Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Ua Haujlwm

Thaum tus tswv tsev nug, "Kuv tus dev puas xav tau kev tiv thaiv kab mob txhua hli?"- lo lus teb yuav luag txhua zaus rov qab los nkag siab tias cov tshuaj twg ua tau hauv lub cev.Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajyog cov kev tshawb fawb tshaj plaws ua ke nrog cov tshuaj tiv thaiv kab mob muaj rau cov dev niaj hnub no. Lawv ua hauj lwm los ntawm ob txoj kev sib cais tab sis ua kom muaj kev lom zem ntxiv, tsom rau ob qho tib si kab mob sab nraud xws li yoov thiab zuam thiab cov kab mob sab hauv xws li kab mob plawv thiab plab hnyuv nematodes hauv ib koob tshuaj txhua hli.

Kab lus no rhuav tshem cov kev tshawb fawb tshuaj tom qab cov khoom lag luam hauv cov lus yooj yim, yog li koj tuaj yeem nkag siab tias vim li cas nws thiaj li ua haujlwm tau -thiab vim li cas nws thiaj li tau txais lub koob npe nrov hauv cov kws kho tsiaj thoob ntiaj teb.

Afoxolaner Thiab Milbemycin Oxime Chewable Tablets

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5 kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas

Ob yam khoom xyaw nquag, ib daim ntawv qhia dav dav

Qhov sib tov muaj ob hom tshuaj sib txawv uas ua haujlwm ua ke: afoxolaner thiab milbemycin oxime. Muaj ntau hom tshuaj sib txawv, thiab txhua tus siv cov tshuaj sib txawv los tua ib yam kab mob. Afoxolaner yog ib qho isoxazoline, uas txhais tau hais tias nws tua cov kab tsuag thiab acari. Milbemycin oxime yog macrolide uas tua cov kab mob. Nws yog tsim los ntawm fermenting khoom los ntawm subspecies Streptomyces hygroscopicus. Ua ke, lawv tiv thaiv ntau tus kab mob hauv ib koob tshuaj uas dev tuaj yeem zom.

Vim li cas Kev Sib Txuas Kev Kho Mob Tseem Ceeb hauv Kev Tswj Kab Mob

Nws tsis muaj peev xwm rau ib qho tshuaj tua kab mob sib txawv uas tus dev yuav tuaj yeem nyob hauv nws lub neej txhua hnub. Kab thiab kab laug sab kab tsuag, xws li fleas thiab ixodid zuam, xav tau cov tshuaj uas tawm tsam lawv cov hlab ntsha. Cov kab mob uas nyob hauv cov tsiaj, xws li cov kab mob plawv (Dirofilaria immitis) thiab cov kab mob hauv plab, xav tau cov tshuaj tua kab mob uas tuaj yeem nkag mus rau hauv lawv cov leeg thiab cov hlab ntsha. Koj tsis tas yuav noj ob yam tshuaj sib txawv vimAfoxolaner thiab milbemycin oxime chewable ntsiav tshuajmuaj ob leeg ntawm lawv. Nws yooj yim dua kom nco ntsoov noj koj cov tshuaj li no, uas ncaj qha nce kev nyab xeeb.

Afoxolaner's Action on GABA-Gated Chloride Channels

Afoxolaner lub hom phiaj ligand-gated chloride ion channels hauv crustacean paj hlwb, feem ntau yog cov uas tswj los ntawm GABA. GABA khi rau cov receptors no thiab qhib cov tshuaj chloride thaum txhua yam zoo. Qhov no slows cov hlab ntsha. Thaum afoxolaner khi rau lub receptor, nws nres cov txheej txheem no los ntawm kev tsis cia cov chloride channel qhib. Tus kab mob no muaj neuronal hyperexcitation uas nws tswj tsis tau, uas txwv tsis pub nws txav thiab tua nws. Nws yog ib qho tseem ceeb kom nco ntsoov tias afoxolaner khi rau kab GABA receptors ntau zog dua li cov tsiaj txhu. Yog vim li cas yoov, zuam, thiab mites tsis tuaj yeem ua rau nws zoo li dev ua tau.

Milbemycin Oxime Txoj Haujlwm ntawm Glutamate-Gated Chloride Channels

Ob qho tib si ntawm qhov nws tsim thiab nws ua haujlwm li cas, milbemycin oxime siv txoj kev sib txawv. Cov paj hlwb thiab cov leeg hlwb hauv cov leeg tsis muaj zog muaj cov tshuaj chloride uas qhib thiab kaw los ntawm glutamate. Tsis muaj cov txheej txheem zoo li no hauv cov vertebrates. Milbemycin oxime ua rau daim nyias nyias permeable rau chloride ions thaum nws khi rau nws. Qhov no ua rau cov membrane ntau dua. Cov hlwb tsis tuaj yeem ua rau muaj peev xwm ua tau zoo ntxiv lawm vim tias lawv raug cuam tshuam. Qhov no ua rau cov kab mob parasite paj hlwb thiab cov leeg tsis muaj zog thiab floppy. Milbemycin oxime muaj lub sijhawm nyuaj nkag mus rau tsiaj lub hlwb los ntawm lawv cov ntshav. Qhov no ntxiv ib txheej ntxiv ntawm kev nyab xeeb rau cov dev uas tau txais cov nqi kho mob.

Cov kab mob sab nraud: yoov, zuam, thiab mites

Cov ntshav ntawm afoxolaner yog nyob ntawm nws qhov siab tshaj plaws ob mus rau plaub teev tom qab nws tau txais los ntawm qhov ncauj. Yim caum- yim feem pua ​​​​ntawm lub cev siv tau, thiab nws ib nrab - lub neej hauv ntshav yog li ob lub lis piam. Cov khoom pib tua hma thiab zuam sai li sai tau thaum nws noj vim nws tawg sai heev. Thaum cov kab mob sab nraud no pub rau cov dev uas tau kho, lawv noj afoxolaner los ntawm lawv cov ntshav. Nws nrawm nrawm rau cov dev vim nws thaiv GABA-gated channels. Yog koj muab lubafoxolaner thiab milbemycin oxime chewable ntsiav tshuajrau miv dev, Ixodes ricinus flea, los yog Rhipicephalus sanguineus flea, nyob rau hauv 24 mus rau 48 teev, lawv ua hauj lwm zoo heev tiv thaiv tag nrho peb.

Internal Parasites: Heartworm thiab Gastrointestinal Nematodes

Milbemycin oxime kuj ua haujlwm zoo ntawm kev tshem cov kab mob uas nyob hauv lub cev. Milbemycin A3 (20%) thiab A4 (80%) ua rau nws, thiab txhua tus muaj nws tus kheej metabolic zog. Qhov siab tshaj plaws ntawm milbemycin A3 tau mus txog ib mus rau ob teev tom qab noj tshuaj, thiab nws nyob hauv lub cev rau 1.6 hnub. Milbemycin A4 tua kab mob rau 3.3 hnub tom qab koob tshuaj kawg thiab rau ib lub hlis tom qab ntawd. Kab mob plawv yog tshwm sim los ntawm L3 thiab L4 theem ntawm Dirofilaria immitis larvae. Nws nres thiab kho cov kab mob los ntawm Toxocara canis, Toxascaris leonina, Acylostoma caninum, thiab Trichuris vulpis zoo heev.

Kaw qhov kev pab them nqi sib txawv ntawm Internal thiab External Parasites

Ntau cov tshuaj tua kab mob tsuas yog ua haujlwm ntawm cov kab mob uas nyob sab hauv lossis sab nraud lub cev. Cov tshuaj tsawg heev ua haujlwm zoo ib yam ntawm ob qho tib si. Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj muaj cov molecules uas tau tsim los kaw qhov sib txawv. Rau cov kab mob plawv thiab cov kab mob hauv plab, milbemycin oxime nkag mus rau hauv cov ntaub so ntswg tob. Afoxolaner, ntawm qhov tod tes, feem ntau ua haujlwm hauv cov hlab ntsha thiab tawv nqaij - cov ntaub so ntswg uas ectoparasites noj. Ob qho tshuaj tuaj yeem txav mus los ntawm cov ntaub so ntswg ntawm tus nqi ntawm 2.6 txog 2.7 L / kg. Qhov no txhais tau hais tias lawv muaj dav hauv lub cev thiab tuaj yeem ncav cuag ob sab nraud thiab sab hauv.

Pharmacokinetic Synergy nyob rau hauv ib lub hli Dosing Schedule

Afoxolaner muaj ib nrab ntawm - lub neej ntawm 14 hnub, uas txhais tau hais tias nws ua rau koj muaj kev nyab xeeb ntawm ectoparasites rau ib hlis. Qee cov tshuaj nyob rau hauv tib chav kawm muaj ib nrab ntev dua -lub neej tshaj milbemycin oxime, tab sis nws tseem ua haujlwm thiab siv tau ib hlis ib zaug kom tshem tawm cov kab mob plawv uas tuaj yeem nres. Yuav kom tua ua ntej lawv loj hlob tuaj, cov larvae xav tau cov ntshav plasma uas nyob ib yam. Qhov sib npaug ntawm cov tshuaj pharmacokinetics ntawm ob cov khoom xyaw nquag txhais tau hais tias noj cov tshuaj los ntawm qhov ncauj ib hlis ib zaug ua rau kev nkag siab thiab ua haujlwm hauv lub neej tiag tiag.

Lub Molecular Cascade Los ntawm Receptor Binding rau Organism Tuag

Ob qho khoom xyaw nquag ua lawv txoj haujlwm los ntawm kev txuas mus rau receptors, thaiv cov channel, thiab depolarizing lossis hyperpolarizing membranes. Qhov no ua rau cov leeg tsis ua haujlwm, ua rau lawv tuag tes tuag taw, lossis tua lawv. Daim ntawv qhia no muaj txiaj ntsig zoo vim nws muaj ob txoj hauv kev uas tuaj yeem siv sib cais. Kab laum yuav tau siv rau ib txoj kev tua nws tus kheej, tab sis lwm txoj kev tseem tuaj yeem tua nws. Qhov no ua rau nws tsis tshua muaj ob tus kab mob sib txawv yuav ua rau muaj kev tiv thaiv ib leeg, uas yog qhov loj ntxiv rau ntev - txoj hauv kev uas kws kho tsiaj kws kho tsiaj pom zoo.

Kev Nyab Xeeb Profile Rooted hauv Receptor Selectivity

Milbemycin oxime chewable ntsiav tshuaj thiab afoxolaner yog ob qho tib si nyab xeeb rau cov dev uas tsis yog MDR1 / ABCB1 noob mutants. Qhov no yog vim lawv tsuas yog txuas rau qee cov receptors. Afoxolaner khi ntau zog rau GABA receptors nyob rau hauv arthropods dua rau cov nyob rau hauv cov tsiaj, thiab milbemycin oxime nyob ntawm glutamate-gated chloride channels uas tsis pom nyob rau hauv vertebrates. Ob yam no ua haujlwm ua ke los ua lub qhov rais kho mob uas loj txaus kom paub tseeb tias cov tshuaj ua haujlwm tiv thaiv kab mob yam tsis muaj teeb meem rau cov neeg laus noj qab haus huv lub cev. Cov dev hnub nyoog qis dua 8 lub lis piam lossis sib dua 2 kg yuav tsum tsis txhob muab cov khoom no. Tsis tas li ntawd, Collies thiab lwm yam tsiaj muaj feem xyuam yuav tsum tham nrog kws kho tsiaj vim tias lawv yuav nkag siab rau cov tshuaj uas ua haujlwm nrog MDR1 noob.

Tam sim no koj paub yuav ua li casafoxolaner thiab milbemycin oxime chewable ntsiav tshuajua hauj lwm, koj tuaj yeem pom yog vim li cas lawv yog txoj hauv kev nrov tshaj plaws kom tshem tau cov kab hauv dev. Nrog tsuas yog ib koob tshuaj txhua hli, qhov sib tov tiv thaiv tag nrho, raws li kev tshawb fawb pov thawj. Rau cov kab mob uas nyob sab nraum lub cev, nws thaiv GABA raws, thiab rau cov kab mob uas nyob hauv lub cev, nws ua rau glutamate channels. Muaj cov ntaub ntawv kev nyab xeeb zoo rau ob qho tib si cov khoom xyaw nquag thaum muab ib hlis ib zaug, thiab qhov tseeb tias txhua lub molecule xaiv lub hom phiaj sib txawv receptor txhawb qhov no.

Qhov no yog qhov uas Bloomtechz tuaj yeem tau txais ntauafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj. Koj tuaj yeem tau txais afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj los ntawm Bloomtechz. Cov nroj tsuag uas lawv ua haujlwm yog 100,000 square meters thiab yog GMP- ntawv pov thawj. Nws muaj kev pom zoo los ntawm US FDA, EU GMP, Nyiv, thiab CFDA. Kev tswj xyuas kev ua tau zoo ntawm peb lub tuam txhab muaj peb theem: kev tshuaj xyuas cov nroj tsuag, hauv -QA/QC tshuaj xyuas, thiab pov thawj los ntawm ib tug thib peb-tsoomfwv tog. Peb tau ua cov tshuaj zoo thiab tshuaj intermediates rau ntau tshaj 12 xyoo, thiab peb cog lus ruaj khov khoom zoo. Peb cov khoom tuaj yeem ua kom haum rau ntau qhov kev xav tau ntawm qhov hnyav, thiab OEM / ODM tuaj yeem siv los hloov pauv. Peb raug ntiav los ntawm cov neeg nyob hauv UK, Australia, Nyiv, Asmeskas, thiab lwm qhov chaw. Tham nrog peb tam sim ntawd, thiab peb yuav pab koj nrog koj qhov kev yuav khoom tom ntej hauv txoj hauv kev uas yog, meej, thiab paub tseeb ntawm nws cov kev txawj ntse.

Email rau peb ntawmSales@bloomtechz.com.

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4. Prichard, RK, & Geary, TG (2019). Kev pom ntawm kev siv hluav taws xob ntawm moxidectin thiab macrocyclic lactones rau kev tswj cov kab mob parasitic nematodes nyob rau hauv lub ntsej muag ntawm kev txhim kho anthelmintic tsis kam. International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv, 10, 69–83.

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6. Mitre, A., Lavergne, N., Crevat, D., & Bousquet-Mélou, A. (2016). Milbemycin oxime pharmacokinetics thiab bioavailability hauv cov dev tom qab kev tswj hwm qhov ncauj ntawm kev sib xyaw chewable formulation. Veterinary Parasitology, 225, 56–62.