Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub tshaj plaws thiab cov neeg muag khoom ntawm ath(1-39) cas 12279-41-3 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo zoo acth(1-39) cas 12279-41-3 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
TSI (1-39), tseem hu ua AII antagonist. Nws yog ib qho hluavtaws peptide compound nrog cov qauv tshuaj tsim los ntawm cov saw peptide uas muaj 10 amino acids. Cov tshuaj no tuaj yeem khi rau angiotensin II (AII) receptor thiab thaiv qhov kev txiav txim ntawm AII, yog li nws muaj txiaj ntsig tseem ceeb hauv kev kawm txog kev ua haujlwm ntawm lub cev ntawm AII thiab kev kho mob. Cov molecules muaj cov nqi ntawm cov amino acid residues, yog li lawv muaj qee lub xeev ntawm kev daws teeb meem.
Lub xeev tus nqi no tsis tsuas yog cuam tshuam rau kev sib cuam tshuam ntawm AII antagonist thiab lwm cov molecules, tab sis kuj muaj kev cuam tshuam loj rau nws cov kev faib tawm thiab cov metabolism hauv lub cev. Hauv kev kho mob ntshav qab zib, nws tuaj yeem ua lub luag haujlwm kho mob los ntawm kev txhim kho insulin tsis kam thiab txo cov ntshav qab zib. Hais txog kev puas siab puas ntsws, AII antagonist yuav muaj kev cuam tshuam zoo rau kev puas siab puas ntsws xws li Parkinson's disorder thiab Alzheimer's disorder los ntawm kev tswj cov kev tso tawm thiab kev xa tawm ntawm cov neurotransmitters.
Peb Cov Khoom Muag Khoom
ACTH(1-39)\\Seractide COA
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| Certificate of Analysis | ||
| Compound npe | ACTH(1-39)\\Seractide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 12279-41-3 | |
| Ntau | 33g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090088 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.26% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.77% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib leeg impurity | <0.8% | 0.32% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 337 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 56 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C207H308N56O58S |
| Exact Mass | 4538.26 |
| Molecular Luj | 4541.14 |
| m/z | 4540.27 (100.0%), 4539.26 (89.8%), 4541.27 (52.9%), 4542.27 (40.3%), 4538.26 (40.1%), 4541.27 (20.9%), 4541.26 (20.7%), 4540.26 (18.6%), 4542.27 (11.9%), 4542.27 (11.0%), 4541.27 (10.7%), 4543.28 (8.5%), 4543.27 (8.3%), 4539.26 (8.3%), 4543.28 (8.2%), 4543.27 (6.3%), 4540.26 (4.8%), 4542.26 (4.5%), 4542.27 (4.3%), 4541.26 (4.1%), 4544.28 (3.9%), 4544.28 (2.8%), 4543.27 (2.4%), 4544.27 (1.8%), 4540.26 (1.8%), 4542.26 (1.4%), 4544.28 (1.3%), 4541.26 (1.1%) |
| Elemental Analysis | C, 54.75; H, 6.84; N, 17.27; O, 20.43; S, 0.71 |
Kev tshawb fawb hauv vitro
Keeb kwm
Cov tshuaj no txhawb kev tsim cov corticosteroids (CS) los ntawm cov qog adrenal. Txawm li cas los xij, melanocortin receptors, uasTSI (1-39)tuaj yeem khi rau, kuj tseem muaj nyob rau hauv lub hauv paus paj hlwb (CNS) thiab ntawm lub cev tiv thaiv kab mob.
Kev Tiv Thaiv Neural
Angiotensin II tau pom tias tiv thaiv cov neurons hauv vitro los ntawm ntau yam kev thuam, suav nrog apoptosis, excitotoxicity, thiab o - cuam tshuam txog kev puas tsuaj.
Kev sim teeb tsa
Kev Kho Mob Nruab Nrab (CM) Kev Npaj
Untreated Astroglia (AS) Kab lis kev cai: Conditioned nruab nrab yog npaj los ntawm untreated astroglia kab lis kev cai.
Angiotensin II-Thiab AS Cultures: Astroglia kab lis kev cai raug kho nrog 200 nM angiotensin II rau 24 teev, ntxuav kom tshem tawm cov tshuaj hormones, thiab tom qab ntawd incubated rau lwm 24 teev hauv Dulbecco's Modified Eagle Medium (DMEM).
Oligodendroglia (OL) Viability Assays
Kev sim thawj zaug: OL viability raug soj ntsuam nyob rau hauv lub xub ntiag ntawm txhais nruab nrab nrog 2% cov me nyuam mos calf serum (NCS) los yog astrocyte-conditioned medium (ASCM) npaj nyob rau hauv DMEM tsis muaj ntshav.
Tswj: Hauv kev sim tom ntej, kev tswj hwm muaj xws li OL hauv nruab nrab nruab nrab nrog 2% NCS.
Cov kev tshawb pom tseem ceeb
Tsis muaj qhov sib txawv tseem ceeb hauv OL Viability
Hauv kev sim thawj zaug, tsis muaj qhov sib txawv tau pom hauv OL kev muaj peev xwm thaum kab lis kev cai hauv nruab nrab tau hais tseg nrog 2% NCS piv rau ASCM (npaj hauv DMEM uas tsis muaj ntshav qab zib). Tom qab 24 teev, OL tuag nyob rau hauv txhua tus mob nws txawv ntawm 1 thiab 4%.
Cov txiaj ntsig zoo sib xws nrog Microglia (MG) CM
Cov txiaj ntsig zoo sib xws tau txais thaum siv microglia- nruab nrab nruab nrab (MG CM), qhia tias cov teebmeem tsis yog tshwj xeeb rau astrocytes ib leeg.
Kev cuam tshuam
Cov teebmeem tsis ncaj
Thaum angiotensin II tiv thaiv neurons ncaj qha, txoj kev tshawb fawb qhia tias nws tsis muaj qhov cuam tshuam ncaj qha rau OL kev muaj peev xwm los ntawm astrocyte-qhov nruab nrab. Qhov no txhais tau hais tias qhov kev tiv thaiv ntawm angiotensin II hauv CNS tuaj yeem tshaj tawm hauv cov neurons lossis tuaj yeem koom nrog lwm hom cell lossis cov txheej txheem tsis ncaj qha ntsig txog OL ciaj sia nyob hauv qhov kev sim teeb tsa no.
Lub luag haujlwm ntawm Astrocytes thiab Microglia
Qhov tsis muaj qhov cuam tshuam loj rau OL kev muaj peev xwm nrog ASCM lossis MG CM qhia tias astrocytes thiab microglia yuav tsis yog thawj tus neeg nruab nrab ntawm angiotensin II cov teebmeem neuroprotective ntawm OLs hauv cov ntsiab lus no. Txawm li cas los xij, qhov no tsis txiav txim siab txog lwm yam kev cuam tshuam ncaj qha lossis kev cuam tshuam uas yuav tshwm sim hauv vivo lossis nyob rau hauv kev sim sib txawv.
Kev kho mob plawv
Daim ntawv thov ntawm sericin hauv kev kho mob plawv plawv tau txais kev saib xyuas thiab kev tshawb fawb. Ntxiv nrog rau kev txo qis ntshav siab thiab txhim kho lub plawv ua haujlwm ntawm cov neeg mob plawv tsis ua haujlwm tau hais los saum toj no, sericin kuj tseem muaj txiaj ntsig zoo rau qhov tshwm sim thiab kev loj hlob ntawm atherosclerosis. Atherosclerosis yog lub hauv paus tseem ceeb ntawm kev mob plawv, thiab AII ua lub luag haujlwm tseem ceeb hauv kev tsim cov atherosclerosis. Sericin tuaj yeem cuam tshuam qhov kev loj hlob ntawm atherosclerosis thiab txo qhov kev pheej hmoo ntawm kev mob plawv los ntawm kev tawm tsam lub luag haujlwm ntawm AII.
Kev kho mob raum tsis zoo
Lub raum yog ib qho ntawm lub hom phiaj tseem ceeb ntawm cov kab mob AII, yog li sericin kuj muaj peev xwm siv tau rau hauv kev kho mob raum tsis zoo. Ntxiv nrog rau lub luag haujlwm uas tau hais dhau los ntawm kev tiv thaiv lub raum ua haujlwm thiab ncua kev ua haujlwm ntawm lub raum tsis zoo, Sericin kuj tseem tuaj yeem muaj txiaj ntsig zoo rau kev kho mob raum tshwj xeeb xws li ntshav qab zib nephropathy. Ntshav qab zib nephropathy yog ib qho teeb meem ntawm cov ntshav qab zib. Sericin tuaj yeem txo qhov kev puas tsuaj rau lub raum thiab txhim kho lub raum ua haujlwm los ntawm kev txhim kho cov ntshav qab zib thiab insulin tsis kam hauv cov neeg mob ntshav qab zib.
Kev kho cov kab mob neurological
Nyob rau hauv xyoo tas los no, ntau qhov kev tshawb fawb tau pom tias covTSI (1-39)system kuj plays lub luag haujlwm tseem ceeb hauv cov kab mob neurological. Raws li tus antagonist ntawm AII, sericin tuaj yeem muaj txiaj ntsig zoo rau kev kho mob ntawm cov hlab ntsha. Piv txwv li, hauv kev kho mob ntawm Parkinson's disorder, sericin tuaj yeem txhim kho cov neeg mob uas muaj lub cev tsis zoo thiab cov tsos mob tsis muaj zog los ntawm kev tswj hwm cov haujlwm thiab kev ua haujlwm ntawm dopaminergic neurons. Hauv kev kho mob ntawm Alzheimer's disorder, sericin tuaj yeem txo qhov kev xav tsis zoo thiab kev coj tus cwj pwm txawv txav hauv cov neeg mob los ntawm kev txo qis neuroinflammation thiab txhim kho qhov sib npaug ntawm neurotransmitter.
Kev kho mob ntshav qab zib
Mob ntshav qab zib mellitus yog ib qho mob ntev ntawm cov kab mob metabolic, uas cuam tshuam nrog kev ua kom tsis zoo ntawm AII system. Sericin tuaj yeem muaj txiaj ntsig zoo rau kev kho mob ntshav qab zib los ntawm inhibiting cov nyhuv ntawm AII, txhim kho insulin tsis kam thiab txo cov ntshav qab zib. Tsis tas li ntawd, sericin kuj tseem muaj kev tiv thaiv thiab kho cov teeb meem ntawm cov mob ntshav qab zib, xws li mob plawv, mob raum, thiab lwm yam.
Kev kho mob qog
Nyob rau hauv xyoo tas los no, kev tshawb fawb tau pom tias AII system tseem ua lub luag haujlwm tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm cov qog. Raws li tus antagonist ntawm AII, sericin tuaj yeem muaj txiaj ntsig zoo rau kev kho cov qog. Qee qhov kev tshawb fawb tau pom tias sericin tuaj yeem cuam tshuam kev loj hlob thiab kev tsiv teb tsaws ntawm cov qog hlwb, txhawb kev apoptosis ntawm cov qog hlwb, thiab yog li siv los tiv thaiv - qog nqaij hlav. Txawm li cas los xij, kev tshawb fawb hauv daim teb no tseem nyob rau theem pib thiab xav tau ntxiv hauv - tshawb nrhiav qhov tob.
Lwm yam kev siv muaj peev xwm
Ntxiv nrog rau cov ntawv thov uas tau hais los saum toj no, sericin kuj tseem muaj lwm yam txiaj ntsig ntawm daim ntawv thov. Piv txwv li, hauv kev kho cov kab mob hauv lub cev tsis zoo, sericin tuaj yeem siv tshuaj kho mob ntawm cov kab mob autoimmune xws li mob caj dab rheumatoid thiab kab mob lupus erythematosus los ntawm kev tswj hwm kev ua haujlwm thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob. Tsis tas li ntawd, sericin kuj tseem muaj txiaj ntsig zoo rau lwm yam kab mob ntev xws li pob txha thiab rog.
Regulatory Effect on Glucose Metabolism
Raws li 39-amino-acid adrenocorticotropic hormone secreted los ntawm pituitary caj pas, angiotensin II indirectly dominates qhov sib npaug ntawm cov kab mob hauv nruab nrog cev los ntawm activating lub hypothalamic -pituitary-adrenal axis. Nws nkoos lub adrenal cortex rau secrete glucocorticoids, markedly activates hepatic gluconeogenesis txoj kev, thiab accelerates kev hloov ntawm tsis-carbohydrate tshuaj xws li amino acids thiab glycerol rau hauv qabzib.
Lub caij no, nws inhibits kev nkag mus thiab siv cov piam thaj peripheral los ntawm cov leeg pob txha thiab cov ntaub so ntswg adipose, txo cov insulin -kev noj qab haus huv nruab nrab, thiab ua kom cov ntshav qabzib nce siab.
Nyob rau hauv lub zog- tsis muaj zog xws li kev ntxhov siab thiab kev tshaib kev nqhis, qhov tso tawm ntawm angiotensin II raug kho. Nws tswj cov ntshav qabzib ruaj khov los ntawm cov txheej txheem saum toj no, ua kom cov khoom siv hluav taws xob yooj yim rau cov khoom nruab nrog cev nrog rau lub hlwb thiab lub plawv, thiab tiv thaiv kev puas tsuaj rau hypoglycemic. angiotensin II ua haujlwm raws li kev tswj hwm tseem ceeb hauv kev tswj hwm lub zog thaum muaj xwm txheej ceev ntawm tib neeg lub cev.
pharmacokinetic zog
AII antagonist feem ntau yog tsim nyob rau hauv anterior pituitary caj pas nyob rau hauv cov lus teb rau kev ntxhov siab, raws li stimulation los ntawm corticotropin - tso cov tshuaj hormones (CRH) los ntawm hypothalamus. Qhov no 39-amino acid peptide hormone qhia txog cov tshuaj pharmacokinetic tshwj xeeb.
Thaum tso zis, nws nkag mus rau hauv cov hlab ntsha sai thiab nkag mus rau cov ntaub so ntswg. Nws lub luag haujlwm tseem ceeb yog txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau zais cov tshuaj steroid, tshwj xeeb yog glucocorticoids xws li cortisol. Qhov kev txhawb nqa no tshwm sim los ntawm kev khi rau AII antagonist receptors (ACTH-R) ntawm adrenal cortical hlwb.
Pharmacokinetics muaj xws li nws nqus, faib, metabolism, thiab excretion. Txawm hais tias cov tshuaj pharmacokinetic tshwj xeeb xws li ntshav ib nrab- lub neej yuav txawv nyob ntawm tus kheej yam thiab cov kev sim, nws feem ntau suav hais tias muaj lub sijhawm luv luv ntawm kev ua haujlwm, yuav tsum tau ua haujlwm tsis tu ncua rau cov teebmeem kev kho mob.
Cov metabolism cuam tshuam nrog enzymatic degradation, feem ntau hauv daim siab thiab ob lub raum, ua rau tshem tawm nws daim ntawv nquag ntawm lub cev. Excretion feem ntau tshwm sim los ntawm txoj kev raum.
Kev Tshawb Fawb Kev Tshawb Fawb
Kab mob Modeling nyob rau hauv nas: Los ntawm kev hloov pauvTSI (1-39)qib hauv cov tsiaj sim xws li nas, cov kws tshawb fawb tuaj yeem ua raws li ntau yam tib neeg kev tsis sib haum xeeb, xws li Cushing's syndrome thiab Addison's disorder. Qhov no tso cai rau kev tshawb nrhiav cov txheej txheem hauv qab thiab cov kev kho mob uas muaj peev xwm.
Cov xwm txheej tshwj xeeb: Piv txwv li, cov kev tshawb fawb tau pom tias nce qib AII antagonist tuaj yeem ua rau hypercortisolism hauv nas, ua rau Cushing's syndrome. Hloov pauv, txo qis tuaj yeem ua rau hypoadrenalism, zoo li Addison tus kab mob.
Kev sib tham nrog Receptors: Kev tshawb fawb txog kev sib cuam tshuam ntawm AII antagonist thiab nws cov receptors, tshwj xeeb tshaj yog cov melanocortin 2 receptor (MC2R), muab kev nkag siab rau nws txoj kev ua kom muaj zog. Qhov kev nkag siab no yog qhov tseem ceeb rau kev tsim cov tshuaj tsom.
Teeb liab Transduction Mechanisms: AII antagonist khi rau MC2R ntawm qhov chaw ntawm adrenal cortical hlwb, ua kom lub cAMP-PKA teeb liab txoj hauv kev. Qhov no, nyob rau hauv lem, txhawb kev hloov ntawm cov cholesterol mus rau cortisol.
Physiological Education
Cov cuab yeej qhia: AII antagonist ua ib qho piv txwv qhia zoo los pab cov tub ntxhais kawm nkag siab tias cov kab mob endocrine ua haujlwm li cas thiab cov tshuaj hormones cuam tshuam rau tag nrho lub cev.
Kev Tshawb Fawb Kev Kawm: Cov kev tshawb fawb tau siv AII antagonist los ua kom pom qhov hypothalamic -pituitary-adrenal (HPA) axis muaj nuj nqi thiab nws lub luag haujlwm hauv kev ntxhov siab thiab kev tswj cov metabolism.
Central Nervous System Kev Tshawb Fawb
Kev faib tawm ntawm Immunoreactive Neurons: Kev tshawb fawb Immunohistochemical tau qhia txog kev faib tawm ntawm AII antagonist immunoreactive neurons hauv tib neeg hypothalamus. Cov neurons no muaj nyob hauv thaj tsam xws li infundibular nucleus, paraventricular nucleus, thiab supraoptic nucleus.
Ua haujlwm hauv CNS: AII antagonist kuj tau pom tias muaj kev cuam tshuam rau cov neurons thiab lub cev tiv thaiv kab mob hauv nruab nrab paj hlwb, koom nrog hauv kev tiv thaiv kab mob thiab kev tiv thaiv kab mob.
nrhiav & kev loj hlob
Cov qauv tshuaj ntawm ACTH tau pom thawj zaug ntawm cov tshuaj hormones ntawm pituitary anterior lobe los ntawm American biochemist PH Bell nyob rau hauv 1954. ACTH tau pom los ua lub luag haujlwm tseem ceeb hauv stimulating adrenal cortex rau synthesize thiab secrete glucocorticoids, xws li cortisol.
Nyob rau xyoo 1960, ntau tus kws tshawb fawb biochemical, suav nrog K. Hofmann, Li Zhuohao, thiab E. Scharrer, tau tshaj tawm txog kev ua tiav ntawm ACTH. Qhov kev sib xyaw ua ke no tau tsim lub hauv paus rau kev tshawb nrhiav ntxiv ntawm nws cov haujlwm physiological thiab muaj peev xwm siv tshuaj kho mob.
Thaum lub sijhawm xyoo 1950, ACTH tau lees paub rau nws lub peev xwm los tswj kev mob thiab kev tiv thaiv kab mob los ntawm kev txhawb nqa adrenal cortex kom zais cov tshuaj endogenous glucocorticoids. Nws tau raug siv los kho cov refractory active lupus erythematosus, rheumatoid mob caj dab, thiab lwm yam kab mob collagen. Txawm li cas los xij, nrog rau qhov tshwm sim ntawm cov hluavtaws glucocorticoids, uas tau muab kev yooj yim dua thiab tus nqi - kev xaiv kho tau zoo, ACTH txhaj tshuaj maj mam txo qis ntawm kev siv tshuaj kho mob.
Nyob rau xyoo 1990, nrog rau kev tsim cov noob thiab cov thev naus laus zis, cov kws tshawb fawb soj ntsuam pom tias AII antagonist yog ib tug tswv cuab ntawm tsev neeg melanocortin. Nws tuaj yeem ua kom muaj tsib lub melanocortin receptors (MCRs) faib thoob plaws hauv lub cev, txhawb kev tiv thaiv - mob, tiv thaiv kab mob, pigmentation, thiab lub zog homeostasis.
Tsis ntev los no, AII antagonist tau siv los kho mob gout, uveitis, ntau yam sclerosis, infantile spasms, psoriatic arthritis, pediatric nephropathy, thiab thawj aldosteronism. Nws tau pom tias muaj txiaj ntsig zoo hauv cov neeg mob uas tsis teb zoo rau cov kev kho mob ib txwm muaj lossis muaj contraindications rau glucocorticoids, ua rau muaj kev txaus siab rau kev kho mob hauv AII antagonist raws li lwm txoj kev kho mob rau cov kab mob inflammatory lossis kev tiv thaiv kab mob.
Cim npe nrov: Ath (1-39) CAS 12279-41-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom