Tsis zoo siv
Tsis yog lawm, lub suab hluavtaws opioid derivative, tau tawm los ua ib tug muaj zog thiab xaiv cov tshuaj tiv thaiv kab mob antidiariarheal hauv kev xyaum kuaj mob. Cov lus tshawb fawb no rho tawm rau hauv cov chaw muag tshuaj, kev ua kom muaj kev nyab xeeb ntawm LOperamide, nrog ib qho kev saib xyuas tshwj xeeb ntawm nws cov kev xaiv raws plab ntau yam hauv kev mob plab. Los ntawm kev txheeb xyuas cov ntaub ntawv uas twb muaj lawm thiab kev sim siab tsis ntev los no los muab kev nkag siab ntawm Loceramide lub luag haujlwm hauv cov tshuaj niaj hnub.
Khoom Code: BM -2-5-107
Lus Askiv Lub Npe: LOperamide
CAS TSIS MUAJ.: 53179-11-6
Molecular Cov Qauv: C29H33Cln2O2
Molecular hnyav: 477.04
Eineecs tsis muaj.: 258-416-5
MDL No.:MFCD00600388
HS code: 28273985
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM Tech Changzhou Hoobkas
Kev Pab Technology: R & Dept. {-4
Peb muab LOperamide Hmoov Cas 53179-11-6}}, Thov saib mus rau lub vev xaib hauv qab no rau cov ncauj lus kom ntxaws cov ncauj lus qhia ntxaws ntxaws thiab cov ntaub ntawv.
Lo lus tseem ceeb: LOperamide, antidiarrheal, cov ntawv thov tshuaj xyuas, tshuaj xyuas, kev nyab xeeb, kev nyab xeeb, kev nyab xeeb, kev nyab xeeb, kev nyab xeeb, kev nyab xeeb
Lub hauv paus rau phau ntawv
Zawv plab, tus cwj pwm los ntawm cov kev tso cai ntawm xoob lossis kua quav, yog qhov cuam tshuam bastraitinal uas muaj peev xwm cuam tshuam zoo heev ntawm lub neej. Nws tuaj yeem tshwm sim los ntawm myriad ntawm cov yam, suav nrog cov kis mob, mob tshwm sim, thiab siv tshuaj. Kev kho mob ib txwm ua feem ntau koom nrog kev hloov kua thiab siv cov tshuaj tiv thaiv kab mob rau kev txo cov tsos mob. LOperamide, ib cov tshuaj sib koom ua ke thiab cov tshuaj noj, sawv ntawm txoj kev xaiv ntawm lub plab zom mov, muab cov kev tswj hwm raws plab zom mov nrog kev phiv tshuaj tsawg kawg nkaus.
|
|
|
Pharmacological cov khoom lag luam ntawm leperamide
LOperamide belongs rau chav kawm ntawm opioid agonists, tshwj xeeb tsim los tsom lub hom phiaj ntawm lub plab zom mov. Tsis zoo li lwm cov opioids, xws li morphine, uas pom tias muaj kev ua pov thawj hauv lub hlwb, yog li txo qhov kev pheej hmoo ntawm kev pheej hmoo ntawm kev cuam tshuam ntawm cov teeb meem nruab nrab. Qhov kev xaiv no yog ntaus nqi rau LOperamide profile, nrog feem ntau ntawm cov tshuaj tau nqus thiab metabolized nyob rau hauv lub plab, txwv nws txoj kev ncig.
Mechanisms ntawm kev ua
LOperamide txoj kev kho mob feem ntau nrog kev sib cuam tshuam los ntawm nws kev sib cuam tshuam nrog μ-opioid receptors nyob rau ntawm cov tub rog nkag mus thiab cov leeg leeg ntawm lub plab zom mov. Qhov kev sib cuam tshuam no ua rau muaj kev cuam tshuam rau kev txwv tsis pub muaj lub plab hnyuv thiab tso pa tawm, yog li lub sij hawm luv luv ntawm cov quav thiab txhim kho cov dej thiab ua kom haum elecancyte. Tshwj xeeb, Lageramide:
Inhibits lub zog
Los ntawm suppressing cov kev cog lus uas tsis tshua muaj zog ntawm cov hnyuv hnyuv, tsis muaj zog qeeb qeeb rau cov quav, tso cai ntau rau cov quav thiab cov electrolytes kom nqus tau.
Kev Ncua Khaub Ncaws
LOperamide tseem ua ntawm txoj hnyuv mucosa kom txo cov paab ntawm chloride thiab bicarbonate ions, ntxiv pab txhawb rau qhov txo qis hauv cov quav.
Txhim Kho
Los ntawm kev nce siab ntawm cov leeg plab hnyuv thiab txhawb cov dej nqus dej thiab cov electrolytes, LOperamide pab kom ruaj khov rau cov quav.
Kho mob hauv ntau yam mob zawv plab
Mob raws plab, feem ntau tshwm sim los ntawm kev kis mob kis lossis kab mob, yog qhov taw qhia rau LOperamide siv. Kev Ntsuam Xyuas Cov Txheej Txheem thiab Kev Ntsuas Cov Meta-AnaTalmes tau ua kom pom LOperamide qhov kev ua tau zoo hauv kev txo qis lub sijhawm thiab cov menyuam muaj mob raws plab nyob rau cov neeg laus thiab menyuam yaus. Hauv cov menyuam yaus, LOperamide tau pom tias muaj kev nyab xeeb thiab kev ua tau zoo, nrog kev txo qis hauv cov quav thiab kev txhim kho xwm yeem. Txawm li cas los xij, kev siv hauv cov menyuam yaus thiab menyuam mos tsis muaj kev sib cav vim muaj kev txhawj xeeb txog qhov muaj peev xwm ua kom muaj kuab lom thiab kev ua kom tsis muaj ntshav ntawm lawv cov ntshav.
LOperamide tseem pom cov ntawv thov hauv kev tswj hwm ntawm Dausrrea, tshwj xeeb tshaj yog nyob rau hauv cov mob plob tsis taus (IBS) nrog raws plab yog cov tsos mob tshwm sim. Kev tshawb nrhiav kev soj ntsuam tshawb xyuas qhov ua tau zoo ntawm LOperamide hydrochloride mranules hauv cov neeg mob plab zom mov, thiab tag nrho cov tsos mob tshaj plaws tom qab kev kho mob. Kev kho kev sib xyaw tau zoo-zam txim, tsis muaj qhov tshwm sim pom tseeb pom.
Neeg ncig ua si raws plab, tshwm sim los ntawm kev kis cov zaub mov tsis huv lossis dej, yog ib qho kev pab cuam uas cuam tshuam rau cov neeg taug kev qaib cov xeeb tub rog. LOperamide tau pom tias muaj txiaj ntsig zoo rau kev txo lub sijhawm thiab qhov hnyav ntawm cov neeg ncig kev raws plab, tshwj xeeb thaum siv nrog cov tshuaj tua kab mob. Los ntawm kev tswj cov tsos mob mob plab zom mov, LOperamide tuaj yeem pab tiv thaiv lub cev qhuav dej thiab pab txhawb txoj kev taug kev kom xis dua.
Qee yam tshuaj noj, xws li tshuaj tua kab mob thiab cov tshuaj tua kho mob, tuaj yeem ua raws plab yog cov khoom noj. LOperamide tau siv ua tiav kev tswj hwm cov tshuaj uas yog zawv plab, muab cov tsos mob kom pom kev yooj yim thiab cov neeg mob txuas ntxiv yam tsis muaj kev cuam tshuam tseem ceeb.
|
|
|
Kev Nyab Xeeb thiab Kev Mob tshwm sim
LOperamide cov ntaub ntawv kev nyab xeeb feem ntau nyiam, nrog cov tsis zoo tshaj plaws ua rau mob me thiab hloov chaw. Cov kev phiv tshwm sim muaj xws li quav tawv, tsam plab, xeev siab, thiab lub plab tsis xis nyob. Txawm li cas los xij, nws yog qhov tseem ceeb los nco ntsoov tias LOperamide yuav tsum tsis txhob siv rau cov neeg mob lossis kab mob rau kev sib kis los ntawm kev rho tawm ntawm kev rho tawm ntawm pathogens.
Tsawg tsawg zaus, kev tsim txom lossis kev ua phem rau LOperamide tuaj yeem ua rau muaj kev nyuaj siab loj, suav nrog kev ua pa kom ua pa, ua kom muaj kev poob siab, thiab kev tuag. Yog li ntawd, nws yog ib qho tseem ceeb kom ua raws li cov lus qhia muab tshuaj thiab zam kev pom zoo rau tus kheej, tshwj xeeb yog cov menyuam yaus thiab cov neeg muaj keeb kwm kev tsim txom.
Cov kev txiav txim siab tshwj xeeb
Kev Siv Pediaric
Thaum LOperamide yog feem ntau suav hais tias muaj kev nyab xeeb thiab ua tau zoo rau cov neeg laus, nws siv nyob rau hauv cov neeg mob pediatric kom muaj kev ceeb toom. Vim yog kev tsis paub txog cov ntshav-lub hlwb lub hlwb hauv cov menyuam mos thiab menyuam yaus, muaj kev phom sij txaus ntshai ntawm nruab nrab lub paj hlwb. Yog li ntawd, LOperamide yuav tsum tau siv nrog kev ceev faj thiab tsuas yog nyob rau hauv kev saib xyuas kev kho mob hauv cov neeg mob no.
Lub raum thiab athairment tsis zoo
Cov neeg mob uas muaj lub raum lossis mob siab tsis tas li yuav tsum tau kho kom haum vim yog hloov cov tshuaj metabolism thiab kev ua kom zoo nkauj. LOperamide yog feem ntau metabolized nyob rau hauv daim siab thiab tawm ntawm ob lub raum. Hauv cov neeg mob uas tsis muaj zog lossis cov tshuaj hepatic ua haujlwm, cov tshuaj yuav nthuav tawm hauv lub cev, ua rau muaj kev pheej hmoo ntawm kev tsis zoo. Yog li ntawd, kev saib xyuas ze zog thiab txhaj tshuaj yuav tsum tau tsim nyog hauv cov neeg mob no.
Kev sib cuam tshuam yeeb tshuaj
LOperamide yuav cuam tshuam nrog lwm cov tshuaj, tshwj xeeb yog cov uas cuam tshuam rau lub siab nruab nrab lossis lub plab zom mov. Kev siv tshuaj sedamide nrog sedatives, tranquilizers, lossis dej caw yuav txhim kho cov teebmeem kev tshuaj tiv thaiv cov tshuaj no. Ib yam li ntawd, cov tshuaj uas nce hauv plab kom muaj zog, xws li cov tshuaj xws li tshuaj laxatives, yuav cuam tshuam qhov kev kho mob ntawm LOperamide. Yog li ntawd, nws yog ib qho tseem ceeb kom qhia cov kws kho mob txog txhua yam tshuaj noj, suav nrog tshuaj, thiab tshuaj ntsuab.
Tag
LOperamide tau tshwm sim los ua cov cuab yeej tseem ceeb hauv kev tswj hwm ntawm ntau yam mob raws plab, muab cov tsos mob zoo tswj tau nrog kev nyab xeeb profile. Nws xaiv qhov kev xaiv ntawm lub plab zom mov, txuas nrog kev phiv tshuaj tsawg kawg nkaus, ua rau nws muaj kev saib xyuas zoo rau ob qho tib si raws plab. Txawm li cas los xij, nws yog ib qho tseem ceeb kom paub txog qhov kev pheej hmoo txaus ntshai cuam tshuam nrog nws siv, tshwj xeeb yog cov neeg mob pediatric thiab cov neeg muaj mob raum lossis mob siab. Los ntawm adhering rau cov lus qhia kev pom zoo thiab saib xyuas cov teebmeem kev sib raug zoo, tus kws kho mob yuav kho tau cov txiaj ntsig ntawm kev noj qab haus huv thaum tsis muaj peev xwm tsawg.
Kev tshawb nrhiav yav tom ntej yuav tsum tsom rau kev tshawb nrhiav kev qhia tshiab rau tus neeg mob sib txawv, thiab tshawb xyuas cov tshuaj sib txawv kom ua rau ntxiv nws cov kev kho mob siv. Ib qho ntxiv, kev tshawb fawb txog kev nyab xeeb ntev thiab ua tau zoo ntawm LOperamide hauv ntau yam mob raws plab yuav muab txoj hauv kev muaj txiaj ntsig zoo rau hauv nws lub luag haujlwm hauv cov tshuaj niaj hnub.