Tshuaj tua kab mobll 37 pevyog ib tug multifunctional peptide tsim los ntawm tib neeg lub cev tiv thaiv kab mob, nrog ib tug molecular hnyav ntawm kwv yees li 3700 Daltons, CAS 597562-32-8, thiab molecular mis CH28N6O5. Nws yog linear peptide muaj li ntawm 37 amino acid residues, nrog rau ib tug zoo them arginine (Arg) thiab ib tug tsis zoo nqi glutamate (Glu). Nws cov qauv theem nrab yog feem ntau yog tsim los ntawm - Muaj cov spirals thiab tsis xwm yeem curls. Nws muaj kev ruaj ntseg zoo hauv kev daws teeb meem. Nws cov tshuaj tiv thaiv kab mob tseem nyob ruaj khov ntawm qhov kub thiab txias thiab muaj qee yam tsis kam mus rau degradation ntawm ntau yam enzymes. Tsis tas li ntawd, cov tshuaj tua kab mob peptide LL-37 kuj tseem muaj tshuaj lom neeg ruaj khov thiab tsis yooj yim los ntawm ntau cov kuab tshuaj organic. Nws muaj lub siab absorbance rau ultraviolet thiab pom lub teeb, thiab yuav luag tsis nqus rau lub teeb infrared. Nyob rau hauv physiological tej yam kev mob, nws muaj ib tug siab solubility nyob rau hauv aqueous tov thiab nthuav cov dej zoo solubility. Nws muaj kev ruaj ntseg zoo ntawm qhov kub thiab txias. Nyob rau hauv physiological tej yam kev mob, nws cov kev ua ub no nyob ruaj khov nyob rau hauv boiling tej yam kev mob thiab muaj ib tug tej yam kev tiv thaiv rau tshav kub kev kho mob nyob rau hauv ib tug tej yam kev mob. Feem ntau yog siv los npaj lwm cov khoom siv lead ua, xws li txhuas oxide, lead carbonate, lead nitrate, thiab lwm yam. Nyob rau hauv cov organic synthesis, nws yuav siv tau los ua ib qho catalyst lossis precursor rau cov tshuaj tiv thaiv catalytic. Tsis tas li ntawd, nws yog dav siv hauv kev lag luam xws li pigments, dyes, roj hmab, textiles, thiab tshuaj pleev ib ce.
Customized Bottle Caps & Corks
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ll 37 pevyog tsim los ntawm precursor protein hCAP-18 encoded los ntawm CAMP noob, uas tau muab faib ua ib feem peptide, Catherine domain, thiab ib feem peptide nquag. Lub hCAP-18 noob nyob rau ntawm chromosome 3, nrog qhov ntev ntawm 1963 bp thiab muaj plaub exons. Exon 1, exon 2, thiab exon 3 encode lub teeb liab peptide feem thiab Catherine domain feem, thaum exon 4 encodes cov nquag peptide feem; N-terminus ntawm LL-37 yog lub teeb liab peptide ib feem ntawm 30 amino acid residues, feem ntau coj kev tso tawm ntawm cov nquag peptide feem. Qhov nruab nrab Cathelin domain feem yog tsim los ntawm 101 amino acid residues, thaum C-terminus nquag peptide feem yog tsim los ntawm 37 amino acid residues, nrog cov kab ke LLGFFRKSKEKIGKEFKRIV QRIKDFLRNLVPRTES. Tom qab lub precursor hCAP-18 tshem tawm cov teeb liab peptide, qhov seem seem yog tsuas yog khaws cia nyob rau hauv daim ntawv ntawm granular protein nyob rau hauv neutrophils los yog epithelial hlwb. Kev tso tawm ntawm cov khoom xyaw nquag LL-37 kuj yuav tsum muaj serine protease 3 kom tshem tawm Catherine ib feem. Cov kev tshawb fawb tau pom tias qhov loj ntawm hCAP-18 enrichment tuaj yeem kuaj pom ntawm lub tshuab ua haujlwm neutrophil cell membrane, yog li kev tso tawm ntawm LL-37 feem ntau tshwm sim rau ntawm lub cell membrane.
Antibacterial peptide LL-37 yog ntau yam peptide tsim los ntawm tib neeg lub cev tiv thaiv kab mob, nrog rau ntau yam kev ua haujlwm lom neeg xws li tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv- mob, tiv thaiv qog, antioxidant, thiab lwm yam.
Antibacterial peptide LL-37 ua lub luag haujlwm tseem ceeb hauv kev tawm tsam cov kab mob pathogenic. Nws muaj qhov dav -spectrum antibacterial thiab antiviral kev ua ub no thiab tuaj yeem tiv thaiv kab mob los ntawm ntau yam kab mob thiab kab mob. Hauv lub cev, nws tuaj yeem rhuav tshem cov cell membrane ntawm cov kab mob, inhibit lawv txoj kev loj hlob thiab kev loj hlob. Rau qee cov kab mob resistant, xws li methicillin-resistant Staphylococcus aureus (MRSA), antimicrobial peptide LL-37 tuaj yeem pab kov yeej kev tiv thaiv. Tsis tas li ntawd, antimicrobial peptide LL-37 tseem tuaj yeem cuam tshuam cov txheej txheem rov ua dua ntawm tus kab mob, yog li tiv thaiv tus kab mob. Yog li ntawd, tshuaj tua kab mob peptide LL-37 muaj ntau yam kev siv hauv tshuaj tua kab mob thiab tshuaj tua kab mob.
Anti-cov nyhuv inflammatory
Ntxiv nrog rau nws cov tshuaj tua kab mob thiab tshuaj tua kab mob, tshuaj tua kab mob peptide LL-37 kuj tseem muaj cov tshuaj tiv thaiv kab mob, uas tuaj yeem txo qhov mob, mob, thiab o. Thaum lub sij hawm tus txheej txheem inflammatory, antimicrobial peptide LL-37 tuaj yeem tswj cov kev ua haujlwm thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, inhibit qhov kev tso tawm ntawm cov tshuaj tiv thaiv kab mob, thiab yog li txo qhov kev mob tshwm sim. Yog li ntawd, antimicrobialll 37 pevkuj muaj ntau daim ntawv thov nyob rau hauv kev tiv thaiv - teb.
Nyob rau hauv xyoo tas los no, kev tshawb fawb tau pom tias tshuaj tua kab mob peptide LL-37 kuj muaj kev tiv thaiv- qog nqaij hlav, uas tuaj yeem cuam tshuam kev loj hlob thiab nthuav tawm ntawm cov qog hlwb. Tshwj xeeb, nws tuaj yeem tswj cov metabolism thiab lub voj voog ntawm cov qog hlwb, ua rau cov qog cell apoptosis, thiab inhibit qog angiogenesis, yog li inhibiting qog loj hlob thiab proliferation. Yog li ntawd, antimicrobial peptide LL-37 kuj muaj kev siv dav hauv kev kho mob qog noj ntshav.
Antioxidant nyhuv
Tsis tas li ntawd, antimicrobial peptide LL-37 kuj muaj cov haujlwm antioxidant, uas tuaj yeem tshem tawm cov dawb radicals thiab oxidation cov khoom hauv lub cev, tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative. Nws tuaj yeem cuam tshuam ncaj qha nrog cov dawb radicals lossis ua haujlwm hauv kev sib koom ua ke nrog lwm cov tshuaj tiv thaiv antioxidants kom tshem tawm cov khoom oxidative hauv lub cev thiab tswj lub cev ua haujlwm. Yog li ntawd, antimicrobial peptide LL-37 kuj muaj kev siv dav hauv cov khoom antioxidant.
Ntxiv nrog rau cov haujlwm lom neeg tau hais tseg, cov tshuaj tiv thaiv kab mob peptide LL-37 kuj tseem muaj lwm yam dej num lom neeg. Piv txwv li, nws tuaj yeem txhawb kev kho qhov txhab, cuam tshuam nrog immunoglobulins, thiab txhim kho kev tiv thaiv. Tsis tas li ntawd, antimicrobial peptide LL-37 tuaj yeem cuam tshuam kev loj hlob thiab kev tsim tawm ntawm qee cov nroj tsuag pathogenic fungi, thiab muaj peev xwm siv tau rau kev ua liaj ua teb. Yog li ntawd, antimicrobial peptide LL-37 kuj muaj kev siv dav hauv lwm cov dej num lom neeg.
Tshuaj tua kab mobll 37 pevyog ib tug multifunctional peptide tsim los ntawm tib neeg lub cev tiv thaiv kab mob, nrog rau ntau yam kab mob xws li tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv -inflammatory, anti- qog, tshuaj tua kab mob, thiab lwm yam. Muaj ob txoj hauv kev siv rau kev sib txuas ntawm antimicrobial peptide LL-37:
Method 1: Tshuaj synthesis method
Tshuaj synthesis yog ib txoj hauv kev siv los ua cov tshuaj tua kab mob peptide LL-37. Txoj kev no feem ntau siv ob txoj kev: kua theem synthesis thiab cov theem khoom sib txuas. Cov txheej txheem ua kua theem ua ke yog kev sib txuas ntawm peptide chains los ntawm kev ntxiv cov khoom pib, cov tshuaj tiv thaiv cov tshuaj tiv thaiv, thiab cov kuab tshuaj tsim nyog rau cov tshuaj tiv thaiv, thiab ua rau cov tshuaj tiv thaiv kab mob. Cov khoom sib txuas-theem synthesis txoj kev vam khom rau cov khoom thauj khoom-theem los kho qhov pib amino acid ntawm cov cab kuj thiab ua kom tiav cov peptide saw condensation cov tshuaj tiv thaiv ntawm cov khoom thauj khoom.
Qhov zoo ntawm cov txheej txheem tshuaj synthesis yog tias nws muaj ntau qhov sib xyaw, tuaj yeem siv rau kev tsim khoom, thiab cov khoom purity siab. Txawm li cas los xij, cov tshuaj tiv thaiv ntawm txoj kev no yog qhov hnyav heev, yuav tsum tau siv ntau cov kuab tshuaj organic thiab cov khoom tsis zoo xws li cov kua qaub thiab cov hauv paus, ua rau muaj kuab paug ib puag ncig, thiab cov txheej txheem tshuaj tiv thaiv yog complex thiab nyuaj rau tswj.
Txoj Kev 2: Txoj Kev Biosynthetic
Biosynthesis yog ib txoj hauv kev los tsim cov tshuaj tua kab mob peptide LL-37 siv cov kab mob lom xws li cov kab mob los yog cov hlwb. Txoj kev no tuaj yeem muab faib ua ob hom: txoj kev ncaj nraim thiab txoj kev tsis ncaj. Txoj kev ncaj qha yog ncaj qha tsim tshuaj tua kab mob peptide LL-37 hauv cov kab mob lom los ntawm microbial fermentation lossis kab lis kev cai ntawm tes. Txoj cai tsis ncaj yog siv cov kab mob los yog cov hlwb ua cov cuab yeej los tsim cov precursor lossis nruab nrab ntawm cov tshuaj tiv thaiv kab mob peptide LL-37, thiab tom qab ntawd dhau mus ntxiv cov tshuaj hloov pauv kom tau txais cov tshuaj tua kab mob peptide LL-37.
Qhov kom zoo dua ntawm biosynthesis yog tias nws siv cov txheej txheem metabolic ntawm cov kab ke lom neeg thiab tsis tas yuav tsum tau siv ntau cov organic solvents thiab teeb meem tshuaj, ua rau muaj kev ua qias tuaj ib puag ncig. Nyob rau tib lub sijhawm, cov txheej txheem ncaj qha lossis tsis ncaj tuaj yeem siv los siv cov yam ntxwv ntawm cov kab mob lom neeg xws li cov kab mob lossis cov hlwb rau kev tsim cov phiaj xwm, txhim kho cov txiaj ntsig thiab purity ntawm cov khoom. Txawm li cas los xij, cov tshuaj tiv thaiv ntawm txoj kev no yog qhov nyuaj, muaj ntau yam los tswj, thiab lub voj voog ntau lawm ntev, ua rau nws nyuaj rau kev ua tiav kev lag luam.
Cov lus nug nquag
LL-37 peptide ua dab tsi?
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Muab cov tswv yim tshiab rau kev kho mob ntev, LL-37cuam tshuam biofilms, tshwj xeeb tshaj yog nyob rau hauv cov tshuaj tua kab mob - cov kab mob resistant. Tso tawm ob qho tib si tiv thaiv - thiab pro- cov teebmeem mob qog noj ntshav, LL-37 plays lub luag haujlwm nyuaj, cuam tshuam rau lub cev tiv thaiv kab mob thiab kev taw qhia txoj hauv kev.
Qhov txawv ntawm BPC 157 thiab LL-37 yog dab tsi?
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LL-37 tswj kev tiv thaiv kab mob thiab kev tswj hwm microbial, thaum BPC-157 ua kom cov ntaub so ntswg kho ntawm qib cellular.. Cov pawg no yog siv thaum kho cov leeg nqaij, cov leeg, lossis cov pob qij txha yog lub hom phiaj tseem ceeb, thiab muaj cov kab mob sib kis los yog cov kab mob sib kis (xws li, qhov chaw phais mob, tom qab- mob o).
Dab tsi yog qhov sib lawv liag ntawm LL-37 peptide?
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Daim ntawv nquag yog LL-37, 37 amino acid peptide muaj ib ntusLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES. Hauv tib neeg, CAMP encodes peptide precursor CAP-18 (18 kDa), uas yog ua tiav los ntawm proteinase 3-mediated extracellular cleavage rau hauv daim ntawv nquag LL-37.
LL-37 piv rau lwm cov peptides li cas?
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LL-37 muaj peev xwm tsim cov aggregates hauv kev daws thiab lipid bilayers thiab yog li,Tsis zoo li lwm cov tshuaj tiv thaiv kab mob peptides, tiv thaiv los ntawm proteolytic degradation(5). Nws cov nqi zoo tso cai rau nws nyiam koom nrog cov phospholipid daim nyias nyias (5).
Cim npe nrov: ll 37 Peptide CAS 597562-32-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom