SS -31 25mg

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm ss-31 25mg hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo ss-31 25mg muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

SS-31 kuj tseem muaj koob tshuaj 25mg,SS -31 25mg, raws li mitochondrial tsom rau hluavtaws tetrapeptide, SS-31 (Elamipretide) tau ua kom pom kev lom zem thiab tseem ceeb hauv ntau yam kab mob vim nws cov qauv molecular tshwj xeeb thiab cov txheej txheem ntawm kev ua. Nws tuaj yeem nkag mus rau hauv cov ntshav- lub hlwb teeb meem, tswj oxidative kev nyuaj siab, thaiv mitochondrial permeability transition pore (mPTP) qhib, muab kev tiv thaiv neuroprotection rau cov kab mob neurodegenerative xws li mob stroke thiab Alzheimer's disease, thiab txhim kho kev txawj ntse thiab lub cev muaj zog; Nws kuj tseem tuaj yeem kho cov kev ua haujlwm mitochondrial ntawm cov hlwb myocardial, txo cov ischemia-reperfusion raug mob, txo qhov mob myocardial infarction, thiab txo lub plawv tsis ua haujlwm, ua rau nws muaj peev xwm siv tshuaj rau kev cuam tshuam cov kab mob plawv; Nyob rau tib lub sijhawm, nyob rau hauv cov kab mob hauv lub raum thiab cov kab mob metabolic, nws tuaj yeem txo qhov kev puas tsuaj ntawm lub raum tubulointerstitium hauv ntshav qab zib nephropathy, inhibit mitochondrial abnormal division thiab inflammatory fibrosis, txhim kho cov kab mob metabolic thiab oxidative kev nyuaj siab raug mob los ntawm cov piam thaj siab, thiab tseem muaj txiaj ntsig zoo hauv kev tiv thaiv kev laus, kev tiv thaiv cov leeg, thiab lwm yam.

 

Peb cov khoom Form

 

TSI-31 COA

Qhov no sawv cev rau ntau qhov kev cuam tshuam cuam tshuam nyob rau hauv mitochondrial homeostasis. Raws li cov khoom siv hluavtaws tetrapeptide tsom mus rau sab hauv mitochondrial membrane, nws yog lub luag haujlwm tiv thaiv hauv lub raum thiab cov kab mob metabolic tsom rau cov xwm txheej tseem ceeb xws li mob ntshav qab zib nephropathy thiab cov kab mob metabolic- cuam tshuam rau lub raum raug mob. Los ntawm kev hloov kho mitochondrial muaj nuj nqi, tswj oxidative kev nyuaj siab, thiab thaiv cov kab mob pathological, nws ua tiav kev tiv thaiv ntawm lub raum cov ntaub so ntswg thiab optimization ntawm metabolic xwm txheej, muab ib tug tshiab mitochondria - lub hom phiaj rau kev cuam tshuam ntawm cov kab mob.

Cov Txheej Txheem Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Lub Raum thiab Metabolic Protective Effects ntawm Elamipretide

 

Kev lees paub ntawm Oxidative Stress Effects:Intracellular reactive oxygen hom (ROS) qib tau kuaj pom los ntawm kev ntws cytometry (siv DCFH-DA fluorescent sojntsuam staining). Colorimetric los yog fluorescent assays ntsuas cov kev ua ntawm intracellular antioxidant enzymes zoo li superoxide dismutase (SOD) thiab glutathione peroxidase (GPx), nrog rau cov ntsiab lus ntawm oxidative kev nyuab siab cim xws li malondialdehyde (MDA) thiab 4-hydroxynonenal (4-HNE). Qhov no qhia meej txog SS-31 cov kev tswj hwm ntawm oxidative kev nyuaj siab.

 

Kev tsim kho ntawm High-Glucose-Induced Cell Models: Siv lub raum tseem ceeb xws li tib neeg lub raum tubular epithelial hlwb (HK-2) thiab glomerular mesangial cells (HMC). Cov hlwb no yog incubated nyob rau hauv high-qabzib nruab nrab (25-30 mmol / L qabzib) kom simulate hyperglycemic pathological ib puag ncig ntawm ntshav qab zib nephropathy. Cov pab pawg tswj cov piam thaj ib txwm thiab mannitol osmotic siab tswj pawg tau tsim ib txhij kom tsis suav nrog osmotic siab cuam tshuam.

Kev tshawb pom ntawm Mitochondrial Function thiab Dynamics: Lub mitochondrial membrane muaj peev xwm nrhiav tau cov khoom siv (JC-1 staining) yog siv nrog fluorescence microscopy lossis flow cytometry los soj ntsuam cov kev hloov hauv daim nyias nyias thiab ntsuam xyuas mitochondrial kev ncaj ncees. Immunofluorescence staining (combining MitoTracker probes to label mitochondria with target protein immunofluorescence) thiab confocal laser scanning microscopy soj ntsuam mitochondrial morphology (xws li, fragmentation), quantifying mitochondrial length/width ratios. Western blotting kuaj pom cov theem qhia ntawm mitochondrial fission proteins (DRP1, FIS1) thiab fusion proteins (Mfn1, Mfn2, OPA1), txheeb xyuas nws txoj cai ntawm mitochondrial dynamic tshuav nyiaj li cas.

Kev soj ntsuam ntawm Cell Damage thiab Apoptosis:** CCK-8 kev ntsuam xyuas ntsuas kev muaj peev xwm ntawm tes, ntsuas kev tiv thaiv ntawm nws tiv thaiv siab - qabzib- ua rau lub raum tubular epithelial cell raug mob. TUNEL staining thiab Annexin V-FITC/PI dual- staining flow cytometry ntes tus nqi apoptosis, txheeb xyuas SS-31 qhov thaiv cov nyhuv ntawm mitochondria-mediated apoptosis.

 

Kev kuaj pom ntawm lub raum Tissue Histopathology:Ntawm qhov kawg ntawm qhov kev sim, cov ntaub so ntswg hauv lub raum tau sau, tsau rau hauv formaldehyde, kos rau hauv paraffin, thiab muab faib rau kev txheeb xyuas kab mob. Cov txheej txheem staining muaj xws li H&E (saib lub raum tubular structural disorder thiab interstitial edema), PAS (nrhiav glomerular mesangial matrix hyperplasia thiab hauv qab daus membrane thickening), thiab Masson's trichrome (quantifying lub raum interstitial fibrosis cheeb tsam). Pathological duab tsom xam systems yog siv rau cov qhab nia, visually ntsuam xyuas cov kev txhim kho cov nyhuvSS -31 25mgntawm lub raum puas tsuaj.

 

Kev txheeb xyuas ntawm Mitochondrial Function thiab Morphology: Lub raum cortex mitochondria raug cais tawm. Txoj kev Clark oxygen electrode ntsuas kev ua haujlwm ntawm mitochondrial respiratory chain complexes (I, III, IV) thiab ATP ntau lawm. Transmission electron microscopy (TEM) soj ntsuam mitochondrial ultrastructure (cristae kev ncaj ncees, fragmentation, o), quantifying qhov feem ntawm mitochondria txawv txav. Qhov no txheeb xyuas qhov rov ua haujlwm ntawm qhov no ntawm lub raum mitochondrial qauv thiab kev ua haujlwm.

Kev soj ntsuam ntawm Metabolic Disorders thiab Systemic Effects: Cov qauv tsiaj raug saib xyuas tas li rau lub cev qhov hnyav, ntshav qabzib, thiab qib glycated hemoglobin (HbA1c) los ntsuas SS-31 txoj cai tswj hwm cov piam thaj metabolism. Cov roj (cholesterol) tag nrho, triglycerides, thiab qib LDL-cholesterol yog ntsuas los ntsuas kev txhim kho hauv lipid metabolism. Nyob rau tib lub sijhawm, cov ntsuas lub raum ua haujlwm xws li cov ntshav urea nitrogen thiab creatinine raug ntsuas los ntsuas cov tshuaj tiv thaiv lub raum tag nrho.

Kev kuaj pom ntawm Inflammatory thiab Fibrotic Molecular Markers: Tag nrho cov protein thiab RNA yog muab rho tawm los ntawm lub raum cov ntaub so ntswg. Western blot thiab RT-qPCR ntes cov lus qhia ntawm cov molecules tseem ceeb xws li DRP1, Mfn2, TGF- 1, -SMA, thiab NF-κB. Immunohistochemistry/immunofluorescence staining localizes cov chaw qhia ntawm lub hom phiaj proteins nyob rau hauv lub raum cov ntaub so ntswg (xws li, lub raum tubular epithelial hlwb, interstitial cheeb tsam), qhia meej lub cellular lub hom phiaj ntawm SS-31 qhov kev txiav txim.

Cov kev tshawb fawb soj ntsuam tuaj yeem paub meej ntxiv txog kev nyab xeeb thiab kev ua tau zoo ntawm qhov no hauv tib neeg, muab pov thawj rau nws daim ntawv thov kho mob:

Clinical Sample Correlation Analysis:

Lub raum biopsy cov ntaub so ntswg thiab cov ntshav kuaj los ntawm cov neeg mob ntshav qab zib nephropathy raug sau tseg. Mitochondrial function markers (piv txwv li, serum 8-OHdG, mitochondrial DNA luam tus lej) thiab cov cim o / fibrosis (TNF- , TGF- 1, -SMA) qib raug ntsuas thiab lawv qhov cuam tshuam nrog qib ntawm lub raum kev ua haujlwm tsis zoo (urinary microalbumin, serum) Kev hloov pauv hauv cov cim no hauv cov neeg mob ntshav qab zibSS -31 25mgKev cuam tshuam kuj tuaj yeem kuaj pom los ntawm kev txheeb xyuas qhov cuam tshuam rau tib neeg.

Clinical Intervention Trial Design:

Me - nplai randomized, ob npaug - dig muag, placebo- tswj kev sim tshuaj yog ua. Cov neeg mob uas muaj -theem mob ntshav qab zib nephropathy thaum ntxov (urinary albumin-to-creatinine ratio 30-300 mg/g) tau cuv npe thiab muab faib ua pab pawg cuam tshuam (kev txhaj tshuaj subcutaneous, nrog cov tshuaj sib txawv) thiab pab pawg placebo. Lub sijhawm cuam tshuam yog 12-24 lub lis piam.

Clinical Effect Evaluation Metrics:

Cov ntsiab lus tseem ceeb suav nrog kev hloov pauv hauv cov zis albumin- rau -creatinine piv thiab kwv yees glomerular filtration rate (eGFR). Cov ntsiab lus thib ob suav nrog kev hloov pauv hauv cov ntshav ntshav ntawm qhov mob / fibrosis cov cim (TNF- , IL-6, TGF- 1), oxidative stress markers (MDA, SOD), nrog rau cov kev hloov hauv lub raum cortical thickness thiab cov ntshav ntws perfusion kuaj pom los ntawm lub raum ultrasound. Qhov xwm txheej ntawm cov tshuaj tiv thaiv tsis zoo kuj raug kaw los ntsuas kev nyab xeeb ntawm tshuaj.

Hauv cov ntsiab lus, los ntawm kev tshawb fawb loj ntawm "kev sim cellular tshawb xyuas qhov cuam tshuam ncaj qha → tsiaj cov qauv luam tawm tag nrho cov kab mob → molecular mechanism tsom xam txheeb xyuas cov hom phiaj kev ua haujlwm → kev tshawb fawb soj ntsuam tshawb nrhiav tus nqi txhais lus," kev tiv thaiv ntawm nws hauv lub raum thiab cov kab mob metabolic tuaj yeem ua tiav thiab nruj me ntsis lees paub. Cov txheej txheem ntawm txhua qib corroborate ib leeg, kom ntseeg tau qhov kev siv tau thiab kev ntseeg siab ntawm cov txiaj ntsig.

• Dab tsi yog cov khoom xyaw hauv elamipretide?

Txhua koob tshuaj 0.5 mL ntawm FORZINITY muaj 40 mg ntawm elamipretide (sib npaug rau 46.8 mg elamipretide hydrochloride), 10 mg benzyl cawv raws li kev khaws cia, thiab 2.07 mg monobasic sodium phosphate (raws li monohydrate).

• elamipretide siv rau dab tsi?

Kev txhaj tshuaj Elamipretide yog siv los txhim kho cov leeg lub zog hauv cov neeg mob Barth Syndrome (tsis tshua muaj tshwm sim hauv cov txiv neej uas ua rau muaj kev ua haujlwm tsis zoo hauv lipid tsim nyog rau kev tsim hluav taws xob uas ua rau muaj kev puas tsuaj rau lub plawv, cov leeg thiab lub cev tsis muaj zog).

• Cov txiaj ntsig ntawm elamipretide yog dab tsi?

Cov txiaj ntsig no qhia tias Elamipretide muaj peev xwm ua kom mitochondria ruaj khov thiab normalize cardiolipin, yog li txhim kho cov leeg nqaij thiab lub zog tsim tawm thaum lub plawv tsis ua hauj lwm thiab tiv thaiv kev mob plawv hypertrophy thiab fibrosis.

Cim npe nrov: ss-31 25mg, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom