Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm fertirelin acetate hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo fertirelin acetate muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Fertirelin Acetateyog ib qho derivative ntawm fertirelin hloov nrog acetate. Nws cov yam ntxwv tseem ceeb nyob rau hauv qhov zoo ntawm cov qauv coj los ntawm kev hloov kho acetate, uas daws tau cov teeb meem ntawm cov dej tsis zoo solubility thiab tsis muaj bioavailability ntawm haiv neeg fertirelin.Nws cov mis molecular yog C₅₅H₇₆N₁₆O₁₂ thiab molecular hnyav yog 12.153. Nws zoo nkaus li hmoov dawb. Kev hloov pauv Acetate ua rau nws cov dej solubility thiab ruaj khov, txhim khu kev nqus hauv lub cev, thiab ua kom nws lub sijhawm ua haujlwm ntev hauv vivo.Raws li cov tshuaj hormonal polypeptide, nws cov peptide sequence yog pGlu-HWSYGLRP-NHEt. Kev taw qhia ntawm acetate tsis hloov nws cov haujlwm tseem ceeb hauv tshuaj. Nws tseem ua los ntawm kev khi rau GnRH receptors nyob rau hauv lub caj pas pituitary los tswj qhov tso tawm ntawm hypothalamic-pituitary-gonadal axis: nws tsim cov kev hloov pauv hloov mus rau theem pib thiab txhawb nqa inhibition ntawm luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH) tso tawm tom qab theem, muaj kev sib deev.
Peb cov khoom Form
Fertirelin acetate COA
 |
||
| Certificate of Analysis | ||
| Compound npe | Fertirelin acetate yog siv | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 66002-66-2 | |
| Ntau | 15g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090051 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |
|
|
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.72% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.51% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib leeg impurity | <0.8% | 0.27% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 93 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 347ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
|
|
||
|
|
||
| Tshuaj Formula | C57H80N16O14 | |
| Exact Mass | 1212.6 | |
| Molecular Luj | 1213.37 | |
| m/z | 1212.60(100.0%), 1213.61(61.6%), 1214.61(18.7%), 1153.58(5.9%), 1154.58(3.5%), 1155.59(2.5%), 1154.59(2.5%), 1155.59(1.5%), 1155.59(1.0%) | |
| Elemental Analysis | C,56.42; H,6.65; N,18.47; O,18.46 | |
Txo cov lus teb Superovulatory
Superovulatory teb yog ib qho kev phiv tshwm sim nyob rau hauv cov kev cai ntawm kev yug me nyuam, tshwj xeeb tshaj yog nyob rau hauv tsiaj yug me nyuam thiab pab reproductive technology (ART) nyob rau hauv tib neeg. Nws yog tshwj xeeb tshaj yog tshwm sim los ntawm ovulation ntau dhau, uas yuav ua rau muaj teeb meem xws li ntau yam cev xeeb tub thiab zes qe menyuam hyperstimulation syndrome (OHSS). Cov xwm txheej zoo li no tsis yog tsuas yog txo qis kev yug me nyuam xwb tab sis kuj tseem tuaj yeem ua rau niam txiv kev noj qab haus huv hauv cov xwm txheej hnyav.
Tau txais txiaj ntsig los ntawm kev ua haujlwm siab pharmacological tau pom zoo los ntawm kev hloov kho acetate,Fertirelin Acetatemuaj peev xwm ua kom tsis txhob muaj ovulation ntau dhau ntawm cov koob tshuaj ntau, ua rau nws yog ib qho tshuaj tseem ceeb hauv cov xwm txheej uas yuav tsum tau muaj kev tswj hwm ntawm ovulation suav. Nws daim ntawv thov feem ntau yog siv rau hauv kev yug tsiaj, thaum nws tseem muaj peev xwm hloov tau rau tib neeg kev yug me nyuam.
Mechanism of Action: Precise Ovulation Regulation based on Acetate Modification
Raws li GnRH analog, cov khoom lag luam muaj cov txheej txheem polypeptide pGlu-HWSYGLRP-NHEt. Kev taw qhia ntawm acetate moiety tsis hloov nws cov haujlwm tseem ceeb ntawm cov tshuaj, tab sis ua kom nws txoj kev sib raug zoo rau pituitary GnRH receptors thiab ua kom nws lub sijhawm ua haujlwm ntev.
Cov txheej txheem tseem ceeb hauv qab qhov inhibition ntawm superovulatory teb yog nws cov kev tswj hwm biphasic:
Ntawm cov koob tshuaj tsawg, nws hloov pauv lub pituitary kom zais luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH), txhawb kev loj hlob ntawm follicular thiab ovulation.
Ntawm cov koob tshuaj ntau nrog kev tswj hwm tas mus li, nws txo qis qhov rhiab heev ntawm pituitary GnRH receptors los ntawm kev tawm tswv yim tsis zoo, txo qis qis qis ntawm LH thiab FSH, yog li inhibiting kev loj hlob thiab ovulation ntawm superfluous follicles thiab ua tiav kev tswj hwm ntawm ovulation tus lej.
Piv nrog rau lwm yam GnRH analogs yam tsis muaj kev hloov kho acetate, cov khoom lag luam qhia qhov zoo sib xws:
Kev hloov pauv acetate txhim kho cov dej solubility, ua kom muaj kev nqus sai tom qab txhaj tshuaj, ua tiav cov txiaj ntsig zoo ntawm cov ntshav plasma, thiab kev txwv lub sijhawm ntawm ovulation ntau dhau.
Txhim khu kev ruaj ntseg ncua nws nyob rau hauv vivo lub sij hawm, tswj kev ruaj ntseg cov teebmeem tsis tas siv ntau zaus, txo qhov kev pheej hmoo ntawm kev tswj tsis tau ovulation vim ncua kev tswj hwm, thiab xyuas kom meej cov kev cai.
Daim Ntawv Thov Tseem Ceeb Scenario: Precise Breeding Regulation in Animal Production
Tam sim no, kev siv cov khoom siv los txo cov lus teb superovulatory feem ntau yog siv rau hauv cov tshuaj kho tsiaj, tshwj xeeb tshaj yog nyob rau hauv loj-loj yug nyuj, yaj thiab lwm yam tsiaj txhu.
Hauv kev ua liaj ua teb hnyav, cov txheej txheem superovulation feem ntau yog siv los txhim kho kev ua haujlwm ntawm cov menyuam. Txawm li cas los xij, ntau dhau ovulation yooj yim ua rau ntau lub cev xeeb tub:
Ntau lub cev xeeb tub hauv nyuj ua rau muaj kev pheej hmoo ntawm dystocia thiab teeb meem kev saib xyuas tom qab yug me nyuam, txo qis tus menyuam txoj sia nyob, thiab yuav ua rau zes qe menyuam puas.
Ntau lub cev xeeb tub hauv ewes tuaj yeem ua rau fetus loj hlob qeeb, tsis txaus tom qab lactation, thiab lwm yam teeb meem, ua rau poob nyiaj txiag ntau.
Cov khoom lag luam zoo daws qhov teeb meem no los ntawm nws cov txiaj ntsig ntawm ovulation-inhibiting nyhuv. Hauv kev xyaum, tom qab kev kho superovulation, cov neeg ua liaj ua teb tswj hwm qhov tsim nyog (feem ntau yog siab) koob tshuaj.Fertirelin AcetateRaws li cov tsiaj nyeg tsiaj, lub cev hnyav thiab kev loj hlob. Nws inhibits kev loj hlob ntxiv thiab ovulation ntawm ntau cov follicles, txwv ovulation mus rau qhov tsim nyog ntau yam (xws li, 1-2 ovulations ib zaug hauv nyuj). Qhov no ua kom muaj kev loj hlob zoo thaum tsis txhob muaj teeb meem cuam tshuam nrog ntau lub cev xeeb tub.
Lub caij no, qhov yooj yim ntawm kev tswj hwm tau them los ntawm kev hloov kho acetate ua rau nws haum rau kev siv loj. Nws tuaj yeem xa tawm sai sai ntawm kev txhaj tshuaj subcutaneous lossis intramuscular, nrog kev ua haujlwm yooj yim thiab pib sai, txo cov nqi zog rau cov neeg yug tsiaj.
Tsis tas li ntawd, cov khoom lag luam kuj tseem ua haujlwm los ntawm kev txo cov lus teb superovulatory hauv kev kho cov kab mob ntawm cov tsiaj yug me nyuam. Piv txwv li, nyob rau hauv nyuj nrog follicular cysts, uas tshwm sim nrog ovulatory ntshawv siab thiab ntau heev estrus, high-dose Fertirelin Acetate inhibits superovulation, tswj lub hypothalamic-pituitary-gonadal axis, txhawb nqa cyst regression, thiab pab rov zoo li qub estrous thiab ovulatory voj voog, ntxiv rau.
Cov kev tshawb fawb cuam tshuam qhia tau hais tias kev cuam tshuam nrog kev siv tshuaj ntau nws txo qhov tshwm sim ntawm cov lus teb superovulatory hauv cov tsiaj nyeg los ntawm ntau dua 60%, txo qis ntau yam kev xeeb tub, thiab ua rau muaj kev noj qab haus huv ntawm niam txiv thiab cov xeeb ntxwv ciaj sia.
Daim ntawv thov kom zoo thiab ceev faj
Nws lub ntsiab zoo yog:
High precision: ovulation naj npawb tuaj yeem tswj tau los ntawm kev kho cov koob tshuaj kom tau raws li qhov yuav tsum tau muaj ntawm cov tsiaj txhu sib txawv.
Kev nyab xeeb siab: Kev hloov pauv acetate ua rau muaj cov metabolism hauv me me hauv vivo, tsis tshua muaj kev pheej hmoo ntawm kev sib xyaw tshuaj lom neeg, kev puas tsuaj tsawg kawg rau cov poj niam cev xeeb tub, thiab kev rov ua haujlwm sai sai tom qab tshem tawm cov tshuaj.
Cov kev ceev faj:
koob tshuaj thiab sij hawm yuav tsum tau tswj nruj me ntsis;
Cov koob tshuaj tsawg dhau tsis ua kom muaj txiaj ntsig zoo inhibition;
Cov koob tshuaj ntau dhau tuaj yeem ua rau ntau dhau ntawm ovulation, ua rau qeeb lossis anovulation.
Kev tswj hwm feem ntau ua tiav 24-48 teev tom qab superovulation, synchronized nrog lub voj voog estrous, kom pom cov nyhuv inhibitory.
Cov koob tshuaj yuav tsum tau hloov kho raws li hom tsiaj, lub cev qhov hnyav, kev yug me nyuam thiab tus kheej sib txawv kom tsis txhob siv qhov muag tsis pom.
Adjuvant Treatment for Human Fertility (Tej zaum Daim Ntawv Thov)
Txawm hais tias cov khoom tam sim no tau pom zoo tsuas yog siv rau cov kws kho tsiaj, raws li GnRH analog, nws cov haujlwm tseem ceeb ntawm cov tshuaj muaj txiaj ntsig zoo ib yam li GnRH-based fertility cov tshuaj hauv tib neeg cov chaw kho mob (xws li triptorelin acetate). Ntxiv mus, qhov zoo ntawm bioavailability tau coj los ntawm kev hloov kho acetate muab nws qhov muaj txiaj ntsig hauv kev pab tib neeg kev ua me nyuam.
Cov kev tshawb fawb ua ntej tau pom tias cov tshuaj tuaj yeem txhawb kev loj hlob ntawm follicular hauv cov poj niam, tshwj xeeb tshaj yog thaum ua ke nrog cov tshuaj xws li estradiol benzoate. Txawm li cas los xij, nws daim ntawv thov tib neeg tseem tsis tau nthuav dav thiab tseem nyob rau hauv kev tshawb fawb thaum ntxov thiab kev soj ntsuam validation theem.
Muaj peev xwm Mechanism: Precise Stimulation and Regulation of Follicular Growth
Hauv kev kho tib neeg fertility, kev loj hlob tsis zoo ntawm follicular thiab ovulatory mob yog qhov ua rau muaj menyuam tsis taus. Clinically, GnRH tshuaj feem ntau yog siv los txhawb kev loj hlob ntawm follicular thiab ovulation los pab txhawb kev xeeb tub.
Lub peev xwm mechanism ntawmFertirelin AcetateNyob rau hauv adjuvant tib neeg fertility kev kho mob yog ze ze rau nws stimulatory nyhuv ntawm nruab nrab thiab tsawg koob tshuaj: Tom qab kev tswj ntawm nruab nrab los yog tsawg koob tshuaj, Fertirelin Acetate khi rau tib neeg pituitary GnRH receptors thiab stimulates lub secretion ntawm LH thiab FSH - cov tshuaj hormones tseem ceeb rau follicular kev loj hlob thiab maturation.
FSH txhawb kev loj hlob ntawm follicular granulosa hlwb thiab txhawb nqa follicular kua secretion, tsav follicular maturation.
LH txhawb nqa follicular rupture thiab ua tiav ovulation.
Piv nrog rau cov qauv GnRH analogs hauv tib neeg cov chaw kho mob, cov khoom lag luam muaj peev xwm zoo vim kev hloov kho acetate:
Cov dej solubility siab dua thiab bioavailability, ua kom nqus tau sai thiab ceev follicular stimulation, shortening lub voj voog txoj kev loj hlob.
Lub sijhawm ua haujlwm ntev dua, tswj cov ntshav plasma ruaj khov thiab zam kev tsis sib xws ntawm kev loj hlob ntawm follicular lossis txawv txav ovulation tshwm sim los ntawm cov tshuaj hloov pauv.
Synergistic li kev loj hlob ntawm follicular thaum ua ke nrog estradiol benzoate:
Estradiol benzoate pab cov tshuaj estrogen los muab qhov chaw zoo endocrine rau folliculogenesis. Ua ke nrog cov khoom, nws ua tau zoo txhim kho follicular maturation thiab ovulation tus nqi, nteg lub hauv paus rau conception.
Kev Tshawb Fawb Txog Thaum Ntxov Kev Tshawb Fawb thiab Kev Txwv Kev Thov
Hauv kev tshawb fawb soj ntsuam thaum ntxov, cov kws tshawb fawb tau tswj hwm qhov nruab nrab-rau-tsawg-dose subcutaneous cov khoom rau cov neeg mob infertile nrog ovulatory ntshawv siab, nrog rau qee tus kuj tau txais estradiol benzoate. Cov txiaj ntsig tau pom muaj kev txhim kho tseem ceeb hauv kev loj hlob ntawm follicular, nce kev loj hlob thiab ovulation tus nqi, thiab tsis muaj kev cuam tshuam tsis zoo rau tib neeg, ua ntej kev pom zoo ntawm kev siv follicular. kev kho mob.
Tsis tas li ntawd, nws yooj yim ntawm kev tswj hwm pab txhawb kev kho mob txhais lus: kev txhaj tshuaj subcutaneous yam tsis muaj cov cuab yeej siv yooj yim tso cai rau kev tswj hwm tus kheej raws li kev qhia kho mob, txhim kho yooj yim heev.
Txawm li cas los xij, ntau qhov kev txwv tam sim no txwv nws txoj kev siv dav hauv tib neeg txoj kev kho fertility:
Cov kev tshawb fawb soj ntsuam tseem nyob rau theem pib, nrog cov qauv me me thiab lub sijhawm luv luv. Cov ntaub ntawv loj loj, cov ntaub ntawv mus sij hawm ntev yuav tsum tau ua kom paub meej txog qhov cuam tshuam ntawm kev xeeb tub, qhov tshwm sim ntawm cev xeeb tub, thiab kev nyab xeeb mus ntev.
Dosage regimens tsis yog tag nrho cov qauv. Cov koob tshuaj zoo tshaj plaws, lub sijhawm, thiab kev sib xyaw ua ke nrog lwm cov tshuaj yuav tsum tau kawm ntxiv thiab ua kom zoo raws li tus neeg mob sib txawv (hnub nyoog, kev ua haujlwm ntawm zes qe menyuam, ua rau muaj menyuam tsis taus, thiab lwm yam).
Cov txheej txheem metabolic thiab koob tshuaj tiv thaiv kev sib raug zoo hauv tib neeg xav tau kev qhia ntxiv kom tsis txhob OHSS thiab ua kom muaj kev nyab xeeb.
Ntau tus paub tab GnRH analogs (xws li triptorelin acetate, leuprorelin acetate) twb tau siv dav hauv kev kho mob. Nws yuav tsum tsim kom muaj qhov tshwj xeeb zoo los ua txhaum los ntawm cov ntawv thov uas twb muaj lawm.
Yav tom ntej Application Prospects
Nrog rau qhov tshwm sim ntawm tib neeg infertility thiab kev xav tau ntau ntxiv rau kev pab cuam kev ua me nyuam technologies, lub neej yav tom ntej ntawm cov khoom raws li qhov muaj peev xwm muaj txiaj ntsig zoo GnRH analog tau cog lus.
Cov lus qhia yav tom ntej muaj xws li:
Ua qhov loj-scale, mus sij hawm ntev soj ntsuam kev sim los tsim kom tau tus qauv, kev nyab xeeb thiab zoo noj cov tshuaj thiab optimize ua ke nrog rau lwm yam fertility agents.
Leveraging acetate hloov kho los tsim cov ntaub ntawv ntau npaum li cas, xws li kev txhaj tshuaj ntev ntev, kom txo tau qhov kev siv ntau zaus thiab txhim kho kev ua raws li tus neeg mob.
Optimizing tus me nyuam txoj kev los txhim kho lub hom phiaj thiab txo cov kab mob endocrine cuam tshuam, ntxiv kev txhim kho kev nyab xeeb.
Kev koom ua ke cov tshuaj precision los tsim cov kev tswj hwm tus kheej raws li cov yam ntxwv ntawm caj ces, kev ua haujlwm ntawm zes qe menyuam thiab qhov sib txawv ntawm tus kheej, ua kom muaj kev tswj hwm kev loj hlob ntawm follicular thiab txhim kho qhov ua tau zoo ntawm kev pab tu me nyuam.
Cim npe nrov: fertirelin acetate, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom