Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm mazdutide peptide hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo mazdutide peptide rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Cov tshuaj peptideyog ib qho tshiab dual - phiaj peptide tshuaj uas ua raws li agonist rau ob qho tib si glucagon-zoo li peptide-1 (GLP-1) receptor thiab glucagon (GCGR) receptor. Qhov tshwj xeeb dual -txoj haujlwm no ua rau nws muaj txiaj ntsig zoo hauv kev kho cov kab mob metabolic, ua rau nws tswj hwm cov ntshav qab zib thiab txhawb lub zog metabolism ib txhij. Cov qauv molecular ntawm Mazdutide tau raug tsim kho kom zoo, nrog rau 40-amino-acid sequence ingeniously ntsuas qhov ua kom muaj txiaj ntsig ntawm ob qho tib si receptors, khaws cov khoom hypoglycemic ntawm cov tsoos GLP-1 analogues thaum ntxiv cov txiaj ntsig metabolic ntxiv los ntawm GC. Cov kev tshawb fawb soj ntsuam tau pom tias Mazdutide tsis tsuas yog txhim kho cov ntshav qab zib hauv cov neeg mob ntshav qab zib hom 2 tab sis kuj txo qhov hnyav, txhim kho lipid profile, thiab txo qis cov kab mob hauv lub siab tsis muaj dej cawv. Nws txoj kev siv tshuab ua kom ntev ntev ua kom muaj kev noj tshuaj ib zaug ib lim tiam lossis ob lub lis piam, ua kom cov neeg mob ua raws li txoj cai. Raws li lub cim tshiab ntawm cov neeg tswj hwm cov metabolism, Mazdutide sawv cev rau kev ua tiav tseem ceeb hauv kev tshawb fawb tshuaj peptide thiab kev txhim kho, muab kev xaiv tshiab rau kev tswj hwm ntawm cov kab mob metabolic nyuaj.
|
|
|
Mazdutide hmoov COA
Mazdutidepeptide(tseem hu ua IBI362 lossis LY3305677) yog ib qho tshiab dual receptor agonist tshuaj. Nws cov txheej txheem tshawb pom tuaj yeem taug qab rov qab mus rau hauv - kev tshawb fawb tob ntawm cov tsiaj nyeg gastric acid tswj cov tshuaj hormone (Oxyntomodulin, OXM). OXM, raws li ib txwm tshwm sim hauv plab hnyuv hormone, yog zais los ntawm plab hnyuv L hlwb thiab muaj ob txoj haujlwm ntawm kev ua kom glucagon-zoo li peptide-1 receptor (GLP-1R) thiab glucagon receptor (GCGR). Cov yam ntxwv no ua rau nws ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub zog sib npaug, qabzib metabolism, thiab tswj qhov hnyav. Cov kev tshawb fawb thaum ntxov tau pom tias kev tswj hwm exogenous ntawm OXM tuaj yeem txhim kho cov ntshav qabzib siab thiab txhawb kev poob phaus, tab sis nws cov peptide ntuj muaj lub neej luv luv thiab yuav tsum tau ua haujlwm ntau zaus, txwv tsis pub nws cov peev xwm siv tshuaj kho mob.
Txhawm rau kov yeej qhov kev txwv no, cov kws tshawb fawb tau ua haujlwm los txhim kho ntev - ua OXM analogues. Txoj kev loj hlob ntawm Mazdutide yog raws li lub hom phiaj no, los ntawm kev hloov kho nws cov qauv kom ncua nws lub sijhawm ua haujlwm. Tshwj xeeb, cov kws tshawb fawb tau qhia txog fatty acyl side chains rau hauv OXM molecule los ua ib qho ntev - ua yeeb yam peptide. Qhov kev hloov kho no ua rau lub sijhawm ntev ntawm cov tshuaj ib nrab -lub neej, ua rau ib zaug - kev tswj hwm txhua lub limtiam zaus thiab txhim kho kev ua raws li tus neeg mob. Thaum ntxov 2020s, cov ntaub ntawv tshawb fawb thaum ntxov ntawm Mazdutide maj mam dhau los ua pej xeem, nthuav tawm nws cov txheej txheem tshwj xeeb raws li ob tus agonist ntawm GLP-1R / GCGR. Piv nrog rau ib leeg receptor agonists, Mazdutide activates ob receptors ib txhij, tsis tsuas yog pab txhawb kev poob phaus thiab cov teebmeem hypoglycemic, tab sis kuj zam cov kev mob tshwm sim ntawm cov ntshav qab zib nce siab los ntawm kev txhawb nqa ntau dhau ntawm glucagon receptor los ntawm kev sib npaug receptor activation.
 |
 |
 |
Kev tshawb fawb soj ntsuam ntawm Mazdutide pib nyob ib ncig ntawm 2021. Cov kev sim thawj zaug feem ntau tsom rau kev nyab xeeb thiab kev ntsuam xyuas ntawm kev ua tau zoo thawj zaug. Kev kawm 1b theem ntau- koob tshuaj nce ntxiv (NCT04466904) tsom rau cov neeg mob suav nrog hom 2 mob ntshav qab zib tau pom tias tom qab 12 lub lis piam ntawm kev kho mob nrog Mazdutide, cov neeg mob cov qib glycated hemoglobin (HbA1c) txo qis, nrog qhov ntau ntawm -1.46% mus rau -2.23%, thiab qhov hnyav nce mus txog -2.23%. Cov ntaub ntawv no tsis tau tsuas yog txheeb xyuas lub dual mechanism ntawm Mazdutide tab sis kuj tau tsim lub hauv paus rau nws txoj kev loj hlob ntxiv hauv thaj tsam ntawm cov kab mob metabolic.
Tom qab ntawd, kev tshawb fawb soj ntsuam ntawm Mazdutide nthuav dav suav nrog cov neeg rog rog thiab rog rog. Hauv 1b theem randomized tswj kev sim luam tawm xyoo 2022, Suav cov neeg laus rog rog uas tau txais kev kho mob Mazdutide rau 12 lub lis piam tau ntsib qhov hnyav tshaj qhov txo mus txog 6.4%, thiab cov tshuaj tau txais txiaj ntsig zoo. Qhov profile kev nyab xeeb zoo ib yam li lwm cov GLP-1 receptor agonists. Qhov txiaj ntsig no ntxiv txhawb nqa lub peev xwm ntawm Mazdutide ua cov tshuaj poob phaus. Nyob rau hauv 2025, txoj kev loj hlob ntawm Mazdutide tau ua tiav ib qho tseem ceeb ua tiav. National Medical Products Administration ntawm Tuam Tshoj (NMPA) tau pom zoo nws siv rau kev tswj qhov hnyav ntawm Suav cov neeg laus rog rog lossis cov neeg mob hnyav, ua rau nws thawj GLP-1 receptor agonist dual GCG / GLP-1 receptor agonist kom tau txais kev pom zoo rau kev poob phaus thoob ntiaj teb.
Nyob rau hauv tib lub xyoo, cov txiaj ntsig ntawm qhov tseem ceeb ntawm theem 3 qhov kev tshawb fawb soj ntsuam ntawm Mazdutide (GLORY-1) tau luam tawm hauv New England Journal of Medicine. Txoj kev tshawb no tau pom tias tom qab 20 lub lis piam ntawm kev kho mob, qhov hnyav ntawm cov neeg mob hauv pawg Mazdutide tau nce ntau dua li cov placebo pab pawg, nce mus txog 5.7%, thaum qib HbA1c poob los ntawm 1.70%. Tsis tas li ntawd, Mazdutide tau nthuav tawm ntau qhov txiaj ntsig metabolic, suav nrog txo lub duav ncig, txhim kho cov ntshav lipids thiab ntshav siab, txo cov ntshav uric acid thiab siab enzyme qib, txo cov rog hauv siab, thiab txhim kho insulin rhiab heev. Cov txiaj ntsig zoo no ua rau Mazdutide sawv tawm hauv kev kho cov kab mob metabolic.
Kev pom zoo thiab kev tso tawm ntawm Mazdutide yog ib qho tseem ceeb hauv kev tshawb nrhiav thiab kev tsim cov tshuaj rau cov kab mob endocrine thiab metabolic. Nws lub tswv yim tshiab dual -receptor agonist mechanism muab lub tswv yim tshiab rau kev kho mob rog thiab muaj feem cuam tshuam txog kev mob metabolic. Raws li lub ntiaj teb thawj cov tshuaj pom zoo ntawm nws hom, Mazdutide tsis tsuas yog ua rau lub lag luam sib txawv tab sis kuj rov kho cov qauv kev kho mob ntawm cov kab mob metabolic los ntawm nws cov ntaub ntawv kho mob zoo heev. Nrog nws cov ntawv thov dav hauv kev kho mob, Mazdutide xav tias yuav muaj kev kho mob zoo dua rau ntau pua lab tus neeg rog rog thiab rog thoob ntiaj teb, thaum tseem txhawb kev tshawb fawb thiab kev loj hlob ntawm dual - receptor agonist tshuaj thiab qhib tshooj tshiab hauv kev kho cov kab mob metabolic.
Los ntawm tob- hiav txwv lom lom lom rau kev tshoov siab rau kev kho peptides
Hauv kev lag luam biomedicine, kos kev tshoov siab los ntawm cov txheej txheem lom neeg lom neeg hauv cov xwm txheej thiab hloov lawv mus rau hauv cov tshuaj kho mob yog ib txoj hauv kev tshiab uas muaj kev sib tw thiab cov cib fim. Mazdutide (Cov tshuaj peptide) yog ib hom tshiab ntawm dual agonist rau glucagon-zoo li peptide-1 receptor (GLP-1R) thiab glucagon receptor (GCGR). Nws txoj kev txhim kho yog ib qho piv txwv zoo ntawm txoj kev tshiab no. Tshwj xeeb yog qhov tseem ceeb yog tias ib feem ntawm nws qhov kev tshoov siab tsim los ntawm - kev tshawb fawb tob txog cov qauv ntawm cov dej hiav txwv tob tob lom lom. Qhov kev tshawb nrhiav hla kev qhuab qhia no tau qhib lub qab ntug tshiab rau kev kho cov kab mob metabolic.
Sib sib zog nqus- hiav txwv lom lom lom: "tsim tshuaj lom neeg" ntawm xwm
Qhov sib sib zog nqus- hiav txwv ib puag ncig, nrog rau nws cov huab cua siab, qhov kub thiab txias, qhov tsaus ntuj thiab cov ecosystem tshwj xeeb, tau ua rau muaj ntau yam txheej txheem nyuaj thiab ua haujlwm ntau yam lom lom lom lom. Cov co toxins no tsis yog tsuas yog cov khoom tseem ceeb ntawm kev tiv thaiv mechanisms ntawm cov kab mob marine, tab sis kuj yog ib qho khoom muaj nqis ntawm cov khoom ntuj tsim chemistry. Piv txwv li, polyether co toxins xws li cov los ntawm cov pob zeb xuab zeb anemone thiab Xijia, nrog rau lawv cov cim trapezoidal cyclic polyamide cov qauv, muaj cov tshuaj toxicity siab heev, thaum peptide co toxins xws li yurolin co toxins tawm dag zog los ntawm lub hom phiaj paub meej mechanisms. Cov yam ntxwv ntawm cov co toxins no yog lawv cov txheej txheem nyuaj heev thiab cov haujlwm tshwj xeeb, muab cov qauv molecular nplua nuj rau kev tsim tshuaj.
Txawm hais tias muaj kev pheej hmoo ncaj qha los ntawm kev siv cov tshuaj toxicity tob- hiav txwv co toxins rau kev txhim kho tshuaj, ntau haiv neeg ntawm lawv cov qauv tshuaj thiab qhov tshwj xeeb ntawm lawv cov kev ua ub no muab kev nkag siab tseem ceeb rau kev tsim tshuaj. Cov kws tshawb fawb soj ntsuam cov qauv molecular ntawm cov co toxins, txheeb xyuas lawv qhov chaw tseem ceeb, thiab siv cov txheej txheem tshuaj synthesis los hloov cov qauv no, hloov lawv los ntawm "tshuaj lom" mus rau "tshuaj". Cov txheej txheem no yuav tsum tsis yog tsuas yog kev nkag siab tob txog cov txheej txheem ntawm kev ua ntawm cov co toxins, tab sis kuj tseem muaj cov txuj ci ntawm cov khoom siv hluav taws xob zoo tshaj plaws thiab cov tswv yim pharmacology.
|
|
|
|
|
Kev tsim qauv molecular ntawm Mazdutide: Lub leap ntawm cov tshuaj lom mus rau kev kho peptide
Txoj kev loj hlob ntawm Mazdutide pib nrog rau hauv - kev tshawb fawb tob ntawm mammalian gastric acid - tswj cov tshuaj hormone (Oxyntomodulin, OXM). OXM yog ib qho tshwm sim hauv plab hnyuv hormone secreted los ntawm plab hnyuv L hlwb, muaj ob tug yam ntxwv ntawm ib txhij activating GLP-1R thiab GCGR, thiab muaj peev xwm tswj lub zog tshuav, qabzib metabolism, thiab tswj qhov hnyav. Txawm li cas los xij, ib nrab-lub neej ntawm ntuj OXM yog luv luv, yuav tsum tau siv ntau zaus, uas txwv tsis pub nws lub peev xwm rau kev siv tshuaj kho mob.
Txhawm rau kov yeej qhov kev txwv no, cov kws tshawb fawb tau tsim lub tswv yim ntawm kev sib sib zog nqus -cov co toxins hauv hiav txwv thiab hloov kho OXM kom ncua nws lub sijhawm ua haujlwm. Tshwj xeeb tshaj yog, lawv tau qhia txog fatty acyl side chain rau hauv OXM molecule, tsim ib lub sijhawm ntev - hluavtaws peptide. Qhov kev hloov kho no ua rau lub sijhawm ntev ib nrab ntawm - lub neej ntawm cov tshuaj, ua rau nws siv tau ib lub lis piam ib zaug, txhim kho kev ua raws li tus neeg mob.
Qhov tseem ceeb tshaj, kev tsim qauv molecular ntawm Mazdutide kuj suav nrog kev nkag siab zoo ntawm cov qauv- kev sib raug zoo ntawm cov co toxins. Piv txwv li, qee cov amino acid residues hauv nws cov kab ke (xws li AEEA-AEEA- -Glu-diacid-C20 linker) tuaj yeem txhim kho txoj kev sib raug zoo rau GLP-1R thiab GCGR los ntawm kev ua raws li cov chaw tseem ceeb hauv cov tshuaj lom. Qhov kev tsim no tsis tsuas yog khaws cov txiaj ntsig dual agonistic ntawm OXM tab sis kuj tseem ua kom zoo dua qhov sib piv ntawm receptor activation, zam cov kev mob tshwm sim (xws li cov ntshav qab zib nce siab los ntawm kev ua kom ntau dhau ntawm GCGR) uas tuaj yeem tshwm sim los ntawm kev txhawb nqa ntawm ib leeg receptor.
Clinical Validation: Txoj Kev Hla Dhau los ntawm Chav Ua Haujlwm rau Tus Neeg Mob
Kev tshawb fawb soj ntsuam ntawmCov tshuaj peptidetau lees paub qhov ua tau ntawm nws lub tswv yim tsim. Ntau qhov kev sim tau pom tias Mazdutide ua tau zoo hauv kev txo cov ntshav qab zib thiab txo qhov hnyav, nrog kev nyab xeeb zoo. Piv txwv li, hauv 2nd-theem kev tshawb fawb soj ntsuam tsom rau cov neeg mob suav nrog hom 2 mob ntshav qab zib mellitus, tom qab 20 lub lis piam ntawm kev kho mob nrog Mazdutide, cov neeg mob cov qib glycated hemoglobin (HbA1c) poob qis, nrog rau qhov hnyav txo mus txog 7.8% thiab qhia txog koob tshuaj - nyob ntawm tus qauv. Ntxiv mus, Mazdutide kuj tau txhim kho cov neeg mob cov ntshav lipids, ntshav siab, thiab insulin rhiab heev, muab lub tswv yim tshiab rau kev tswj hwm ntawm metabolic syndrome.
|
|
|
|
Qhov kev ua tiav ntawm cov txiaj ntsig no yog sib cais tsis tau los ntawm kev tshoov siab hloov pauv ntawm cov qauv sib sib zog nqus - hiav txwv toxins. Kev tsim ntawm Mazdutide tsis tsuas yog ua kom pom qhov tseeb ntawm kev ua haujlwm ntawm ntuj molecules, tab sis kuj nthuav tawm lub peev xwm zoo ntawm kev hloov kho tshuaj hauv kev txhim kho cov tshuaj pharmacokinetic ntawm cov tshuaj.
Yav tom ntej Outlook: Los ntawm Kab Mob Metabolic mus rau Broader Fields
Txoj kev vam meej ntawm Mazdutide tau teeb tsa tus qauv tshiab rau kev kho cov kab mob metabolic, tab sis nws qhov cuam tshuam mus deb dhau qhov no. Raws li kev nkag siab ntawm dual agonist mechanism ntawm GLP-1R/GCGR tob zuj zus, Mazdutide thiab nws cov analogues yuav tsum ua kom pom qhov muaj peev xwm kho tau hauv thaj chaw xws li tsis yog- cawv steatohepatitis (NASH) thiab kab mob plawv. Tsis tas li ntawd, nws lub tswv yim tsim kuj tseem muab cov ntaub ntawv siv rau kev txhim kho ntawm lwm cov tshuaj ntau lub hom phiaj, txhawb kev hloov pauv hauv kev tshawb fawb tshuaj los ntawm "ib lub hom phiaj" mus rau "kev tswj hwm network".
Los ntawm cov co toxins ntawm tob- hiav txwv creatures mus rau kev tshoov siab rau kev kho mob peptides, txoj kev loj hlob ntawm Mazdutide qhia tau hais tias lub zoo meej kev koom ua ke ntawm xwm thiab technology. Nws ua rau peb nco ntsoov tias xwm muaj suav tsis txheeb "kev txawj ntse" uas tseem tsis tau pom, thiab lub hom phiaj ntawm cov kws tshawb fawb yog los hloov qhov kev txawj ntse no rau hauv cov tshuaj uas muaj txiaj ntsig rau tib neeg los ntawm kev siv thev naus laus zis tshiab. Nyob rau hauv lub neej yav tom ntej, raws li peb txuas ntxiv tshawb nrhiav qhov nyuaj ntawm cov roj ntsha molecules, peb muaj peev xwm ua tim khawv txog kev yug los ntawm ntau cov tshuaj zoo li Mazdutide, coj kev cia siab tshiab rau tib neeg kev noj qab haus huv.
Cov lus nug nquag
mazdutide peptide ua dab tsi?
+
-
Mazdutide, ib tug dual agonist ntawm glucagon-zoo li peptide-1 receptor (GLP-1R) thiab glucagon receptor (GCGR), tau pom tias tib lub sijhawm txo lub cev hnyav, ntshav qabzib, thiab lwm yam comorbidities cuam tshuam nrog kev rog hauv cov neeg mob T2DM.
Puas yog mazdutide zoo dua tirzepatide?
+
-
Mazdutide vs tirzepatide: Cov txiaj ntsig poob phaus
Kev sim tshuaj hauv Suav teb tau pom tias tib neeg noj 6mg ntawm mazdutide poob qhov nruab nrab ntawm 14% ntawm lawv lub cev hnyav tom qab 48 lub lis piam. Lwm qhov kev sim hauv Suav pom tias tib neeg noj 15mg ntawm tirzepatide (Mounjaro) poob 17.5% ntawm lawv lub cev hnyav tom qab 48 lub lis piam.
Thaum twg mazdutide tau pom zoo hauv Suav teb?
+
-
Lub Rau Hli 2025
Thaum Lub Rau Hli 2025, mazdutide tau txais kev pom zoo thawj zaug, hauv Suav teb, rau kev siv (ua ke nrog kev tswj hwm kev noj zaub mov thiab ua kom lub cev muaj zog) nyob rau hauv ntev -lub sij hawm tswj lub cev hnyav hauv cov neeg laus nrog lub cev - qhov ntsuas qhov hnyav (BMI) ntau dua lossis sib npaug li 28 kg / m2 lossis nrog BMI Ntau dua lossis sib npaug rau 24 kg / m2.
Cim npe nrov: mazdutide peptide, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom