Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm NA-931 peptide hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo na-931 peptide rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
NA-931 Peptide, Cov khoom lag luam bioglutide yog lub ntiaj teb thawj zaug ua kom muaj cov kab mob hauv kev kho mob ntawm kev kho cov kab mob gluabolic {2/2 2 Cov tshuaj insulin zoo li kev loj hlob-1 tus nqi (iGF-1R). Nws cov kev ua tshuab ntawm kev nqis tes ua yog raws cov txiaj ntsig synergistic ntawm ntau lub hom phiaj, tab sis kuj tsis ua tiav qhov kev tswj hwm ntshav zoo thiab kev txhim kho ntshav qab zib thiab metabolic.
Na - 931, raws li lub ntiaj teb thawj zaug ua haujlwm ntawm kev kho mob hauv cov kab mob hauv av (GCGR), glucagon receptor (GLP-1R) Kev Loj Hlob Qhov Loj-1 tus nqi (iGF-1R).
Bioglutid tau qhia txog kev ua haujlwm ntawm kev kho mob ntawm kev rog dhau los, kev tiv thaiv cov leeg kom txaus siab los ntawm ntau yam kev cuam tshuam.
Kev tshwm sim poob phaus phaus: Bioglutid tau pom koob - Nyob hauv cov kev sim siab hnyav. Piv txwv li, hauv 13 lub lim tiam theem II lub tsev kho mob sim ua ib qho kev ua haujlwm poob qis ntawm 13.8%, piv rau tsuas yog 11.9% hauv daim foos. Ntau tus neeg sau ntawv yog 72% ntawm bioglutID kho cov neeg mob ua tiav tsawg kawg 12% phaus poob, piv rau tsuas yog 1.9% hauv daim foos. Ib qho ntxiv, hauv 28 Hnub Kawm Ua Ntej, cov Biogluttern daim ntawv qhia txog qhov poob phaus ntawm li 6.3%, qhia tias nws poob phaus yog txhawb nqa thiab ruaj khov.
Cov leeg mob tiv thaiv me me: kev ua haujlwm hnyav tsis muaj tshuaj, thaum bioglutod signifcantic sib tsoo thiab txhawb nqa cov leeg nqaij synthesis los ntawm kev ua haujlwm igf-1r.
Nyob rau hauv theem II kev sim siab, cov leeg leeg loj (SMI) ntawm cov neeg mob hauv bioglutid nce los ntawm 1.7% nce los ntawm "poob nthav". Cov xeeb ceem no ua rau nws xaiv qhov zoo tshaj plaws rau cov neeg mob rog nrog cov leeg atrophy.
Cov Kev Nyab Xeeb Kev Nyab Xeeb: Qhov tshwm sim ntawm cov kev nyuaj siab ntawm bioglutod yog signifcanticant cov tshuaj sib xws. Nyob rau theem II kev sim siab, tsuas yog 7.3% ntawm cov neeg koom nrog lub xeev siab thiab 6.3% cov xwm txheej me lossis tsis muaj cov lus ceeb toom ntawm cov xwm txheej phem. Txoj kev tswj hwm qhov ncauj tau txhim kho tus neeg mob ua raws li thiab muab yooj yim rau kev kho ntev}} kev kho mob.
NA-931 PeptideUa tau zoo nyob rau hauv kev txhim kho cov ntshav ntshav qab zib ntau los ntawm ntau- hom phiaj ua haujlwm sib koom ua ke, tshwj xeeb yog cov neeg mob rog nrog hom 2 Ntshav Qab Zib Hom 2.
Ntshav qab zib Cov kev cai: Ua Haujlwm ntawm GLP-1R thiab GIPR tuaj yeem tsim cov kua pleev roj av, thiab yog li txo cov ntshav ntshav qab zib ntshav qab zib. Nyob rau tib lub sijhawm, GCGR ua haujlwm txhawb nqa cov kev cai ntawm hepatic qab zib tawm, thaum IGF-1R Enttake, sib sau cov leeg metees ntawm "Mob leeg nqaij pancle". Nyob rau hauv theem kuv, bioglutid txo cov ntshav ntshav qab zib los ntawm 1.8 mmol / l thiab glycosylated hemroglobin (HBA1C) los ntawm hom 2 hom phiaj GLP-1 analog.
Metabolic muaj kev txhim kho kom meej: Bioglutid tsis yog txo cov ntshav qab zib, tab sis kuj synchronously txhim kho cov tswv yim metabolic xws li ntshav lipids thiab cov ntshav siab. Theem II kev sib hais qhia tias tus neeg mob lub duav taug kev poob qis los ntawm 284%, tiv thaiv kev muaj peev xwm ntau dhau ntawm cov kev tswj hwm metabolic.
Kev tiv thaiv ntev ntev: Los tswj cov leeg ua tau zoo los ntawm kev ua yeeb yam hauv IGF-1R yuav txo qis kev phom sij ntawm cov ntshav qab zib. Cov leeg yog lub ntsiab lus metabolic thiab cov nqaij muaj zog tuaj yeem ua rau cov tshuaj insulin tsis kam. Cov leeg tiv thaiv ntawm bioglutid pab tsim lub voj voog tsim txiaj ntawm "Lub cev yuag poob cov leeg nqaij cov leeg".
Cov ntaub ntawv hauv tsev kho mob: DUAL ABPTITY ntawm Kev Ntsuas Lub Cev yuag thiab kev txhim kho metabolic
Kev tshawb fawb txog bioglutod tau lees paub nws kev nyab xeeb thiab kev ua tau zoo los ntawm ntau -}} theem sim
Theem kuv sim (bioglutid-050)
Tsim: randomized, ob npaug - qhov muag tsis pom kev, suav nrog kev ua si dhau los, tsis hais leej twg ntawm cov ntshav qab zib hom 2 lossis tsis yog).
Qhov tshwm sim:
Lub cev yuag yuag: 6.4% poob phaus nyob rau hauv 28 hnub (thiab 5.1% poob phaus hauv 12 lub lis piam (150MG koob tshuaj).
Kev tswj ntshav kom haum ntshav: Kev yoo ntshav qab zib ntawm hom 2 tus neeg mob ntshav qab zib tsawg dua los ntawm 1.8 MMOL / L, thiab glycosylated hemoglobin (HBA1C) tsawg dua 0.9%.
Kev Nyab Xeeb: Tsis muaj cov npe ntawm cov nyom tshwm sim (xeev siab nyob ntawm 7.3%, raws plab 6.3%), tsis muaj cov leeg poob.
Theem II Kev Sib Tham (NCT06564753)
Tsim: A 13 lub lis piam Randomized, ob {{1} {}
Qhov tshwm sim:
Lub cev yuag: Daim ntawv FERE 150MG Dose tau ploj qhov nruab nrab ntawm 14.8% (piv rau 12,2% ntawm cov neeg tuaj koom nrog 12% (piv rau tsuas yog 2% hauv daim ntawv Faccebo).
Cov ntsuas metabolic: lub duav ntawm txoj kev zom ntshav tsawg tsawg ntawm 9.2CM, yoo pleev cov tshuaj insulin tsawg tsawg tsawg ntawm 34%, thiab cov triglycerides txo li 28%.
Kev Nyab Xeeb: Cov txheej txheem kev nyab xeeb feem ntau yog me me (xeev siab 8.1%, raws plab mogea 6.3%), uas tsis muaj cov xwm txheej tsis zoo.
Theem II Txuas Txuas Txuas (NCT06732245)
Tsim: ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawmNA-931 PeptideMonotherapy lossis hauv kev sib txuas nrog tirzepatide.
Tus nqi kho ua ntej: Qhov hnyav poob ntawm cov kev kho mob sib txuas tau zoo dua li ntawm cov nyhuv ntawm multiotheritection ntawm multi {1} {1}- kev kho mob.
Kev Kawm Tshawb Xyuas: Kev siv tau ntawm kev ua tau zoo thiab kev nyab xeeb los ntawm theem kuv mus rau theem III
Kev tshawb fawb tsim qauv: Randomized, ob npaug {{0} {{tus neeg mob tsis pom kev, ib qho / pd / pd yam ntxwv ntawm bioglutide.
Cov Ntsiab Lus Tseem Ceeb:
Kev Nyab Xeeb: Tsis muaj cov xwm txheej nyuaj (xeev siab tau tshaj tawm tias muaj kev cuam tshuam tsis zoo rau 5% thiab tsis muaj duab kos npe ntxiv nrog kev txhaj tshuaj ntau dua.
PK Cov yam ntxwv nqus dej: Lub sijhawm nqus tshuaj sai sai (Tmax) ntawm 1 {}} 2 teev, txhawb nqa ib hlis ib zaug.
Cov nyhuv pd: tom qab ib koob tshuaj, ob qho tib si ua kom ntshav qab zib (150 mg) Tom qab ntau cov koob tshuaj, lub cev yuag yog koob tshuaj - nyob ntawm seb, nrog qhov hnyav nruab nrab ntawm 12.7% (thiab daim ntawv ntawm 150 mg daim ntawv ntawm 12 lub lis piam.
Kev tsim qauv tsim qauv: Randomized, ob {- Tus neeg mob sib tw, cuam tshuam nrog kev sib raug zoo lossis sib npaug lossis sib npaug ntawm 27 kg / m ²). Cov neeg mob tau muab faib ua daim ntawv placebo, qhov tsis muaj koob tshuaj noj (75} {}}
Cov Ntsiab Lus Tseem Ceeb:
Lub cev poob phaus:
Qhov hnyav nruab nrab poob rau hauv high - Dose daim ntawv yog 13,8% (vs {% hauv cov teebmeem ntawm thaj chaw placebo), thiab tom qab kho kom haum rau cov teebmeem kev sib txuam, nws yog 11.9%.
72% ntawm cov neeg mob nyob rau hauv lub siab - dose daim ntawv uas ploj ntau dua lossis sib npaug rau 12% hauv daim ntawv placebo).
Qhov qis -} Dose daim ntawv muaj qhov hnyav nruab nrab phaus ntawm 9.3% (nrog 45% ntawm cov neeg mob poob ntau dua lossis sib npaug ntawm 10% hnyav.
Txhim kho ntawm cov ntsuas metabolic:
Kev tswj ntshav ntshav qab zib: hauv qhov siab - Daim ntawv zom ntshav, HBOL / L (thiab Glycated hemblobin (HBA1C) tsawg dua los ntawm 0.8% (thiab FaceBo+0.1%).
Cov ntshav lipid licid: tag nrho cov roj cholesterol thiab tsawg - lawb lipoprotein cholesterol (LDL -. Nyeem nqi tsawg dua.
Kev Ruaj Ntseg:
Qhov tshwm sim ntawm cov teeb meem tsis zoo yog 7.3% (xeev siab) thiab 6.2% (mob plab zom mov, thiab tsis ntuav thiab tsis ntuav me me thiab tsis ntuav thiab tsis ntuav me me thiab tsis ntuav me me thiab tsis ntuav.
Tsis muaj cov leeg poob: pom los ntawm dual lub zog x {{{} Daim duab ray absibretry (thaum high {1} {1} Daim ntawv txheej txheem ruaj khov, thaum daim ntawv placebo pom kev txo me ntsis.
Tsis muaj tus hypoglycemic Txheej xwm: tsis muaj qhov siab ntshav siab mob (ntshav ntshav qab zib<3.0 mmol/L) was reported in any form.
Kev tshawb fawb tsim: ib randomized, ob - cov neeg mob lub ntsej muag, los cuam tshuam nrog cov neeg ua haujlwm ntawm bioglutide thiab terzepatide (5 mg) rau 24 lub lis piam ntawm kev kho mob.
Cov txiaj ntsig ua ntej:
Lub cev poob phaus:
Qhov hnyav nruab nrab poob rau hauv daim ntawv sib txuas yog 18,5% (piv rau 14.2% hauv daim foos Midotherapy thiab 2.1% hauv daim foos Facothopebo).
65% ntawm cov neeg mob hauv daim ntawv sib txuas uas poob ntau dua lossis sib npaug rau 158% hauv daim foos Memotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim foos packotherapy thiab 0% hauv daim ntawv Facothopebo).
Kev Ruaj Ntseg:
Qhov tshwm sim ntawm cov kev tsis sib haum hluav taws xob hauv cov ntawv sib txuas (12.7%) yog siab me dua li ntawd hauv cov tshuaj mootherapy (8.3%), tab sis txhua tus tau mob me me thiab tsis ua rau cov tshuaj txiav tawm.
Tsis muaj cov cim kev nyab xeeb tshiab, thiab sib txuas nrog kev kho mob tsis yog signifcantic ua kom cov kev pheej hmoo ntawm hypoglycemia lossis cov leeg.
Biomed kev lag luam npaj yuav pib ua ntu theem III chaw kho mob (NCT06824) uas muaj kev ua haujlwm ntev, thiab cuam tshuam rau cov qauv ntawm cov hlab ntsha ntawmNA-931 PeptideCov. Cov ntsiab lus theem nrab xaus suav nrog cov qhab nia zoo, kev kho mob ntawm cov nyhuv metabolic thiab cov khoom muaj ntshav qab zib.
Cim npe nrov: NA-931 Peptide, Cov Chaw Tsim Khoom, Chaw Tsim Khoom, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, lag luam Wholesale, yuav, nqe, loj, loj, rau muag