Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm Teriparatide Peptide hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo teriparatide peptide rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Teriparatide Peptideyog 34 {- amino - acid polypeptide. Nws cov essence yog cov nquag n-} Termo fragment ntawm cov neeg siv khoom ntawm tib neeg parathyroid (pth). Raws li pob txha acabolic regolic, nws tuaj yeem sib txawv ntawm cov kab mob me me: los ntawm cov tshuaj tiv thaiv kab mob sib txawv, nws tuaj yeem nqus cov tshuaj uas tsuas yog ua kom muaj kev tiv thaiv kev txwv. Cov mechanism no ua kom zoo nce tus naj npawb ntawm cov pob txha trabeculae, txhim kho pob txha micriviture, thiab txhim kho pob txha ceev thiab pob txha ua kom muaj zog. Clinically, nws yog tsuas yog siv los kho cov kab mob caj pas loj nrog kev pheej hmoo siab, tshwj xeeb yog cov neeg mob ua kom txo qis ntawm pob txha caj qaum thiab pob txha caj qaum. Vim tias nws muaj kev txaus ntshai ntawm Osteosarcoma, cov kev kho mob feem ntau yog txwv tsis pub dhau ob xyoos, sawv cev rau cov kws paub zoo hauv cov txha caj qaum.
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Teriparatide hmoov coa
Kev sib piv ntawm cov tshuaj molecular ntawm cov tshuaj ua txhawb cov pob txha thiab anti {- pob txha resorption
Cov pob txha - kev txhawb nqa cov tshuab ntawm Teriparatide
Teriparatide yog qhov amino -}}}}} (rhpth1-34) ntawm qhov hnyav ntawm tib neeg parathyroid (pth), nrog txoj kev molecular hnyav ntawm 4117.8 da. Cov PTH ntuj yog muaj 84 cov amino acids, thaum Teriparatide khaws cov chaw ua haujlwm tseem ceeb ntawm lub pth1 receptor (pth1r) nyob saum npoo ntawm pob txha hlwb.
Daim phiajcim transduction txoj kev
Tom qab Teriparatide khi rau Pth1R, nws ua kom lub GS protein- kev ntes ntawm {}} {4 {} Qhov no dual - txoj kev tswj hwm tshuab ua rau:
Kev sib txawv ncaj qha rau kev sib txawv ostaueblast sib txawv:Up {-}}}}}}} phosphatase (alp), ostmeocalase (ostmeocal (col1a1), thiab txhawb nqa matrix massalization;
Kev tswj hwm cov pob txha rov qab ua haujlwm:Inhibit osteoclast kev ua si los ntawm iGF-1 Autocrine Circuit Court kom tsis txhob muaj pob txha rov zoo;
Txhim kho pob txha microsness: nce cov tuab thiab sib txuas ntawm trabeculae, ua kom zoo dua ua rau pob txha zoo.
Kev tswj hwm kev sib cais ntawm pob txha rov tsim kho
Cov nyhuv ntawm Teriparatide yog lub sijhawm - nyob ntawm:
Thaum ntxov theem (1-3 lub hlis):Tsuas yog txhawb nqa cov kev nthuav dav thiab sib txawv ntawm osteoblasts, thiab pob txha muaj pob txha (xws li Pinp) nce ntxiv;
Nruab nrab - sij hawm (3-6 lub hlis):Cov pob txha tsim thiab pob txha rov ua kom muaj qhov sib npaug ntawm cov kev sib npaug, thiab pob txha pob zeb hauv av (BMD) pib nce ruaj khov;
Long-term (>12 lub hlis):Tsis tu ncua txhim kho pob txha microstructure thiab txo qhov kev pheej hmoo ntawm kev tawg.
Molecular txheej txheem ntawm anti -} cov pob txha resorpt tshuaj
Anti - pa reet cov tshuaj kho cov pob txha txo qis los ntawm kev ua haujlwm ntawm kev ua haujlwm thiab feem ntau suav nrog cov hauv qab no:
Bisphosphonates
Bisphosphorhonates inhibit osteoclast - Cov pob txha mediated los ntawm binding rau pob txha hydroxyapatite. Nws cov tshuab ntawm kev nqis tes ua xws li:
Inhibition ntawm farnesic pyrophosphate synthease (FPPs): thaiv cov isoprene ntawm cov me g protein hauv ostauoclasts, ua rau osteoclast apoptosis;
Inducing Osteapast Apoptosis: Los ua kom lub Mitochondrial txoj kev lossis txoj kev tuag receptor txoj kev;
Inhibit Osteneoclast neeg nrhiav haujlwm: txo cov lus qhia ntawm qeb duas thiab inhibit qhov sib txawv ntawm Osteoclast ua ntej.
Denosumab
Disumab is a fully humanized RANKL monoclonal antibody that inhibits osteoclast differentiation and activation by blocking the RANkL-RANK signaling pathway. Nws cov yam ntxwv muaj xws li:
High -}}}}}}}}}}}}}} diss diss aff BREUNDL: Kev cais tawm tsis tu ncua (KD) yog 10 ^ -12 m, uas yog ntau dua li ntawm ntuj offg;
Sai sai txo cov pob txha tig cov cim: CTX qib tuaj yeem txo qis nyob rau hauv 3 hnub tom qab kev tswj hwm;
Cov nyhuv reversible: pob txha tig cov cim tuaj yeem rov qab mus rau qib hauv paus hniav hauv 6 txog 12 hlis tom qab rho tshuaj.
Calccins
Callitonin inhibits ostauoclast kev ua si los ntawm kev khi rau cov calcitonin receptor (ctr) nyob rau ntawm osteoclasts. Nws cov tshuab ntawm kev nqis tes ua xws li:
Qhib lub chaw pw hav zoov / PKA Txoj kev: Txo cov pa hluav taws xob calcium ion concentration hauv Osteoclasts thiab inhibit cytoskeletal rov qab;
Txo cov ostausoclasts: inhibit qhov proliferation thiab sib txawv ntawm osteoclast ua ntej;
Central analgesic nyhuv: relieves pob txha mob los ntawm kev ua kom zoo opioid receptors hauv hypothalamus.
Mechanism sib piv thiab xaus
Kev sib piv ntawm cov cuab yeej tshuaj xyuas
Hloov pauv cov pob txha ntxhia (BMD)
BMD li kev cuam tshuam ntawm Teriparatide
Cov kev tshawb fawb soj ntsuam tau qhia tias kev kho mob teriparatide tuaj yeem nce BMD hauv tus txha nqaj qaum thiab ntsag.
Lumbar BMD
Qhov nruab nrab, nws nce los ntawm 9.7% -13.5% tom qab 18 lub hlis ntawm kev kho;
Tag Nrho Cov Ntiav BMD
Nws nce los ntawm qhov nruab nrab ntawm 2.6% -6.2% tom qab 18 lub hlis ntawm kev kho;
Femoral caj dab BMD
Qhov nce nruab nrab yog 2.8% -5.5% tom qab 18 lub hlis ntawm kev kho mob.
BMD cov tshuaj kho tau zoo ntawm anti - ris} cov pob txha resorpt tshuaj
Bisphosphonates
Tom qab 3 xyoos kev kho mob, lub lumbar BMD nce los ntawm 5.3% -8.8%, thiab lub duav tau nce los ntawm 2.2% -6.2%.
DESUMAB
Tom qab 3 xyoos kev kho mob, Lumbar BMD nce los ntawm 9.2%, thiab tag nrho cov duav tau nce los ntawm 6.0%.
Calcc calccor
Tom qab ib xyoos ntawm kev kho mob, lub lumbar BMD nce los ntawm kwv yees li 1% mus rau 2%, thiab cov nyhuv tsis muaj zog tshaj qhov ntawm lwm cov tshuaj.
Txo txoj kev pheej hmoo ntawm pob txha
Kev Tiv Thaiv Kev Tiv Thaiv Pob Tswb ntawm Teriparatide
Vertebral Qhov Kev Txhaum: Txo kev pheej hmoo los ntawm 65% (thiab cov ntsiab lus);
Tsis - txha caj qaum} pob txha lov: txo qhov kev pheej hmoo los ntawm 53% (thiab lwm qhov chaw);
Cov tsev kho mob lov: Txo kev pheej hmoo los ntawm 55% (thiab cov ntsiab lus).
Qhov Kev Tiv Thaiv Kev Tiv Thaiv Kev Tiv Thaiv Kev Tiv Thaiv ntawm Anti - r} cov pob txha resorpt tshuaj
Bisphosphtonates:
Vertebral Kev Lag Luam Loj: Txo kev pheej hmoo los ntawm 40% -70%;
Tsis - Qhov chaw muag khoom tawg: txo kev pheej hmoo los ntawm 20% -50%;
DESUMAB
Pob txha caj qaum pob txha pob zeb: txo kev pheej hmoo los ntawm 68%;
Tsis - txha caj txha lov: txo kev pheej hmoo los ntawm 20%;
Calccins
Vertebral Kev Lag Luam Loj: txo qhov kev pheej hmoo los ntawm kwv yees li 36% nkaus xwb hauv cov poj niam postmenopausal;
Tsis - txha caj tsw: Tsis muaj cov nyhuv tsis muaj tseeb.
Kev sib piv thiab cov ntsiab lus ntawm cov teebmeem kev cuam tshuam
Kev Nyab Xeeb thiab Kev Ruaj Ntseg
Kev txiav txim kev nyab xeeb ntawmTeriparatidepeptide
Txaus ntshai ntawm osteosarcoma
Cov kev sim tsiaj tau pom tias ntev {{0} ext} Txoj kev pheej hmoo ntawm Osteasarcoma, tab sis tib neeg cov kev pheej hmoo sim ua tsis tau lees tias qhov sib txheeb. Lub FDA tau tshem tawm lub neej kev kho tsis pub dhau ntawm 24 lub hlis, tab sis cov lus qhia hauv tsev tseem tau khaws cov kev txwv no.
Hypercalcemia
Qhov tshwm sim ntawm hypercalcemia thaum lub sijhawm kev kho mob Teriparatide yog kwv yees 11%, thiab nws tau muaj ntau dua hauv cov neeg mob uas tsis muaj lub txim txhaum. Cov ntshav calcium ntshav yuav tsum tau saib xyuas. Cov tshuaj yuav tsum raug muab ncua yog tias tsim nyog.
Lwm qhov kev cuam tshuam tsis zoo
Xeev siab (txog 11%), limb mob (li 7%), mob taub hau (li 6%);
Kev txhaj tshuaj tiv thaiv cov kev tiv thaiv (kwv yees li 3%), feem ntau me me mus rau nruab nrab;
Orthoostatic hypotension (tsis tshua muaj, qhov tshwm sim<1%).
Kev txiav txim siab kev nyab xeeb ntawm ovi - ris} cov pob txha resorpt tshuaj
Bisphosphonates
Mob Phease Reveluctions: Ua npaws, myalgia, inttralgia (qhov tshwm sim kwv yees li 10% -30%);
Mandibular Osteonecros (Osej): Qhov tshwm sim hauv qhov ntev yog kwv yees li 0.1% -1%, thiab nws yog qhov sib thooj nrog lub sijhawm ntawm cov tshuaj.
Atypical femoral fractures (AFF) : The risk increases with long-term use (>3 xyoos), muaj qhov tshwm sim ntawm kwv yees li 0.03% -0.1%.
DESUMAB
Hypocalcemia: Qhov tshwm sim yog kwv yees li ntawm 1.7%, thiab calcium ntxiv thiab vitamin d yog qhov yuav tsum tau ua.
ONJ: Qhov tshwm sim yog kwv yees li 1% -2%, uas yog siab tshaj qhov ntawm bisphosphonates.
Cov pob txha tsis ua pob txha ua haujlwm tom qab siv tshuaj tawg: Qhov kev pheej hmoo ntawm pob txha caj qaum ua rau nce hauv ib xyoos tom qab rho yeeb tshuaj.
Calccins
Risk of malignant tumors: Long-term use (>6 lub hlis) Yuav ua kom muaj kev pheej hmoo ntau rau kev pheej hmoo ntawm cov qog (lossis =1.43);
Kev sib haum: Qhov tshwm sim muaj feem yog kwv yees li 0.1% rau 1%. Thaum muaj mob hnyav, yuav tsum tau siv tshuaj yeeb.
Cov ntsiab lus ntawm kev nyab xeeb
Cov Kev Pab Kho Mob Kho Mob thiab Cov Lus Taw Qhia
Muaj feem
Raws li "Cov Kws Tshaj Lij Suav Kev Pom Zoo ntawm kev kho cov osteoporoticle nrog teriparaticotic (2024 tsab)", cov neeg mob hauv qab no raug pom zoo kom sivTeriparatidepeptideUa ntej:
Cov neeg mob uas muaj kev pheej hmoo heev ntawm kev tawg
Tsis ntev los no, brittle tawg (xws li pob txha ntawm lub ntsag, vertebal lub cev, thiab distal radius) tau tshwm sim;
Ntau txau osteoporotic
Kev kho mob pob txha thaum lub sijhawm anti {{0} osteoporosis kev kho mob.
Cov neeg mob uas muaj cov osteoporotic thaum lub sijhawm perioperative
Kev siv thaum ntxov tuaj yeem txhawb kev kho kom zoo thiab txo qhov kev pheej hmoo ntawm kev txhim kho sab hauv tsis ua haujlwm.
Cov neeg mob uas muaj cov pob txha dawb
Thaum ua tau zoo ntawm cov tshuaj tiv thaiv ib txwm muaj - cov pob txha resorptic tsis txaus siab, hloov kho kev kho mob tuaj yeem txiav txim siab.
Daim phiaj npaj kho
Cov tshuaj pom zoo: 20ug / hnub, subcutaneous txhaj tshuaj, nrog ib chav kho tsis tshaj 24 lub hlis;
Cov neeg laus cov neeg mob: Tsis tas yuav kho qhov ntau npaum li cas raws li hnub nyoog;
Cov neeg mob uas muaj lub qhov tsis txaus: Siv nrog ceev faj yog EGFR<30ml/min, and closely monitor the blood calcium level.
Kev kho mob ua ntu zus: Tom qab ua tiav ntawm Teriparatide, anti {- Cov pa tshuaj kho mob yuav tsum tau los tswj hwm lossis ntxiv rau BMD.
Yam sib pauv
Tej yam tsis xws luag:
Ostay Dagormis
Keeb kwm ntawm radiotherapy rau cov kab mob pob txha
Cov pob txha metastasis ntawm qog
Hypercalcemia
Lub cev tsis muaj lub txim tsis txaus (EGFR<15ml/min)
Cov hluas hnub nyoog qis dua 18 xyoo thiab cov uas muaj epiphyses.
Tus txheeb ze sib txawv:
Cev xeeb tub thiab tub rog poj niam
Thawj hyperarathyroidism.
Kev Tshawb Fawb Yav Tom Ntej
Ntev - ua yeeb yam npaj thiab cov txheej txheem tswj hwm tshiab
Txhawb ntso - Tshaj tawm cov tsom iav xws li Plgaper Cov ntaub ntawv xws li Plga, lawv tuaj yeem muab ib zaug ib hlis twg, yog ib hlis dhau los ua kev zam txim.
Transdermal Patches: Nyob rau theem II Kws tshawb nrhiav kev tshawb fawb theem, lawv yuav tsum txhim kho cov tshuaj kho mob rau cov neeg mob laus.
Hauv zos txawj txhawb nqa -}}} {1} {collagen Machineries yas, siv rau kev kho pob txha thiab txhawb cov pob txha kho kom zoo.
Kev Kho Mob Ib Leeg thiab Genotyping
Pth1r Polymorphism: Qhov sib txawv ntawm RS10500783 cuam tshuam rau kev kho mob ntawm Teriparatide, thiab genotyping yog pab tau tshuaj ntsuam cov pej xeem tseem ceeb.
Artificial kev twv ua ntej ua ntej qauv: ua ke ntawm FRAX® Cov qhab nia, pob txha tig cov cim ntaus cim thiab ntau} gene tau txais kev txiav txim siab ntawm tus kheej.
Kev ua kom zoo ntawm kev sib xyaw ua ke cov tswv yim
Teriparatide + Bisphosphtonates: Kev kho mob ua ntu zus tuaj yeem nce BMD hauv tus txha nqaj qaum thiab ntsag.
Teriparatide + Desumab: Kev kho mob ua ke rau ib xyoos tuaj yeem nce lub duav tau nce hip bmd, tab sis tsis muaj cov ntaub ntawv ntawm kev txo qis ntawm pob txha lov.
Luv -}}}} Termined Kev Kho Mob: nws yog siv rau cov neeg mob uas tau kuaj mob me me, tab sis tus nqi thiab cov txiaj ntsig yuav tsum tau ntsuas.
Tag
Teriparatidepeptide, raws li tsuas yog cov pob txha uas tau pom zoo {{0} ext estoting tshuaj, muab cov kev kho mob tshiab rau cov neeg mob uas tsis tshua muaj kev pheej hmoo. Cov kev thov sib xyaw ua ke ntawm cov tswv yim ntawm nws nrog anti- cov pob txha resorptures tuaj yeem ua tiav cov nyhuv nrawm nrawm. Nyob rau yav tom ntej, nrog kev txhim kho ntawm ntev- ua yeeb yam npaj thiab kev nce qib ntawm lub luag haujlwm ntawm tus kheej hauv kev kho mob cov txha epteoporosis. Txawm li cas los xij, nws txoj kev saib xyuas kev nyab xeeb tseem yuav tsum tau saib xyuas tas mus li, tshwj xeeb yog qhov ntev {6} ostosarcoma pheej hmoo. Cov kws kho mob yuav tsum nruj me ntsis npaj cov qauv qhia thiab cov phiaj xwm kev kho kom zoo rau cov txiaj ntsig zoo rau cov neeg mob.
Cim npe nrov: Teriparatide Peptide, cov chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag