Seractide

1. Kev kuaj mob thiab kho cov kab mob endocrine

Hauv endocrinology, kev siv tseem ceeb ntawmseractidenyob rau hauv kev kuaj mob ntawm adrenocortical insufficiency thiab kev kho mob ntawm cov kab mob tsawg tsawg. Featuring siab tshwj xeeb thiab pib sai sai ntawm qhov kev txiav txim, nws tau dhau los ua ib qho tseem ceeb hauv kev kuaj mob thiab kev kho mob.Rau kev kuaj mob ntawm adrenocortical insufficiency, nws yog siv nyob rau hauv lub ceev ceev ACTH stimulation test, uas ua hauj lwm raws li tus qauv kub rau kev sib txawv ntawm thawj theem ntawm adrenocortical insufficiency. Cov txheej txheem txheej txheem suav nrog kev txhaj tshuaj ntawm 250 ug nws, ua raws li kev ntsuas cov ntshav cortisol ntawm 30 thiab 60 feeb raws li.

Cov lus teb ntawm lub cev ib txwm txhais tau tias yog qib siab cortisol ntau dua lossis sib npaug ntawm 550 nmol / L; qib qis dua qhov pib no qhia txog kev ua haujlwm tsis zoo ntawm adrenocortical. Cov neeg mob uas muaj qhov tsis txaus (qhov txhab ntawm lub qog adrenal nws tus kheej) qhia qhov txawv txav tsis txaus ntseeg, thaum cov neeg uas muaj qhov tsis txaus siab (pituitary lossis hypothalamic lesions) tuaj yeem nthuav tawm qeeb lossis me me teb.

Piv nrog rau tej yam ntuj tso ACTH, nws muaj ntau dua purity thiab zoo stability, thiab tsis cuam tshuam los ntawm endogenous ACTH. Nws tuaj yeem cuam tshuam ntau dua qhov kev ua haujlwm cia ntawm adrenal cortex thiab txo qis kev kuaj mob.

Hauv kev kho cov kab mob tsis tshua muaj, nws yog thawj - kab kws kho mob rau cov me nyuam mos spasms (West syndrome), tshwj xeeb tshaj yog tsim rau cov tshuaj hormone- cov neeg mob me me. Infantile spasms yog ib qho mob encephalopathy loj heev hauv cov menyuam mos thiab cov menyuam yaus, uas tshwm sim los ntawm kev sib kis ntau zaus nrog hypsarrhythmia ntawm electroencephalography. Kev kho mob qeeb yuav ua rau muaj kev loj hlob ntawm kev txawj ntse. Nws txhawb nqa glucocorticoid secretion los ntawm adrenal cortex los ntawm kev ua kom MC2R, thiab lub sijhawm no ua haujlwm ncaj qha rau hauv nruab nrab paj hlwb MC1R thiab MC4R txhawm rau tiv thaiv cov kab mob hauv lub cev tsis zoo, ua tiav kev tswj hwm spasm ntawm ob lub tswv yim.

Tsis tas li ntawd, nws tuaj yeem siv los ua kev kho mob ntxiv rau kev mob rov qab ntawm ntau yam sclerosis. Nws txo qis hauv nruab nrab paj hlwb demyelination thiab edema los ntawm stimulating glucocorticoid secretion, thiab ncaj qha activates central MC4R los tiv thaiv neurons, inhibit apoptosis thiab excitotoxicity, shorten lub sij hawm rov qab tom qab relapse, thiab txo cov kev pheej hmoo ntawm kev tsis taus. Nws kuj tseem tswj cov kev kho mob zoo hauv qee cov tshuaj hormone- cov neeg mob tiv taus.

2. Kev kho mob autoimmune

Nrog rau cov khoom muaj zog immunomodulatory, nws nthuav tawm cov txiaj ntsig kho mob zoo hauv ntau yam kab mob autoimmune, tshwj xeeb tshaj yog rau qee qhov mob ntawm cov hlab ntsha.

Hauv kev kho mob rheumatoid mob caj dab (RA), nws tawm dag zog los tiv thaiv - mob los ntawm ob lub tswv yim: ntawm ib sab, nws ua rau cov hypothalamic-pituitary-adrenal (HPA) axis los txhawb glucocorticoid secretion thiab inhibit synovial hyperplasia thiab inflammatory reactions hauv pob qij txha.

Ntawm qhov tod tes, nws ncaj qha ua rau lub cev tiv thaiv kab mob xws li macrophages thiab T lymphocytes, txo qis kev qhia ntawm pro- cov kab mob inflammatory (IL-1 , TNF- , IL-6) thiab nce qib ntawm cov tshuaj tiv thaiv kab mob IL-10, yog li alleviating pob qij txha o, thiab txo qis kev ua haujlwm thaum sawv ntxov. lupus erythematosus (SLE),seractideFeem ntau yog siv rau cov mob refractory, tshwj xeeb tshaj yog cov neeg mob nyuaj nrog lub hauv nruab nrab lub paj hlwb lossis lub raum kev koom tes. SLE yog ib hom kab mob autoimmune uas cuam tshuam nrog kev tsim cov autoantibody thiab kev tiv thaiv kab mob.

Cov khoom no inhibits B lymphocyte proliferation thiab autoantibody secretion, txo cov deposition ntawm lub cev tsis muaj zog nyob rau hauv lub raum thiab central paj hlwb, alleviates lub raum o thiab proteinuria, tiv thaiv central neurons, thiab txhim kho cov tsos mob neuropsychiatric.

Piv nrog rau ib txwm muaj siab - koob tshuaj glucocorticoid kev kho mob, nws siv cov koob tshuaj qis dua nrog qhov tshwm sim ntawm qhov tshwm sim tsis zoo. Nws tuaj yeem txo tus kab mob rov zoo dua thiab txhim kho cov neeg mob lub neej zoo. Ntxiv mus, nws muaj kev txwv tsis pub siv tshuaj kho mob hauv cov kab mob ankylosing spondylitis, kab mob sclerosis thiab lwm yam kab mob autoimmune, feem ntau yog siv los tiv thaiv kev tiv thaiv - kev kho mob thiab kev tiv thaiv kab mob sib npaug.

Raws li ib qho kev xaiv MC2R agonist, nws yog ib qho cuab yeej siv ntau hauv kev tshawb fawb endocrinology thiab neuroscience. Nws cov purity siab (Ntau dua lossis sib npaug rau 98%), muaj zog tshwj xeeb thiab kev ruaj ntseg zoo ua rau nws yog qhov kev xaiv zoo tshaj plaws rauhauv vitrokev sim ntawm tes thiabhauv vivotsiaj qauv kev kawm.

Hauv kev tshawb fawb txog HPA axis kev tswj hwm kev ua haujlwm, nws raug siv los tshawb nrhiav cov txheej txheem tswj hwm ntawm pituitary -adrenal axis. Nws yog siv los txhawb cov hlwb adrenocorticalhauv vitrotxhawm rau soj ntsuam tus qauv ntawm glucocorticoid secretion thiab qhia meej txog kev tswj hwm ntawm ACTH ntawm adrenocortical cell sib txawv thiab steroid synthesis. Hauvhauv vivokev sim, txhaj tshuaj rau hauv cov tsiaj tuaj yeem simulate HPA axis ua kom nyob rau hauv kev ntxhov siab, ua kom yooj yim rau kev tshawb fawb txog kev sib raug zoo ntawm kev ntxhov siab thiab kev tiv thaiv kab mob, cov metabolism thiab kev ua haujlwm ntawm neural.

Hauv kev tshawb fawb txog neuroscience, nws yog siv los txheeb xyuas cov haujlwm ntawm lub cev ntawm melanocortin receptors (tshwj xeeb tshaj yog MC1R thiab MC4R). Piv txwv li, hauv kev tshawb fawb txog cov txheej txheem tiv thaiv neuroprotective, nws tau txais los txheeb xyuas lub luag haujlwm ntawm MC4R- kho PI3K / Akt teeb liab txoj hauv kev hauv kev tiv thaiv neuronal. Hauv kev tshawb fawb txog kev noj qab haus huv kev tswj hwm thiab lub zog metabolism, lub hauv paus MC4R kev ua haujlwm los ntawm nws yog siv los soj ntsuam kev hloov pauv hauv kev noj zaub mov thiab kev siv lub zog hauv cov tsiaj, tshawb nrhiav lub luag haujlwm ntawm melanocortin receptors hauv metabolic homeostasis. Tsis tas li ntawd, nws muaj feem xyuam rau adrenocortical cell kab lis kev cai thiab kev sim tiv thaiv neuronal, muab kev txhawb nqa rau kev tshawb fawb txog cov kab mob ntawm cov kab mob ntsig txog.

1. Cov Kab Mob Neurodegenerative thiab Neuroprotection

Cov kev tshawb fawb hauv paus tau pom tias nws muaj cov teebmeem neuroprotective tseem ceeb, uas qhia tau tias muaj peev xwm rau kev kho mob Alzheimer's disease, Parkinson's disease, cerebral ischemia / stroke, spinal cord raug mob thiab lwm yam kab mob neurological.

Hauv kev tshawb fawb cerebral ischemia/stroke, nws ua los ntawm glucocorticoid- txoj kev ywj pheej. Ntawm qhov concentration ntawm 200-400 nM, nws muaj peev xwm tiv thaiv nas forebrain neurons los ntawm apoptosis thiab excitotoxicity induced los ntawm glutamate, NMDA thiab hydrogen peroxide, txo infarct ntim thiab txhim kho neurological cov qhab nia.

Nws cov txheej txheem cuam tshuam nrog MC4R-kev ua kom sib haum xeeb ntawm PI3K/Akt txoj hauv kev, inhibition ntawm oxidative stress thiab inflammatory factor tso tawm, thiab upregulation ntawm lub hlwb- muab tau los ntawm neurotrophic factor (BDNF) qhia.

Hauv kev tshawb nrhiav kab mob Alzheimer,seractidealleviates Ib qho amyloid deposition thiab ntau tau protein ntau hyperphosphorylation hauv lub hlwb, txhim kho kev txawj ntse hauv cov qauv tsiaj. Hauv cov qauv kab mob Parkinson, nws tiv thaiv dopaminergic neurons, inhibits microglial activation ntau dhau, thiab ncua lub cev muaj zog ua haujlwm poob.

Hauv kev tshawb fawb txog kev raug mob ntawm tus txha caj qaum, nws inhibits ntau tshaj astrocyte proliferation thiab glial caws pliav, thaum txhawb nqa axonal regeneration thiab myelin kho los txhim kho lub cev muaj zog thiab hnov ​​​​tsw ua haujlwm zoo hauv cov tsiaj sim. Tam sim no, cov kev tshawb fawb tseem ceeb tseem nyob rau theem pib sim, tsis tau nws ntau -cov khoom siv tshuaj tiv thaiv neuroprotective muab cov kev taw qhia tshiab rau kev cuam tshuam ntawm cov kab mob neurodegenerative.