Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm pramlintide acetate cas 196078-30-5 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo pramlintide acetate cas 196078-30-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pramlintide acetate hmoovyog ib qho khoom siv hluavtaws peptide compound. Cov xim txawv los ntawm dawb mus rau yuav luag dawb, uas yog txiav txim los ntawm lub cev lub cev ntawm nws cov hmoov khoom. Cov mis mos molecular yog C173H273N51O56S2, CAS 196078-30-5, nrog rau qhov hnyav molecular ntawm kwv yees li 3951.41000. Soluble hauv acetic acid (me me) thiab DMSO (me me). Nyob rau hauv dej, nws solubility yog tsawg. Nws yog ib qho peptide compound, thiab nws cov viscosity yuav cuam tshuam rau nws qhov hnyav molecular thiab kev sib cuam tshuam ntawm intermolecular. Nyob rau hauv physiological tej yam kev mob, nws viscosity yuav cuam tshuam rau nws tis thiab pharmacokinetic zog nyob rau hauv vivo.
Surface nro yog qhov attraction ntawm nto molecules thaum ib yam khoom los rau hauv kev sib cuag nrog ib tug roj los yog kua. Rau peptide tebchaw, lawv qhov nro saum npoo yuav cuam tshuam nrog molecular polarity thiab hnyav sib cuam tshuam. Thermal stability muaj feem xyuam rau nws cov qauv tshuaj thiab ib puag ncig tej yam kev mob. Thaum qhov kub thiab txias, qee cov khoom siv tshuaj lom neeg tuaj yeem tawg lossis cov khoom sib txuas tuaj yeem raug degradation.
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Customized Bottle Caps Thiab Corks:
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Pramlintide Acetate COA
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Tshuaj Formula |
C171H267N51O53S2 |
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Exact Mass |
3946.92 |
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Molecular Luj |
3949.44 |
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m/z |
3947.92 (100.0%), 3948.93 (91.9%), 3946.92 (54.1%), 3949.93 (28.2%), 3949.93 (27.7%), 3948.92 (18.8%), 3950.93 (17.6%), 3949.92 (17.3%), 3949.93 (10.9%), 3947.92 (10.2%), 3950.93 (10.0%), 3949.92 (9.0%), 3950.92 (8.3%), 3950.93 (7.3%), 3951.94 (6.6%), 3948.92 (5.9%), 3950.93 (5.3%), 3950.93 (5.2%), 3948.92 (4.9%), 3951.93 (3.3%), 3951.93 (3.1%), 3951.93 (3.0%), 3951.93 (2.5%), 3951.93 (2.5%), 3950.92 (1.7%), 3948.92 (1.6%), 3952.93 (1.6%), 3951.92 (1.6%), 3949.93 (1.5%), 3951.94 (1.2%), 3949.92 (1.2%) |
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Elemental Analysis |
C, 52.00; H, 6.81; N, 18.09; O, 21.47; S, 1.62 |
Kev siv cov tshuaj insulin hauv kev kho mob ntshav qab zib
Pramlintide acetate hmoovyog ib qho hluavtaws polypeptide compound, uas yog siv los kho cov ntshav qab zib thiab cov teeb meem cuam tshuam.
Hom 1 mob ntshav qab zib mellitus yog vim kev puas tsuaj ntawm pancreatic islet beta hlwb, ua rau tsis muaj insulin kiag li. Cov neeg mob yuav tsum tau cia siab rau kev kho mob exogenous insulin, tab sis kev kho tshuaj insulin feem ntau ua rau muaj kev hloov pauv hauv postprandial hyperglycemia thiab ua ntej noj mov hypoglycemia. Raws li kev kho mob ntxiv rau cov tshuaj insulin, tuaj yeem txhim kho tus mob no zoo.Muaj ntau qhov kev sim tshuaj ntsuam xyuas tau pom tias hauv cov neeg mob ntshav qab zib hom 1, kev sib xyaw ntawm cov acetate thiab insulin tuaj yeem txo qis cov ntshav qabzib tom qab, txo cov ntshav qabzib hloov pauv.
Thiab tsis txhob ua rau muaj kev pheej hmoo ntawm hypoglycemia.Piv txwv li, ib txoj kev tshawb fawb pom tias kev sib xyaw ntawm cov acetate no tuaj yeem txo qis cov ntshav qabzib hauv cov ntshav siab txog li 50 mg / dL thiab txo qis HbA1c qib piv rau kev siv insulin ib leeg. Qhov pib koob tshuaj acetate no feem ntau yog 15 μg, ua ntej noj mov.
Kev kho mob ntshav qab zib hom 2
Hom 2 mob ntshav qab zib mellitus yog ib qho kev tsis txaus ntawm cov tshuaj insulin los ntawm insulin tsis kam thiab pancreatic beta cell tsis ua haujlwm. Cov neeg mob feem ntau pib nrog kev cuam tshuam hauv kev ua neej thiab kev kho mob ntawm qhov ncauj hypoglycemic, tab sis raws li qhov mob hnyav zuj zus, kev kho tshuaj insulin yuav tsim nyog. Cov acetate no kuj tsim nyog rau kev kho mob insulin adjuvant ntawm cov neeg mob ntshav qab zib hom 2. Hauv cov neeg mob ntshav qab zib hom 2, acetate tuaj yeem txo qis HbA1c qib, txo qhov hnyav nce, thiab txhim kho cov ntshav lipid profile.A 26 lub lis piam multicenter, randomized, ob npaug - dig muag, placebo - tswj kev sim pom tau tias piv rau cov placebo pab pawg, cov neeg mob hauv pawg kho mob acetate no tau nce qib 16, H 6. poob, thiab txo qis hauv cov qib triglyceride. Zoo ib yam li cov neeg mob ntshav qab zib hom 1, cov neeg mob ntshav qab zib hom 2 yuav tsum tau saib xyuas kev pheej hmoo ntawm hypoglycemia.
Daim ntawv thov hauv Kev Tshawb Fawb
Nws tswj cov ntshav qab zib kom qeeb los ntawm kev ncua lub plab zom mov, inhibiting glucagon secretion, thiab ua kom satiety. Hauv kev tshawb fawb hauv paus,pramlintide acetate hmoovtuaj yeem siv los ua cov cuab yeej siv tshuaj los kawm txog cov txheej txheem molecular thiab qhia txoj hauv kev ntawm kev tswj cov ntshav qabzib. Piv txwv li, txhawm rau soj ntsuam qhov cuam tshuam ntawm cov acetate ntawm islet beta cell muaj nuj nqi, insulin rhiab heev thiab cov kua nplaum hauv siab yuav pab peb nkag siab txog cov kab mob thiab cov tswv yim kho mob ntshav qab zib. Nws tuaj yeem ua rau kom satiety, txo cov zaub mov kom tsawg, thiab pab tswj qhov hnyav. Hauv kev tshawb fawb yooj yim, acetate tuaj yeem siv los kawm txog cov txheej txheem neuroendocrine ntawm kev tswj qhov hnyav.
Piv txwv li, kev soj ntsuam cov teebmeem ntawm cov acetate no rau ntawm qhov chaw tswj kev noj qab haus huv hypothalamic, leptin signaling pathway, thiab adipose cov ntaub so ntswg metabolism tuaj yeem muab cov tswv yim tshiab rau kev kho mob rog. Cov tshuaj no tuaj yeem txhim kho cov ntshav lipid profile, txo cov qib triglyceride, thiab nce siab -cov roj lipoprotein ceev. Hauv kev tshawb fawb yooj yim, cov acetate no tuaj yeem siv los kawm txog cov txheej txheem molecular thiab kev tswj hwm ntawm lipid metabolism. Piv txwv li, kev soj ntsuam cov teebmeem ntawm acetate ntawm lipoprotein metabolism, cov roj cholesterol rov qab thauj, thiab kev sib txawv ntawm adipocytes tuaj yeem pab kom nkag siab tob txog cov kab mob thiab cov tswv yim kho mob ntawm metabolic syndrome.
Daim ntawv thov hauv kev tshawb fawb neuroprotective
Hauv kev tshawb fawb yooj yim, acetate tuaj yeem siv los kawm txog cov kab mob thiab cov tswv yim kho mob ntawm cov kab mob neurodegenerative. Piv txwv li, kev soj ntsuam cov teebmeem ntawm acetate ntawm neuronal apoptosis, paj hlwb regeneration, synaptic plasticity, thiab neuroinflammation tuaj yeem muab cov phiaj xwm tshiab rau kev kho cov kab mob neurodegenerative. Nws tuaj yeem muaj cov teebmeem neuroprotective, txo cov neuronal apoptosis thiab txhawb cov paj hlwb. Hauv kev tshawb fawb yooj yim, acetate no tuaj yeem siv los kawm txog cov txheej txheem molecular thiab kev tswj hwm txoj hauv kev kho cov hlab ntsha.
Piv txwv li, kev soj ntsuam cov teebmeem ntawm acetate ntawm neural stem cell txawv, axonal loj hlob, tsim myelin, thiab neural muaj nuj nqi rov qab tuaj yeem muab cov tswv yim tshiab rau kev kho cov kab mob neurological xws li txha caj qaum thiab mob stroke. Hauv cov qauv tsiaj, amygdalin analogs tuaj yeem txhim kho kev txawj ntse thiab kev kawm thiab lub peev xwm nco. Hauv kev tshawb fawb hauv paus, acetate tuaj yeem siv los tshawb xyuas cov txheej txheem neural thiab cov kev taw qhia txog kev paub txog kev ua haujlwm zoo. Piv txwv li, kev soj ntsuam cov teebmeem ntawm acetate ntawm neuronal plasticity, synaptic kis tau tus mob, neurotransmitter tso tawm, thiab neuroinflammation hauv hippocampus tuaj yeem muab cov phiaj xwm tshiab rau kev kho mob ntawm kev paub tsis meej.
Cov txheej txheem ntawm kev txiav txim ntawm acetate planin feem ntau suav nrog cov hauv qab no:
- Inhibition ntawm glucagon secretion: Acetic acid praline peptide tuaj yeem cuam tshuam qhov tso tawm ntawm glucagon, yog li txo qis cov piam thaj hauv siab thiab txo cov ntshav qab zib.
- Txhawb nqa cov tshuaj insulin secretion: Acetic acid propranolol tuaj yeem txhawb nqa cov tshuaj insulin secretion, txhim kho cov tshuaj insulin lom neeg, thiab yog li txhim kho lub cev kev siv cov piam thaj.
- Inhibition ntawm lub plab khoob: Propranolol acetate tuaj yeem ua rau txo qis hauv plab hnyuv, yog li ua kom lub sijhawm nyob ntawm cov zaub mov hauv lub plab thiab ua kom qeeb ntawm kev nqus ntawm cov piam thaj.
- Kev tsis qab los noj mov: Propranolol acetate tuaj yeem txo qis qab los noj mov, txo cov khoom noj, thiab yog li txo lub cev hnyav thiab cov ntshav qab zib.
Pranin acetate yog ib hom tshuaj uas siv ntau yam. Nws tsis yog tsuas yog siv los kho cov ntshav qab zib thiab lwm yam teeb meem, tab sis kuj muaj antioxidant, tiv thaiv -inflammatory thiab immunomodulatory teebmeem. Nws cov txheej txheem ntawm kev ua haujlwm cuam tshuam nrog ntau yam xws li inhibiting glucagon secretion, txhawb cov insulin secretion, inhibiting gastric emptying thiab qab los noj mov.
Acetylpristinamycin IIA yog peptide zoo li cov tshuaj tua kab mob feem ntau siv los kho cov kab mob sib kis. Nws cov qauv yog complex, muaj ob polycyclic aromatic compounds thiab ib tug peptide saw muaj 12 amino acids. Vim muaj kev koom tes ntawm cov kws tshaj lij kev lag luam, lub chaw soj nstuam synthesis txoj kevpramlintide acetate hmoovyuav tsum muaj kev txhawb nqa thiab cov cuab yeej siv tau meej. Cov hauv qab no tsuas yog qhia luv luv rau cov txheej txheem synthesis.Lub chaw soj nstuam synthesis ntawm acetate planin tuaj yeem muab faib ua ob ntu, uas yog cov synthesis ntawm polycyclic aromatic compounds thiab cov synthesis ntawm peptide chains.
Ntawm lawv, polycyclic aromatic compounds yog tsuas yog tau los ntawm cov khoom ntuj extraction los yog semi synthetic txoj kev, thaum peptide chains tau los ntawm tshuaj synthesis los yog genetic engineering cov tswv yim.
Lub synthesis ntawm acetate planin muaj ntau yam tshuaj tiv thaiv cov kauj ruam, thiab cov hauv qab no yog cov piv txwv ntawm cov tshuaj sib npaug rau qee cov kauj ruam tseem ceeb:
1. Synthesis ntawm polycyclic aromatic compounds:
Sodium hydroxide decomposes lub precursor:
C30H31TSIS MUAJ3+NaOH → C13H12O2+C17H19TSIS MUAJ2+NWS3+H2O
Acetone Acetylation Reaction:
C13H12O2+ CH3COCH3 → C15H14O4
Dimethyl carbonate txo:
C15H14O4+ CH3OCOCl + FeCl2 → C30H34O8+ FeCl3+ CH3OH + HCl
2. Peptide saw synthesis (kev siv tshuaj lom neeg:
Kev sib txuas ntawm L-alanine nrog 2-Cl-Z-L-Ser (tBu) - OH:
H2N (CH2)2COOH + ClZSer(tBu)-OH → H2N (CH2)2CO-ZSer(tBu)-OH + H2O
Peptide chain extension:
H2N (CH2)2CO-ZSer(tBu)-OH + H-Ala(tBu)-OH → H2N (CH2)2CO-ZSer(tBu)-Ala(tBu)-OH + H2O
Tshem tawm kev tiv thaiv puag:
H2N (CH2)2CO-ZSer(tBu)-Ala(tBu)-OH + HF → H2N (CH2)2CO-Ser-Ala-OH + C4H10+ HF
Peptide chains khi rau acid pawg ntawm polycyclic aromatic compounds:
H2N (CH2)2CO-Ser-Ala-OH + C30H34O8 → C32H38N2O9
3. Synthesis ntawm polycyclic aromatic compounds
Tam sim no, polycyclic aromatic tebchaw ntawm acetate planin peptide yog tsuas yog tau los ntawm natural product extraction los yog semi hluavtaws txoj kev. Cov kauj ruam tshwj xeeb yog raws li nram no:
(1) Txoj kev rho tawm cov khoom ntuj tsim: Extract fermentation broth los yog cov kab mob hauv lub cev uas muaj cov khoom siv los ntawm cov kab mob xws li Streptomyces pristinaespiralis uas tsim cov acetaminophen.
(2) Semi hluavtaws txoj kev: Lub precursor ntawm acetic acid planin muab rho tawm los ntawm cov kab mob yog hloov mus rau hauv acetic acid planin los ntawm ib tug series ntawm tshuaj tiv thaiv. Cov kauj ruam tseem ceeb suav nrog:
- Lub precursor yog decomposed los ntawm sodium hydroxide kom tau polycyclic aromatic compounds.
- Acetylation cov tshuaj tiv thaiv ntawm polycyclic aromatic tebchaw nrog acetone yields nruab nrab cov khoom nyob rau hauv daim ntawv ntawm acetate.
- Cov khoom nruab nrab raug txo nrog dimethyl carbonate thiab ferrous chloride kom tau txais procyanidin acetate.
4. Synthetic peptide chains
Cov saw peptide ntawm acetate planin yog tsim los ntawm 12 amino acids thiab tuaj yeem tau los ntawm kev siv tshuaj lom neeg los yog cov txheej txheem kev tsim kho caj ces.
(1) Txoj kev siv tshuaj lom neeg: Fmoc solid-theem synthesis method tau siv los ua ke cov acetate planin peptide saw. Cov kauj ruam tshwj xeeb suav nrog:
- Ua ntej, L-alanine ntawm C-terminus yuav ua ke nrog 2-Cl-Z-L-Ser (tBu)-OH, thiab tom qab ntawd maj mam txuas mus rau N-terminus kom txog thaum tiav acetate planin peptide saw.
- Tshem tawm cov pab pawg tiv thaiv los ntawm cov tshuaj reagents xws li hydrofluoric acid lossis trifluoroacetic acid kom tau txais cov saw peptide nthuav tawm.
- Kev khi cov saw peptide nthuav tawm nrog cov pab pawg acid nyob rau hauv polycyclic aromatic compound kom tau txais acetate planin peptide.
(2) Genetic engineering technology: Los ntawm kev ntxig cov noob ntawm acetate planin rau hauv ib qho kev qhia vector thiab siv cov kab mob xws li Escherichia coli rau kev qhia thiab kev ua kom huv, ntau cov acetate planin tuaj yeem tau txais. Txoj kev no tuaj yeem tsis tsuas yog nce ntau lawm, tab sis kuj txo cov pa phem thiab cov nqi.
Cov ntaub ntawv
Wang Huange, Xiao Xue, Hu Hao, thiab lwm yam. Tsim kom muaj nyob rau hauv vitro kev soj ntsuam txoj kev rau tib neeg amygdalin analogue pramlintide [J]. Phau ntawv Journal of China Pharmaceutical University, 2012, 43 (4): 355-360
(Tsim ib txoj hauv kev tshawb nrhiav kev ua haujlwm ntawm tes rau Pramlintide los muab lub hauv paus rau kev tswj kom zoo)
Edelman S, Maier H, Wilhelm K. Pramlintide hauv kev kho mob ntshav qab zib mellitus [J]. BioDrugs, 2008, 22(6): 375-386.
(Systematically tshuaj xyuas lub pharmacological mechanism thiab soj ntsuam kev ua tau zoo ntawm Pranin nyob rau hauv hom 1/2 mob ntshav qab zib)
Maha S Al-Keilani, et al. Pramlintide, ib qho tshuaj tiv thaiv kab mob ntshav qab zib, yog cov tshuaj tiv thaiv kab mob hauv cov kab mob qog noj ntshav thiab ua ke nrog cov tshuaj kho mob ib txwm siv [J]. Clinical Pharmacology, 2018, 10:23-29.
(Tshaj qhia txog cov nyhuv inhibitory ntawm pramlintide acetate ntawm kev mob qog noj ntshav thiab nws cov txiaj ntsig zoo nrog cov tshuaj kws khomob)
SYMLIN (pramlintide acetate) txhaj (https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021332s007_S016.pdf)
Kev txhaj tshuaj Pramlintide (https://medlineplus.gov/druginfo/meds/a605031.html)
Cov lus nug nquag
Pramlintide qis npaum li cas A1C?
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Pramlintide, ib qho hluavtaws analogue ntawm amylin, txo qis 2-teev cov ntshav qabzib tom qab ntawm 3.4 thiab 5 mmol / L, txo A1C los ntawm 0.2% mus rau 0.7% thiab tsis cuam tshuam rau cov ntshav qabzib ceev.
Lub sijhawm siab tshaj plaws rau pramlintide yog dab tsi?
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Txawm hais tias kev lag luam cov tshuaj insulin feem ntau ua rau pom qhov ua tau siab tshaj plaws hauv 60-90 feeb, pramlintide elicits nws qhov siab tshaj plaws ntawm ib ncig ntawm 20-30 feeb tom qab kev tswj hwm.
pramlintide puas tuaj yeem ua rau poob phaus?
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Pramlintide ntawm 120 ug tid thiab 360 ug bid thiab tid tau ua tiav qhov kev txo qis hauv lub cev hnyav piv rau cov placebo ntawm lub hli 4 (kuaj thiab ITT-LOCF P < 0.05). Hauv cov caj npab no, 44–47% ntawm cov ntsiab lus (kwv yees) tau ua tiav ntau dua lossis sib npaug li 5% poob phaus piv rau 28% ntawm cov placebo-cov kev kawm.
Cim npe nrov: pramlintide acetate cas 196078-30-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom