Ganirelix acetatePuas yog hluavtaws bioctive peptide nrog cov molecular cov qauv c80H113446-29-7, thiab tus txheeb ze molecular hnyav ntawm 1570.71 g / mol. Ib tug dawb lossis yuav luag dawb crystalline hmoov. Lub infrared spectrum qhia cov cim ntawm cov yam ntxwv peaks kom paub nws cov qauv molecular. Mas siv rau kev kho kev ntxiv lawm tshob. Nws muaj cov txiaj ntsig dav hauv kev tshawb fawb hauv kev tshawb fawb, tshwj xeeb yog kev tshawb fawb txog kev noj qab haus huv, hauv kev yug vitro, ua ntej yug menyuam, thiab lwm yam kab mob. Nrog rau qhov tob zuj zus ntawm kev tshawb fawb thiab kev txhim kho kev sim khomob, nws cov ntaub ntawv thov yuav muaj dav dav.
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Customized raj yas thiab corks:
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Tshuaj Cov Qauv |
C80H112Cln17o13 |
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Muaj pes tsawg leej |
1554 |
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Molecular hnyav |
1555 |
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m/z |
1554 (100.0%), 1555 (86.5%), 1556 (37.0%), 1556 (32.0%), 1557 (27.7%), 1558 (11.8%), 1557 (10.4%), 1555 (6.3%), 1556 (5.4%), 1559 (3.1%), 1556 (2.7%), 1557 (2.3%), 1557 (2.3%), 1558 (2.2%), 1557 (2.0%), 1558 (1.7%), 1556 (1.1%) |
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Kev Ntsuam Xyuas |
C, 61.78; H, 7.26; Cl, 2.28; N, 15.31; O, 13.37 |
Ganirelix acetateMuaj ntau yam siv hauv kev tshawb fawb txog kev kho mob, thiab cov hauv qab no yog nws qhov tseem ceeb:
1. Kev Tshawb Fawb Kev Customeriver:
Siv los ua kev tawm tsam hauv kev tshawb fawb txog kev ua me nyuam kev noj qab haus huv, feem ntau ua rau muaj kev tso tawm ntawm gonadotropins. Qhov no ua rau cov kws tshawb nrhiav kom tswj tau raws li cov qib kev kuaj mob, yog li nkag siab zoo dua lub cev thiab pathological cov txheej txheem ntawm kev ua me nyuam system. Los ntawm kev siv nws, cov kws tshawb fawb tuaj yeem kawm cov kev cuam tshuam ntawm cov tshuaj hormones ntawm cov txheej txheem xws li cov tshuab hluav taws xob, txuas ntxiv qhia cov haujlwm ua haujlwm ntawm kev ua me nyuam system.
2. IVF Tshuab:
Hauv IVF cov kev pab cuam, nws yog siv los inhibit tso tawm ntawm LutionInizing Hormone, yog li tiv thaiv lub Luteinizing ua kom muaj kev sib xyaw ua ke. Qhov no yog qhov tshwj xeeb tshaj yog rau kev tshawb fawb thiab kev tswj hwm kev tswj kav Ovarian Hindwatulation (Ohss yog feem ntau cuam tshuam nrog ib qib nce hauv Luteinizing cov tshuaj luteinizing. Los ntawm kev siv Ganirelixacetate, cov kws tshawb nrhiav thiab cov kws kho mob tuaj yeem nkag siab zoo xws li ohss, li kev txhim kho tus nqi ua tiav ntawm hauv cov khoom lag luam vitro.
3. Kev Tshawb Nrhiav Thaum Yug Menyuam:
Ntxiv rau nws cov ntawv thov hauv kev ua me nyuam kev noj qab haus huv thiab hauv cov tshuaj vitro fertilization, nws tseem siv nyob rau hauv kev tshawb nrhiav thaum ntxov. Nws cov nyhuv ntawm kev tawm tsam ntawm gonadotropin {}} tso tawm cov kev cog lus kom qeeb qeeb thiab ua kom muaj kev loj hlob ntxiv thiab kev loj hlob ntxiv rau tus me nyuam hauv plab. Qhov no yog qhov tseem ceeb rau kev tshawb fawb thiab kev kho mob ntawm kev yug menyuam ntxov, uas tuaj yeem pab lub neej zoo thiab kev noj qab haus huv ntawm cov menyuam mos.
Cov Lus Qhia Yooj Yim
Acetic acid ganrelic yog cov hluavtaws peptide nrog cov kev ua si ntawm kev tawm tsam kev tawm tsam ib txwm muaj tshwm sim Gonadotropin {}} tso cov tshuaj hormones (GNRH). Nws cov tshuaj lom neeg lub npe yog n- acetyl -}}} naphthalene) - D - Alanyl {13 {-}}}}} pyridine) - D - Alanyl {}} l {}}}}}}}}}}}}}}}}}}}}}}}}} [bis (ethylenemethylene)]- D - l-l-leucyl-n6- [bis (ethelenemethylene)] - L-LYSINYL-L-PROLLAR-D-PROPANMIDE ACETTATE. Acetic Acid Ganeric txhaj yog qhov kev daws teeb meem tsis muaj kob uas muaj xim tsis muaj xim, feem ntau nrog 0.5ml: 0.25mg (suav nrog Ganeric).
Lub tsev loj ntawm kev nqis tes ua
Acetic acid ganrelic is a GnRH antagonist that competitively blocks the gonadotropin-releasing hormone (GnRH) receptor on pituitary gonadotropic cells and subsequent transduction pathways. Nws ua rau muaj kev tiv thaiv sai thiab thim rov qab inhibitory nyhuv ntawm cov kev zais ntawm gonadotropins. Cov txheej txheem no ntawm kev ua tau zoo nyob rau hauv cov teebmeem tseem ceeb thiab chaw soj ntsuam muaj txiaj ntsig ntawm acetic acid ganciclovir ua ntej thiab tom qab poj niam Ivf qe muab rov qab.
Ntau yam kev siv hauv kev tshawb fawb kho mob
1. Tiv thaiv ua ntej pib ntawm Luteinizing Hormone (LH) Peak
Ntawm cov poj niam tau txais tswj lub zes qe menyuam xob txhawb (cos), acetic acid ganciclovir yog siv los tiv thaiv kom tsis txhob ua ntej ntxov. LH lub ncov yog qhov kev tshwm sim tseem ceeb hauv zes qe menyuam dhia kev voj voog, uas kos cim lub maturation ovulation. Txawm li cas los xij, thaum lub sij hawm kos duab, ntxov ntxov ua ntej peaks tuaj yeem ua rau ovulation ovulation ntawm cov hauv paus ntawm tus kheej ntawm kev xeeb tub. Acetic Acid Ganrelic tau zoo tiv thaiv lh ncov thaum lub taub hau nyob rau hauv lub anterior pilitary caj dab, kom muaj peev xwm txhim kho ib txwm muaj rau theem paub tab.
2. Txhawb cov follicular kev loj hlob
Acetic acid ganciclovir ua lub luag haujlwm tseem ceeb hauv kev txhim kho follicular. Nws pab cov poj niam tau txais cov hauv paus kom paub meej thaum kos duab los ntawm cov kev tswj hwm cov tshuaj hormones yam. Hauv cov neeg mob tau txais COS kho, kev sib xyaw ua ke acetic acid thiab follicle stimulating hormone (FSS) tuaj yeem txhim kho qhov ntau thiab zoo thiab cov hauv paus. Qhov no yog qhov tseem ceeb rau kev txhim kho cov nqi cev xeeb tub thiab cov embryo zoo.
3. Txhaaj amenorrhea
Acetic acid txhaj tshuaj tua ntawm Ganarik tau simulate cov pituitary peak zais cia, ua tiav cov nyhuv ntawm kev ua yeeb yam amenorrhea. Muaj qee kis, xws li endometrisosis, uterine fibroids, thiab lwm yam kab mob gynlecological, kev taw qhia amenorrhea tuaj yeem yog ib txoj kev kho mob. Acetic Acid Ganrelic Alleviates Cov tsos mob ntsig txog cov tsos mob zoo los ntawm kev ua haujlwm ntawm zes qe menyuam thiab cov qib tshuaj txo qis.
4. Kev kho mob ntawm Envometriosis
Acetic Acid GancicLovir kuj tau pom tias muaj txiaj ntsig tseem ceeb hauv kev kho mob ntawm endometrisosis. Endometriosis yog ib tus mob gynecological uas tuaj yeem ua rau cov tsos mob xws li mob plab thiab ntxiv lawm tshob. Acetic acid ganrelic txo cov khoom siv tshuaj pleev tau los ntawm downregulating tus nqi endomerous GNRH qib thiab qhov tshwm sim ntawm cov ntshav tawm ntawm cov hlab ntshav tshiab. Qhov no pab rau kev mob mob, tswj tus kab mob zuj zus, thiab txhim kho tus neeg mob muaj kev muaj txiaj ntsig.
5. Kev tiv thaiv ntawm Polycystic Ovary syndrome (PCOS)
Acetic acid ganciclovir, raws li GNRH kev thaiv av, tuaj yeem tiv thaiv qhov tshwm sim ntawm Polycystic Ovary syndrome. PCOs yog ib qho kev sib txawv endocolic uas tuaj yeem ua rau cov tsos mob xws li ovield tsis zoo thiab hyperandrogenism hauv cov poj niam. Acetic acid ganrelic txhim kho zes qe menyuam thiab fertility los ntawm kev tso tawm ntawm gonadotropins nyob rau hauv lub anterior pilitary caj pas, txo cov qib caj dab, txo cov qib thiab Androgen. Qhov no yog qhov tseem ceeb tshaj plaws rau kev kho mob PCOS.
6. Txo lossis tiv thaiv kev hyparian hypuam hypdrome (Ohss)
Ohss yog ib qho kev sib txuam thaum lub kos duab, uas tuaj yeem ua rau cov tsos mob xws li ASCITAL, thiab ua pa nyuaj. Acatic Acid Garcelol txo qhov xwm txheej ntawm Ohss los ntawm kev txwv tsis pub muaj tus zes qe menyuam thiab txo tau cov tshuaj estrogen. Tsis tas li ntawd, acetic acid ganciclovir tuaj yeem kho cov kev kho tom qab ntawm IVF, tso cai qee tus ovulation ovulation induction induction los yog zam Ohss cov tsos mob.
7. Txhim kho qhov ua tiav ntawm kev pab cuam thev naus laus zis thev naus laus zis
Daim ntawv thov ntawm acetic acid ganirik nyob rau hauv pab txhim kho me nyuam thev naus laus zis tuaj yeem txhim kho kev xeeb ceem thiab embryo zoo. Nws ua kom muaj kev txhim kho hauv cov hauv paus rau theem paub tab thiab ntau thiab ntau ntawm cov qe ua los ntawm kev tswj hwm cov tshuaj hormones muaj txiaj ntsig. Qhov no yog qhov tseem ceeb rau kev txhim kho tus nqi ua tiav ntawm kev pab cuam thev naus laus zis. Tsis tas li ntawd, acetic acid garenicol kuj tseem tuaj yeem txo qhov tshwm sim ntawm cov teeb meem xws li Ohos thiab ects cev xeeb tub, yog li txhim kho kev muaj peev xwm ntawm cov neeg mob.
Acetic acid, as an important bioactive compound, has a wide range of applications in pharmaceuticals, biotechnology, and medical research. Hom no muab txoj hauv kev yooj yim los npaj siab siab - purityGanirelix acetateThiab glycyrrhetinic acid, uas tsis yog yooj yim rau kev khiav lag luam tab sis kuj haum rau kev lag luam khoom lag luam. Cov hauv qab no yog cov kauj ruam ntxaws ntxaws:
(1) Sib tov cov khoom lag luam ntawm Ganrike uas tsim nyog ntawm acetic acid aqueous daws, do tusyees, kom txog thaum cov khoom lag luam ntawm Ganrike yog yaj tag. Kev tshuaj lom neeg rau cov kauj ruam no yog:
C80H113Npuag18O13 + C2H4O2 → C80H113Npuag18O13(Acetic acid ganrike).
(2) Maj mam ntxiv ntxiv Ethyl acetate kev daws thiab kho tus nqi ntawm qhov sib xyaw kom haum rau qhov tsim nyog (feem ntau 4.5-5.5), yog li ntawd ganerk thiab acetic acid tsim cov ntsev. Kev tshuaj lom neeg rau cov kauj ruam no yog:
C80H113Npuag18O13 + C2H5Tsis muaj2 → C80H113Npuag18O13-C2H5Tsis muaj2(Acetic acid garnier acetate) + h2O
(3) precoumate txoj kev sib xyaw, lim nws tom qab ua kom tiav nag lossis daus, thiab muab cov khoom siv ntawm ganrike li cas.
(1) Daws cov tau txais Ganaric acetate hauv qhov tsim nyog ntawm acetic acid aqueous daws los tsim cov tshuaj tsis zoo.
(2) purify los ntawm chromatography. Xaiv cov chaw ua haujlwm chromatographic kem, xws li Silica Gel, ua haujlwm rau cov pa roj carbon, thiab lwm yam. Ntxuav nrog acatic acid aqueous daws li lub mobile theem. Kev sib cais thiab kev ua kom huv tau tiav raws li qhov sib txawv hauv kev ua tiav kev ua tiav ntawm ganiric acetate thiab lwm yam impurities. Sau cov ntawv tsis huv, mloog zoo thiab crystallize kom tau acetic acid ganerik muaju.
(1) qhuav cov tau acetic anid garnet muaj muaju kom tshem tawm cov dej noo thiab cov kuab tshuaj. Lub tshuab nqus tsev qhuav lossis qhov cub kom qhuav siv tau, nrog qhov ntsuas kub tau tswj hwm ntawm 30-50℃txog thaum tsis muaj dej stains ntawm lub lead ua.
(2) Cov muaju qhuav tau ua kom muaj kev ntsuas zoo kom ntseeg tau tias kev ua raws li cov qauv uas tau ua ntej (xws li 99.82%). Kev ua kom zoo ua kua chromatography, roj chromatography, lossis huab hwm coj huab hwm coj los siv tau rau kev kuaj pom. Lub caij no, ntsuas qhov siab tshaj plaws ib qho Ipurity cov ntsiab lus kom ntseeg tau tias nws yog qis dua tus nqi pub dawb (xws li 0.04%).
Cov txiaj ntsig thiab cov ntsiab lus tsim tshiab:
1. Hom no tsuas yog siv acetic acid a a a acid acetonitrile daws teeb meem thiab kev phom sij organic thiab ua rau nws muaj ntau puag ncig ua phooj ywg.
2. Cov khoom lag luam ntawm Ganarike tau raug ntxuav los ntawm chromatography tom qab ntsev ua kom siab dua qub, ua rau cov ntsiab lus actetic acid ganarike nrog cov ntsiab lus tsis loj tshaj plaws uas tsis muaj txiaj ntsig.
3. Tag nrho cov txheej txheem npaj yuav tsis qhia ntxiv cov ionsions, kom ntseeg tau lub purity thiab zoo ntawm cov khoom.
4. Yooj yim rau kev khiav lag luam, tsis tas yuav muaj cov cuab yeej ua thiab cov xwm txheej, tsim nyog rau kev tsim khoom.
Kev Xav Tau Lag Luam
Qhov kev thov tau rau cov kev pab tsim kho me nyuam ntau ntxiv: nrog cov kev nce qib ntxiv ntawm kev muaj menyuam yaus, qhov kev thov kom tau txais txiaj ntsig tas li. Raws li ib tug kev tawm tsam ntawm cov follicist stimulating hormone (FSH) kev kho mob, cov khoom no tuaj yeem tiv thaiv kev ua tiav ntawm kev ua me nyuam thev naus laus zis. Yog li ntawd, nws cov khoom lag luam xav tau yuav tsum tau loj hlob txuas ntxiv.
Nrog rau kev siv zog ntawm cov pej xeem hauv ntiaj teb kev laus, teeb meem kev muaj peev xwm tau ua rau muaj kev saib xyuas ntau dua thiab ntau tsev neeg. Qhov no txuas ntxiv txhawb kev txhim kho ntawm cov kev pab cuam thev naus laus zis thiab muab lub chaw ua lag luam dav dav rau cov tshuaj ntsig txog cov tshuaj ntsig.
Kev sib tw ua lag luam
Tam sim no, muaj ntau hom khoom ntawm kev ua lag luam nrog qee tus nqi sib txawv. Hom paub txog thiab tus nqe kom tau txais txiaj ntsig yuav ua qhov tseem ceeb hauv kev sib tw ua lag luam. Nrog rau kev nce qib nruam ntawm kev kho mob thev naus laus zis, kev tshawb fawb thiab kev tsim kho tshiab yuav dhau los ua qhov tseem ceeb rau kev sib tw ua lag luam. Kev lag luam yuav tsum muaj kev tshawb nrhiav txuas ntxiv thiab txhim kho cov khoom lag luam zoo thiab ua tau zoo, txhawm rau kom tau raws li kev thov kev lag luam.
Thev naus laus zis thev naus laus zis
Kev tsim kho cov qauv tshuaj yooj yim thiab muaj txiaj ntsig zoo xws li thaj chaw noj mov thiab kev hloov chaw, yuav pab txhim kho cov neeg mob kev coj noj coj ua thiab kev nplij siab. Tshawb nrhiav kev kho ua ke ntawm cov tshuaj no nrog lwm cov tshuaj los txhim kho kev kho nyiaj kho mob thiab txo cov kev mob tshwm sim yuav muab qhov chaw dav dav rau nws daim ntawv thov hauv khw.
Cov Cai thiab Cov Kev Cai
Kev hloov kho cov tshuaj pom zoo hauv ntau lub tebchaws yuav cuam tshuam ncaj qha rau kev ua lag luam thiab lub sijhawm ua yeeb yam tshiab. Kev lag luam yuav tsum muaj kev tswj hwm txoj cai tswjfwm zoo thiab cov tswv yim kev lag luam kom raws sijhawm. Ntxiv dag zog rau kev tiv thaiv cov cuab yeej kev tiv thaiv kev tiv thaiv cov cuab yeej thiab cov kev txaus siab ntawm kev lag luam yuav muab cov kev lees paub kom muaj kev lees paub thiab nthuav dav ua lag luam.
Tiam sis kev loj hlob
Nrog rau cov neeg muaj kev pab muaj me nyuam thev naus laus zis thiab nce zuj zus ntawm cov pej xeem laus, kev ua lag luam uas yuav tsum tau txuas ntxiv mus nthuav dav.
Nrog kev nce qib txuas ntxiv thiab kev tsim kho thev naus laus zis, nws cov thawj tswj hwm kev kho, thiab lwm yam yuav ua tiav thiab txhim kho kom tau raws li cov neeg mob ntxiv.
Nrog kev sib koom ua ke thiab qhib ntawm kev ua lag luam kho mob thoob ntiaj teb, cov tshuaj tshiab no yuav maj mam txav mus rau kev ua lag luam thoob ntiaj teb, nqa cov kev txhim kho ntau dua rau cov lag luam.
Cim npe nrov: Ganirelix Acetate CAS 123246-29-7, lwm tus neeg, chaw tsim khoom, chaw tsim khoom, chaw lag luam, yuav, nqe, loj, rau muag