3-Nitrobenzaldehydeyog ib qho organic compound nrog cov mis molecular C7H5NO3, CAS 99-61-6, thiab molecular hnyav ntawm 151.13. Feem ntau daj lossis xim av crystalline lossis hmoov hmoov. Nws cov xim yuav txawv nyob ntawm purity, batch, los yog cia tej yam kev mob. Nws yog soluble hauv dej, tab sis soluble hauv dej kub. Hauv cov kuab tshuaj organic xws li ether thiab chloroform, nws kuj muaj cov solubility zoo. Nws yog ib qho tsis muaj zog acidic compound nrog tus nqi pKa ntawm ib ncig ntawm 7. Qhov no txhais tau hais tias nws tuaj yeem nyob ruaj khov nyob rau hauv acidic thiab alkaline tej yam kev mob, tab sis nyhav kom pom zoo stability nyob rau hauv acidic tej yam kev mob. Nws yog multifunctional organic intermediate uas muaj peev xwm hnov mob nrog ntau lwm cov tebchaw los ua ke lwm cov organic sib txuas. Piv txwv li, nws tuaj yeem hnov mob nrog cawv los ua cov ester tebchaw; React nrog aldehydes los tsim ketone tebchaw; React nrog amines los tsim amide tebchaw, thiab lwm yam. Cov tebchaw no muaj nuj nqis heev hauv kev lag luam xws li tshuaj engineering, tshuaj, thiab tshuaj tua kab.
(Product link:https://www.bloomtechz.com/synthetic-chemical/organic-intermediates/3-nitrobenzaldehyde-99-cas-99-61-6.html )
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Cov txheej txheem hluavtaws hluavtaws yog ib txoj hauv kev siv los ua ke 3-Nitrobenzaldehide.
(1) Cov tshuaj tiv thaiv condensation: PhoH + HCHO → PhCHOPh + H2O
(2) Kaw cov tshuaj tiv thaiv: PhCHOPh + HNO3 → PhCHO + HNO2+H2O
Ntawm lawv, Ph sawv cev rau phenyl, HCHO sawv cev rau formaldehyde, PhCHO sawv cev rau benzaldehyde, HNO3 sawv cev rau nitric acid, thiab HNO2 sawv cev nitrite.
Reaction txoj cai:
Lub hauv paus ntsiab lus ntawm cov khoom siv hluavtaws yog siv phenol, formaldehyde, thiab nitric acid ua raw cov ntaub ntawv, tsim cov resin los ntawm cov tshuaj tiv thaiv condensation, thiab tom qab ntawd hloov cov resin rau hauv 3-Nitrobenzaldehide los ntawm cov tshuaj tiv thaiv kaw. Hauv cov txheej txheem no, phenol thiab formaldehyde thawj zaug tau txais cov tshuaj tiv thaiv condensation los tsim phenolic resin. Tom qab ntawd, cov resin nkag mus rau lub voj voog kaw nyob rau hauv qhov kev txiav txim ntawm nitric acid, tsim 3-Nitrobenzaldehide.
Kev sim cov kauj ruam:
(1) Npaj reagents thiab cov twj paj nruag: phenol, formaldehyde, nitric acid, sodium hydroxide, dej distilled, stirrer, tus pas ntsuas kub, dropper, hwj, thiab lwm yam.
(2) Ntxiv qhov tsim nyog ntawm phenol thiab formaldehyde rau lub khob thiab do kom sib npaug.
(3) Ua kom sov qhov sib tov rau qhov kub thiab txias (feem ntau yog 80-100 degree ) thiab tuav nws rau lub sijhawm (feem ntau yog 1-2 teev) kom tso cai rau cov tshuaj tiv thaiv condensation mus ntxiv.
(4) Tom qab cov tshuaj tiv thaiv condensation tiav, ntxiv cov nitric acid kom tsim nyog rau lub hwj, txuas ntxiv cua sov thiab nplawm.
(5) Khaws cov tshuaj tiv thaiv kub rau ib lub sij hawm (feem ntau yog 1-2 teev) kom cov resin mus rau qhov kaw-voj cov tshuaj tiv thaiv nyob rau hauv qhov kev txiav txim ntawm nitric acid.
(6) Tom qab ua tiav cov tshuaj tiv thaiv, dilute cov tshuaj tiv thaiv nrog dej distilled, thiab tom qab ntawd kho tus nqi pH kom nruab nrab nrog sodium hydroxide.
(7) Cais cov tsim tawm 3-Nitrobenzaldehide los ntawm cov tshuaj tiv thaiv los ntawm kev pom.
(8) Ntxuav thiab ziab: Ntxuav lub ncuav mog qab zib nrog cov dej uas tsim nyog, thiab tom qab ntawd qhuav nrog cov dej tsis muaj sodium sulfate.
(9) Kev Tshawb Fawb: Tshawb xyuas seb cov khoom puas yog 3-Nitrobenzaldehide los ntawm infrared spectroscopy, nuclear magnetic resonance, thiab lwm yam.
Txo 3-nitrobenzoic acid rau 3-Nitrobenzaldehide yog ib qho tshuaj lom neeg cov tshuaj tiv thaiv.
(CH3CO) 2O+2NaOH → CH3COONa+NaOCH3
Qhov sib npaug ntawm cov tshuaj tiv thaiv no sawv cev rau cov tshuaj tiv thaiv ntawm acetic anhydride thiab sodium hydroxide los tsim sodium acetate thiab methanol. Qhov no yog ib qho kev sib pauv ester uas tau ua tiav los ntawm kev sib pauv cov haujlwm ntawm cawv hydroxyl thiab carboxyl pawg.
Reaction txoj cai:
Ua ntej, peb yuav tsum nkag siab txog cov qauv thiab cov khoom ntawm 3-nitrobenzoic acid thiab 3-Nitrobenzaldehide. 3-nitrobenzoic acid yog carboxylic acid nrog ib pawg carboxyl thiab ib pawg nitro. Thiab 3-Nitrobenzaldehide yog ib qho aldehyde nrog ib pawg aldehyde thiab ib pawg nitro.
Txhawm rau txo 3-nitrobenzoic acid rau 3-Nitrobenzaldehide, peb yuav tsum siv tus neeg sawv cev txo kom txo nws cov carboxyl pawg mus rau ib pawg aldehyde. Cov tshuaj txo qis muaj xws li cov hlau hydrides, cawv hydrides, boranes, thiab lwm yam. Ntawm lawv, cawv hydrides (xws li NaBH4) yog ib qho kev siv cov tshuaj txo qis uas tuaj yeem txo cov carboxyl pawg rau aldehyde pawg.
Cov txheej txheem ntawm kev txo cov tshuaj tiv thaiv yog tias cov cawv hydride ua ntej ntxiv rau carbonyl pawg ntawm pawg carboxyl los tsim cov cawv ntsev. Tom qab ntawd, qhov no alkoxide txo qis ntxiv rau aldehydes. Lub caij no, pawg nitro tseem tsis hloov pauv thaum lub sijhawm txo cov txheej txheem.
Kev sim cov kauj ruam:
(1) Npaj reagents thiab cov twj paj nruag: 3-nitrobenzoic acid, NaBH4, ethanol, da dej dej khov, stirrer, dropper, test tube, thiab lwm yam.
(2) Dissolve 3-nitrobenzoic acid nyob rau hauv ethanol thiab ntxiv ib tug tsim nyog tus nqi ntawm NaBH4.
(3) Muab cov tshuaj tso rau hauv ib da dej dej khov kom tso cai kom txo cov tshuaj tiv thaiv rau lub sijhawm.
(4) Kev soj ntsuam cov tshuaj tiv thaiv kev nce qib: Raws li cov tshuaj tiv thaiv nce ntxiv, cov xim ntawm cov tshuaj yuav hloov maj mam los ntawm daj mus rau xim tsis muaj xim.
(5) Tom qab cov tshuaj tiv thaiv tiav lawm, ntxiv cov dej kom tsim nyog nrog lub dropper kom tsis txhob muaj cov tshuaj tiv thaiv.
(6) Ntxiv ib qho tsim nyog ntawm dilute hydrochloric acid rau cov tshuaj tiv thaiv los ntawm ib tug dropper kom ua tiav qhov nruab nrab pH tus nqi.
(7) Cais cov tsim tawm 3-Nitrobenzaldehide los ntawm cov tshuaj tiv thaiv los ntawm kev pom.
(8) Ntxuav thiab ziab: Ntxuav lub ncuav mog qab zib nrog cov dej uas tsim nyog, thiab tom qab ntawd qhuav nrog cov dej tsis muaj sodium sulfate.
(9) Kev Tshawb Fawb: Tshawb xyuas seb cov khoom puas yog 3-Nitrobenzaldehide los ntawm infrared spectroscopy, nuclear magnetic resonance, thiab lwm yam.
Ntxiv nrog rau ntau yam kev sib xyaw ua ke tau hais los saum no, kuj tseem muaj ntau txoj hauv kev rau kev sib xyaw ua ke 3-Nitrobenzaldehide:
Txoj kev oxidation: Siv oxidants xws li nitric acid, poov tshuaj permanganate, thiab lwm yam. los oxidize benzaldehyde rau 3-Nitrobenzaldehide.
1. Theem hloov catalysis txoj kev: Nyob rau hauv qhov kev txiav txim ntawm ib theem hloov catalyst, 3-Nitrobenzaldehide yog synthesized los ntawm phenol, formaldehyde, thiab nitric acid ua raw khoom.
2. Electrochemical txoj kev: Nyob rau hauv ib tug electrolytic cell, tsim nyog electrodes thiab electrolytes yog siv los oxidize benzaldehyde rau 3-Nitrobenzaldehide los ntawm cov txheej txheem electrolysis.
3. Biocatalytic method: Siv cov enzymes lossis microbial catalysts los hloov benzaldehyde rau hauv 3-Nitrobenzaldehyde.
Nws yuav tsum tau muab sau tseg tias sib txawv synthesis txoj kev yog haum rau txawv tej yam kev mob thiab yuav tsum tau, thiab kev xaiv ntawm tsim nyog synthesis txoj kev yuav tsum tau raws li tej yam kev mob. Lub caij no, vim qhov nyuaj thiab txaus ntshai ntawm cov tshuaj tiv thaiv tshuaj, nws yog ib qho tseem ceeb uas yuav tsum tau xyuam xim rau kev nyab xeeb thiab ua raws li kev sim thiab cov txheej txheem kev khiav hauj lwm thaum ua cov tshuaj synthesis.