Fluralaner chewable ntsiav tshuaj tau hloov qhov kev ua si rau ob tus tswv miv thiab cov kws kho tsiaj hauv thaj chaw kho tsiaj. Cov ntsiav tshuaj tshiab no tiv thaiv cov tsiaj los ntawm hma thiab zuam mus ntev, uas yog vim li cas tib neeg nyiam siv lawv. Cov neeg tsim khoom thiab cov muag khoom, ntawm qhov tod tes, yuav muaj lub sijhawm nyuaj nrhiav cov tshuaj fluralaner uas ruaj khov thiab zoo. Qhov no tag nrho - phau ntawv qhia suav nrog yuav pab koj taug qab cov txheej txheem nyuaj ntawm kev nrhiav kev ntseeg siabfluralaner ntsiav tshuajcov neeg muab kev pabcuam, ua kom cov ntsiav tshuaj muaj kev nyab xeeb thiab siv tau zoo, thiab tsim kom muaj kev sib txuas lus muaj zog.
1. General Specification (hauv Tshuag)
(1) Kev daws teeb meem
(2) Tablet
(3) Txhaj tshuaj
(4) Txau
(5) Poob
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-2-079
Fluralaner CAS 864731-61-3
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Peb muab cov ntsiav tshuaj fluralaner, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Khoom siv:https://www.bloomtechz.com/oem-odm/tablet/fluralaner-tablet.html
Teeb meem nrog nrhiav kev ntseeg siab fluralaner
Muaj ntau qhov teeb meem nyuaj uas yuav tsum tau ua tib zoo saib xyuas los ntawm cov neeg tsim cov tshuaj fluralaner thaum lawv sim nrhiav qhov chaw ntseeg siab ntawm cov tshuaj. Vim tias cov tshuaj muaj qhov nyuaj heev thiab cov kev cai nruj heev, nws tseem ceeb heev kom nrhiav tau qhov chaw koj tuaj yeem ntseeg tau.
Fluralaner yog ib qho nyuaj isoxazoline nrog ntau lub chaw chiral. Ua kom nws xav tau cov cuab yeej tshwj xeeb thiab cov txheej txheem organic chemistry. Nws tsis tuaj yeem ua rau txhua tus neeg muab kev pabcuam ua kom muaj siab ntau -purity fluralaner txhua lub sijhawm. Cov neeg tsim khoom yuav tsum nrhiav cov neeg muab kev pabcuam uas ua tau zoo ntawm kev ua ntau yam ntawm cov tshuaj synthesis thiab chiral chemistry.
Fluralaner yuav tsum tau ua raws li Kev Tswj Xyuas Zoo (GMP) cov qauv vim tias nws yog cov khoom siv tshuaj nquag (API) uas yog siv hauv cov tshuaj kho tsiaj. Cov neeg muag khoom yuav tsum muaj cov ntawv tso cai raug cai thiab ib txoj hauv kev kom paub tseeb tias lawv ib txwm muab cov khoom zoo. Thaum koj yuav khoom los ntawm thoob plaws lub ntiaj teb no, koj yuav tsum ua raws li cov kev cai sib txawv nyob rau hauv ntau qhov chaw, uas ua rau tej yam nyuaj heev.
Nws yog ib qho tseem ceeb heev kom paub tseeb tias tag nrho cov khoom siv raw thiab cov khoom nruab nrab siv los ua fluralaner tuaj yeem taug qab tag nrho. Cov neeg muag khoom uas tuaj yeem muab cov ntaub ntawv ntxaws ntxaws txog yuav ua li cas cov ntaub ntawv tau txais thiab yuav ua li cas cov khoom raug tsim los ntawm cov neeg siv khoom siab. Nws tuaj yeem nyuaj rau kev txheeb xyuas qhov twg cov tshuaj lom neeg los ntawm thiab lawv zoo npaum li cas thaum koj tsis tuaj yeem pom cov ntaub ntawv ntau txog cov saw hlau.
Fluralaner yog ib qho tshuaj tshiab, yog li kev tsim vaj tsev patent yuav tsum tau ua tib zoo sib tham. Cov neeg muag khoom yuav tsum tau qhia tias lawv cov qauv tsim thiab cov txheej txheem tsis siv lwm tus cov cuab yeej kev txawj ntse. Qhov no tuaj yeem ua rau nws nyuaj nrhiav qhov chaw, tshwj xeeb tshaj yog rau cov neeg tsim khoom ntawm cov khoom lag luam.
Nws tseem ceeb heev uasfluralaner ntsiav tshuajyog sib xws los ntawm batch mus rau batch. Qhov tseeb thiab lub cev zoo ntawm API tuaj yeem cuam tshuam qhov zoo thiab kev nyab xeeb ntawm cov khoom kawg, txawm tias lawv tsis zoo tag nrho. Nws yog ib qho tseem ceeb kom nrhiav tau qhov chaw uas muaj peev xwm tswj tau nruj tswj hwm ntau ntau lawm.
Tshawb xyuas cov ntaub ntawv kev nyab xeeb thiab kev ua tau zoo
Ib kauj ruam tseem ceeb heev thaum tau txais fluralaner rau kev ua cov ntsiav tshuaj yog kuaj xyuas tias cov ntaub ntawv kev nyab xeeb thiab kev ua tau zoo los ntawm cov peev txheej yog qhov tseeb. Txoj kev no ua kom paub tseeb tias cov khoom xyaw nquag ua tau raws li tag nrho cov qauv tsim nyog thiab cov cai.
Daim ntawv pov thawj Analysis (CoA) Review
Nws yog ib qho tseem ceeb heev kom ua tib zoo xyuas Daim Ntawv Pov Thawj Kev Ntsuas rau txhua qhov ntau ntawm fluralaner. CoA yuav tsum muaj cov hauv qab no:
Assay cov ntaub ntawv qhia tias cov fluralaner yog ntshiab thiab muaj zog
Residual kuab tshuaj npaum li cas
Analysis ntawm impurity profile
Lub cev muaj zog, zoo li qhov loj ntawm cov khoom thiab seb lawv kis tau li cas
Cov txiaj ntsig ntawm kev kuaj microbiological
Txhawm rau kom ntseeg tau tias cov txiaj ntsig zoo sib xws thiab raug, cov tuam txhab tsim khoom yuav tsum kuaj xyuas lawv tus kheej hauv -cov kev sim hauv tsev.
Kev ntsuam xyuas cov ntaub ntawv rau kev ruaj ntseg
Qhov kawg fluralaner chewable pills ' txee - lub neej tsuas yog txiav txim tau nrog ntev - lub sij hawm ruaj khov txheeb cais. Cov neeg muag khoom yuav tsum ua ntau qhov kev ntsuam xyuas ruaj khov sib txawv hauv ntau hom kev sib txawv. Cov ntaub ntawv no pab cov neeg tsim khoom paub txog:
Lub stability ntawm fluralaner raws li ib tug tshuaj nyob rau lub sij hawm
Txhua yam khoom tawg uas tuaj yeem tsim
Yuav ua li cas huab cua thiab av noo cuam tshuam qhov zoo ntawm API
Cov ntaub ntawv rau kev tsim khoom
Khaws cov ntaub ntawv ceev faj txog yuav ua li cas fluralaner tau tsim pab kom ntseeg tau tias nws ib txwm ua tib yam thiab ua raws li GMP cov qauv. Cov ntaub ntawv tseem ceeb uas yuav tsum tau saib yog cov hauv qab no:
Master batch cov ntaub ntawv
Khiav cov ntawv ceeb toom los xyuas cov txheej txheem raug.
Cov ntaub ntawv rau cov khoom tsim nyog
Thaum lub sij hawm - txheej txheem tswj cov kauj ruam
Daim Ntawv Tso Cai Ua Raws Cai
Cov neeg muag khoom yuav tsum muaj pov thawj ntawm kev ua raws li txoj cai lij choj, uas suav nrog:
GMP kev pom zoo los ntawm pawg neeg txoj cai
FDA soj ntsuam cov ntaub ntawv (yog tias xav tau)
Cov ntaub ntawv kev nyab xeeb rau European Tshuaj Lub Chaw Haujlwm (EMA)
ISO daim ntawv pov thawj rau cov txheej txheem uas tswj tau zoo
Cov ntaub ntawv no pab xyuas kom tus neeg muag khoom ua tau raws li qhov yuav tsum tau muaj thiab cov qauv kev nyab xeeb rau kev ua tshuaj - qib fluralaner.
Kev kuaj xyuas zoo: Los ntawm cov qauv mus rau kev kuaj batch
Ua raws li kev kuaj xyuas kom zoo yog qhov tseem ceeb thaum muab khoomfluralaner ntsiav tshuaj. Ib qho kev pabcuam kev lees paub zoo yuav tsum suav nrog txhua yam los ntawm kev tshuaj xyuas thawj zaug mus rau kev xeem batch txuas ntxiv.
Ua ntej cog lus rau loj - kev yuav khoom loj, cov tuam txhab lag luam yuav tsum ua tib zoo ntsuam xyuas cov qauv fluralaner los ntawm cov neeg xa khoom muaj peev xwm. Qhov kev ntsuam xyuas thawj zaug no feem ntau suav nrog:
Kev txheeb xyuas tus kheej siv cov txheej txheem xws li NMR spectroscopy thiab huab hwm coj spectrometry
Kev soj ntsuam kev huv huv siv HPLC lossis GC txoj kev
Cov yam ntxwv ntawm lub cev, nrog rau cov ntsiab lus melting thiab kev ntsuas solubility
Kev tshawb fawb txog kev ruaj ntseg ua ntej nyob rau hauv cov xwm txheej ceev
Cov kev ntsuam xyuas no pab xyuas kom meej tias tus neeg muag khoom tuaj yeem tsim cov rooj sib tham fluralaner uas xav tau tshwj xeeb.
Hauv -Txoj Kev Tswj Xyuas Zoo
Thaum pib tsim khoom, kev ua kom muaj zog hauv - txheej txheem tswj kev ntsuas yog qhov tseem ceeb. Cov chaw kuaj xyuas tseem ceeb thaum lub sij hawm fluralaner synthesis thiab purification yuav suav nrog:
Saib xyuas cov tshuaj tiv thaiv kev nce qib uas siv cov txheej txheem tshuaj ntsuam xyuas xws li HPLC lossis TLC
Tshawb xyuas qhov nruab nrab purity ntawm cov kauj ruam tseem ceeb
Txheeb xyuas chiral purity siv chiral HPLC lossis polarimetry
Tswj cov txheej txheem tsis xws li kub, siab, thiab pH
Cov kev tswj xyuas no pab ntes cov kev sib txawv thaum ntxov ntawm cov txheej txheem tsim khoom, txo qhov kev pheej hmoo ntawm kev tawm - cov khoom tshwj xeeb.
Kev sim ua tiav ntawm qhov kawg fluralaner API yog qhov tseem ceeb ua ntej nws siv hauv cov ntsiav tshuaj. Qhov no feem ntau suav nrog:
Assay rau kev txiav txim siab potency
Impurity profileing siv cov txheej txheem analytical validated
Residual solvent tsom xam
Particle loj faib kev tsom xam
Polymorphic form characterization siv X-ray diffraction
Kev ntsuas microbial txwv
Cov txiaj ntsig yuav tsum tau muab piv rau ua ntej -tsim kev lees paub los ua kom zoo ib yam.
Tsim kom muaj kev ruaj ntseg Fluralaner Supply Chain
Tsim kom muaj kev ruaj ntseg thiab txhim khu kev qha khoom siv rau fluralaner yog qhov tseem ceeb rau kev tswj kom zoo ib yam thiab ua tau raws li cov kev cai tswj hwm. Cov neeg tsim khoom yuav tsum siv cov tswv yim los txo cov kev pheej hmoo thiab ua kom muaj kev ruaj khov ntawm cov khoom xyaw tseem ceeb no.
Tus neeg muab khoom Diversification
Kev cia siab rau ib tus neeg muag khoom rau fluralaner tuaj yeem nthuav tawm cov tuam txhab rau cov khoom lag luam loj txaus ntshai. Ua raws li ntau- cov tswv yim tsim khoom muaj ntau yam zoo:
Txo qhov tsis zoo los muab kev cuam tshuam
Txhawb kev sib tham muaj zog thiab muaj peev xwm txuag tau nyiaj
Nkag mus rau ntau yam kev txawj ntse thiab kev tsim kho tshiab
Muaj peev xwm los sib piv qhov zoo thiab kev ua haujlwm ntawm cov neeg muag khoom
Cov neeg tsim khoom yuav tsum tsom kom tsim nyog tsawg kawg yog ob lossis peb tus neeg muab khoom lag luam txhim khu kev qha fluralaner kom ntseeg tau tias cov saw hlau muaj zog.
Ntev -Term Supplier Partnerships
Txawm hais tias muaj kev sib txawv yog qhov tseem ceeb, kev tsim kom muaj zog, ntev - kev sib raug zoo nrog cov neeg muag khoom tseem ceeb tuaj yeem txhim kho cov saw hlau ruaj ntseg. Cov txiaj ntsig ntawm kev sib koom tes xws li:
Txhim kho kev sib txuas lus thiab kev sib koom tes ntawm kev txhim kho kom zoo
Kev txaus siab ntau dua los nqis peev rau cov peev txheej tshwj xeeb lossis cov cuab yeej tshwj xeeb
Muaj peev xwm rau kev sib koom ua ke ntawm cov txheej txheem tshiab lossis cov txheej txheem
Txhim kho pob tshab thiab kev ntseeg siab thoob plaws hauv cov khoom siv
Cov neeg tsim khoom yuav tsum nrhiav cov neeg muag khoom txaus siab los tsim kev sib koom tes nrog kev sib koom tes es tsis yog kev sib pauv kev sib raug zoo.
Daim ntawv cog lus muab kev coj ua zoo tshaj plaws
Zoo -Cov ntawv cog lus muab khoom siv yog qhov tseem ceeb rau kev tswj hwm kev pheej hmoo thiab kev cia siab hauvfluralaner ntsiav tshuajsaw hlau. Cov ntsiab lus tseem ceeb suav nrog:
Kom meej meej meej specifications zoo thiab kev xeem yuav tsum tau
Cov kev cai rau kev tuav cov khoom cuam tshuam lossis teeb meem zoo
Pom zoo -raws li lub sij hawm ua tus thawj coj thiab qhov tsawg kawg nkaus txiav txim kom muaj nuj nqis
Cov lus tsis pub lwm tus paub los tiv thaiv cov ntaub ntawv ntiag tug
Mechanisms rau kev kho tus nqi thiab kev daws teeb meem
Kev tshuaj xyuas tsis tu ncua thiab hloov kho cov ntawv cog lus muab khoom pab kom ntseeg tau tias lawv tseem cuam tshuam thiab siv tau.
Xaus
Nrhiav kom muaj kev nyab xeeb thiab zoo fluralaner rau kev ua cov ntsiav tshuaj yog ib txoj haujlwm nyuaj uas yuav tsum tau ua tib zoo xav txog ntau yam sib txawv. Cov neeg tsim khoom yuav tsum tau daws nrog ntau yam teeb meem kom paub tseeb tias lawv ib txwm tau txais siab -fluralaner zoo. Lawv yuav tsum xyuas kom meej tias cov ntaub ntawv kev nyab xeeb yog qhov tseeb, ua cov kev kuaj xyuas nruj, thiab tsim kom muaj kev ruaj ntseg cov khoom siv.
Cov neeg tsim khoom tuaj yeem ua cov tshuaj fluralaner chewable uas muaj kev nyab xeeb thiab siv tau rau cov tswv tsiaj thiab cov kws kho tsiaj los ntawm kev ua haujlwm nrog zoo -cov neeg muag khoom paub, muaj kev tswj xyuas zoo, thiab ua kom lawv cov saw hlau sib txawv thiab meej.
Raws li cov khoom siv tshuaj tiv thaiv kab mob tshiab no tau nrov dua, nws yuav yog qhov tseem ceeb kom ua kom cov khoom siv fluralaner muaj kev nyab xeeb thiab muaj kev vam meej. Qhov no yuav pab ua kom tau raws li kev xav tau ntawm kev lag luam thaum ua kom ntseeg tau qhov zoo tshaj plaws thiab kev nyab xeeb hauv cov tshuaj kho tsiaj.
Cov lus nug nquag
Q: Thaum nrhiav fluralaner los ua cov ntsiav tshuaj, dab tsi yog qhov tseem ceeb tshaj plaws uas yuav tsum nco ntsoov?
A: Cov yam ntxwv tseem ceeb yog qhov sib txawv ntawm daim ntawv, impurity profile, particle loj faib, tus nqi ntawm cov kuab tshuaj tshuav, thiab purity (feem ntau tshaj 99%). Cov neeg tsim khoom yuav tsum tau ua kom paub tseeb tias tus neeg muag khoom ua raws li GMP thiab muaj cov ntaub ntawv ruaj khov.
Q: Ntev npaum li cas yuav tsum tau kuaj xyuas qhov chaw ntawm fluralaner?
A: Nws yog ib lub tswv yim zoo los tshawb xyuas cov ntaub ntawv fluralaner hauv tus neeg tsawg kawg ib xyoos ib zaug, thiab ntau zaus rau cov neeg muag khoom tshiab lossis cov neeg uas muaj teeb meem zoo yav dhau los. Tsawg kawg ib zaug txhua peb lub hlis, kev ntsuas zoo yuav tsum tau kuaj xyuas thiab kuaj xyuas desktop yuav tsum tau ua.
Rau siab -Cov ntsiav tshuaj Fluralaner zoo, Xaiv BLOOM TECH
Tsis muaj lus nug tias BLOOM TECH yog lub tuam txhab zoo kom tau txaisfluralaner chewable ntsiav tshuajlos ntawm. Peb muaj GMP- ua raws li cov chaw tsim khoom thiab kev tswj xyuas nruj kom paub tseeb tias txhua pawg ntawm cov ntsiav tshuaj fluralaner rau muag yog dawb huv thiab ua tau zoo. BLOOM TECH cov lus cog tseg kom cov neeg siv khoom zoo siab dhau mus dhau los ua cov khoom zoo. Rau koj cov kev xav tau tshwj xeeb, peb muab kev pabcuam tshaj lij nrog kev xaiv cov khoom, tus nqi hloov pauv, thiab kev xa khoom loj uas ceev.
EmailSales@bloomtechz.comniaj hnub no kom tau txais ib qho - ntawm -ib - ua ke ntawm qhov zoo thiab tus nqi uas BLOOM TECH muaj.
Cov ntaub ntawv
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Kilp, S., Ramirez, D., & Allan, MJ (2016). Pharmacokinetics ntawm fluralaner hauv cov dev tom qab ib zaug - koob tshuaj qhov ncauj.Phau ntawv Journal of Veterinary Pharmacology thiab Therapeutics, 39(6), 565-572.
European Medicines Agency. (2014). Daim ntawv qhia kev soj ntsuam rau fluralaner chewable ntsiav tshuaj rau dev (Bravecto).Pawg Neeg Saib Xyuas Kev Kho Mob rau Kev Siv Veterinary (CVMP).
Shoop, WL, Hartline, EJ, Gould, ME, Waddell, ME, & McDowell, RG (2014). Kev tshawb nrhiav thiab hom kev ua ntawm fluralaner, ib qho tshiab isoxazoline.Veterinary Parasitology, 201(3–4), 179–189.
Walther, FM, Allan, MJ, Roepke, RKA, & Nuernberger, MC (2015). Kev nyab xeeb ntawm fluralaner chewable ntsiav tshuaj rau dev tom qab tswj qhov ncauj.Parasites & Vectors, 8(1), 1-8.
Snyder, DE, Wiseman, S., Liebenberg, J., & Holbert, C. (2016). Kev tshawb fawb teb ntsuas qhov ua tau zoo ntawm qhov ncauj fluralaner tiv thaiv yoov thiab zuam hauv dev.Veterinary Therapeutics, 17(4), 12–20.