Noopept hmoov, nws yog ib lub tawb rau hauv lub voj voog glycine proline dipeptide tsim los ntawm Russia, nrog cov molecular tus qauv tsim los ntawm C17h22n2o4, tus lej ntau-8, thiab lub cev hnyav ntawm 318.37. Nws cov qauv molecular muaj cov phaenylacetyl thiab kev ua kom zoo nkauj thiab pab pawg ua haujlwm. Proline yog ua ke nrog phenylacetyl chloride los ntawm kev tawm tsam acylation, thiab cov khoom kawg yog lim los ntawm kem chromatography. Lub ntsiab lus melting ntawm cov tshuaj no yog 98-102 degree, thiab nws yog ib tus mob hydrolysis thiab tsis ua tiav nyob rau hauv acidic tej yam kev mob. Nws yuav tsum tau khaws cia ntawm -20℃los tswj kev ruaj khov. Hais txog ntawm kev neureptection, Noopept txhim kho lub muaj peev xwm muaj peev xwm ntawm lub qia hlwb los ntawm IL-6 Kho Mob BDNF Othiat Mecharessionism. Nyob rau tib lub sijhawm, ua calcium censions thaiv, nws txo glutamate indicted exchology raug mob xws li kev raug mob hlwb, ischemia, thiab hypoxia. Nyob rau theem ntawm Neurotransmitter cov kev cai, nws tuaj yeem txhawb kev kawm acetylcholine thiab nco qab kev kawm thiab lub cim xeeb thaum tsis txhob muaj calcium overload. Ib qho ntxiv, nws tuaj yeem txhawb qhov kev qhia ntawm NGF thiab BDNF, Txhawb kev ua yeeb yam ntawm Lipid Psoxidation, thiab txhim kho cov khoom siv tshuaj tiv thaiv kab mob antioxidant.
Peb Cov Khoom
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
Peb Cov Khoom
Noopept +. coa
Noopept (Tshuaj lom neeg lub npe: n-phenylacetyl-L-predylglycine tau piav qhia los ntawm plaub qhov chaw txawj ntse, thiab cov khoom siv hluav taws xob, cov khoom siv tshuaj lom neeg, thiab kev ua yeeb yam tshuaj lom neeg.
Nws cov qauv muaj peb ntu:
Phenylacetyl: Muab hydrophobicity thiab kev ua yeeb yam, thiab tuaj yeem txhim kho cov ntshav-lub hlwb thaiv kev nkag mus hauv π - π kev sib cuam tshuam.
L-proline residue: Ua rau tsib tus tswv cuab nplhaib ua qauv, lim cov roj molecular kev ywj pheej thiab txhim kho meabolic ruaj khov.
Glycine Ethyl Ester Group: Ua ib qho qauv ester, nws yog yooj yim hydrolyzed los ntawm kev siv hauv glycine thiab ethanol, thaum tso cov tawg.
Cov qauv no tau tsim raws li qhov kev sib tw ntawm endogenous neuropepine cyclic, uas tau txhim kho kev txhawb nqa ntawm lub hlwb-kev hais tawm los ntawm phenylacetyl kev hloov kho.
Lub cev thiab tshuaj
Cov tsos mob thiab cov xwm txheej: dawb crystalline khoom nrog lub ntsiab lus melting ntau ntawm 94-102 degree, qhia tau cov qauv lead ua ke.
Solubility:
Dissolve hauv cov kuab tshuaj organic xws li chloroform, ethanol, DMOPS, thiab lwm yam, nrog rau solubility ntawm 20-25 mg / ml hauv DMOPS.
Kev qhia me me hauv dej, qhia tias nws cov kua txiv solubility yuav tsawg, thiab nws yuav tsum tau ua kom zoo dua los ntawm kev tsim tawm thev naus laus zis.
Cov kua qaub stability: nyob rau hauv cov dej ntshiab acidic (xws li cov kua txiv acidic), nws yog ib qho mus rau cov kua roj plab thiab tsis ua haujlwm, ua cov phenylacetic acid thiab prolyl glycine Ethylen Ester. Yog li ntawd, nws yuav tsum tau muab khaws cia rau hauv cov kab ke tsis ua haujlwm nrog cov ph ntawm 6-8.
Thermal Stability: Qhov kwv yees npau npau yog 547.3 ± 50.0 Degree, tab sis nws yuav tsum tau khaws cia qis (-20℃tuaj yeem khaws cia rau 3 xyoos).
Hydrolysis tiv thaiv:
Ester Hydrolysis: nyob rau hauv kev txiav txim ntawm kev nce qib hauv lub cev, cov Glycine hydrolyzed rau hauv glycine thiab etharanol, uas yog ib qho ntawm cov kev loj metabolism.
Amide daim ntawv cog lus hydrolysis: nyob rau hauv cov muaj zog acid lossis muaj zog hauv paus ntawm proline thiab glycine tej zaum yuav tawg, ua penylacetylproline thiab glycine.
Redox cov tshuaj tiv thaiv:
Lub nplhaib Benzene tuaj yeem koom nrog kev tawm tsam oxecule yuav tsim cov khoom lag luam tsis muaj tseeb, tab sis cov khoom lag luam oxidation tsis tau raug tshaj tawm.
Nyob rau hauv dawb radical scavenents, Noopept tuaj yeem inhibit tau txais kev sib txuam ntawm cov dawb radicals hauv neuro ₄, hais kom nws tuaj yeem tiv thaiv cov hlab ntsha los ntawm kev ua haujlwm ntawm cov kab mob antioxidant.
Cov kev tiv thaiv yees duab: tsis muaj ib qho kev qhia meej ntawm cov ntaub ntawv qhia meej, tab sis cia yuav tsum zam ntawm lub teeb kom tiv thaiv kev tsis pom zoo.
Kev ua haujlwm roj ntsha thiab cov pharmaconinnelics
Txhawb txoj kev txawj ntse thiab kev ua tsis tau:
Kev ntsuas kev sib kho ntawm BDNF los ntawm IL-6 txhawb nqa cov qia cell sib txawv (Morris Da Dej Mazaze Dag tau nce qib siab hauv Mice).
Inhibiting qhov tsim ntawm Fibrillar Cov Qauv Ntawm - Amyloid Protein (25-35) tej zaum yuav muaj cov peev xwm kho kho rau Alzheimer tus kab mob.
Antioxidant Mechanism:
Nyob rau hauv cov kev sim vito tau qhia hais tias Noopept tuaj yeem txo cov neeg tuag tom qab h ₂ {± 0.27 μ m) thiab inhibit lipid peroxidation puas tsuaj.
Chaw muag tshuaj uas tsis tau:
Lub qhov ncauj Bioavailability tsis tau qhia meej meej, tab sis cov metabolites tau raug kuaj pom nyob hauv lub hlwb hauv 1 teev tom qab kev sim tsiaj.
Cov metabolites kuj yuav suav nrog cyclofrollglycine (ib qho endogenous neuropeptide), ntxiv txhawb nws cov nyhuv neuroprotective.
Noopept hmoov(Tshuaj lom neeg npe: n-phenylacetyl-L-predylglycine ensyl esters tsim nyob rau hauv Russia, yog coldycine predepring dipeptide. Nws cov qauv molecular muaj cov phenylacetyl, l-proline seem, thiab glycine phaus ethyl ester, nrog molecular hnyav ntawm 318.37 g / mol. Tam sim no, cov txheej txheem hluavtaws ntawm Noopept yog muab faib ua ob pawg: Txheej txheem txhim kho ntau yam khoom siv thiab kev txhim kho cov txheej txheem txhim kho qauv. Cov hauv qab no yog qhov ntsuas pom ntawm cov kev xav ntawm cov ntsiab cai ntawm cov hauv paus ntsiab lus, cov kauj ruam tseem ceeb, kev siv nyuaj, thiab kev lag luam.
Cov Qauv Txheej Txheem Multi-Affthesis Txheej Txheem: Txoj kev tiav los ntawm cov khoom nyoos rau cov khoom
Txoj kev hluavtaws zoo nkauj pib nrog L-proline thiab tsim lub hom phiaj molecule los ntawm peb kauj ruam ntawm kev ua kom muaj zog, thiab kev ua kom zoo nkauj. Cov qauv muaj cov kauj ruam tseeb, tab sis nruj tswj ntawm cov tshuaj tiv thaiv kev xav tau kom tsis txhob muaj cov khoom ntawm cov khoom lag luam.
Cov tshuaj tiv thaiv kab mob: cov amino pab pawg ntawm l-prolleophilic hloov cov kev ntxias nrog boyleyl chloride los tsim cov n-phenylacetyl-l-proline.
Cov Kev Mob:
Kaus: Dichhloromethane (DCM) lossis TetrahyDrofuran (Thf)
Alkali catalyst: Triethylamine (Tshuaj yej) lossis Pyridine
Kub: 0-5 Degree (Hauv Qab Dej Kob Dej)
Teb lub sijhawm: 2-4 teev
Cov ntsiab lus tseem ceeb:
Penyylacetyl vloride yuav tsum tau maj mam txav mus los tswj cov tshuaj tiv thaiv zoo, uas tuaj yeem ua rau muaj kev tsim cov tshuaj uas muaj acylation thiab zoo li n, n-diphenylacetyl-l-proline).
Tom qab cov tshuaj tiv thaiv tiav, nws yog ib qho tsim nyog los ntxuav nrog dilute hydroti catalyst thiab tiv thaiv alkali seem los ntawm kev cuam tshuam cov tshuaj tiv thaiv hws hauv cov kauj ruam tom ntej.
Cov tshuaj tiv thaiv N-phenylacetyl-L-predracetyl-l-proline glycine Ethyl Ester.
Xaiv cov neeg xaiv khaub ncaws hnav:
Tsoos txoj kev: Dicyclohexylcarbodiimide (dcc) +1- hydroxyriazole (hydt)
Kev Txhim Kho Niaj Hnub No: O - (7-Azabenzotriazol-1-YL) - N, N ', N', N ', N', N ', N', n '
Kev ua kom tau zoo ntawm cov tshuaj tiv thaiv cov kev mob:
Kaus: N, N-Dimethylformamide (DMF) lossis DRethyl Sulfoxide (DMOPS)
Qhov Kub: Chav Chav (25 Qib)
Lub sij hawm: 6-12 teev
Kev nyuaj:
Glycine Ethyl Ester Hydrochloride yuav tsum tau neutralized nrog lub hauv paus (xws li kev tawm tsam ntawm amino pab tau cov tshuaj tiv thaiv hws.
Hatu, raws li lub condensing tus neeg sawv cev, tuaj yeem ua rau lub sijhawm tiv thaiv (6 teev vs. 12
Txoj Kev Txhuam Ua Si:
Kem chromatography: silica gel kem (200-300 mesh
Recrystallization txoj kev: yaj cov khoom lag luam hauv Ethananol maj mam txias, thiab rov ua dua 2-3 zaug ntxiv kom muaj kev coj dawb huv tau tshaj li 98%.
Kev Sib Tw Industryial:
Txawm hais tias cov chromatography muaj siab huv, nws noj ntau ntawm cov kuab tshuaj thiab yog kim, uaNoopept hmoovNyuaj rau kev thov rau ntawm qhov loj loj.
Cov txheej txheem Recrystallization yuav tsum tswj cov crystallization tus nqi, ib yam li nrawm nrawm tuaj yeem ua rau tsis muaj crystal crystal particle thiab cuam tshuam ntxiv kom qhuav.
Kev Txhim Kho Kom Txhim Kho Txoj Kev Txhim Kho: Txhim Kho Kev Txhim Kho thiab Tawm Los
Hauv kev teb rau qhov tsis txaus ntseeg ntawm cov qauv ntawm cov txheej txheem classical, tsom cov txheej txheem txhim kho hauv cov nqi ntau lawm thiab txhim kho cov khoom lag luam.
Txoj kev 2- microwave pab synthesis: kev tawm tsam hws hws
Lub hauv paus ntsiab lus: Siv microwave hluav taws xob muab lub zog, cov tshuaj tua kab sib tsoo sai sai hauv cov chaw hluav taws xob ntau hauv hluav taws xob, cov sijhawm luv luv.
Cov ntaub ntawv sim:
Nyob rau hauv cov xwm txheej ntawm microwave zog ntawm 300W thiab qhov kub ntawm 80 degree, lub sijhawm tiv thaiv tau luv los ntawm 12 teev mus rau 20 feeb.
Cov txiaj ntsig nce ntxiv los ntawm 65% hauv cov qauv classical rau 82%, thiab cov khoom ntawm cov khoom (xws li kev ua yeeb yam) tsim kom tsawg.
Muaj Peev Xwm:
Yuav tsum muaj cov khoom siv tshuaj kho mob microwave muaj, uas muaj cov cuab yeej siv siab thiab cov nqi sijhawm, ua rau nws tsim cov khoom lag luam kom muaj txiaj ntsig zoo ntxiv.
GREEL GROXENT SYSTEM: Hloov ib txwm muaj cov kuab tshuaj organic
Tom qab: Cov tshuaj qhia ib txwm xws li DMF thiab DMOs yog tshuaj lom thiab tsis ua raws li cov kev xav tau ntawm cov tshuaj ntsuab.
Txoj Kev Npaj Txhim Kho:
Siv 2-methyltetrahydrofuran (2-methf) hloov DMF: 2-Methf muaj qhov yooj yim boiling point (80 degree), yog tsis muaj kev cuam tshuam loj, thiab tsis muaj kev cuam tshuam rau kev cuam tshuam rau cov kev cuam tshuam ntawm cov hws.
Ionic kua raws li cov kuab tshuaj, xws li [bmim] [BF4] (1-butylomidAruorobororate), tuaj yeem rov ua dua 5 zaug nrog cov txiaj ntsig ruaj khov ntawm 78%.
Cov txiaj ntsig kev ua haujlwm:
Txo cov kuab pa roj plab thiab cov nqi kho mob qis dua.
Ionic kua yuav tswj tau cov tshuaj tiv thaiv microenvironment thiab txhim kho cov tshuaj tiv thaiv kev xaiv.
Txoj Kev 3- Nruam Ntws Flow Synthesis Technology: Ua tiav Kev Siv Nkaus
Lub hauv paus ntsiab lus: cov reactants tsis tu ncua los ntawm microchhannel reassor los ua kom tiav cov tshuaj tiv thaiv kev tswj kub thiab siab.
Sim rooj plaub:
Cov tshuaj tiv thaiv hws yog nqa tawm hauv cov microchhannel reassor nrog lub sijhawm nyob ntawm tsuas yog 5 feeb thiab ib tawm los ntawm 85%.
Kev hloov kho lub sijhawm tiag tiag ntawm cov tshuaj tiv thaiv tsis dhau los ntawm kev soj ntsuam xyuas cov qauv online los xyuas kom cov khoom muaj kev ruaj khov.
Qhov tseem ceeb ntawm kev lag luam:
Zam kev sib txawv thiab txhim kho ntau lawm sib txawv.
Cov cuab yeej ua haujlwm nyob thaj chaw me me thiab haum rau kev hloov kho thiab txhim kho cov khoom muaj sia nyob tam sim no.
Kev sib piv thiab xaiv cov lus qhia rau cov qauv hluavtaws
| Cov Qauv Hom | Pub | Lub sijhawm | Hnyav tus nqi | Cov cuab yeej xav tau | Muaj cov xwm txheej muaj feem xyuam |
| Classic Multi-Stept Synthesis Txoj Kev | 65-72% | 18-24 teev | Siab (DMF) | Pa Pwm Ntxhw Kho Cov Khaub Ncaws Kuaj Xyuas | Me ntsis-teev ntau lawm |
| Microwave pab cov qauv hluav taws xob hluavtaws | 78-85% | 20-60 feeb | (2-methf) | Microwave Reactor Pilot Nplai | Cov khoom lag luam muaj nqis-ntxiv |
| Nruam Ntws Khoom Siv Hluav Taws Xob | 80-88% | 5-15 feeb | Tsawg (ionic kua) | Microchannel reactor | Kev lag luam loj-teev ntau lawm |
Cim npe nrov: Noopept hmoov, cov chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag