Diphenylphphine oxide, molecular formula C12h11111111s, ua txhaum rau cov khoom siv tshuaj ntsuab, yog ib qho tseem ceeb ntawm cov tshuaj lom neeg thiab cov tuaj yeem hloov alkali hlau cyanides li coupling cov neeg sawv cev kom sauv heterocyclic sib txuas, xws li cov tshuaj ntsuab sib xyaw ua ke, diphtylphosphin muaj peev xwm yuav raug muab tso rau hauv olefins tsis muaj tshuaj kuab lossis catalysts . pha2p (o) h reacts nrog aldehydes los tsim 1, {} .
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Tshuaj Cov Qauv |
C12H1111OP |
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Muaj pes tsawg leej |
202 |
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Molecular hnyav |
202 |
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m/z |
202 (100.0%), 203 (13.0%) |
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Kev Ntsuam Xyuas |
C, 71.28; H, 5.48; O, 7.91; P, 15.32 |
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Cov cuab yeej tshuaj
Reactivity:
Cov phosphorus cov pa nyiaj hauv daihenylphin oxide muaj cov lus teb ntau thiab tuaj yeem koom nrog ntau yam lus teb, ntxiv rau cov lus teb txuas ntxiv, thiab lwm yam lus teb, thiab .
Stability:
Ruaj khov nyob rau hauv inert cua thiab chav sov, tab sis noo noo yuav tsum tau coj mus rau hauv tus account vim nws rhiab rau ya raws .
TOXICITY:
Belongs rau cov tshuaj lom tsawg, tab sis tseem yuav tau daws tau raws li kev ua haujlwm kev nyab xeeb tshuaj lom neeg ua haujlwm {}}
Diphenylphphine oxide(DPPO, CAS Number 4559-70-0), raws li ib qho tseem ceeb organic synthesis, Wittig Horner Cov Qauv Kev Lag Luam, Kev Lag Luam Kev Lag Luam, thiab lwm yam}
Plays ib lub luag haujlwm tseem ceeb hauv cov tshuaj tua kab mob zoo, tshwj xeeb tshaj yog cov khoom tseem ceeb hauv cov tshuaj ntsuab synthesis.
2.1 synthesis ntawm tshuaj ntsuab
Synthesis ntawm paraquat: dppo tuaj yeem hloov cov tshuaj ntsuab alkali nyob rau hauv hwj dej sib xyaw ua ke rau heeltat yog ib qho kev xaiv sib chwv tshuaj ntsuab
Lwm cov tshuaj tua tsiaj: DPPO tseem siv tau los ua ke lwm yam tshuaj tua kab thiab cov khoom siv sib xyaw ua ke nrog cov kev ua haujlwm sib txawv thiab tuaj yeem npaj tau cov kev ua haujlwm sib txawv tuaj yeem tau npaj}
2.2 Yam tshuaj tua kab
Txhim Kho Cov Tshuaj Siv Tshuaj Siv Tshuaj: DPPO thiab nws cov derivatives tuaj yeem sib xyaw ua ke los txhim kho cov tshuaj tua kab, yog li ua kom muaj tshuaj tua kab, yog li ua kom zoo rau tshuaj uas.
Txo cov tshuaj txo qis: Los ntawm kev ua kom muaj kev ua tau zoo, kev siv tshuaj tua kab tuaj yeem txo qis, txo cov pa phem ib puag ncig .
Daim Ntawv Thov nyob rau hauv kev txhim kho chairal nigands
Chiral ligands ua lub luag haujlwm tseem ceeb hauv cov synthesis, thiab dppo yog cov khoom siv tseem ceeb rau synthesizing phosphine liigands .
3.1 synthesis ntawm chiral phosphine liigands
Coupling teb: DPPO (PH2 (O) H) tuaj yeem yauv teb chaws txuas ntxiv rau cov lus diphine oxide, ib txwm siv chiral ligand .
Chiral catalysis: chiral phosphine lihaib pom zoo tshaj plaws hauv cov lus teb asymmetric
3.2 Cov Khoom Siv Hluav Taws Xob
Complex molecular synthesis: siv dppo li cov khoom siv raw, xws li}}} { teb xws li tshuaj thiab cov khoom siv science .
Cov ntaub ntawv muaj nuj nqis: Chairal phosphine Ligands kuj tseem siv tau los npaj cov khoom siv chiral nrog cov haujlwm tshwj xeeb, thiab lwm yam .
Ntxiv nrog rau cov chaw thov tseem ceeb tau hais los saud, DPPO tseem pom muaj txiaj ntsig zoo hauv ntau lub teb .
6.1 Cov Khoom Siv Tshuaj Yooj Yim
Cov Kev Tswj Xyuas Kev Ncaj Ncees:Diphenylphphine oxidePuas yog cov khoom siv hluav taws xob feem ntau siv rau hauv chav kuaj, uas tuaj yeem siv rau kev txhim kho thiab kev txhim kho muaj ntau yam organic .
Kev tshawb nrhiav kev tshawb xyuas: Hauv kev ntsuas tshuaj, DPPO tuaj yeem siv los ua cov tshuaj txheem lossis reacht rau kev txheeb xyuas cov qauv lossis kev ntsuas ntsuas}}}
6.2 Cov tshuaj nruab nrab hauv vaj huam sib luag
Khoom siv yeeb tshuaj: DPPO thiab nws cov nyiaj ntawm cov neeg ua haujlwm tau siv los ua cov tshuaj synthesis thiab koom rau hauv cov tshuaj npaj ntawm ntau yam yeeb tshuaj .
Kev Tsim Tshuaj Yeeb: Hauv kev tsim qauv tshuaj, DPPO tuaj yeem siv los ua cov lus sib xyaw nrog cov kev sib tw ua haujlwm tshwj xeeb, muab cov neeg sib tw molecules rau kev txhim kho tshuaj tshiab .
6.3 Khoom Siv Kev Tshawb Fawb
Npaj cov khoom siv ua haujlwm: DPPO thiab nws cov deppo thiab nws cov derivatives tuaj yeem siv los npaj cov ntaub ntawv nrog cov ntaub ntawv tshwj xeeb, cov ntaub ntawv tshwj xeeb, sib nqus, thiab lwm yam}
Nanomaterials: Hauv teb ntawm nanomaterials, dpose tuaj yeem siv ua lub qhov nruab deg lossis stabilizer txhawm rau txhim kho qhov tsis txaus thiab ruaj khov ntawm nanomaterials .
DPPO, raws li cov khoom siv hluav taws xob tseem ceeb hauv nruab nrab, muaj cov khoom siv tshuaj ntau tshaj plaws hauv kev lag luam hauv ntau yam kev lag luam} Txuas ntxiv mus cog lus . Lub sijhawm no, txhawb nqa kev txhim kho kev txhim kho hauv DPPO {}}
DPPO yog qhov tseem ceeb hauv nruab nrab hauv cov txheej txheem econicen los txhim kho cov txheej txheem hluav taws xob muaj qhov yooj yim, nws yog qhov nyuaj {{. Los ntawm kev tshuaj xyuas cov ntaub ntawv, peb tsim ib lub lauj kaub lauj kaub ua ke rau cov khoom sib txuas, thiab tshawb cov lus teb tshwj xeeb ntawm cov qauv no {}}
Cov txheej txheem saptthesis tshwj xeeb ntawm diphenylphin oxide yog raws li hauv qab no:
Hnyav 23 {{. 3 g (0 20.0}}}}}}}}}}}}}}}}}}}}}}}}}}} Sib tov . nyob rau hauv lub tshuab ziab khaub ncaws, do ntawm 60℃rau hauv chav dej sov, ntxiv rau hauv 100} Tom qab cov dej khov nab kuab thiab maj mam hliv qhov kev daws rau 60 ml dej thiab 20 ml muaj lub ntsej muag hydrochloric acid. Siab do thiab hydrolyze (30℃{{{{}} degree) cais cov organic txheej. Dej txheej extracted nrog toluene (50 ml × 5), sib koom ua ke nrog 10% naoh 100}}), thiab cais cov toluene txheej. Qhuav lub anhydrous sodium sulfate, yaj lub teeb ua kua rau thaum muaj 17,6 21%, thiab cov ntsiab lus txiav txim los ntawm HPLC yog 95.6%.
Diphenylphinphin oxide (dppo), raws li ib qho tseem ceeb ntawm cov ntaub ntawv hauv cov kab ke, thiab cov ntaub ntawv kawm paub ntau yam, thiab cov khoom siv hluav taws xob, thiab cov ntaub ntawv tshwj xeeb, thiab cov khoom siv hluav taws xob, thiab cov khoom siv hluav taws xob zoo li no yuav muab cov ntsiab lus zoo tshaj plaws ntawm cov qauv tseem ceeb ntawm diphenylphin oxide .
1.1 Cov Ntsiab Cai
Cov qauv no siv cov pa phosphorus oxychhlide (pocl} li lithium aluminium hydride (lialh ₄) .
1.2 Cov Kauj Ruam
Friedel Crafts teb: Hauv qab catalysis ntawm anhydrous aluminium chloride (alcl3), pocl ₂ thiab bancl ₂
Cov lus teb txo: Ph ₂ pcl tau hnov nrog lithium cov kuab tshuaj kom txo cov kuab tshuaj tsw qab los txo cov kuab tshuaj kom txo tau cov tshuaj pleev kom huv si los rau diphenylphephin oxide.
1.3 Qhov zoo thiab qhov tsis zoo
Cov txiaj ntsig: Cov khoom siv raw yog yooj yim kom tau thiab cov lus teb muaj cov neeg mob hnyav me.
Qhov tsis zoo: Kev ua kom huv ntawm cov lej nruab nrab PCl yog qhov nyuaj thiab muaj cov neeg sawv cev tsawg dua, muaj kev tiv thaiv nruj me ntsis thaum lub sijhawm ua haujlwm
2.1 Cov Ntsiab Cai
Cov qauv no siv diothyl phosphite li cov khoom siv raw (xws li phenyl magnesium los tsim diphenylphos ntsev, thiab tom qab ntawd tau txaisdiphenylphphine oxidelos ntawm kev kho cov kua qaub .
2.2 Cov Kauj Ruam
GrignArd teb: reacting diothyl phosphite nrog grignard reaskse los tsim diphenylphos ntsev .
Cov tshuaj acid: reacting daihenyfphosphines ntsev nrog acidic acid) kom tau txais diphenylphosphin oxide.
2.3 Qhov zoo thiab qhov tsis zoo
Cov txiaj ntsig zoo: Cov lus teb yuav muaj mob heev thiab cov txiaj ntsig yog qhov siab .
Qhov tsis zoo: Kev npaj thiab khaws cia ntawm grignit reagents yuav tsum ua kev nyab xeeb nruj heev, thiab los ntawm cov lus teb .
3.1 Cov Kev Cai
Cov qauv no siv rau Tripherylphosphine Oxide (phia po) raws li cov khoom siv raw, thiab hloov pauv ntawm cov hlau me me thiab cov polyol sib xyaw .
3.2 cov kauj ruam
Cov lus teb txo: Raws li cov pa roj inert, tripyenylphos micround), thiab undergoes ib qho kev kub siab (xws li cov tshuaj ethylene) Ntsev .
Hydrolysis teb: reacting sodium diphenylphosphin oxide nrog dej kom tau diphenylphephin oxide .
3.3 Qhov zoo thiab qhov tsis zoo
Cov txiaj ntsig: Lub raw khoom tripherylphs oxide tuaj yeem tau los ntawm kev lag luam ntawm cov kuab tshuaj thiab cov lus teb rov qab rau cov kuab tshuaj
Qhov tsis zoo: Kev siv ntawm nws yog xim hlau sodium yuav tsum tau ua kev nyab xeeb ceev faj, thiab los ntawm cov txheej txheem teb, xav tau tom qab kev ua kom huv si.
4.1 daihenylphine chloride hydrolysis txoj kev
Txoj kev siv no siv cov tshuaj uas muaj cov khoom siv los ntawm cov khoom siv.
4.2 Microwave pab pawg hluav taws xob hluavtaws
Nyob rau hauv xyoo tsis ntev los no, microwave-pab qhia hluav taws xob tau siv nyob rau hauv cov txheej txheem {}}} Txawm li cas los xij, rau cov xwm txheej Microwave, rau cov xwm txheej Microwave, rau cov txheej txheem Researh thiab tseem tsis tau muaj Industrialized .
5.1 Sib Piv Ntawm Cov Qauv Synthesis
Friedel Crafts Txo Txoj Kev: Cov ntaub ntawv tso tawm tau yooj yim muaj, tab sis cov txiaj ntsig yog qhov txo tus neeg sawv cev yog qhov siab .
Grignard reamet txoj kev: Cov lus teb yog qhov kev hloov me me thiab cov txiaj ntsig yog qhov siab, tab sis kev npaj ntawm grigard reagnts yuav tsum nruj me ntsis rau kev nyab xeeb .
Tripyenyfphosphosphopaph Txoj kev hloov pauv: Cov khoom siv tsis muaj roj, tab sis siv cov khoom siv me me, tab sis siv cov pa rov qab zoo nkauj, thiab cov siab tawv
Lwm cov txheej txheem synthesis, xws li hydrolysis ntawm diphenylphhine chloride thiab microwave-pab synthesis, txhua qhov tsis zoo, tab sis tseem tsis tau muaj.
5.2 Xaiv cov qauv hluavtaws
Hauv kev ua haujlwm tswv yim, tsim nyog cov hluavtaws hluavtaws uas tsim nyog thiab cov kev xav tau ntawm cov khoom siv Raw thiab cov qauv kev hloov pauv siab tuaj yeem xaiv; Yog tias kev teb cov lus me me thiab cov txiaj ntsig graint reaset. tib lub sijhawm, ib puag ncig cov txheej txheem thaum lub sijhawm teb chaws yuav tsum tau txiav txim siab {}
Diphenylphphine oxide, raws li ib qho tseem ceeb organic synthemes, muaj ntau cov lus qhuab qhia thiab kev xav tau zoo thiab muaj kev txhawb nqa hauv Synthements thiab ib puag ncig zoo tshaj plaws thiab kev txhawb nqa zoo nkauj, muab kev txhawb zog zoo for the industrial prodution of diphenylphosphin oxide. Meanwhile, optimizing and improving existing synthesis methods is also one of the future researh directions, aiming to improve response efficiency, reduce costs, and minimize environmental pollution.
Cim npe nrov: diphenylphos oxide cas 4559-70-0, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqe, loj, rau muag