Tshaj tawm
Cov tshuaj no raug txwv tsis pub muag, peb lub vev xaib tsuas tuaj yeem tshawb xyuas cov ntaub ntawv yooj yim. ntawm cov tshuaj no, peb tsis muag lawv!
Lub Kaum Hli 22, 2024
Testosterone propionate hmoovyog ib qho tshuaj organic nrog cov tshuaj formula C22H32O3. Nws yog ib qho tshuaj androgen. Dawb mus rau dawb crystalline hmoov, yooj yim soluble nyob rau hauv ethanol, ether, pyridine thiab lwm yam organic solvents, soluble nyob rau hauv zaub roj, insoluble nyob rau hauv dej. Clinically, nws yog haum rau testis, cryptorchidism thiab txiv neej hypogonadism; Gynecological kab mob xws li menorrhagia thiab hysteromyoma; Senile osteoporosis thiab aplastic anemia. Laboratory reagents feem ntau yog siv nyob rau hauv kev tshawb fawb thwmsim.
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| Tshuaj Formula | C22H32O3 |
| Exact Mass | 344.24 |
| Molecular Luj | 344.50 |
| m/z | 344.24 (100.0%), 345.24 (23.8%), 346.24 (2.7%) |
| Elemental Analysis | C, 76.70; H, 9.36; O, 13.93 |
Testosterone propionate hmoov, yog ib qho hluavtaws anabolic steroid uas muaj qhov tso tawm qeeb qeeb piv rau lwm yam testosterone esters. Nws cov ntawv thov muaj ntau haiv neeg thiab nthuav dav thoob plaws ntau thaj chaw kho mob thiab kho mob. Hauv qab no yog cov ncauj lus kom ntxaws txog nws cov ntawv thov:
Txiv neej Hormone Replacement Therapy:
- Hypogonadism: Testosterone propionate yog siv los kho cov txiv neej hypogonadism, ib qho mob tshwm sim los ntawm qib testosterone qis. Qhov no suav nrog cov xwm txheej xws li andropause (txiv neej laus nrog txo qis testosterone), Klinefelter syndrome, thiab lwm yam qauv ntawm thawj lossis theem ob ntawm cov qog ntshav tsis ua haujlwm.
- Kev sib deev tsis zoo: Nws kuj tuaj yeem raug sau rau kev kho mob ntawm kev sib deev tsis zoo hauv cov txiv neej, suav nrog kev txo qis libido thiab erectile kawg, uas cuam tshuam nrog qis testosterone qib.
Ntshav Qab Zib:
- Testosterone propionate nkoos erythropoiesis (cov ntshav liab ntau lawm) los ntawm nws qhov kev ua ntawm ob lub raum, ua kom cov erythropoietin ntau lawm. Qhov no ua rau nws muaj txiaj ntsig zoo hauv kev kho mob ntshav qab zib, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob ntshav qab zib yog tshwm sim los ntawm qhov tsis txaus ntawm endogenous testosterone ntau lawm.
Pob txha Health:
- Nws txhawb cov pob txha ceev thiab lub zog los ntawm kev txhawb nqa calcium thiab phosphorus absorption, uas pab tiv thaiv thiab kho pob txha ntawm cov txiv neej.
Cov leeg nqaij thiab lub zog:
- Hauv qhov chaw kho mob, testosterone propionate tuaj yeem pab txhawb cov leeg nqaij thiab lub zog hauv cov tib neeg uas muaj cov leeg mob xws li cachexia lossis cov neeg rov zoo los ntawm cov mob hnyav lossis raug mob.
Kev siv tshuaj dermatological:
- Cov tawv nqaij mob: Testosterone propionate tau siv los kho qee yam ntawm daim tawv nqaij ntawm cov txiv neej, xws li txiv neej qauv baldness, qhov twg nws yuav ua rau cov plaub hau loj hlob. Txawm li cas los xij, nws txoj kev siv tshuaj dermatological tseem ceeb yog hauv kev kho mob ntawm daim tawv nqaij uas cuam tshuam nrog cov qib testosterone qis, xws li pruritus ani (khaus khaus ib ncig ntawm lub qhov quav) thiab qee hom kab mob dermatitis.
Tsis siv tshuaj kho mob (Ceeb toom: Tsis raug cai thiab tsis pom zoo):
- Testosterone propionate, zoo li lwm yam anabolic steroids, tau raug tsim txom los ntawm cov neeg ncaws pob thiab cov neeg tsim lub cev los txhim kho cov leeg nqaij, lub zog, thiab kev ua haujlwm. Txawm li cas los xij, nws siv rau cov hom phiaj tsis yog kev kho mob tsis raug cai thiab tuaj yeem ua rau muaj kev phiv loj heev, suav nrog tab sis tsis txwv rau cov teeb meem hauv plawv, mob siab, thiab mob hlwb.
Dosage thiab Administration
Kev noj tshuaj
Qhov ntau npaum ntawm testosterone propionate txawv nyob ntawm tus neeg mob thiab cov lus teb rau kev kho mob. Feem ntau cov koob tshuaj intramuscular ntau ntawm 25 txog 50 mg txhua 2 mus rau 3 hnub.
Kev tswj hwm
Nws yog siv intramuscularly, feem ntau nyob rau hauv cov nqaij gluteal los yog deltoid. Qhov kev tso tawm qeeb qeeb ntawm testosterone propionate tso cai rau kev txhaj tshuaj tsawg dua piv rau lwm cov testosterone esters.
Kev txheeb xyuas tus kheej
Noj li 5 mg ntawmTestosterone propionate hmoov, muab tso rau hauv lub raj me me, ntxiv {{0}}.2ml ntawm methanol kom yaj nws, ntxiv li 3mg ntawm hmoov zoo ntawm sodium nitroferricyanide, txog 50mg ntawm sodium carbonate thiab ammonium acetate feem, co nws zoo. , tso nws rau 10 mus rau 30 feeb, thiab nws yuav tsum tshwm xiav thiab ntshav. Noj li 0.5mg ntawm cov khoom no, muab tso rau hauv ib lub raj me me, ntxiv txog 1mg ntawm isoniazid thiab 1ml ntawm methanol kom yaj nws, ntxiv 1 poob ntawm dilute hydrochloric acid, thiab nws yuav tig daj. Lub infrared absorption spectrum ntawm cov khoom no yuav tsum ua raws li kev tswj spectrum (spectrum teeb 434 daim duab). Chromatographic tej yam kev mob thiab system haum xeem siv octadecyl silane bonded silica gel ua muab tub lim; Methanol dej (65:35) yog theem mobile; Qhov ntsuas wavelength yog 254nm.
Tus naj npawb ntawm cov ntawv theoretical xam raws li lub ncov progesterone yuav tsum tsis pub tsawg dua 1000, thiab qhov kev daws teeb meem ntawm lub ncov ntawm progesterone thiab cov khoom siv hauv cov txheej txheem siab kawg yuav tsum ua tau raws li qhov yuav tsum tau ua. Kev npaj cov txheej txheem sab hauv Siv li 25mg ntawm diethylstilbestrol, ntsuas kom raug, muab tso rau hauv 25ml ntim ntim, yaj hauv methanol, dilute nws mus rau qhov ntsuas, thiab co nws. Txoj kev txiav txim siab noj li 25mg ntawm cov khoom, ntsuas kom raug, muab tso rau hauv 25ml ntsuas lub khob, yaj hauv methanol, dilute nws mus rau qhov ntsuas, thiab co nws; Ua kom raug ntsuas 5ml ntawm cov tshuaj thiab 5ml ntawm cov txheej txheem sab hauv, muab tso rau hauv 25ml ntim ntim, dilute lawv mus rau qhov ntsuas nrog methanol, co lawv, thiab noj 5 μL Txhaj cov kua chromatograph thiab sau cov chromatogram; Noj cov tshuaj progesterone uas tsim nyog thiab txiav txim siab los ntawm tib txoj kev. Muab xam los ntawm qhov chaw siab tshaj raws li tus txheej txheem sab hauv.
Cov tshuaj tiv thaiv tsis zoo
17- Alkyl hloov pauv testosterone yog tshuaj lom rau lub siab thiab tuaj yeem ua rau daj ntseg. Kev siv lub sij hawm ntev rau cov poj niam cov neeg mob yuav ua rau cov txiv neej xws li pob txuv, hirsutism, lub suab ntxhib, thiab kev sib deev muaj siab hloov. Thaum pom lub siab ua haujlwm tsis zoo thiab feminization, cov tshuaj yuav tsum tau nres tam sim ntawd. Cov koob tshuaj loj tuaj yeem ua rau feminization, edema, daim siab puas, jaundice, kiv taub hau, thiab lwm yam.
Cov neeg uas muaj kev fab tshuaj yuav tsum tsis txhob noj tshuaj tam sim ntawd. Tsis txhob siv rau cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm, mob qog noj ntshav prostate thiab cov poj niam cev xeeb tub. Yog tias muaj crystal nag lossis daus hauv kev txhaj tshuaj, nws tuaj yeem ua kom sov thiab yaj ua ntej txhaj tshuaj. Txwv tsis pub rau cov poj niam cev xeeb tub thiab lactating thiab cov neeg mob qog noj ntshav prostate; Thaum noj tshuaj, daim siab ua haujlwm yuav tsum tau kuaj xyuas tsis tu ncua. Yog tias muaj kev puas tsuaj rau daim siab, cov tshuaj yuav tsum tau txo lossis nres; Cov koob tshuaj yuav tsum raug txo rau cov menyuam yaus ua ntej puberty, thiab lub hnub nyoog ntawm pob txha yuav tsum tau ntsuas txhua 6 lub hlis.
Nyob rau hauv cov tshuaj tiv thaiv esterification, Testosterone Propionate ua raws li ib tug catalyst, thiab lub mechanism ntawm kev txiav txim yog raws li nram no:
1. Cov tshuaj tiv thaiv tseem ceeb:
Testosterone Proposition yog koom nrog esterification cov tshuaj tiv thaiv ntawm cawv thiab acids. Cov tshuaj tiv thaiv no tshwm sim ntawm 17% ntawm testosterone molecule Ntawm pawg hydroxyl. Tshwj xeeb, pawg propionate hauv Testosterone Propionate tau txais cov tshuaj tiv thaiv esterification nrog 17 Cov pab pawg hydroxyl ntawm txoj haujlwm ua ke los tsim cov ester bonds.
2. Catalyst muaj nuj nqi:
Testosterone Proposition plays lub luag haujlwm catalytic hauv cov tshuaj tiv thaiv esterification. Nws muab ib qho chaw catalytic uas ua rau nws yooj yim dua rau cawv thiab kua qaub molecules rau ib leeg. Los ntawm kev txo qhov ua kom lub zog ntawm cov tshuaj tiv thaiv, Testosterone Propionate txhawb cov tshuaj tiv thaiv esterification.
3. Cov kev mob tshwm sim:
Esterification cov tshuaj tiv thaiv feem ntau yuav tsum tau ua raws li qee yam kev mob, suav nrog qhov ntsuas kub kom tsim nyog, reactant concentration, thiab kev xaiv hnyav. Testosterone Propionate, ua ib qho catalyst, tuaj yeem txhawb cov tshuaj tiv thaiv esterification hauv cov tshuaj tiv thaiv me me.
Hauv cov ntsiab lus, cov txheej txheem ntawm kev ua ntawm Testosterone Propionate hauv cov tshuaj tiv thaiv esterification yog los ntawm kev sib cuam tshuam ntawm nws pawg propionate ester thiab testosterone molecule Hydroxyl pawg tau txais cov tshuaj tiv thaiv esterification, tsim ester bonds. Nyob rau hauv cov txheej txheem no, Testosterone Propionate ua raws li ib tug catalyst, txo cov activation zog ntawm cov tshuaj tiv thaiv thiab txhawb esterification cov tshuaj tiv thaiv.
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