ThymopentinRaws li cov organic compound, muaj cov qauv tshuaj ruaj khov thiab muaj tsib amino-acid residues: arginine, lysine, aspartic acid, valine, thiab tyrosine. Nws cov mis molecular yog CHN9O9, CAS 69558-55-0. Cov qauv no tshwj xeeb molecular endows nws nrog cov khoom solubility tshwj xeeb. Nws yooj yim soluble hauv cov kuab tshuaj organic xws li methanol, ethanol, thiab acetone, uas tuaj yeem cuam tshuam kev cuam tshuam ntawm Thymopeptide molecules thiab ua rau lawv tawg ntau dua hauv cov kuab tshuaj.
Lub caij no, thymopen yog me ntsis soluble hauv chloroform, uas tej zaum yuav yog vim nws cov polarity tsis muaj zog thiab tsis muaj zog cuam tshuam nrog thymopenti molecules. Ntxiv rau, thymopenti yog insoluble nyob rau hauv tsawg polar solvents xws li dej, roj av ether, thiab benzene, uas muaj feem xyuam rau pawg polar nyob rau hauv nws cov qauv molecular.
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Customized Bottle Caps Thiab Corks:
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Thymopentin COA
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| Certificate of Analysis | ||
| Compound npe | Thymopentin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 69558-55-0 | |
| Ntau | Customized | |
| Ntim txheem | Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090029 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav, -20 degree | |
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| Tshuaj Formula | C30H49N9O9 | |
| Exact Mass | 679.37 | |
| Molecular Luj | 679.78 | |
| m/z | 679.37 (100.0%), 680.37 (32.4%), 680.36 (3.0%), 681.37 (2.7%), 681.37 (2.4%), 681.37 (1.8%) | |
| Elemental Analysis | C, 53.01; H, 7.27; N, 18.54; O, 21.18 | |
Cov khoom siv kho qhov muag kuj tsim nyog them rau. Nyob rau hauv tej yam kev mob, xws li nyob rau hauv ib tug glacial acetic acid ib puag ncig, nws muaj peev xwm nthuav tawm cov kev hloov kho qhov muag, nrog kev sib hloov ntawm ( ) 17D -126.6 ± 2℃. Nws muaj ntau yam kev ua haujlwm lom neeg hauv tib neeg lub cev. Nws lub plasma ib nrab-lub neej yog luv luv, tsuas yog li 30 vib nas this, uas txhais tau hais tias nws lub sijhawm ua haujlwm hauv lub cev yog luv luv thiab yuav tsum tau siv ntau zaus los tswj nws txoj kev kho mob. Nyob rau tib lub sijhawm, thymopenti tuaj yeem txhawb kev tsim cov neeg T cell los ntawm tib neeg embryonic qia hlwb, yog li koom nrog hauv kev tswj hwm thiab kev saib xyuas ntawm cov kab mob immunologic.
Thymopeptide yog peptide uas muaj kev ua haujlwm lom neeg dav dav uas ua haujlwm ntau yam tseem ceeb hauv tib neeg lub cev. Raws li immunologic modulator,thymopentin nyob rau hauv cov ntshavtuaj yeem cuam tshuam rau kev sib txawv, kev loj hlob, thiab kev ua haujlwm ntawm cov hlwb immunologic, yog li tswj kev ua haujlwm ntawm cov kab mob immunologic.
Nws kuj muaj cov txiaj ntsig ntawm kev txhim kho thymic atrophy.
Thaum lub caj pas thymus shrinks vim muaj ntau yam laj thawj, lub immunologic kev ua haujlwm ntawm lub cev yuav raug cuam tshuam. Los ntawm kev txhaj tshuaj Thymopeptide, nws tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm thymocytes, txhim kho thymic muaj nuj nqi, thiab yog li txhim kho qhov tshwm sim ntawm thymic atrophy.
Nws kuj muaj los tiv thaiv- qog nqaij hlav.
Nws tuaj yeem cuam tshuam kev loj hlob thiab kev sib kis ntawm cov qog hlwb, ua rau cov qog cell apoptosis, thiab yog li ua tiav cov txiaj ntsig ntawm kev kho cov qog. Tsis tas li ntawd, kuv tuaj yeem txhim kho lub cev kev tiv thaiv kab mob thiab kev tshem tawm muaj peev xwm tiv thaiv qog nqaij hlav, tiv thaiv cov qog nqaij hlav nyob deb, thiab tsim cov kab mob metastatic tshiab.
Nws kuj ua lub luag haujlwm tseem ceeb hauv kev kho kab mob siab B.
Nws tuaj yeem txhawb kev ua haujlwm ntawm mononuclear macrophage system hauv daim siab, tshem tawm cov tshuaj necrotic hauv daim siab, thiab txo qis kev puas tsuaj rau daim siab. Lub caij no, thymopenti tseem tuaj yeem txhawb lub siab cell rov tsim dua tshiab.
Nws kuj muaj cov txiaj ntsig ntawm kev txhim kho daim siab ua haujlwm.
Lub siab yog ib qho tseem ceeb ntawm cov kab mob metabolic hauv tib neeg lub cev. Thaum lub siab ua haujlwm tsis zoo, cov metabolism thiab detoxification ua haujlwm ntawm lub cev yuav cuam tshuam. Thymopeptide tuaj yeem txhim kho daim siab ua haujlwm.
Thymopeptide kuj muaj cov tshuaj tiv thaiv antioxidant thiab hypoglycemic.
Nws tuaj yeem tshem tawm cov dawb radicals hauv lub cev, txo cov kev ntxhov siab oxidative, thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj. Tib lub sijhawm, thymopenti tuaj yeem tswj cov ntshav qabzib metabolism.
Hauv kev siv tshuaj kho mob
Thymopenti tau siv dav rau kev kho mob ntawm ntau yam kab mob xws li qog nqaij hlav, kab mob siab B, thiab kab mob autoimmune. Nws tsis tuaj yeem ua haujlwm tsuas yog kev kho mob ntxiv los txhim kho kev kho mob.
Thymopantin tseem tuaj yeem txhawb nqa qhov sib txawv thiab kev loj hlob ntawm T lymphocytes hauv thymus, rov tsim kho lub cev ntawm cov cellular immunologic tshuav nyiaj li cas, thiab txhim kho lub cev muaj peev xwm tiv thaiv kab mob, kab mob ntxeem tau thiab qog cell proliferation. Nws tuaj yeem tswj hwm qhov tso tawm ntawm ntau yam cytokines, nruab nrab cov lus teb inflammatory ntau dhau, thiab tiv thaiv cov ntaub so ntswg ntawm lub cev los ntawm overactivation thiab kev puas tsuaj. Vim nws cov ntshav plasma luv heev ib nrab-lub neej, kev npaj kho mob feem ntau yog tsim los ua khov- cov hmoov qhuav rau kev txhaj tshuaj, uas tuaj yeem nkag mus rau hauv lub cev sai sai tom qab kev tswj hwm thiab siv cov tshuaj tiv thaiv kab mob tam sim ntawd.
Tsis tas li ntawd, kev ua haujlwm ntawm thymopetin kuj cuam tshuam los ntawm ntau yam. Piv txwv li, tib neeg keeb kwm caj ces, hnub nyoog, poj niam txiv neej, thiab lwm yam yuav cuam tshuam rau kev ua haujlwm ntawm thymopntin. Lub caij no, kev sib cuam tshuam tshuaj kuj tseem cuam tshuam rau kev ua tau zoo thiab kev nyab xeeb ntawm thymopntin. Yog li ntawd, thaum siv thymopntin, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo xav txog cov xwm txheej no thiab tsim cov phiaj xwm kho tus kheej. Txawm li cas los xij, nws yuav tsum raug sau tseg tias thymopenti tsis haum rau txhua tus neeg. Rau cov neeg tshwj xeeb xws li cov poj niam cev xeeb tub, cov neeg muaj kev fab tshuaj, thiab cov neeg muaj lub siab thiab lub raum tsis ua haujlwm, thymopenti yuav tsum tau siv ceev faj kom tsis txhob muaj kev phiv.
Txoj hauv kev ntawm kev ua ntawm thymopenti feem ntau suav nrog cov hauv qab no - Txhawb txoj kev loj hlob thiab kev loj hlob ntawm T hlwb los ntawm thymus: Thymopeptide, raws li cov tshuaj hormones secreted los ntawm thymus, tuaj yeem txhawb txoj kev loj hlob thiab loj hlob ntawm T hlwb hauv thymus. Txoj hauv kev ntawm kev ua no feem ntau cuam tshuam nrog kev sib cuam tshuam ntawm tes thiab cov teeb liab hloov mus rau hauv thymus, yog li cuam tshuam rau kev loj hlob thiab kev sib txawv ntawm T hlwb.Signal transduction mediated by receptors: Thymopeptide tuaj yeem qhib txoj hauv kev hauv lub cev los ntawm kev khi rau cov receptors tshwj xeeb ntawm thymocytes.
Cov kev taw qhia no tuaj yeem tswj hwm cov noob qhia, kev tsim cov protein, thiab kev ua haujlwm ntawm tes hauv cov hlwb, yog li cuam tshuam rau kev ua haujlwm thiab kev ua haujlwm ntawm T hlwb thiab lwm lub cev tiv thaiv kab mob.Regulating cytokine ntau lawm: Thymopeptide yuav cuam tshuam rau immunologic teb los ntawm kev tswj cov khoom tsim thiab tso tawm ntawm lwm cov cytokines. Piv txwv li, nws tuaj yeem txhawb kev tsim cov cytokines, yog li txhim kho qhov tseem ceeb ntawm lub cev tiv thaiv kab mob thiab lawv lub peev xwm tiv thaiv kab mob.Tshwj xeeb cuam tshuam rau kev ua haujlwm ntawm lub cev tiv thaiv kab mob: Thaum kawg,thymopentin nyob rau hauv cov ntshavkuj tseem tuaj yeem cuam tshuam ncaj qha rau kev ua haujlwm ntawm lub cev tiv thaiv kab mob. Nws tuaj yeem tswj hwm kev ua haujlwm ntawm cov hlwb immunologic los ntawm kev hloov pauv cov txheej txheem hauv cellular metabolic, protein synthesis, thiab cellular qauv.
Thymopenin, raws li ib qho tshuaj immunomodulatory, muaj ntau yam kev siv hauv kev kho mob. Nws yog tsim los ntawm tsib amino-acid residues: arginine, lysine, aspartic acid, valine, thiab tyrosine. Nws yog ib feem ntawm thymidine II hauv thymic secretions. Lub npe tshuaj ntawm thymopntin yog N - [N - [N - [NL arginil-L- lysine] - L - - aspartic] - L- valine] -} L{14} molecular formula nrog L{14} C30H49N9O9. Thymopenin feem ntau yog muaj nyob rau hauv daim ntawv ntawm dawb khov- qhuav xoob blocks los yog hmoov thiab feem ntau yog siv los ua thymopntin txhaj tshuaj.
Qhov no ua rau nws txoj kev ua lom neeg los ntawm kev tswj hwm qhov sib txawv, kev loj hlob thiab kev ua haujlwm ntawm T lymphocytes hauv tib neeg lub cev, txhim kho cellular immunologic muaj nuj nqi thiab txhim kho lub cev tiv thaiv kab mob, kab mob thiab fungal. Nws yog dav siv nyob rau hauv kev kho mob adjuvant rau qis immunologic muaj nuj nqi tshwm sim los ntawm cov kab mob ntev, qog rehabilitation, raws li zoo raws li immunologic dysfunction ntsig txog postoperative rov qab. Nrog cov qauv tshuaj lom neeg ruaj khov thiab siab purity siab, nws muaj kev nyab xeeb zoo, kev ua haujlwm me me thiab cov tshuaj tiv thaiv tsis zoo, ua rau nws muaj cov tshuaj tiv thaiv kab mob tiv thaiv kab mob polypeptide uas muaj txiaj ntsig zoo hauv kev kho mob niaj hnub.
Basic Mechanism Of Action Ntawm Cov tshuaj no
Lub luag haujlwm tseem ceeb ntawm thymopntin yog los txhawb qhov sib txawv ntawm T lymphocytes thiab tuaj yeem khi rau T cell receptors, yog li txhim kho lub cev tiv thaiv kab mob. Nws cov txheej txheem physiological tshwj xeeb suav nrog cov hauv qab no:
(1) Inducing T cell sib txawv:
Thymopenin tuaj yeem xaiv ua kom muaj kev hloov pauv ntawm Thy-1- pre thymocytes rau hauv Thy{1}}T hlwb.
Cov txheej txheem kev sib txawv no yog kho los ntawm kev nce qib hauv intracellular cAMP, uas txhawb kev hloov pauv ntawm T hlwb los ntawm qhov tsis paub tab mus rau lub xeev laus.
(2) Ua kom cov hlwb immunologic:
Thymopenin tuaj yeem qhib CD4 thiab CD8 cov hlwb zoo, ua kom lub neej ntev ntawm Tc hlwb, thiab tseem qhib Th cells, inducing txoj haujlwm ntawm Ts hlwb. Cov teebmeem no pab kom lub cev teb sai sai rau cov kab mob.
Daim Ntawv Thov Ib Ntus ntawm Nws Hauv Cov Kab Mob Sib Txawv
Hauv tsev kho mob, thymopntin feem ntau yog siv rau kev kho mob ntawm cov qog nqaij hlav, kab mob autoimmune, theem nrab immunodeficiency thiab kis kab mob. Hauv qab no yog daim ntawv thov ua ntu zus thiab cov txheej txheem ntawm kev ua ntawm thymopntin hauv cov kab mob sib txawv:
Adjuvant Therapy For Malignant Tumors
(1) Txhawb T Lymphocyte Differentiation:
Thymopenin ua ntej txhim kho lub cev tiv thaiv- qog muaj peev xwm los ntawm kev txhawb nqa T lymphocyte sib txawv, ua rau muaj pes tsawg leeg thiab kev ua haujlwm ntawm T hlwb.
(2) Txhim kho qhov tseem ceeb ntawm Natural Killer Cells:
Thymopenin kuj tseem tuaj yeem ua rau muaj qhov tseem ceeb ntawm cov tshuaj tua kab mob ntuj, ua rau lawv muaj txiaj ntsig zoo hauv kev txheeb xyuas thiab tua cov qog hlwb.
(3) Txhim kho Phagocytic Function Ntawm Macrophages Thiab Neutrophils:
Los ntawm kev txhim kho phagocytic kev ua haujlwm ntawm macrophages thiab neutrophils, thymopntin pab tshem tawm cov qog hlwb thiab cov kab mob hauv lub cev.
Adjuvant Kev Kho Mob Ntawm Secondary Immunodeficiency Thiab Kab Mob Sib Kis
Cov neeg mob uas muaj kev tiv thaiv kab mob thib ob thiab cov kab mob sib kis feem ntau muaj kev ua haujlwm tsis zoo.Thymopentintuaj yeem ua raws li hauv qab no:
(1) Txhim kho lub cev tiv thaiv kab mob:
Thymopenin txhawb kev sib txawv thiab ua kom T lymphocytes, txhim kho lub cev tiv thaiv kab mob thiab ua kom muaj txiaj ntsig zoo hauv kev tiv thaiv kab mob.(2) Txhim kho phagocytic kev ua haujlwm ntawm macrophages:
Thymopenin tuaj yeem txhim kho phagocytic kev ua haujlwm ntawm macrophages thiab txhim kho lawv lub peev xwm los tshem tawm cov kab mob.
(3) Txhawb nqa interferon ntau lawm:
Thymopenin tuaj yeem txhawb kev tsim cov interferon, yog li txhim kho lub cev tiv thaiv kab mob.
Los ntawm kev tswj hwm qhov kev faib ua feem ntawm T lymphocyte subsets, nws pab txhawb kev tiv thaiv kab mob ntawm lub cev thiab txo qhov tshwm sim ntawm cov kab mob hauv nruab nrab thiab cov kab mob sib kis.
Cov lus nug nquag
Thymopentiin yog ib qho me me -molecule immunomodulatory peptide uas muaj tsib amino-acid residues: arginine, lysine, aspartic acid, valine, thiab tyrosine. Nws lub npe tshuaj yog N - [N - [N - [NL arginil-L-lysine] - L - - aspartic] - L-}valine] - L- tyrosine 9 tus naj npawb ntawm C thiab C 69558-55-0. Nws yog ib qho active fragment muab tau los ntawm thymidine II nyob rau hauv thymic secretions, feem ntau yog tam sim no raws li dawb lyophilized xoob blocks los yog hmoov.
Thymopentiin feem ntau ua rau nws cov teebmeem los ntawm kev tswj hwm qhov sib txawv, kev loj hlob thiab kev ua haujlwm ntawm T lymphocytes, yog li txhim kho lub cev cellular immunologic muaj nuj nqi. Nws tuaj yeem txhawb kev tsim cov neeg T cell, qhib lub ntuj tua cov hlwb thiab macrophages, tswj cytokine secretion, thiab pab tswj lub cev immunologic homeostasis. Tsis tas li ntawd, nws muaj cov tshuaj tiv thaiv- qog, daim siab- tiv thaiv thiab tiv thaiv kab mob, tshwj xeeb tshaj yog txhawb kev kho kab mob siab B thiab cov qog nqaij hlav malignant.
Clinically, Thymopentiin feem ntau yog siv los ua lyophilized hmoov rau kev txhaj tshuaj, uas yog reconstituted nrog sterile ib txwm saline rau subcutaneous los yog intravenous txhaj. Nws lub plasma ib nrab -lub neej yog li 30 vib nas this, yuav tsum tau tswj xyuas kom muaj kev kho mob. Nws muaj kev nyab xeeb zoo nrog cov tshuaj tiv thaiv tsis zoo; Cov tshuaj tiv thaiv hauv zos xws li mob me lossis liab liab ntawm qhov chaw txhaj tshuaj yog ib ntus, thiab cov tshuaj tiv thaiv kab mob xws li qib qis - kub taub hau yog qhov tsawg thiab mob me.
Thymopentiin yog dav siv nyob rau hauv kev kho mob xyaum ua ib tug immunomodulator. Nws yog tsuas yog siv rau kev kho mob qog nqaij hlav malignant, pab txhim kho lub cev tiv thaiv - qog immunologic teb thiab txo cov tshuaj kho mob -induced immunologic suppression. Nws kuj yog siv rau hauv kev kho mob ntawm tus kab mob siab B, kab mob tiv thaiv kab mob tsis muaj zog, thiab kev ua haujlwm ntawm kev tiv thaiv kab mob tom qab, nrog rau kev kho mob ntxiv rau cov kab mob sib kis los ntawm kev tiv thaiv qis.
Cim npe nrov: thymopentin cas 69558-55-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom