Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm foxo4-dri 10mg hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo foxo4-dri 10mg rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
FOXO4-DRI 10 mgyog ib tug cell permeability peptide antagonist, belongs rau anti-aging peptides. Nws lub luag haujlwm tseem ceeb yog txhawm rau ua kom apoptosis ntawm cov hlwb laus los ntawm kev thaiv kev cuam tshuam ntawm FOXO4 thiab p53, yog li tshem tawm cov hlwb laus hauv lub cev thiab ncua kev laus tag nrho. Nws yog ib qho kev hloov pauv uas tau hloov kho hauv cov hlwb senescent. Nws khi rau cov qog suppressor protein p53, tsim ib txoj hauv kev uas tiv thaiv p53 los ntawm inducing cell apoptosis thiab es tsis txhob txhawb cell aging (tus kheej -kev tiv thaiv mechanism ntawm cell voj voog ntes). Cov amino acid sib lawv liag ntawm cov khoom no simulates thaj tsam tseem ceeb hauv FOXO4 uas khi rau p53, tab sis tsis muaj kev ua haujlwm ntawm FOXO4. Yog li ntawd, nws muaj peev xwm sib tw khi rau p53, thaiv kev tsim ntawm FOXO4-p53 complex, tso cov apoptosis inducing muaj nuj nqi ntawm p53, thiab txhawb kev laus hlwb kom nkag mus rau apoptosis program. Nws tuaj yeem nthuav tawm lub peev xwm los ntxias apoptosis ntawm senescent hlwb hauv ntau cov kab ntawm tes, xws li PDL9 hlwb thiab TM3 Leydig hlwb, tab sis tsis muaj qhov cuam tshuam loj rau cov hlwb uas tsis yog senescent. Qhov tshwj xeeb no tshwm sim los ntawm kev qhia siab ntawm FOXO4-p53 kev cuam tshuam hauv cov hlwb senescent.
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FOXO4-DRI COA
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| Certificate of Analysis | ||
| Compound npe | FOXO4-DRI | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 2460055-10-9 | |
| Ntau | 50g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090045 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.47% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.28% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.47% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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FOXO4-DRI 10 mg, raws li kev tiv thaiv - laus peptide tsom rau kev tshem tawm ntawm cov hlwb senescent, feem ntau yog siv los ntawm nws cov txheej txheem ntawm kev thaiv kev cuam tshuam ntawm FOXO4 thiab p53 thiab inducing apoptosis ntawm senescent hlwb. Nws tau pom tias muaj peev xwm tseem ceeb hauv kev tiv thaiv- kev tshawb fawb txog kev laus, kev kho kab mob, kev noj qab haus huv, thiab kev cuam tshuam fibrosis.
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Anti- tshawb fawb txog kev laus
Cov txheej txheem tseem ceeb ntawm FOXO4-DRI yog kev sib tw khi rau p53, rhuav tshem "kev tiv thaiv mechanism" ntawm cov hlwb senescent. Senescent hlwb inhibit apoptotic signals vim yog kev sib txuas ntawm FOXO4 thiab p53, muaj sia nyob tau ntev thiab secrete senescence-sociated secretory phenotype (SASP), uas ua rau muaj kev puas tsuaj rau cov ntaub so ntswg microenvironment thiab lub cev ua haujlwm poob qis. FOXO4-DRI thaiv qhov kev sib cuam tshuam no, tso tawm p53 los qhib txoj hauv kev mitochondrial apoptotic, tshwj xeeb yog inducing apoptosis ntawm cov hlwb senescent, thaum muaj kev cuam tshuam me me rau cov hlwb noj qab haus huv. Hauv cov qauv tsiaj, FOXO4-DRI txo qis kev qhia ntawm cov cim kev laus (xws li -galactosidase, p16Ink4a, p21), inhibits qhov tso tawm ntawm SASP (xws li IL-1 / , TNF- , MMP2), yog li txo cov nqaij o thiab puas. Piv txwv li, nyob rau hauv cov nas laus lawm, FOXO4-DRI los ntawm kev tshem tawm senescent interstitial hlwb nyob rau hauv lub testis txo qhov tso tawm ntawm SASP, txhim kho cov spermatogenic microenvironment, txhim kho cov phev zoo thiab kom muaj nuj nqis ntawm cov laus nas, thiab restores cov kev qhia ntawm testosterone synthesis-related proteins}1{{21}. Tsis tas li ntawd, FOXO4-DRI tseem txhawb nqa kev loj hlob ntawm kev txhawb nqa hlwb, txhim kho lub peev xwm spermatogenic thiab muaj peev xwm ua rau cov tsiaj muaj hnub nyoog.
Kev Kho Mob
Daim ntawv thov ntawm FOXO4-DRI hauv kev kho kab mob feem ntau tsom rau kev kho mob qog nqaij hlav thiab kev cuam tshuam fibrosis. Hauv kev kho mob qog noj ntshav, FOXO4-DRI induces apoptosis ntawm qog-sociated senescent cells, inhibits SASP nyob rau hauv cov qog microenvironment, thiab txo qhov invasive thiab metastatic peev xwm ntawm cov qog. Piv txwv li, FOXO4-DRI tsub kom qhov rhiab heev ntawm cov tsis yog{15}}mob qog nqaij hlav qog nqaij hlav hauv hlwb thiab lwm cov qog hlwb rau kev kho mob hauv xov tooj cua, txhawb kev apoptosis tom qab siv hluav taws xob kho mob, thiab txo qhov muaj peev xwm ntawm clone tsim thiab kev tsiv teb tsaws ntawm tes. Hauv kev cuam tshuam fibrosis, FOXO4-DRI qhib txoj hauv kev PI3K/AKT, txo oxidative kev nyuaj siab, thiab thim rov qab hluav taws xob los yog bleomycin{17}}induced pulmonary fibrosis. Hauv cov qauv nas ntawm hluav taws xob-induced pulmonary fibrosis (RIPF), FOXO4-DRI txo collagen deposition nyob rau hauv lub ntsws cov ntaub so ntswg, txo cov kev qhia ntawm col1 1 thiab -SMA, thiab txo tus naj npawb ntawm -galactosidase-zoo hlwb. Tsis tas li ntawd, FOXO4-DRI tseem inhibits qhov kev qhia ntawm P21 thiab P16Ink4a noob thiab cov proteins, nrog rau kev qhia ntawm SASP noob (xws li IL-1, IL-1, TNF- thiab MMP2), yog li txhim kho lub ntsws histology thiab ua pa ua haujlwm.
Kev Noj Qab Nyob Zoo
Daim ntawv thov ntawm FOXO4-DRI hauv kev ua haujlwm ntawm kev ua menyuam yaus feem ntau tsom mus rau qhov tsis txaus testosterone secretion hauv cov txiv neej nas hnub nyoog. Raws li lub hnub nyoog nce, cov qe ntshav interstitial hlwb maj mam muaj hnub nyoog, ua rau poob ntawm testosterone synthesis muaj peev xwm. FOXO4-DRI tshem tawm cov aging interstitial hlwb nyob rau hauv lub testis, txo qhov tso tawm ntawm SASP, txhim kho cov spermatogenic microenvironment, li no pab txhawb cov phev zoo thiab kom muaj nuj nqis ntawm cov laus nas. Tsis tas li ntawd, FOXO4-DRI kuj rov kho qhov kev qhia ntawm testosterone synthesis-related proteins (3 -HSD, CYP11A1), nce qib testosterone qib, thiab txo qhov interstitial SA- -gal kev ua si. Cov kev tshawb pom no muab cov tswv yim muaj peev xwm rau kev cuam tshuam ntawm txiv neej ncua kev ua haujlwm gonadal poob.
Fibrosis cuam tshuam
Daim ntawv thov ntawm FOXO4-DRI hauv kev cuam tshuam fibrosis tsis txwv rau pulmonary fibrosis, tab sis kuj txuas mus rau daim siab thiab lub raum fibrosis thiab lwm yam. Nws cov txheej txheem feem ntau cuam tshuam nrog inhibiting myofibroblast sib txawv thiab extracellular matrix deposition, yog li txhim kho histology thiab kev ua haujlwm. Piv txwv li, nyob rau hauv lub bleomycin-induced pulmonary fibrosis qauv, FOXO4-DRI kuj qhia tau hais tias tseem ceeb los tiv thaiv fibrosis. Tsis tas li ntawd, FOXO4-DRI activates PI3K / AKT txoj kev, txo oxidative kev nyuaj siab, thiab ntxiv alleviates fibrotic puas.
FOXO4-DRI10mg ibyog ib qho tshuaj tiv thaiv - laus peptide tsim los ntawm kev sib cuam tshuam ntawm FOXO4 protein thiab p53. Kev tsim khoom ntawm nws cov 10mg formulation muaj cov kauj ruam tseem ceeb xws li peptide synthesis, purification, zoo tswj, ntim thiab cia.
Peptide Synthesis
FOXO4-DRI yog tsim los siv cov khoom siv-theem peptide synthesis (SPPS) cov txheej txheem, uas yog txoj hauv kev tseem ceeb hauv thaj chaw peptide synthesis. Cov txheej txheem no yuav maj mam ntxiv cov amino acid residues mus rau ib qho khoom noj khoom haus -phase carrier los tsim cov phiaj peptide saw. Cov amino acid sib lawv liag ntawm FOXO4-DRI tau raug tsim kho kom zoo, nrog rau D-hom amino acids yog cov khoom tseem ceeb. Qhov kev tsim no txhim khu kev tiv thaiv protease thiab stability ntawm peptide, nrog rau kev txhim kho nws cov cell permeability. Thaum lub sij hawm tsim cov txheej txheem, kev sib txuas ntawm cov amino acid ntawm txhua kauj ruam yuav tsum muaj kev tswj xyuas meej ntawm cov tshuaj tiv thaiv, xws li kub, pH tus nqi, thiab lub sij hawm tshuaj tiv thaiv, los xyuas kom meej qhov tseeb folding thiab purity ntawm peptide. Tsis tas li ntawd, thaum lub sij hawm synthesis txheej txheem, kev tiv thaiv cov pab pawg yuav tsum tau siv los tiv thaiv sab saw functional pawg ntawm cov amino acids, tiv thaiv tsis tsim nyog tshwm sim thaum lub synthesis txheej txheem.
Purification thiab Validation
Cov khoom sib xyaw ua ke FOXO4-DRI cov khoom tsis zoo yuav tsum tau ua kom huv si kom tshem tawm cov impurities thiab txhim kho purity. Cov txheej txheem purification feem ntau suav nrog kev ua haujlwm siab ua kua chromatography (HPLC), thiab lwm yam. Cov txheej txheem no tuaj yeem cais thiab ntxuav cov polypeptide raws li nws qhov hnyav molecular, nqi zog, thiab lwm yam ntxwv. Lub purified FOXO4-DRI yuav tsum tau ua raws li kev tswj xyuas nruj kom paub tseeb tias nws cov purity ua tau raws li qhov yuav tsum tau muaj (feem ntau ntau dua los yog sib npaug rau 98%), thiab nws muaj qhov tseeb amino acid ib ntus thiab cov qauv. Kev tswj xyuas kev ua tau zoo kuj suav nrog kev sim tshuaj lom neeg, uas yog, los ntawm kev sim ntawm tes lossis kev sim tsiaj txhawm rau txheeb xyuas tias FOXO4-DRI tuaj yeem cuam tshuam kev cuam tshuam ntawm FOXO4 thiab p53 thiab induce apoptosis ntawm senescent hlwb.
Cov ntsiab lus tseem ceeb hauv kev tsim khoom
Kev xaiv raw khoom
Kev tsim khoom ntawm FOXO4-DRI yuav tsum tau siv cov khoom zoo amino acid raw khoom. Cov ntaub ntawv nyoos no yuav tsum tau ua raws li kev tswj hwm nruj kom ntseeg tau tias lawv purity thiab zoo raws li qhov yuav tsum tau ua.
Cov tshuaj tiv thaiv kab mob tswj
Thaum lub sij hawm txheej txheem synthesis, kev tswj ntawm cov tshuaj tiv thaiv kab mob yog qhov tseem ceeb. Cov yam ntxwv xws li qhov kub thiab txias, pH tus nqi, thiab lub sijhawm tshuaj tiv thaiv tag nrho cuam tshuam rau kev sib xyaw ua haujlwm thiab purity ntawm polypeptide. Yog li ntawd, thaum lub sij hawm tsim cov txheej txheem, cov xwm txheej no yuav tsum tau tswj kom meej meej kom ntseeg tau qhov tseeb synthesis ntawm polypeptide.
Purification txheej txheem optimization
Cov txheej txheem purification yog ib kauj ruam tseem ceeb hauv kev tsim khoomFOXO4-DRI 10 mg. Los ntawm kev ua kom zoo dua cov kev ua kom huv thiab cov txheej txheem, purity thiab rov qab tus nqi ntawm polypeptide tuaj yeem nce ntxiv, thiab cov nqi tsim khoom tuaj yeem txo.
Kev tswj kom zoo yog nruj
Kev tswj hwm zoo yog qhov tseem ceeb hauv kev tsim cov txheej txheem ntawm FOXO4-DRI. Los ntawm kev tswj xyuas nruj nruj, kev ua kom huv thiab zoo ntawm polypeptide tuaj yeem ua kom tau raws li qhov yuav tsum tau ua, yog li ua kom nws cov kev ua haujlwm lom neeg thiab kev nyab xeeb.
Ntim thiab Cia
Lub ntim ntawm 10mg koob tshuaj ntawm FOXO4-DRI feem ntau yog siv lub kaw lus thiab lub teeb-tiv thaiv tsim los tiv thaiv kev degradation los yog deterioration ntawm peptide thaum lub sij hawm cia. Cov khoom ntim yuav tsum muaj cov khoom thaiv zoo los tiv thaiv kev cuam tshuam ntawm lwm yam xws li oxygen thiab noo noo ntawm peptide. Hais txog cov xwm txheej khaws cia, FOXO4-DRI yuav tsum tau khov ntawm -20℃lossis qis dua txhawm rau tswj nws txoj kev ruaj ntseg thiab kev ua haujlwm lom neeg. Thaum lub sij hawm kev thauj mus los, cov kev ntsuas rwb thaiv tsev kuj yuav tsum tau coj los xyuas kom meej tias cov peptide tsis cuam tshuam los ntawm qhov kub thiab txias thaum lub sij hawm thauj mus los.
FAQ
1. Lub hom phiaj tseem ceeb ntawm kev tshawb fawb thiab cov hauv paus ntsiab lus ntawm kev siv tshuab yog dab tsi?
Ib qho peptide molecule nyob rau hauv kev tshawb fawb, tsim los xaiv cuam tshuam nrog cov protein sib cuam tshuam, txhawm rau txhawb nqa cellular homeostasis thiab ua haujlwm.
2. Kev tshawb fawb tam sim no li cas?
Tam sim no, nws yog feem ntau nyob rau hauv preclinical thiab thaum ntxov tshawb fawb theem thiab tseem tsis tau raug tso cai rau kev ua lag luam tso tawm los ntawm ib lub teb chaws tshuaj tswj lub koom haum raws li ib tug kws tshuaj.
3. Yuav tau txais thiab siv li cas?
Tam sim no nws tsuas yog siv rau kev tshawb fawb lub hom phiaj thiab tsis muaj rau pej xeem. Txhua daim ntawv thov tib neeg muaj peev xwm yuav tsum tau txais kev pom zoo yav tom ntej thiab ua raws li kev coj ua nruj me ntsis ntawm cov kws kho mob.
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