Taw qhia
Engineered somatostatin analogs zoo liPasireotidethiab Octreotide yog siv los kho ntau yam kab mob neuroendocrine xws li Cushing's kab mob thiab acromegaly. Txawm hais tias sib koom qee qhov sib xws hauv cov qauv thiab kev ua haujlwm, cov tshuaj no tsis zoo ib yam. Peb yuav tsom mus rau Pasireotide thiab Octreotide cov txheej txheem ntawm kev ua haujlwm, kev ua tau zoo hauv kev kho tus kab mob cushing, thiab cov kev mob tshwm sim hauv cov ntawv blog no.
Dab tsi yog qhov txawv ntawm Pasireotide thiab Octreotide ntawm lawv cov txheej txheem ntawm kev ua haujlwm?
Txawm hais tias Pasireotide thiab Octreotide yog ob qho tib si siv los kho cov tshuaj lom neeg, lawv cov txheej txheem ntawm kev ua, tshwj xeeb tshaj yog lawv cuam tshuam li cas rau lub cev receptors, yog pom meej meej.
- Octreotide
Lub Course of Activity
Octreotide yog ib hom kev tsim cov tshuaj somatostatin, uas ua rau lub cev tsis txhob xa cov tshuaj sib txawv.
Stabilizing qhov muaj ntawm Manufactured Mixtures
Los ntawm kev txwv nws qhov kev ua rau somatostatin receptors, octreotide tiv thaiv kev tso tawm ntawm kev loj hlob hormone (GH), insulin-zoo li kev loj hlob zoo (IGF-1), glucagon, thiab ob peb yam tshuaj lom neeg hauv plab xws li gastrin thiab serotonin. Qhov kev cuam tshuam no txhawb nqa cov tshuaj muaj feem cuam tshuam rau theem nrab xws li acromegaly, carcinoid jumble, thiab kev kis kab mob hauv plab los ntawm kev txo cov hluavtaws tso tawm.
- Pasireotide
Kev cog lus ruaj khov dua rau receptors
Pasireotide muaj qhov zoo dua los khi rau ntau yam subtypes ntawm somatostatin receptors dua li octreotide, tso cai rau nws ua rau muaj kev cuam tshuam ntau dua hauv av inhibitory ntawm kev tso tawm hluavtaws. Pasireotide tau ua tiav zoo tiv thaiv kev tso tawm cov tshuaj lom hauv plab hnyuv xws li GH, IGF-1, insulin, glucagon, thiab lwm yam los ntawm kev txwv nws qhov kev ua rau ntau yam ntawm cov receptors.
Expanded Productivity
Hauv qee yam mob, xws li acromegaly thiab Cushing's kab mob, qhov twg nws tau ua tiav octreotide hauv kev sim tshuaj, pasireotide tuaj yeem tswj cov tsos mob ntsig txog cov tshuaj hormones zoo dua li octreotide. Qhov no yog vim qhov tseeb tias pasireotide khi rau ntau yam receptors.
Hauv kev xaus, txawm tias qhov tseeb tiaspasireotidethiab octreotide ob leeg inhibit hormone secretion, lawv cov txheej txheem ntawm kev ua txawv. Pasireotide muaj kev sib raug zoo ntau dua rau ntau yam ntawm somatostatin receptor subtypes dua li octreotide ua. Octreotide feem ntau khi rau somatostatin subtype 2 receptors. Txawm hais tias Pasireotide tuaj yeem ua haujlwm zoo dua rau cov xwm txheej tshuaj lom neeg vim nws qhov dav dav receptor-txhim kho qhov profile, ob cov tshuaj txuas ntxiv ua cov kev kho mob zoo uas tuaj yeem tsim kho rau txhua tus neeg mob cov kev xav tau tshwj xeeb.
Qhov kev ua tau zoo ntawm Pasireotide piv rau Octreotide hauv kev kho tus kab mob Cushing li cas?
Kev tshawb fawb soj ntsuam tau tsom mus rau kev sib piv Pasireotide qhov ua tau zoo hauv kev kho tus kab mob cushing rau Octreotide's.
Pasireotide
Pasireotide tau tshwm sim los ua kom yuam kev hauv kev kho mob ntawm cushing, tshwj xeeb tshaj yog rau cov neeg uas tsis tau teb cov kev kho mob sib txawv lossis raug cuam tshuam los ntawm lawv.
Kev kho mob Pasireotide tau pom tias txo qis qis qis cortisol hauv cov zis thiab txhim kho cov tsos mob xws li qhov hnyav nce, kub siab, thiab piam thaj tsis kam rau cov neeg mob Cushing's disease.
Octreotide
Hauv kev kho mob ntawm Cushing's mob, octreotide tau pom tias muaj kev vam meej hauv kev txo qis cortisol thiab tswj cov kev cuam tshuam thib ob hauv qee cov neeg mob.
Octreotide, es tsis txhob Pasireotide, yeej khi rau somatostatin subtype 2 receptors (sst2) thiab muaj kev txwv ntau dua receptor limiting profile. Hauv qee tus neeg mob, qhov no yuav ua rau kev txwv ntawm ACTH tso tawm thiab cortisol tsim tsis muaj zog.
Txawm hais tias Octreotide tuaj yeem ua rau muaj kev vam meej hauv qhov tsis pom tseeb ntawm Cushing tus kab mob, nws txoj kev muaj peev xwm yuav raug txwv rau cov neeg mob uas tsis teb rau kev kho mob raws li kev pom zoo lossis cov uas tau ntsib qhov tshwm sim tsis zoo.
Tag nrho hauv tag nrho, txawm tias qhov tseeb tias Pasireotide thiab Octreotide yog ob qho tib si siv hauv kev kho mob ntawm Cushing,Pasireotidetej zaum yuav muaj zog dua vim tias nws lub peev xwm los khi rau ntau qhov ntau ntawm cov receptors. Txawm li cas los xij, tus neeg mob tus yam ntxwv, lub hom phiaj kev kho mob, thiab kev kam rau siab tag nrho muaj kev cuam tshuam rau kev xaiv tshuaj. Cov kws kho mob tshwj xeeb yuav tsum ua tib zoo tshuaj xyuas txhua qhov kev nkag siab tus mob thiab cov lus teb rau kev kho mob txhawm rau xaiv txoj kev kho mob zoo tshaj plaws.
Puas muaj qhov sib txawv ntawm cov kev mob tshwm sim ntawm Pasireotide thiab Octreotide?
Txawm hais tias Pasireotide thiab Octreotide yog ob qho tib si cov tswv cuab ntawm cov chav kawm ntawm somatostatin analogs thiab qhia qee qhov kev tsis zoo tib yam, lawv cov kev mob tshwm sim yog qhov txawv. Los tom ntej no yog kev ntsuam xyuas ntawm Pasireotide thiab Octreotide cov nyhuv thib ob profile
- ► Pasireotide
Qab zib heev
Hyperglycemia, uas tuaj yeem tshwm sim los ntawm kev cuam tshuam ntawm insulin lossis kev cuam tshuam ntawm cov tshuaj insulin, tej zaum yog Pasireotide qhov tshwm sim feem ntau tshwm sim. Cov neeg mob uas muaj ntshav qab zib lossis muaj qhov tsis zoo ntawm cov piam thaj yuav tsum tau saib xyuas thiab tswj xyuas cov ntshav qabzib siab uas tshwm sim los ntawm pasireotide.
01
GI yam uas muaj teeb meem
Feem ntau cov kev mob tshwm sim hauv plab hnyuv ntawm kev kho pasireotide yog raws plab, xeev siab, thiab mob plab. Cov tshuaj tiv thaiv kab mob los yog kev hloov koob tshuaj kuj yuav tsum tau nyob rau hauv qee qhov xwm txheej los tswj cov kev mob tshwm sim no.
02
Gallstones
Pasireotide tuaj yeem ua rau muaj qhov tshwm sim ntawm gallstone tsim, uas tuaj yeem ua rau xeev siab, ntuav, thiab mob plab. Cov neeg mob yaum kom Pasireotide yuav tsum tau pom rau cov cim qhia txog kev ua si hauv gallstone, thiab cov txheej txheem tsim kho lub koom haum yuav ua tiav yog qhov tseem ceeb.
03
Kev puas tsuaj ntawm cov hlab plawv
Bradycardia, lossis lub plawv dhia qeeb, tau txuas nrog pasireotide hauv qee cov neeg mob, tshwj xeeb tshaj yog cov neeg uas muaj teeb meem plawv yav dhau los.
04
►Octreotide
Cov teeb meem GI
Kev kho Octreotide, raws li Pasireotide, tuaj yeem ua rau mob plab zom mov zoo li kev khiav, queasiness, thiab mob plab. Cov tsos mob no feem ntau muaj qhov hnyav ntawm me me mus rau nruab nrab, thiab lawv yuav ploj mus yog tias kev kho mob txuas ntxiv lossis hloov pauv ntau npaum li cas.
01
Ntshav qab zib siab
Vim tias nws cov kev cuam tshuam cuam tshuam rau insulin emission thiab kev zom cov piam thaj, octreotide tuaj yeem ua rau hyperglycemia. Cov neeg mob uas kho Octreotide tuaj yeem ntsib cov ntshav qabzib nce siab, yuav tsum tau kuaj xyuas ze thiab hloov tshuaj rau ntshav qab zib.
02
Ntawm Qhov Chaw Txhaum Cai, Cov Lus Teb
Cov lus teb nyob ze xws li kev txom nyem, nthuav dav, thiab liab ntawm qhov chaw infusion yuav tshwm sim nrog octreotide infusions. Kev txwv cov teebmeem no tuaj yeem ua kom yooj yim dua los ntawm kev siv cov txheej txheem infusion raug cai thiab pivoting infusion qhov chaw.
03
Broken Gallbladder
Kev kho nrog Octreotide tuaj yeem txhim kho qhov tshwm sim ntawm lub zais zis tawg thiab kev txhim kho gallstone, zoo li Pasireotide tau ua. Nws yog ib qho tseem ceeb uas yuav tsum tau saib xyuas cov tsos mob ntawm tus kab mob gallbladder, thiab yog tias muaj teeb meem tshwm sim, cov kev kho mob tsim nyog yuav xav tau.
04
Cov ntaub ntawv:
1. Colao, A., Petersenn, S., Newell-Price, J., Findling, JW, Gu, F., Maldonado, M., ... & Boscaro, M. (2012). Ib 12-hli theem 3 kev tshawb fawb ntawm pasireotide hauv Cushing tus kab mob. New England Journal of Medicine
2. Lacroix, A., Gu, F., Gallardo, W., Pivonello, R., Yu, Y., Witek, P., ... & Boscaro, M. (2018). Kev ua tau zoo thiab kev nyab xeeb ntawm pasireotide ib hlis ib zaug hauv Cushing tus kab mob: kev sim tshuaj 12 lub hlis. Lancet Diabetes & Endocrinology
3. Petersenn, S., Salgado, LR, Schopohl, J., Portocarrero-Ortiz, L., Arnaldi, G., Lacroix, A., ... & Biller, BM (2017). Kev kho mob mus sij hawm ntev ntawm Cushing's kab mob nrog pasireotide: 5- xyoo tau los ntawm kev tshawb nrhiav qhib-daim ntawv txuas ntxiv ntawm Phase III sim. Endocrine
4. Pivonello, R., Arnaldi, G., Scaroni, C., Giordano, C., Cannavò, S., Iacuaniello, D., ... & Colao, A. (2019). Kev kho mob nrog pasireotide hauv Cushing tus kab mob: kev paub Italian multicentre raws li "cov pov thawj tiag tiag hauv ntiaj teb". Endocrine
5. Bruns, C., Lewis, I., Briner, U., Meno-Tetang, G., & Weckbecker, G. (2002). SOM230: ib qho tshiab somatostatin peptidomimetic nrog dav somatotropin tso tawm inhibiting factor (SRIF) receptor binding thiab ib qho tshwj xeeb antisecretory profile. European Journal of Endocrinology
6. Gadelha, MR, Wildemberg, LE, Bronstein, MD, Gatto, F., & Ferone, D. (2017). Somatostatin receptor ligands hauv kev kho mob ntawm acromegaly. Pituitary
7. Schmid, HA, & Schoeffter, P. (2004). Kev ua haujlwm ntawm cov multiligand analog SOM230 ntawm tib neeg recombinant somatostatin receptor subtypes txhawb nqa nws cov txiaj ntsig hauv cov qog nqaij hlav neuroendocrine. Neuroendocrinology
8. Gomes-Porras, M., Cárdenas-Salas, J., & Álvarez-Escolá, C. (2020). Somatostatin analogues hauv kev kho mob: kev tshuaj xyuas. International Journal of Molecular Sciences
9. Cuevas-Ramos, D., & Fleseriu, M. (2014). Somatostatin receptor ligands thiab tiv thaiv kev kho mob hauv pituitary adenomas. Phau ntawv Journal of Molecular Endocrinology
10. Shen, M., Shou, X., Wang, Y., Zhang, Z., Wu, J., Mao, Y., ... & Shen, Y. (2010). Cov nyhuv ntawm presurgical ntev-acting octreotide kev kho mob nyob rau hauv acromegaly cov neeg mob nrog invasive pituitary macroadenomas: ib tug prospective randomized txoj kev tshawb no.