv kauj ruam (5), kev tsis muaj kev cia siab, kev kho kom zoo nkauj yog raws li hauv qab no: Siv TRifluoroacetic acid los tshem tawm cov pab pawg BIc tiv thaiv cov amino pab pawg; Tshem cov ion impurities los ntawm cov tshuaj tiv thaiv kev siv ion txauv resin; Siv cov pa roj carbon rau kev txiav tawm. Los ntawm cov kauj ruam no, lub siab- Cov khoom lag luam purity hom, txhaj tshuaj tiv thaiv, tuaj yeem tau txais. Kev tshuaj lom neeg tshwj xeeb yog raws li hauv qab no:

Tsis pub tiv thaiv:

Rink - nh - ch₂C (ch₃)₃+ CF₃Cooh → rink - nh - ch₂Ch=CHCOOH + CH₃Cooh + CO₂+H₂O

Desalination thiab decolorization: nws tsis koom nrog kev ua kom muaj kuab lom thiab ua kom tshem tawm cov tshuaj tiv thaiv thiab ua kom zoo dua qub, txhim kho cov tshuaj huv thiab cov tsos zoo ntawm cov khoom.

Txoj kev no muaj cov txiaj ntsig hauv qab no: yooj yim kev ua haujlwm, cov khoom siv tsis yooj yim, cov nqi tsawg, thiab cov txiaj ntsig tau tsawg, thiab muaj txiaj ntsig zoo. Los ntawm kev los txais cov txheej txheem ntawm iodine oxidation ntawm linear Valroproide Resin hauv cov khoom ua kua dej, thiab cov khoom tawm los ntawm 10%-20%. Tag nrho cov txiaj ntsig ntawm cov qauv no tuaj yeem ncav cuag 68%, nrog cov neeg nyoos peptide peptide ntawm 85%.

VapreotideYog cov tshuaj siv nrog ntau cov qauv tshuaj, thiab nws cov tshuaj lom neeg ua haujlwm ua rau nws siv tau ntawm kev kho mob. Ntxiv rau kev siv rau kev kho mob ntawm Esophageal vixee hauv cov neeg mob daim siab ualroe, Valrotrhide, Valroproide kuj tseem muaj cov tshuaj lom neeg siv:

Daim ntawv thov hauv cov kab mob system digestive

 

Kev kho mob ntawm mob qog nqaij hlav
Cov kab mob pathogenesis ntawm mob pancreatitis yog theem nrab pancrecic tus kheej lub plab zom vim tias muaj kev sib zog ntawm cov zom zom zom cov zom zom. Somatostatin analogs yog cov muaj zog tshaj plaws pancreatic exocrry in excition,
Kho cov plab zom mov thiab pancreatic fistulas
Somatostatin thiab nws txoj kev sib piv tau inhibit tso tawm thiab tso pa tawm ntawm ntau lub sijhawm cov khoom noj hauv cov hnyuv, thiab txhim kho dej thiab nqus roj thiab txhim kho hluav taws xob. Vaptin tuaj yeem txo cov khoom lag luam nyob ib ncig ntawm lub fistulate qhib los ntawm kev kho tshuab no, ua rau kev kho tus kheej ntawm kev kho mob plab thiab pancreatic fistulas.

Daim ntawv thov hauv cov kab mob endocrine

 

Kho Kev Phaj Liab
Kev liab yog yog cov kev cuam tshuam ntawm kev ua yeeb yam ntawm lub cev, GH) los ntawm cov kabmob pituitary, ua rau muaj kev tsis txaus ntseeg ntawm lub cev thiab sab hauv kev ua kom muaj lub cev tsis sib xws. Gh Adenomas tsuas yog nthuav qhia SSTR2 thiab SSTR5, thiab Vasopressin muaj kev sib raug zoo rau ob qho kev sib tham no. Thaum cov neeg mob tsis haum rau kev phais, Valproide tej zaum yuav yog ib qho uas xav paub cov qog ua kom zoo nkauj thiab rov ua kom cov qog ua kom zoo nkauj, raws li nws muaj peev xwm ua tau ib qib dab tsi ntawm} Kuv thiab GH hauv cov neeg mob.
Kev kho mob ntshav qab zib retinopathy
Photocoagulation yog thawj qhov kev xaiv rau kev kho mob ntshav qab zib retinopathy (DR), tab sis ntshav qab zib muaj kev tiv thaiv kab mob ntshav qab zib Tib neeg retina, tshwj xeeb tshaj yog cov xim epithelium, muaj ntau sst thiab sstr. Cov neeg mob uas muaj cov neeg mob DR thiab DME muaj qis dua ntawm Ischojenesis ntawm Dr thiab Ntshav Barrier kev cuam tshuam cuam tshuam nrog hauv DME pathogenesis. Vaptin yuav tau txais kev tawm dag zog neuresegulatory thiab anti agiogenic cuam tshuam rau lub retina, tiv thaiv kom ntshav thiab tiv thaiv kev ncaj ncees ntawm cov ntshav pawv.

Daim ntawv thov hauv kev kho mob mob

 

SST ua rau peripheral sstr todpress lub cev pom ntawm Nociceptive Stimuli. Cov nyhuv analgesic ntawm SST tuaj yeem ua tiav los ntawm kev cuam tshuam ntawm Capsaicepin gated Ion Raws, thiab Vasopressin tuaj yeem siv rau kev kho mob thaum Opioid cov tshuaj muaj txiaj ntsig. Ntau cov kev tshawb fawb cov kws kho mob tau lees tias qhov system, kev mob siab, thiab mob qog noj ntshav, mob pob txha, mob caj dab, thiab mob plab.

Kev tswj hwm kev tiv thaiv kab mob
Somatostatin thiab nws txoj kev analogues tuaj yeem tswj lub cev tiv thaiv kab mob ntawm lub cev. Lub Vaptin tuaj yeem txhim kho lub cev kev soj ntsuam lub cev thiab kev tshem tawm ntawm cov haujlwm thiab kev tiv thaiv kev tiv thaiv kab mob, pab lub cev paub thiab meej cov qog.

Lub tshuab ntawm cov qog ua si ntawm varpropide

 

Kev tiv thaiv ncaj qha rau cov qog cell proliferation
Vaptin khi rau SSTENY rau Adenylate cyclate thiab inhibits nws cov kev ua si, yog li inhibiting qog cell proliferation. Nyob rau tib lub sijhawm, nws tuaj yeem qhib cov protein phosphatase, inhibit DNA thiab ua rau cov mob qog ntawm lub voj voog ntawm lub voj voog ntawm lub cell, tsis muaj peev xwm txuas ntxiv mus ntxiv.
Inhibit qog angiogenesis
Txoj kev loj hlob thiab metastasis ntawm cov hlav yog nyob ntawm kev tsim cov ntshav tshiab. Vaptin muaj kev cuam tshuam rau ntau yam uas tsim cov qog ntshav, thiab lwm yam ntawm cov qog noj ntshav thiab cov qog nqaij hlav thiab metastasas.

VapreotidePuas yog hluav taws xob cyclic octapecectide nrog lub npe tshuaj lom neeg D - Phenyylalanine - typtine {}}}}}} tryptamide [2-7] disulfide monosuccinate. Nws cov mis molecular yog c₅₇h₇₀n₁₂o₉s₂ thiab nws cov molecular hnyav yog kwv yees li 1131.37. Cov qauv sib xyaw no muaj cov qauv cyclic ruaj khov los ntawm kev cuam tshuam cov ntawv cog lus, tso cai rau nws cov tshuaj lom neeg thiab kev ua si lom neeg.

Hais txog cov khoom siv lub cev, vapreotide yog ib qho dawb rau tawm - Cov txiaj ntsig zoo li ntawm 16-180 degree, thiab ib qho kev kwv yees npau npau txog li 1540.9 degree. Cov yam ntxwv no qhia cov kev sib txuas lus muaj zog thiab muaj cov qauv muaj zog ntawm cov molecule. Hais txog cov dej solubility, vapreotide cov khoom pov thawj zoo solubility, nrog dej daws teeb meem txog li ntawm nws cov kev nqus tau thiab faib rau hauv lub cev.

Nyob rau hauv cov nqe lus ntawm cov qauv kev ruaj ntseg sib txuas, cov qauv cyclic txuas cov cysteine ​​seem (Cys2-Cys2-CYS7) los ntawm kev tsis txaus siab rau kev sib raug zoo thiab kev txwv tsis pub muaj tshuaj lom neeg. Qhov kev ruaj khov no ua rau nws tswj hwm nws cov kev ua haujlwm nquag hauv ob qho tib si hauv Vitro thiab hauv Vivo kev sim, ntev nws lub sijhawm txiav txim. Qhov chaw cia khoom yog nruj, uas yuav tsum muaj kev cia siab nyob rau hauv ib puag ncig vim qhov kub thiab kev sib cav sib ceg lossis cov kev cuam tshuam loj.

Nyob rau hauv cov nqe lus ntawm biological kev ua si, vapreotide, raws li cov hluavtaws hluavtaws ntawm sstrinostatin, ua rau muaj kev sib txuam nrog SSTR2 thiab SSTR5 subtypes ntawm Somatostatin receptors. Nws cov tshuab ntawm kev ua haujlwm suav nrog inhibiting tawm ntawm vasoetactive peptides thiab txo portal venous siab. Nws tau pom tias tseem ceeb ua tau zoo rau kev kho mob mype esophageal vixing los ntshav thiab tiv thaiv kev rov qab los los ntshav tom qab kev kho mob endoscopic. Cov chaw kuaj sim tau lees tias qhov kev tawm tsam sai- tso cai rau kev tiv thaiv hemautic thiab kom tiv thaiv kev mob los ntshav li 5 hnub tom qab phais tas.

Nyob rau hauv cov nqe lus ntawm daim ntawv thov teb, cov tshuaj lom neeg ntawm vapreotide ua nws ib qho cuab yeej zoo tshaj plaws rau kev tshawb fawb txog lub neej. Hauv kev sim kws tshuaj nqa tshuaj, nws yog siv los ua tus qauv peptide rau kev kawm receptor- Mediared signaling txoj kev thiab cov txheej txheem cellular; Hauv kev ntsuas molecular kev ntsuas, nws txoj kev tswj hwm ntawm tes - theem kev ua haujlwm pab txhawm rau kawm cov kab mob tshwm sim thiab kev txhim kho. Ntxiv mus, vapreotide tuaj yeem ua ke nrog cov qauv tshuaj fluorescent los muab cov kev tshawb nrhiav venro, txuas ntxiv nthuav nws cov ntawv thov hauv kev tshawb fawb tshawb fawb.

Cim npe nrov: Vapreotide CAS 10322-11-3, Chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, rau muag