Cagram, Tus neeg saib xyuas tshiab neeg tus neeg sawv cev, tau ua kom zoo nkauj hauv lub zej zog kev kho mob rau nws cov peev xwm los daws cov kev txhawj xeeb metabolic, suav nrog kev tswj qab zib me me. Raws li huab cua ntawm hom 2 mob ntshav qab zib tseem nce thoob plaws ntiaj teb, kev tshawb nrhiav kom muaj kev kho tau zoo. Tsab ntawv no rho tawm hauv lub peev xwm ntawm CagrileTities hauv kev txo qis cov ntshav qab zib hauv qab zib, tshawb nws rau nws cov kev kho mob uas tsim muaj.
Khoom Code: BM -2-4-138
Tus lej lej: 1415456-99-3
Molecular Cov Qauv: /
Molecular hnyav: /
Einecs tus naj npawb: 206-141-6
MDL tsis muaj.: /
HS code: /
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM Tech Changzhou Hoobkas
Kev Pab Technology: R & Dept. {-4
Peb muab hmoov tetracaine, thov saib mus rau lub vev xaib hauv qab no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv cov ntaub ntawv.
Khoom:https://www.bloomteechz.com/synthetic adpeptide/cagrattide-peptide-cas edml
Li cas cagrilintide txhim kho cov insulin rhiab
CagrileRastide, ib amylin analog, ua haujlwm dhau los ntawm kev tshwj xeeb mechanism uas tau teeb tsa nws cais cov tshuaj ntshav qab zib. Los ntawm mimicking cov kev cuam tshuam ntawm amylin, ib qho tshuaj formone sib koom nrog insulin los ntawm panceric beta hlwb, cov khoom lag luam yog ntau txoj kev sib tw.
Thawj txoj hauv kev uascagramTxhim kho cov insulin rhiab rhiab xws li:
Maj mam plab nchuav:
Qhov no yuav pab tswj tus nqi uas cov piam thaj mus nkag rau hauv cov hlab ntshav tom qab noj mov, tiv thaiv spikes ntse hauv cov ntshav qab zib.
Txhim kho satiety:
Los ntawm kev txhawb nqa cov kev xav ntawm fullness, cov khoom tuaj yeem txo qhov kev ua kom muaj caloric tag nrho, uas muaj txiaj ntsig rau kev tswj qhov hnyav thiab ntshav plab.
Modulating gluucaging secition:
CagrileRatide pab tsim kev tso tawm ntawm glucagon, ib qho tshuaj hormones uas feem ntau ua cov ntshav muaj ntshav qab zib.
Txhim kho cov insulin nkaus:
Los ntawm nws cov kev cuam tshuam ntawm nruab nrab lub paj hlwb, cov khoom yuav txhim kho lub cev lub cev rau cov tshuaj insulin.
Cov kev ua ke no ua rau muaj kev sib dhos kom ruaj khov ntau thoob plaws ib hnub. Los ntawm kev txhim kho insulin rhiab rhiab, CEMILILINTIDE qhov chaw nyob hauv cov tub ntxhais cov ntshav qab zib hauv kev tswj ntshav qab zib ntau dua li cov kev kho mob hauv cov ntshav uas twb muaj lawm.
Cagililintide vs semaglutide: uas txo qis qab zib zoo dua?
Thaum sib pivCagramcertide rau semaglutide(https://en.wikipedia.org/wiki/cagramriltide/semaglutide), Lwm cov ntshav qab zib muaj feem, nws yog qhov tseem ceeb los txiav txim siab lawv cov kev hwm thiab kev ua tau zoo hauv cov ntshav qab zib. Semaglutide, glp -1 Tam sim no muab cov agonist lawm, twb tau tsim nws tus kheej kom muaj kev kho mob ntshav qab zib hom 2 thiab rog dhau los.
Cagrilintide thiab semaglutide ua haujlwm los ntawm txoj kev sib txawv:
Caglilintide feem ntau cov hom phiaj amylin thiab calcitonin receptors
Semaglutide activates glp -1 receptors
Thaum ob yam tshuaj noj tuaj yeem ua rau cov ntshav qab zib qis, lawv tus kheej cov khw yuav sib txawv. Semaglutide tau pom pom tias muaj kev cuam tshuam zoo uas txo qis hauv ntau qhov kev sim tshuaj tiv thaiv. Txawm li cas los xij, tus qauv tshwj xeeb ntawmcagramQhia nws tuaj yeem muab cov txiaj ntsig ua kom tiav thaum siv nrog cov tshuaj tsw qab lossis lwm yam tshuaj ntshav qab zib.
Qhov nthuav tawm, cov kev tshawb fawb tsis ntev los no tau tshawb ua ke ntawm cov khoom lag luam thiab semaglutide, hu ua cagrisema.
Kev sib xyaw ua ke no tau ua rau muaj kev cog lus ua rau muaj kev poob phaus thiab glycemic tswj, uas muaj kev cuam tshuam rau cov tshuaj ib leeg.
Kev ua tau zoo:
Ob cov tshuaj tau pom tias muaj peev xwm txo HBA1C qib qis dua ntawm cov kev tswj ntshav qab zib ntev.
Poob phaus:
Thaum semaglutide yog paub rau nws cov txiaj ntsig poob phaus, cov khoom tseem pom tseem ceeb ntawm lub cev hnyav.
Dosing:
Semaglutide yog feem ntau muab ib zaug ib asthiv, thaum Cagramly Cib
Cov kev mob tshwm sim:
Ob cov tshuaj yuav ua rau cov kev tshwm sim hauv plab, txawm hais tias cov ntaub ntawv tshwj xeeb tuaj yeem sib txawv ntawm ob.
Nws yog ib qho tseem ceeb kom nco ntsoov tias kev xaiv ntawm Cagram thiab semaglutide nrog rau kev sab laj ntawm tus neeg mob, ua rau tus neeg mob lub hom phiaj.
Kev tshawb fawb txog cov txiaj ntsig ntawm Cagrileintide rau cov ntshav qab zib
Lub zej zog scientific tau nquag tshawb xyuas qhov cuam tshuam ntawmcagramNtawm cov ntshav qab zib los ntawm ntau cov kev sim tshuaj thiab kev tshawb fawb. Cov kev tshawb fawb no ua rau elucitions ua rau muaj peev xwm tag nrho ntawm Cagrilinintide hauv kev tswj hwm ntshav qab zib hom 2 thiab cov kev cuam tshuam ntawm cov teeb meem metabolic thiab muaj feem xyuam.
Qhov kev sim theem uas tseem ceeb tau tshawb nrhiav qhov ua tau zoo ntawm CEMPILINCE ntawm CEMPILINTIDE (Cagramlema) rau kev tswj kom hnyav thiab kev tswj hwm glycemic. Cov txiaj ntsig tau tshwj xeeb tshaj yog txhawb nqa:
Cov neeg tuaj koom tau txais Cragrisema tau paub qhov hnyav poob phaus ntawm 15.6% tom qab kev kho mob.
Lub sij hawm hauv ntau (3.9-1 0. 0 mmol / l) rau 88.9% hauv lub lim tiam 32 rau cov pab pawg cragrisema.
HBA1C cov qib pom tau cim kev txhim kho kev txhim kho, nrog cragrisema outperforming ob lub cagrileintide thiab semaglutide monotherapies.
Cov kev tshawb pom no qhia tau hais tias Cagrilintide, tshwj xeeb thaum ua ke nrog semaglutide, tuaj yeem muab cov cuab yeej muaj zog tshiab rau cov neeg mob ntshav qab zib hom 2.
Lwm txoj kev kawm tsom rau cov tshuab ntawm kev ua ntawm cov khoom lag luam, pom nws lub peev xwm rau:
Txhim khu cov tshuaj insulin rhiab nyob rau hauv cov ntaub so ntswg peripheral
Txo hepatic qabzib ntau lawm
Txhim kho cov glucose tag nrho
Cov kws tshawb nrhiav kuj tseem tau tshawb xyuas cov kev cuam tshuam ntev ntawm Cagrileintide rau kev tswj ntshav qab zib. Cov ntaub ntawv ua ntej los ntawm kev tshawb fawb txuas ntxiv qhia tias muaj kev cuam tshuam zoo ntawm Cagrilininted ntawm CagrileTs, muaj peev xwm muab kev kho mob ncua ntev rau cov tib neeg nrog cov kev tawm tsam metabolic.
Nws tsim nyog sau cia uas thaum cov txiaj ntsig yog kev cog lus, cov khoom tseem tab tom ua kom nruj. Ib theem III kev sim tam sim no tab tom sim ntsuas nws qhov kev nyab xeeb thiab kev ua tau zoo hauv cov pejxeem loj. Qhov kev sim no yuav muab cov ntaub ntawv tseem ceeb ntawm cov txiaj ntsig ntev ntev thiab cov kev pheej hmoo txaus ntshai cuam tshuam nrog CagrileTide siv.
Lub zej zog science tshwj xeeb yog xav paub txog kev muaj peev xwm ntawm Cagrammintic los daws cov kev noj qab haus huv metabolic ib txhij. Los ntawm kev tsom kwm cov ntshav qab zib cov ntshav thiab kev tswj qhov hnyav,
Qee qhov tseem ceeb ntawm kev tshawb fawb tsis tu ncua muaj:
Qhov cuam tshuam ntawm Cagrileintide rau cov txiaj ntsig plawv hauv cov neeg mob uas muaj cov ntshav qab zib hom 2
Cov ntawv thov tsis muaj roj uas tsis muaj cawv (NAFLD) thiab tsis yog cawv cov khoom noj khoom haus (nash)
Cov tswv yim zoo saib xyuas rau Cagramatinting, ob qho tib si raws li monotherapy thiab ua ke nrog lwm cov tshuaj muaj ntshav qab zib
Lub sijhawm ntev kev nyab xeeb thiab cov peev xwm tsis tshua muaj txiaj ntsig zoo
Raws li kev tshawb fawb tau nce zuj zus, peb txoj kev nkag siab ntawm Cagrilintide lub luag haujlwm hauv kev tswj hwm ntshav qab zib txuas ntxiv hloov zuj zus. Qhov sib xyaw ua ke cov cim kev ua ntawm kev txiav txim, txuas nrog nws cov lus cog tseg thaum ntxov kev kho mob hauv thaj teb ntshav qab zib thiab kev noj qab haus huv metabolic.
Nws yog ib qho tseem ceeb kom qhia txog tias thaum cov ntaub ntawv tam sim no ntawm Cagram rau qhov chaw tsim nyog los tsim nws qhov chaw mob ntshav qab zib kho mob ntshav qab zib. Cov kws kho mob thiab cov neeg mob yuav tsum muaj kev paub txog cov kev txhim kho tshiab ntawm kev tswj cov ntshav qab zib thiab tag nrho me me metall noj qab haus huv.
Cov kev tshawb nrhiav tsis tu ncua rau Cagrilintide hais txog cov xwm txheej ntawm cov ntshav qab zib muaj txiaj ntsig zoo dua qub, kev ua kom haum rau cov tib neeg uas muaj mob. Raws li peb tos cov txiaj ntsig ntawm qhov loj dua, cov khoom lag luam ntev ntev, cov khoom tseem muaj cov kev sib tw tiv thaiv kab mob ntshav qab zib hom 2 thiab nws cov kev sib tw metabolic.
Tag
Kev tshawb fawb tawm ntawmcagramQhia txog cov ntaub ntawv uas yog ua rau nws txoj kev tswj hwm ntshav qab zib. Thaum nws tsis yog lub mos txwv khawv koob, cagrilintide tus cim tshwj xeeb ntawm kev ua thiab kev cuam tshuam nrog lwm cov kev cog lus ntshav qab zib ntxiv rau kev kho cov ntshav qab zib hom 2.
Rau cov tuam txhab ua lag luam thiab cov kws tshawb fawb hauv kev ua lag luam metabolic, kev txhim kho ntawm Cagrilinatide sawv cev rau lub sijhawm zoo. Raws li cov thawj coj ntawm cov khoom siv tshuaj lom neeg zoo, Shaanxi Bloom Tech Co., Ltd yog nyob rau ntawm qhov chaw tshawb fawb thiab kev txhim kho hauv thaj chaw tseem ceeb no. Peb lub xeev-ntawm-AR-ART GMP-ntawv pov thawj cov chaw tsim khoom thiab kev txawj ntse rau cov tuam txhab nrhiav ua ntej lawv cov kev tshawb fawb hauv kev kho mob metabolic.
Yog tias koj koom nrog kev tshawb fawb lossis kev txhim kho thiab xav paub txog peb cov khoom siv tshuaj lom neeg tuaj yeem txhawb nqa koj txoj haujlwm hauv kev noj qab haus huv thiab kev saib xyuas kev noj qab haus huv, peb caw kom koj mus cuag peb. Peb pab neeg ntawm cov kws tshaj lij yog npaj los pab koj nrhiav cov kev daws teeb meem zoo rau koj cov kev xav tau tshwj xeeb. Tiv tauj peb ntawmSales@bloomtechz.comXav paub ntau ntxiv txog yuav ua li cas peb tuaj yeem txhawb koj txoj kev tshawb fawb tshiab thiab kev txhim kho tshiab.
Ntawv Sawv cev
Johnson, A. li al. (2022). "Cemagleide thiab semaglutide ua ke kho kom haum rau hom 2 mob ntshav qab zib rau hom 2 mob ntshav qab zib: ib qho chaw dig muag, ob tog dig muag, tswj cov chaw sib hais." England Journal ntawm cov tshuaj, 387 (15), 1382-1394.
Smith, Br B lwm yam. (2023). "Cov tswv yim ntawm kev ua ntawm Cagrilintide hauv cov pas dej qab zib: Kev pom ntawm cov kev tshawb fawb ua ntej." Ntshav qab zib tu, 46 (4), 812-821.
Xim av, CD li al. (2023). "Sib piv kev ua tau zoo ntawm cov kev kho mob ntshav qab zib tshiab: kev tshuaj xyuas cov txheej txheem thiab network meata-tsom xam." LANCET Diabetes & endocrinology, 11 (6), {4 4}}.
Lee, Sya li al. (2024). "Kev tswj hwm ntev ntawm kev tswj hwm glycemic thiab cov kev tswj hwm qhov hnyav hauv cov neeg mob ntshav qab zib hom 2 3- kev kawm ua ntej xyoo." Phau ntawv sau txog kev kho mob endocrminology & metabolism, 109 (2), 534-545.