Thaum xaiv ntawmfluralaner ntsiav tshuajthiab ivermectin rau canine parasite tswj, kws kho tsiaj thiab cov tswv tsiaj ntsib kev txiav txim siab tseem ceeb. Cov ntsiav tshuaj Fluralaner muaj kev tiv thaiv ntev ntev nrog ib koob tshuaj ib zaug txhua 12 lub lis piam, thaum ivermectin xav tau kev tswj hwm txhua hli tab sis muab kev pabcuam dav dav. Qhov sib txawv tseem ceeb yog nyob rau hauv lawv cov txheej txheem ntawm kev ua, lub sijhawm ntawm kev ua tau zoo, thiab kev nyab xeeb profiles hla ntau hom dev.
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1. General Specification (hauv Tshuag) |
Peb muab cov ntsiav tshuaj fluralaner, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Khoom siv:https://www.bloomtechz.com/oem-odm/tablet/fluralaner-tablet.html
Nkag siab txog Fluralaner Mechanism thiab Daim Ntawv Thov
Fluralaner hais lus rau kev ua tiav hauv veterinary parasitology ua ib qho isoxazoline compound. Qhov no dynamic kho daim gamma-aminobutyric corrosive (GABA) thiab L-glutamate-gated chloride channels hauv arthropod paj hlwb. Cov cuab yeej fluralaner ntawm kev ua ub no tshwj xeeb tshaj yog lub hom phiaj invertebrate neurons thaum tswj kev ruaj ntseg rau cov kab mob mammalian.
Cov kws kho mob xav tau piav qhia tias fluralaner rau dev ua tiav cov ntshav ntshav siab hauv 24 teev ntawm kev tswj qhov ncauj. Lub compound qhia tau hais tias bioavailability zoo kawg li thaum tswj kev noj qab haus huv, ncav cuag 79% assimilation tus nqi. Cov kws tsim tshuaj siv cov tswv yim nthuav dav ntxiv los lav qhov kev tso tawm tsis tu ncua thiab cov txiaj ntsig kho zoo tshaj plaws.
Cov yam ntxwv tseem ceeb ntawm fluralaner
Kev ncua ib nrab -lub neej li ntawm 12-15 hnub hauv canine plasma
High lipophilicity ua rau cov ntaub so ntswg faib
Tsawg kawg ntawm cov metabolism hauv hepatic txo cov kev pheej hmoo ntawm kev siv tshuaj
Kev nyab xeeb zoo heev nrog kev ntsuas ntsuas siab tshaj 100-fold
Yog tias koj xav tau kev tiv thaiv kab mob txuas ntxiv nrog qhov tsawg tsawg zaus, cesfluralaner ntsiav tshuajformulations muab kev yooj yim dua piv rau cov kev kho mob txhua hli.
Ivermectin Properties thiab Veterinary Applications
Ivermectin muaj qhov chaw nyob hauv avermectin chav kawm ntawm macrocyclic lactones inferred los ntawm Streptomyces avermitilis laus. Cov tshuaj no sib txuas tshwj xeeb rau glutamate-gated chloride channels pom nyob rau hauv cov paj hlwb invertebrate thiab cov leeg hlwb. Cov ntawv tso cai txhim kho chloride particle porousness, ua rau hyperpolarisation thiab inevitable parasite paralysis.
Veterinary ivermectin cov ntsiab lus qhia dav dav -spectrum viability tiv thaiv kab mob sab hauv thiab sab nraud. Qhov sib xyaw ua ke tau tsom mus rau cov kab mob plawv, cov kab mob hauv plab, thiab qee yam ectoparasites. Ua li ntawd, raws li nws yuav, keeb kwm polymorphisms hauv MDR1 qhov kev qhia zoo ua rau muaj kev txhawj xeeb txog kev nyab xeeb hauv cov tsiaj tshwj xeeb.
Cov yam ntxwv ntawm Ivermectin
Kev nqus sai nrog cov ntshav plasma siab kawg ntawm 3-4 teev
Cov ntaub so ntswg nthuav dav thiab kev sib txuas ntawm cov protein
Hepatic metabolism ntawm cytochrome P450 txoj hauv kev
Hloov pauv kev tshem tawm ib nrab - lub neej li 12-56 teev
Yog tias koj xav tau tus nqi - siv tau dav dav - spectrum parasite tswj nrog tsim cov ntaub ntawv kev nyab xeeb, ces ivermectin tseem yog ib qho kev xaiv siv tau rau cov neeg tsim nyog canine.
Kev sib piv ua tau zoo: Duration thiab Spectrum Analysis
Kev tshawb fawb txog kev ua tau zoo ntawm Fluralaner qhia txog kev tiv thaiv ntev li 12 lub lis piam tiv thaiv yoov thiab zuam. Kev sim tshuaj ntsuam xyuas nrog 847 tus dev tau pom 100% dev mub tua cov txiaj ntsig khaws cia thoob plaws lub sijhawm kho. Zuam hom suav nrog Ixodes ricinus, Dermacentor reticulatus, thiab Rhipicephalus sanguineus pom 95-100% kev tuag.
Cov ntaub ntawv kuaj pom tau hais tias fluralaner tswj kev kho mob ntau hauv cov ntshav thiab daim tawv nqaij rau lub sijhawm ntev:
Flea efficacy: >99% tua tus nqi ntawm 12 lub lis piam tom qab- kev tswj hwm
Tick control: >95% kev ua tau zoo ntawm ntau hom
Ceev ntawm kev tua: Hnyav tshem tawm hauv 8 teev, zuam hauv 12 teev
Ivermectin ua kom pom cov qauv kev ua tau zoo sib txawv uas tsom rau feem ntau ntawm cov kab mob sab hauv. Kev noj txhua hli ntawm 6-12 mcg / kg muab txhim khu kev qha tiv thaiv kab mob plawv nrog 100% kev ua tau zoo thaum siv tas li. Txawm li cas los xij, kev tswj hwm flea thiab zuam yuav tsum tau txhaj tshuaj ntau dua thiab qhia tias muaj kev txwv tsis pub ua haujlwm.
Kev sib piv cov ntaub ntawv qhia tau hais tias:
Kev tiv thaiv kab mob plawv: Ivermectin 100%, fluralaner tsis qhia
Flea tswj: Fluralaner superior nrog 12 lub lis piam ntev
Tiv thaiv zuam: Fluralaner qhia txog kev ua tau zoo
Yog tias koj xav tau kev tswj hwm flea thiab zuam nrog kev tswj hwm tsawg zaus, cesfluralaner ntsiav tshuajkev kho mob muab kev yooj yim tsis sib xws thiab kev tiv thaiv ruaj khov.
Kev Nyab Xeeb Profile thiab Kev Txiav Txim Siab
Kev soj ntsuam kev nyab xeeb ntawm Fluralaner suav nrog kev tshawb fawb txog toxicology thoob plaws ntau haiv neeg. Qhov sib xyaw ua ke qhia tau hais tias muaj kev zam zoo heev nrog cov xwm txheej tsis zoo tsawg tshaj plaws tau tshaj tawm hauv kev sim tshuaj. Kev soj ntsuam ib txwm muaj xws li mob plab hnyuv me uas cuam tshuam tsawg dua 2% ntawm cov tsiaj kho.
Qoob loo-kev txiav txim siab txog kev nyab xeeb tshwj xeeb nyiam fluralaner vim nws cov txheej txheem tsom rau arthropod-cov receptors tshwj xeeb. Collie yug me nyuam nrog MDR1 kev hloov pauv ua rau mob fluralaner yam tsis muaj teeb meem, tsis zoo li ivermectin uas yuav tsum tau hloov kho koob tshuaj lossis lwm txoj kev kho mob.
Kev sib piv kev nyab xeeb tseem ceeb suav nrog:
MDR1-sensitive breeds: Fluralaner qhia tsis muaj contraindications
Overdose kam rau ua: Fluralaner tswj kev nyab xeeb ntawm 5x tshuaj kho
Kev sib cuam tshuam tshuaj: tsawg heev nrog fluralaner, ntau yam nrog ivermectin
Kev txwv hnub nyoog: Ob leeg pom zoo rau menyuam dev tshaj 8 lub lis piam
Fluralaner cov kev mob tshwm sim tseem txwv feem ntau rau cov tsos mob ntawm lub plab zom mov. Kev tshaj tawm dav dav- kev soj ntsuam kev lag luam uas muaj ntau dua 2 lab kev kho mob tau lees paub qhov profile kev nyab xeeb zoo heev. Cov kev ceeb toom tsis zoo tshwm sim nyob qis dua 0.1% thoob plaws txhua tus neeg saib xyuas.
Yog tias koj xav tau kev tswj xyuas cov kab mob txhim khu kev qha rau MDR1-sensitive breeds, ces fluralaner sawv cev rau kev xaiv kho kom zoo dua piv rau ivermectin lwm txoj kev.
Dosage Guidelines thiab Administration Protocols
Fluralaner kev xam ntau npaum li cas ua raws cov txheej txheem ncaj qha raws li qhov hnyav ntawm lub cev. Cov koob tshuaj pom zoo yog li ntawm 25-56 mg / kg txhua 12 lub lis piam. Cov khw muag tshuaj muab cov ntsiav tshuaj yooj yim qhov ntau thiab tsawg uas haum rau dev los ntawm 2-56 kg lub cev hnyav.
Standard dosing cov lus qhia muaj xws li:
2-4.5 kg dev: 112.5 mg ntsiav tshuaj
4.5-10 kg dev: 250 mg ntsiav tshuaj
10-25 kg dev: 500 mg tab
25-56 kg dev: 1400 mg ntsiav tshuaj
Fluralaner qhov ncauj tswj hwm yuav tsum tau noj zaub mov kom zoo dua qhov nqus. Cov kev tshawb fawb soj ntsuam pom tau tias 2.5-fold nce bioavailability thaum noj mov. Lub fluralaner chewable ntsiav tshuaj formulation txhim khu palatability thaum xyuas kom meej koob tshuaj.
Kev siv tshuaj Ivermectin sib txawv heev raws li cov kab mob parasites. Kev tiv thaiv kab mob plawv yuav tsum tau 6-12 mcg / kg txhua hli, thaum cov kab mob hauv plab hnyuv xav tau 200 mcg / kg. Qhov kev siv tshuaj yooj yim no ua rau muaj peev xwm rau kev suav yuam kev thiab kev tswj xyuas yuam kev.
Yog tias koj xav tau yooj yim dosing raws tu qauv nrog txo qhov ua yuam kev, cesfluralaner ntsiav tshuajformulations muaj superior practicality piv rau txawv txawv ivermectin regimens.
Regulatory Status thiab Pharmaceutical Manufacturing
Fluralaner Veterinary siv tau txais kev pom zoo los ntawm kev tswj hwm txoj hauv kev thoob plaws lub khw loj. Lub Chaw Haujlwm Saib Xyuas Tshuaj European, FDA Center for Veterinary Medicine, thiab lwm cov tub ceev xwm thoob ntiaj teb tau tso cai ua lag luam raws li kev ua tau zoo thiab kev ntsuas kev nyab xeeb.
Kev tswj xyuas kev ua tau zoo
Cov qauv kev tsim tshuaj rau cov tshuaj fluralaner yuav tsum ua raws li Kev Ua Haujlwm Zoo (GMP) cov lus qhia.
Active ingredient purity >98.5%
Kev ntsuas kev sib cais ua tau raws li cov qauv tshuaj pharmacopeial
Cov ntaub ntawv ruaj ntseg txhawb nqa lub neej 36-hli
Cov kev tshawb fawb bioequivalence lees paub qhov sib npaug ntawm kev kho mob
Tsis txhob tso cai rau cov menyuam yaus uas tsis muaj kev saib xyuas rau cov neeg laus siv cov khoom no ib leeg, cov menyuam yaus yuav tsum tsis txhob cia cov menyuam yaus nyob ib leeg nrog cov khoom siv, kev pheej hmoo ntawm txhaws.
Tsis tu ncua xyuas cov ntsia hlau xoob, cov khoom puas lossis cov seams tawg thiab hloov cov khoom puas yog tias tsim nyog. Thaum disassembling lossis assembling, thov ua raws li phau ntawv qhia ua tib zoo kom tsis txhob muaj kev puas tsuaj.
Fluralaner muaj peev xwm tej yam kev mob qhia tias muaj peev xwm nyob rau hauv 25℃nrog kev ruaj ntseg los ntawm dampness thiab lub teeb. Cov xwm txheej no ua rau muaj tshuaj lom neeg ruaj khov thiab pab lub zog thoob plaws hauv lub neej.
Cov kws kho mob zoo ua tiav cov txheej txheem kev lees paub zoo. Sprout TECH khaws GMP-cov chaw ua haujlwm tau ntawv pov thawj hla 100,000 square metres nrog cov ntawv pov thawj los ntawm US, EU, JP, thiab CFDA cov kws tshaj lij kev tswj hwm. Lub tuam txhab cov kev cai tswj kev ua tau zoo suav nrog triple -tier kev soj ntsuam, lav cov khoom zoo tsis tu ncua.
Yog tias koj xav tau cov khoom lag luam muaj txiaj ntsig zoo nrog cov txiaj ntsig zoo thoob ntiaj teb, ntawm lub sijhawm ntawd cov neeg tsim khoom muab cov khoom sib xws thiab kev tswj hwm ua raws.
Kev ua lag luam thiab kev xav txog kev lag luam
Kev lag luam kws tshuaj siv rau fluralaner nthuav dav yav dhau los tus khub tsiaj tshuaj rau hauv kev tshawb nrhiav thiab kev txhim kho cov haujlwm. Txoj hauv kev sib xyaw tshuaj yuav tsum muaj kev txawj ntse tshwj xeeb ntawm chemistry thiab ua kom muaj peev xwm ua tau zoo. Mechanical scale tiam thov kom niaj hnub npaj tswj thiab kev tswj hwm ntuj.
Fluralaner pharmacokinetics tshawb xyuas cov tsav tsheb rau kev txhim kho cov ntsiab lus tshiab thiab cov qauv kev xa khoom. Cov tuam txhab tshuaj muaj txiaj ntsig zoo rau kev txhim kho bioavailability thiab txhawb nqa - tso tawm ua ntej. Cov kev txhim kho no ua rau qhib rau kev cog lus tsim cov koom haum nrog cov peev txheej tshwj xeeb.
Kev xav txog kev tsim khoom
Complex synthetic txoj kev yuav tsum tau advanced organic chemistry
Cov qauv tswj xyuas nruj nruj rau kev siv tshuaj kho tsiaj
Kev ua raws li ib puag ncig rau kev tswj cov tshuaj khib nyiab
Supply saw kev ntseeg siab rau cov khoom siv raw khoom sib xws
Tsis txhob tso cai rau cov menyuam yaus uas tsis muaj kev saib xyuas rau cov neeg laus siv cov khoom no ib leeg, cov menyuam yaus yuav tsum tsis txhob cia cov menyuam yaus nyob ib leeg nrog cov khoom siv, kev pheej hmoo ntawm txhaws.
Tsis tu ncua xyuas cov ntsia hlau xoob, cov khoom puas lossis cov seams tawg thiab hloov cov khoom puas yog tias tsim nyog. Thaum disassembling lossis assembling, thov ua raws li phau ntawv qhia ua tib zoo kom tsis txhob muaj kev puas tsuaj.
BLOOM TECH txoj kev koom tes hauv natural union thiab kws tshuaj ib nrab ntawm kev tsim cov haujlwm ua lub tuam txhab ua tus tsim nyog rau fluralaner-cov tshuaj muaj feem cuam tshuam. Lub koom haum cov ntaub ntawv teev tseg 12 xyoo suav nrog cov koom haum nrog 24 lub tuam txhab tshuaj thoob ntiaj teb.
Yog tias koj xav tau cov tshuaj tshwj xeeb sib xyaw ua ke rau kev siv tshuaj kho tsiaj, ntawm qhov kev paub txog cov neeg tsim khoom nrog cov ntaub ntawv teev tseg tau muab lub sijhawm zoo rau lub koom haum.
Xaus
Kev sib piv ntawm cov ntsiav tshuaj fluralaner thiab ivermectin nthuav tawm cov ntsiab lus tshwj xeeb ntawm kev txaus siab rau txhua qhov sib xyaw nyob ntawm cov hom phiaj tshwj xeeb. Fluralaner tshaj qhov kev cia siab nyob rau hauv muab amplified kab thiab zuam tswj nrog predominant kev ruaj ntseg profiles tshaj tag nrho cov menyuam dev yug. Ivermectin tseem muaj txiaj ntsig rau kev tiv thaiv kab mob plawv thiab dav -spectrum sab hauv parasite tswj. Veterinary kws tshaj lij yuav tsum xav txog cov khoom suav nrog kev cuam tshuam ntawm kev yug menyuam, kab mob parasite, kev nplij siab, thiab kev ua raws li cov neeg siv khoom thaum xaiv cov tshuaj zoo tagnrho. Kev lag luam kws tshuaj tau nce zuj zus mus rau ob lub tebchaw los ntawm kev txiav txim siab cov ntsiab lus thiab cov ntaub ntawv tsim tawm, lav kev tswj xyuas kev nkag mus tau ntawm cov tshuaj veterinary tseem ceeb.
Koom tes nrog BLOOM TECH rau hwm Fluralaner Manufacturing Solutions
BLOOM TECH sawv raws li koj qhov kev ntseeg siabFluralaner ntsiav tshuaj khoom muagnrog kev txawj ntse tsis sib xws hauv kev tsim tshuaj thiab kev lees paub zoo. Peb GMP-cov chaw muaj ntawv pov thawj xa cov khoom zoo tsis tu ncua- cov khoom zoo raws li cov qauv kev cai thoob ntiaj teb thoob plaws US, EU, JP, thiab CFDA cov cai. BLOOM TECH muab cov nqi sib tw nrog triple-tier kev soj ntsuam zoo, cov nyiaj tau los ruaj khov, ERP taug qab, tag nrho cov nyiaj rov qab lav, thiab 24/7 kev txhawb nqa, muab ib qho - nres kev daws teeb meem rau cov kws kho tsiaj.
Npaj kom muaj kev ruaj ntseg fluralaner ntsiav tshuaj tsim kev koom tes? Peb pab neeg ua haujlwm tau npaj siab los tham txog koj cov kev xav tau tshwj xeeb thiab muab cov kev daws teeb meem. Tiv tauj peb ntawmSales@bloomtechz.comtxhawm rau tshawb xyuas seb BLOOM TECH tuaj yeem pab txhawb koj li kev tsim kho tshuaj thiab cov hom phiaj tsim khoom li cas.
Cov ntaub ntawv
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2. Rohdich, N., Roepke, RK, & Zschiesche, E. (2014). Ib qho randomized, qhov muag tsis pom, tswj thiab ntau- qhov chaw hauv cheeb tsam kev kawm piv rau kev ua tau zoo thiab kev nyab xeeb ntawm Bravecto™ (fluralaner) tawm tsam Frontline™ (fipronil) hauv flea- thiab zuam - dev kis. Parasites & Vectors, 7, 83.
3. Meadows, C., Guerino, F., & Sun, F. (2014). Ib txoj kev tshawb nrhiav qhov muag tsis pom kev sib piv cov txiaj ntsig ntawm qhov ncauj tshuaj fluralaner (Bravecto ™) thiab siv tshuaj pleev imidacloprid / flumethrin (Seresto®) tiv thaiv kab mob ntawm cov dev. Veterinary Parasitology, 204(3-4), 371-378.
4. Ozoe, Y., Asahi, M., Ozoe, F., Nakahira, K., & Mita, T. (2010). Cov tshuaj tiv thaiv kab mob isoxazoline A1443 yog ib lub zog thaiv kab mob ligand -gated chloride channels. Biochemical thiab Biophysical Research Communications, 391(1), 744-749.
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6. Gassel, M., Wolf, C., Noack, S., Williams, H., & Ilg, T. (2014). Tus tshiab isoxazoline ectoparasiticide fluralaner: xaiv inhibition ntawm arthropod -aminobutyric acid- thiab L-glutamate-gated chloride channels thiab insecticidal/acaricidal kev ua. Kab Biochemistry thiab Molecular Biology, 45, 111-124.