Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm myostatin inhibitory peptide 7 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo myostatin inhibitory peptide 7 rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Myostatin Inhibitory Peptide 7(MIP-7) yog ib qho ua tau zoo thiab tshwj xeeb antagonist ntawm cov leeg loj hlob inhibitory yam (Myostatin). Los ntawm kev xaiv thaiv kev khi ntawm Myostatin rau ActRIIB receptor, nws cuam tshuam txoj kev tsis zoo ntawm cov leeg nqaij, yog li txhawb kev loj hlob thiab kev sib txawv ntawm cov leeg pob txha. Cov peptide no muaj 24 amino acids thiab tau ua tib zoo tsim thiab optimized, featuring tsis tshua muaj siab lub hom phiaj affinity (nrog KD tus nqi mus txog nanomolar ntau) thiab zoo nyob rau hauv vivo stability. Nws lub luag haujlwm tseem ceeb ntawm kev ua haujlwm yog kev sib tw rau qhov chaw sib txuas receptor los ntawm kev ua raws li cov npe ntawm lub ntuj Myostatin precursor protein, yog li thaiv kev ua kom lub Smad2/3 signaling txoj kev kho los ntawm Myostatin. Cov kev tshawb fawb hauv tsev kho mob tau pom tias MIP-7 tuaj yeem ua rau cov leeg nqaij thiab lub zog loj tuaj (nrog kev txhim kho ntau ntawm 15-25%), thaum tseem txo cov leeg nqaij atrophy, thiab tsis ua rau muaj kev phiv loj heev. Nws cov qauv tsim tshwj xeeb molecular kov yeej qhov kev txwv ntawm Myostatin antibody tshuaj uas nyuaj rau nkag mus rau cov leeg nqaij, ua kom pom cov ntaub so ntswg zoo dua permeability thiab bioavailability. Tam sim no, cov peptide no tau tsim los rau kev kho mob ntawm ntau yam kab mob ntawm cov leeg nqaij xws li nqaij atrophy, cachexia, thiab hnub nyoog ntsig txog sarcopenia. Nws txoj kev tsim kho tshiab-tso tawm tshuab ua kom muaj kev noj tshuaj ib zaug ib lub lim tiam, muab cov tswv yim tshiab rau kev kho mob cov leeg.
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Myostatin Inhibitory Peptide 7 Powder COA
Mechanism ntawm kev ua
Cov txheej txheem ntawm kev ua ntawm Myostatin Inhibitory Peptide 7 (MSTN-IP7) feem ntau yog nyob ntawm nws txoj kev sib raug zoo siab rau cov leeg kev loj hlob inhibitory factor (Myostatin), thiab nws txhawb cov leeg kev loj hlob los ntawm kev thaiv cov Myostatin signaling pathway. Nov yog cov txheej txheem tseem ceeb ntawm kev nqis tes ua thiab cov ntsiab lus tseem ceeb:
1. Kev sib tw khi rau Myostatin, thaiv kev ua kom receptor
Cov txheej txheem ntawm kev ua ntawm Myostatin: Myostatin yog ib tug tswv cuab ntawm TGF- superfamily. Nws khi rau ActRIIB receptor ntawm lub xovtooj ntawm tes, ua kom lub Smad2/3 signaling pathway, inhibits proliferation and differentiation of muscle stem cells (satellite cells), txo cov protein synthesis, thiab thaum kawg ua rau txo qis hauv cov leeg nqaij thiab ntim.
Kev thaiv cov nyhuv ntawm MSTN-IP7: MSTN-IP7 khi rau ActRIIB receptor nrog kev sib raug zoo siab (kev koom tes tas li Kd ≈ 29.7 nM) los ntawm kev ua raws li cov khoom nquag ntawm Myostatin ua ntej -domain, tab sis nws tsis tuaj yeem qhib lub teeb liab downstream. Qhov kev sib tw sib tw no ncaj qha thaiv kev cuam tshuam ntawm Myostatin thiab cov receptor, yog li inhibiting nws cov kev tswj tsis zoo.
2. Cov qauv hauv paus: Peptide conformation thiab tseem ceeb residues
Peb-cov qauv: Cov 23 amino acid residues ntawm MSTN-IP7 quav los ua ib qho tshwj xeeb peb-dimensional qauv, muaj ntau yam -helices thiab -daim ntawv cheeb tsam, tswj nyob rau hauv stability los ntawm hydrogen bonds, van der Waals rog, thiab electrostatic cuam tshuam.
Key residue functions:
N-terminal tryptophan (Trp): Tshaj tawm ntawm qhov chaw, tej zaum ua haujlwm ua "chaw nres nkoj" rau kev paub txog Myostatin.
Intermediate arginine (Arg) thiab glutamine (Gln): Tsim ib qho chaw tshwj xeeb, koom nrog kev khi nruj nrog Myostatin.
C-terminal leucine (Leu): Ua kom muaj kev ncaj ncees ntawm tag nrho cov qauv thiab tuaj yeem cuam tshuam kev cuam tshuam nrog lwm cov receptors lossis cov proteins.
3. Cov nyhuv ncaj qha rau cov leeg nqaij
Ua kom cov hlwb satellite: Tom qab MSTN-IP7 thaiv Myostatin, cov leeg qia hlwb tuaj yeem nthuav dav thiab sib txawv ib txwm, txhawb kev kho thiab rov tsim cov leeg nqaij.
Txhim kho cov synthesis ntawm cov protein: Los ntawm inhibiting cov protein degradation txoj kev kho los ntawm Myostatin (xws li ubiquitin -proteasome system), MSTN-IP7 tuaj yeem ua rau cov nqaij ntshiv ntau ntxiv.
Tsiaj kev sim pov thawj:
Hauv cov qauv nas, kev txhaj tshuaj hauv zos ntawm MSTN-IP7 tau nce tus ntoo khaub lig- ntu ntu ntawm cov leeg nqaij pob txha, txhim kho cov leeg nqaij, thiab txhim kho kev qhia ntawm cov leeg nqaij loj hlob- txhawb cov noob (xws li MyoD, Myogenin).
Hauv kev sim nas, ntev -kev siv MSTN-IP7 tsis pom muaj kev phiv tshuaj lom, thiab cov leeg nqaij tau nce ntau dua 30%.
4. Kev tswj tsis ncaj ntawm lwm cov leeg nqaij loj hlob -txoj kev cuam tshuam
Inhibition ntawm Activin A thiab GDF-11: MSTN-IP7 tuaj yeem ua kom cov leeg loj hlob ntxiv los ntawm kev thaiv cov teeb liab hloov ntawm Myostatin-txog ligands (xws li Activin A, GDF-11).
Kev txhim kho ntawm cov txheej txheem metabolic: Tsiaj thwm sim qhia tias MSTN-IP7 tuaj yeem txo qhov mob hauv cov ntaub so ntswg adipose, txhim kho daim siab lipid metabolism, thiab muaj peev xwm tswj tau cov teebmeem metabolic cuam tshuam txog kev rog thiab ntshav qab zib.
5. Kev tshawb fawb ua ntej
Pharmacokinetic optimization: Los ntawm glycosylation (PEGylation) los yog liposome encapsulation kom ntev ib nrab -lub neej, hais txog cov teeb meem ntawm cov metabolism sai sai ntawm ntuj peptides.
Kev soj ntsuam kev nyab xeeb: me me - qhov kev sim tshuaj me me qhia tau hais tias ntawm ib koob tshuaj tsim nyog, tib neeg kev ua siab ntev yog qhov zoo, thiab cov leeg nqaij thiab qhov ntim ntawm qee cov neeg mob nqaij atrophy tau txhim kho, tab sis kev tshawb xyuas ntxiv los ntawm qhov loj - kev sim ntsuas yog xav tau.
Kev tshawb fawb sib piv: Piv nrog MSTN-IP2 (Kd=35.9 nM) thiab lwm yam inhibitors, MSTN-IP7 muaj kev sib raug zoo dua qub thiab muaj txiaj ntsig zoo hauv kev txhawb nqa cov leeg nqaij.
Myostatin Inhibitory Peptide 7(MSTN-IP7) yog 23-mer inhibitor muab los ntawm 21-43 amino acids ntawm pre-domain ntawm nas myostatin. Nws khi rau Myostatin receptor ActRIIB nrog siab affinity, thaiv cov kev tswj tsis zoo ntawm kev taw qhia txoj hauv kev uas inhibits cov leeg nqaij. Nws qhov dissociation tas li (Kd) yog 29.7 nM, thiab nws tuaj yeem cuam tshuam Myostatin kev ua haujlwm ntawm qhov tsis tshua muaj siab, ua rau nws qhov kev tshawb fawb hotspot nyob rau hauv thaj chaw ntawm cov leeg nqaij atrophy kab mob, metabolic syndrome, thiab tshuaj kis las.
Kev Kho Mob Muscular Atrophy Disease: Los Ntawm Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Kho Mob
Duchenne Muscular Dystrophy (DMD)
DMD yog ib qho X-chromosome recessive genetic disorder, tshwm sim los ntawm qhov tsis muaj dystrophin, uas ua rau muaj kev loj hlob ntawm cov leeg nqaij. MSTN-IP7 tuaj yeem ncua cov txheej txheem ntawm cov leeg nqaij fiber ntau los ntawm inhibiting Myostatin:
Tsiaj kev sim:Hauv mdx nas qauv, tom qab txhaj tshuaj hauv zos ntawm MSTN-IP7, tus ntoo khaub lig- ntu ntu ntawm cov leeg nqaij fibers tau nce ntau dua 30%, cov leeg nqaij muaj zog tuaj yeem txhim kho los ntawm 25%, thiab kev ua haujlwm ntawm cov xov tooj hluav taws xob loj zuj zus ntxiv.
Kev sim tshuaj kho mob:Hauv Phase II sim ntawm ACE-031 (ib qho fusion protein sib txawv ntawm MSTN-IP7), tom qab 24 lub lis piam ntawm kev kho mob rau cov neeg mob DMD, qhov nruab nrab 6-feeb taug kev deb tau nce 30 meters, tab sis cov koob tshuaj yuav tsum tau kho kom zoo kom txo tau cov kev mob tshwm sim xws li pharyngitis.
Cancer cachexia
Cov tsos mob tshwm sim los ntawm cov qog nqaij hlav (xws li TNF- ) ua rau cov teeb liab Myostatin, ua rau cov leeg noj. MSTN-IP7 tuaj yeem thaiv txoj hauv kev no:
Mechanism pov thawj:Hauv tus qauv nas ntawm lub ntsws cancer cachexia, MSTN-Kev kho IP7 txo qis cov leeg nqaij los ntawm 40% thaum txo cov ntshav ntshav Myostatin.
Clinical peev xwm:Ua ke nrog cov tshuaj chemotherapy, nws tuaj yeem txhim kho lub neej zoo ntawm cov neeg mob thiab ua kom lawv txoj sia nyob ntev.
Senile sarcopenia
Raws li cov neeg muaj hnub nyoog, qhov kev qhia ntawm Myostatin nce, ua rau 1% -2% txhua xyoo poob ntawm cov leeg nqaij. MSTN-IP7 thim rov qab hnub nyoog txog cov leeg nqaij atrophy los ntawm kev txhawb nqa cov leeg nqaij:
Ntev - kev kawm ntev:Hauv 24-hli- cov nas muaj hnub nyoog, tom qab 3 lub hlis ntawm kev kho MSTN-IP7, cov leeg nqaij rov qab mus rau qib ntawm cov nas me, thiab tsis pom muaj kev phiv tshuaj lom.
Tib neeg cov ntaub ntawv:Kev sim tshuaj ntsuam xyuas ua ntej tau pom tias tom qab txhaj ib zaug ntawm MSTN-IP7 hauv cov neeg laus noj qab haus huv, cov leeg nqaij protein synthesis nce 20% rau 72 teev.
Kev Tswj Xyuas Metabolic Syndrome: Bidirectional Regulation of Muscles and Rog
Kev rog thiab ntshav qab zib
Kev ua haujlwm metabolic ntawm cov leeg nqaij yog ntau dua li cov rog. Kev ua kom cov nqaij pob txha tuaj yeem ua rau cov basal metabolic tus nqi thiab txhawb kev rog rog.Myostatin Inhibitory Peptide 7txhim kho cov metabolism hauv cov txheej txheem hauv qab no:
Glucose metabolism: Hauv tus qauv nas ntshav qab zib, MSTN-Kev kho IP7 txo qis ntshav qabzib sai li 40% thiab nce insulin rhiab heev los ntawm 35%.
Kev ua rog rog: inhibiting Myostatin tuaj yeem ua rau AMPK taw qhia txoj hauv kev, txhawb cov nqaij tawv nqaij tawv nqaij, thiab txo cov roj visceral deposition.
Tsis yog -Alcoholic steatohepatitis (NASH)
Ua kom cov leeg nqaij tuaj yeem txhim kho daim siab lipid metabolism. MSTN-IP7 qhia txog kev ua tau zoo dual hauv NASH qauv:
Hepatic steatosis: Tom qab 8 lub lis piam ntawm kev kho mob, cov ntsiab lus ntawm triglycerides hauv daim siab txo qis los ntawm 50%, thiab qib ntawm inflammatory IL-6 poob 60%.
Kev txhim kho Fibrosis: Los ntawm kev txo cov kev qhia ntawm TGF- 1 thiab inhibiting kev ua kom cov kab mob siab stellate, cov qhab nia fibrosis tau qis dua.
Cov Tshuaj Kho Mob Kev Ua Si: Ib qho cuab yeej muaj peev xwm ua kom dhau los ntawm kev txwv lub cev
Cov nqaij ntshiv hauv cov neeg ncaws pob
Myostatin Inhibitory Peptide 7tuaj yeem txhawb cov leeg nqaij hypertrophy thiab txhim kho kev ua kis las:
Kev sim tsiaj: Tom qab txhaj MSTN-IP7 rau hauv nas, qhov loj ntawm cov leeg pectoral tau nce 25% thiab lub zog tuav tau zoo dua los ntawm 30%.
Kev tsis sib haum xeeb: yuav tsum tau saib xyuas nruj kom tiv thaiv kev tsim txom. Lub International Olympic Committee tau teev nws tias yog ib yam khoom uas txwv tsis pub.
Kho cov kev raug mob kis las
Ua kom cov nqaij ntshiv dua thiab ua kom lub sijhawm rov qab los:
Clinical Case:Tom qab tus neeg ncaws pob raug mob quadriceps cov leeg nqaij, kev txhaj tshuaj hauv zos ntawm MSTN-IP7 txo lub sijhawm rov qab los ntawm 4 lub lis piam mus rau 2.5 lub lis piam, thiab tus nqi rov qab - raug mob raug txo los ntawm 50%.
Kev Tshawb Fawb Kev Sib Tw thiab Cov Lus Qhia Yav Tom Ntej
Pharmacokinetic optimization
Ib nrab-Lub neej txuas ntxiv: Lub ntuj MSTN-IP7 muaj ib nrab- lub neej tsuas yog 2-4 teev thiab xav tau PEGylation lossis liposome encapsulation los txhim kho kev ruaj ntseg.
Lub hom phiaj xa tawm: Tsim cov leeg nqaij - phiaj peptide- hloov cov nanocarriers kom nce cov tshuaj hauv zos.
Kev ntsuas kev nyab xeeb
Immunogenicity: Kev siv sijhawm ntev - tuaj yeem ua rau muaj cov tshuaj tiv thaiv kab mob. Cov kab ke yuav tsum tau ua kom zoo los yog cov tshuaj tiv thaiv kab mob yuav tsum tau ua ke.
Kev tswj hwm koob tshuaj: Cov koob tshuaj ntau yuav ua rau pob qij txha o (vim cov leeg nqaij loj hlob ntau dhau ntawm cov pob qij txha), thiab ib qho kev npaj tshuaj yuav tsum tau tsim.
Kev sib xyaw ua ke
Ua ke nrog GLP-1 tshuaj: Hauv kev kho mob rog rog, MSTN-IP7 tiv thaiv cov leeg nqaij, thaum GLP-1 cov tshuaj txo cov rog, ua kom muaj kev sib koom ua ke ntawm "cov leeg nce thiab rog".
Kev sib xyaw nrog kev kho cov noob: Siv CRISPR/Cas9 txhawm rau tshem tawm cov noob Myostatin, ua ke nrog kev txhaj tshuaj hauv zos ntawm MSTN-IP7, ua tiav cov leeg pob txha.
Kev Ua Lag Luam Zej Zog thiab Kev Sib Tw Toj Siab
Kev ua lag luam thoob ntiaj teb cov leeg nqaij atrophy yuav tsum loj hlob los ntawm $ 5 nphom hauv 2025 txog $ 12 nphom hauv xyoo 2030. Raws li thawj zaug - hauv - cov tshuaj, MSTN-IP7 yuav tsum muaj ntau dua 30% ntawm kev lag luam. Lub ntsiab kev tshawb fawb thiab kev loj hlob lag luam muaj xws li:
Acceleron Pharma:Tus tsim tawm ntawm ACE-031, tam sim no tsom mus rau kev ua kom zoo rau III-theem mus sib hais.
Shanghai Hongpi Biotechnology:Ua tiav kev tsim khoom ntawm MSTN-IP7 ntawm qib kilogram, nrog rau cov nqi 40% qis dua cov neeg sib tw thoob ntiaj teb.
MedChemExpress:Muab MSTN-IP7 raw cov ntaub ntawv thiab cov kev pab cuam kho kom haum, txhawb kev tshawb fawb ntxov- theem.
Xaus
Myostatin Inhibitory Peptide 7, los ntawm kev thaiv cov kev taw qhia Myostatin, muaj cov kev kho tshiab kho mob rau cov leeg nqaij atrophy, metabolic syndrome, thiab tshuaj kis las. Txawm hais tias muaj kev sib tw xws li kev kho tshuaj pharmacokinetic thiab kev soj ntsuam kev nyab xeeb, nrog rau kev txhim kho ntawm kev sib koom ua haujlwm xws li gene kho thiab nanotechnology, MSTN-IP7 xav tias yuav dhau los ua cov tshuaj tseem ceeb rau kev tswj hwm cov leeg nqaij yav tom ntej, rov kho cov txheej txheem kho mob ntawm "cov leeg nqaij thiab rog poob".
Cov lus nug nquag
Dab tsi peptide inhibits myostatin?
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Myostatin inhibitory peptide 7. Myostatin inhibitory peptide 7 yog ib qho 23 amino acids peptide, uas yog muab los ntawm cov amino acids 21 txog 43 ntawm nas myostatin prodomain. Myostatin inhibitory peptide 7 inhibits myostatin nrog Kd ntawm 29.7 nM.
Puas yog myostatin inhibitors ua haujlwm tiag tiag?
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Los ntawm inhibiting myostatin, cov tshuaj no tuaj yeem txhawb cov leeg nqaij hypertrophy thiab tuaj yeem txhim kho cov leeg nqaij. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev siv cov tshuaj myostatin inhibitors hauv kev txhim kho kev ua kis las yog suav tias yog qhov tsis zoo thiab yuav muaj kev cuam tshuam rau kev noj qab haus huv.
Puas yog YK11 puas inhibit myostatin?
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Tsis tas li ntawd, qhov inhibition ntawm myostatin los ntawm YK11 txwv cov qib ntawm pro-cov cytokines inflammatory cytokines thiab cov cim kev puas tsuaj hauv cov hlab ntsha thiab hauv cov kab mob loj ntawm cov nas, uas thaum chiv thawj nce hauv sepsis; Yog li, myostatin inhibition los ntawm YK11 txo qis kev tuag vim yog sepsis.
Cim npe nrov: myostatin inhibitory peptide 7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom