Gs -441524 Hmoov tau tawm los ua kev pab cuam rau felitonitis (FIPs}Gs 441524 Hmoovyog metabolized nyob rau hauv feline lub cev ua tsis ncaj ncees {{} Cov me nyuam yaus hauv miv, thiab cov txheej txheem kev kuaj pom zoo, thiab nrhiav cov kev.
1. General Specification (hauv Tshuag)
(1) kev txhaj tshuaj
20mg, 6ml; 30Mg, 8ml; 40mg, 10ml
(2) Ntsiav tshuaj
25/45 / 60/0mg
(3) API (hmoov ntshiab)
(4) ntsiav tshuaj xovxwm tshuab
https: // www . . com / ntsiav tshuaj-ncej
2. Kev Customization:
Peb yuav sib tham ntawm ib leeg zuj zus, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm tsuas yog .
Intern Code: BM -2-1-049
Gs -441524 CAS 1191237-69-0
Kev tsom xam: HPLC, LC-MS, HNMR
Kev txhawb thev naus laus zis: R & Dept .-4
Peb muab cov gs -441524 hmoov, thov saib cov vev xaib nram qab no rau cov ncauj lus kom ntxaws ntxaws thiab cov khoom lag luam .
Khoom:https: // www . bloomtechz. com / synthetic-inclediates / gs {}} HTML
Qhov tseem ceeb metabolic enzymes rau gs -441524 activ activ activ
Txoj kev taug kev ntawm gs -441524 hauv miv yog cov enzymes muaj ntau cov enzymes koom nrog nws cov tshuaj papacologically nquag .
Phosphorherlation: thawj kauj ruam
Cov metabolism ntawm gs -441524 pib nrog tus niam txiv muaj kev sib haum xeeb hauv kev sib haum xeeb thiab lub raum cov nqaij mos rau tus ribonucleoside, hloov gs {{} mus rau hauv nws cov kev ua kom zoo nkauj ntxiv (gs {4 4}}}} tsis muaj Ak kev ua, Gs {-441524 yuav nyob twj ywm papacologically inert thiab tsis muaj peev xwm ua kom nws cov tshuaj tiv thaiv antiviral {}}
Tom ntej Phosphorholdation Kauj Ruam
Thaum gs -441524, feem ntau muaj raws liGs 441524 Hmoov, tau hloov pauv mus rau hauv nws cov txheej txheem monophosphate yog qhov tsim nyog los ua kom tiav {}} . Cov enzymes ua ntu zus Phosphate pawg rau Monophosphate, ua rau lub diphosphate thiab thaum kawg lub mus ua haujlwm, tso cov khoom siv tshuaj tiv thaiv kab mob antiviral intenantly cov kev kho mob muaj peev xwm ntawm gs {{}, raws li tsuas yog tus qauv tsim nyog los cuam tshuam nrog tus tsov ntxhuav acid synthes.
Lub luag haujlwm ntawm Cytochrome P450 enzymes
Txawm hais tias Cytochrome P450 (CYP) tsis koom nrog kev ua haujlwm ntawm cov engool. metabolatic} Kuv cov tshuaj tiv thaiv ntawm gs -441524 thiab tej zaum nws intermediales . Qhov no txhais tau tias kev ua kom tau cov tshuaj ntawm cypping thiab tshem tawm kev siv tshuaj kom sai li sai tau li cas los xij
Puas yog lub siab ua ntej-pib cov nyhuv txo cov txiaj ntsig bioavailability?
Lub Siab Ua Haujlwm Thawj zaug ua haujlwm yog qhov kev siv tshuaj ntawm lub siab ua ntej mus txog qhov kev cuam tshuam nrog cov nyhuv ua ntej ua ntej, nkag siab txog nws cov nyhuv ua ntej. cov tswv yim .
Qhov ncauj vs . kev txhaj tshuaj gs -441524
Thaum muab cov lus qhia txog qhov ncauj lus,Gs 441524 Hmoovtej zaum yuav raug rau thawj-hla kev cuam tshuam {} {} Txawm li cas los xij thiab nyob ntawm lub siab muaj nuj nqi thiab metabolic tus nqi thiab metabolic tus nqi.
Cov tswv yim los txhim kho Bioavailability
Txhawm rau txo cov peev xwm ntawm cov txheej txheem dhau los ntawm thawj zaug, ntau cov tswv yim tuaj yeem ua haujlwm:
Sublingual Administre: Tso Gs -441524 Nyob rau hauv cov ntshav, bypassing lub siab .
Interic txheej: Tsim cov txheej txheem:-441524 nrog cov txheej txheem enteric thiab txhawb nqa cov hnyuv.
Co-Administration Insibitors: Qee lub chaw sib txuas ua lub luag haujlwm rau gsabolism hauv gsabolism, muaj peev xwm nce nws cov peev txheej {} 2}}
Cov kev txiav txim siab ntawm tus kheej
Muab cov peev xwm hloov tau nyob rau hauv bioavailability vim yog thawj-cov kws kho tsiaj tuaj yeem pab coj cov kev hloov kho no {}}
Yuav ua li cas los txheeb xyuas GS -441524 metabolites hauv ntshav ntshav?
Yog qhov tseeb tau txais thiab kev ua kom muaj tseeb ntawm gs -441524 Thiab kho cov tshuaj metaling {}}}}} .
LC-MS / MS yog tus txheej txheem kub rau kev kuaj pom thiab cov txheej txheem ntawm cov txheej txheem hauv cov ntxaij vab tshaus tuaj yeem ntsuas qhov sib txuas thiab nws cov derivatives .
HPLC, thaum tsis tshua hnov dua LC-MS, tseem tuaj yeem siv los tshawb xyuas GS ... 2}} Cov qauv siv hluav taws xob feem ntau yog siv rau cov kws kho tsiaj kho mob}}}
Elisa-ua cov kev cia siab tau tsim kho kom pom kev ntawm gs -441524 Koj tsis tshua muaj txiaj ntsig thiab yuav haum rau kev saib xyuas kev saib xyuasGs 441524 HmoovRaws li tus qauv siv .
Cov qauv kev coj ua kom raug yog qhov tseem ceeb rau kev paub yog ntawm gs {{0} metabolites. Qhov no feem ntau cuam tshuam:
Plasma Extraction: Qum Plasma los ntawm tag nrho cov ntshav kuaj
Protein nag lossis daus: tshem cov protein uas tuaj yeem cuam tshuam nrog kev tsom xam
Cov Khoom Siv Txheej Txheem Extraction: Zoo siab thiab ua kom dawb huv ntawm kev nyiam
Kev txhais cov gs -441524 metabolite qib yuav tsum muaj kev txiav txim siab ntawm ntau yam:
Lub sijhawm txij li koob kav ntev
Noj tshuaj thiab txoj kev tswj hwm
Tus Kheej Cat Cov Lus Qhia Txog Cov Me Me
Muaj cov tshuaj hloov kho lossis kev noj qab haus huv
Cov kws kho tsiaj yuav tsum ua cov metabolite theem nrog cov chaw kho mob teb rau cov tswv yim kho kom zoo kom ua tau zoo {}}
Tag
Nkag siab lub metabolism ntawmGs 441524 HmoovHauv cov miv yog qhov tseem ceeb rau kev ua kom zoo dua qub rau kev txiav txim siab tseem ceeb rau kev txiav txim siab txog kev txiav txim siab txog kev txiav txim siab txog kev txiav txim siab thiab saib xyuas .
Raws li kev tshawb fawb hauv daim teb no txuas ntxiv hloov zuj zus los muab cov kws kho mob, cov kws kho tsiaj txhu tuaj yeem ua haujlwm rau cov miv cuam tshuam rau cov fip .
Puas yog koj yog lub tuam txhab kws tshuaj nrhiav cov gs-zoo gs -441524 hmoov rau kev tshawb fawb lossis ntau lawm? Saib tsis muaj ntxiv dua li Bloom Tech. nrog peb cov kev cog lus rau cov khoom siv ntau lawm thiab kev paub zoo rau peb cov tshuaj lom neeg {9} Tsis txhob plam ntawm peb tus nqi Gs -441524 hmoov thiab lwm yam tshuaj chev kuab tshuaj rau peb {}}}}}Sales@bloomtechz.comlos tham txog koj cov kev xav tau thiab peb tuaj yeem txhawb nqa koj cov kev tshawb fawb lossis cov hom phiaj ntau lawm.
Ntawv Sawv cev
1. Johnson, . "}}"}} "}}"} "}"} "}"} "}"} "}"} "}"} "}"} "}"} "}
2. Smith, b {}}}}}} "}}"}} "est}"}} "est}"}} "}}"}}
3. chen, l {{}} "}"}} "}}"}} "}}" {} "}"
4. rodriguez, m . "} {} {... {6} {... {6} {...." recative biochemistry and. " Pharmacology, 255, 109234.