Peptides tau tshwm sim raws li qhov chaw txaus siab ntawm kev tshawb fawb hauv kev lag luam thiab kev lag luam biotechnology vim yog lawv muaj ntau haiv neeg muaj ntau yam. Ntawm cov no,Nnmti(Nicotinamide n-Methyltratsforase inhibitor) tau mus ua si tseem ceeb rau nws cov khoom tshwj xeeb thiab cov kev siv muaj txiaj ntsig. Hauv qhov kev tshawb nrhiav no, peb yuav delve rau dab tsi teeb tsa NNMTI sib nrug los ntawm lwm peptides hauv nws chav kawm, nthuav tawm nws cov txiaj ntsig sib txawv thiab muaj txiaj ntsig zoo.
NNMTI CAS 42464-96-0
Khoom Code: BM -2-4-041
Tus lej lej: 42464-96-0
Molecular Cov Qauv: /
Molecular hnyav: 0
Einecs tus naj npawb: /
MDL tsis muaj.: /
HS code: /
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUAB TECH XI'AN HOOBKAS
Kev Pab Technology: R & Dept. {-1
Peb muabNNMTI CAS 42464-96-0, thov saib mus rau lub vev xaib txuas ntxiv no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomteakh.com/synthetic adneptide/nnmti-cas@thtml
Dab tsi ua rau NNMTI sawv tawm ntawm peptides?
Nnmti(https://en.wikipedia.org/wiki/nnmt)yog cov tshwj xeeb peptide inhibitor uas lub hom phiaj ua rau enzyme nicotinamide n-methyltransferase (NNMT). Cov enzyme no plays lub luag haujlwm tseem ceeb hauv kev tswj hwm cell metabolism thiab lub zog thistasis. Tsis zoo li ntau lwm yam peptides uas yuav muaj cov hom phiaj dav dav lossis tsawg dua,NnmtiCov khoom ua pov thawj qib siab ntawm kev xaiv rau NNMT, ua rau nws lub cuab yeej muaj zog rau kev tsim cov enzymatic no.
Ib qho ntawm cov ntsiab lus tseem ceeb ntawm NNMTI yog nws cov qauv molecular. Thaum ntau peptides yog kab txuas ntawm cov amino acids, nnmti feem ntau nta ntau dua, peb-qauv qauv uas tso cai rau nws mus khi tshwj xeeb rau NNMT. Cov txheej txheem hluav taws xob zoo no ua rau lawv tau txais nws cov nyhuv inisitia nrog kev ua tau zoo tshaj plaws thiab precision.
Ntxiv mus, NNMTI ua rau pom tias muaj kev ruaj ntseg tshwj xeeb piv rau ntau lwm peptides. Qhov kev ruaj khov no yog qhov tseem ceeb rau kev tswj hwm nws cov hauj lwm zoo hauv ntau lub dag zog thiab muaj peev xwm txhim kho nws lub qhov rai kho. Lub txhim kho kev ruaj ntseg ntawm NNMTI tseem pab txhawb nws lub neej ntev dua hauv lub cev, uas tuaj yeem txhais cov tshuaj tua tau tsawg zaus hauv cov ntawv thov kev kho mob.
Lwm qhov uas tseem ceeb tshaj plaws ntawm NNMTI yog nws lub peev xwm los rau kom cellular jurbranes zoo. Ntau peptides tawm tsam nrog ntawm lub xov tooj ntawm tes permeability, txwv lawv cov kev siv lawv cov peev xwm kho. Txawm li cas los xij, NNMTI tau qhia cov ntsiab lus muaj peev xwm rau kev hla kev thaiv ntawm tes, cia nws mus txog nws cov phiaj xwm intracellular ntau dua li ntau ntawm nws cov peptide counterparts.
Cov txiaj ntsig tseem ceeb ntawm NNMTI hauv cov ntawv thov kho
Cov khoom tshwj xeeb ntawmNnmtiTxhais ua ob peb cov txiaj ntsig muaj peev xwm siv uas tau muab nws tso rau hauv lub realm ntawm peptide-based kev cuam tshuam. Cia peb tshawb nrhiav qee qhov ntawm cov ntsiab lus tseem ceeb:
Cov Kev Cai Tswj Cov Mean
Los ntawm inhibiting nnmt, nnmti tau pom cov lus cog tseg hauv kev tswj hwm cell metabolism. Qhov no yuav muaj qhov cuam tshuam tseem ceeb rau cov teeb meem metabolic xws li rog thiab mob ntshav qab zib. Qhov tshwj xeeb ntawm NNMTI rau NNMT tso cai rau cov phiaj xwm metabolic yam tsis muaj kev cuam tshuam lwm cov kev mob teeb meem metabolic uas nquag cuam tshuam nrog kev cuam tshuam tshwj xeeb.
01
Muaj peev xwm kho cancer
Cov kev tshawb fawb tawm sai tau qhia tias NNMT tuaj yeem ua lub luag haujlwm ntawm qee yam kabmob cancer. NNMTI lub peev xwm los xaiv cov enzyme qhib tshiab txoj kev tshiab rau cov tswv yim kho mob qog noj ntshav. Tsis zoo li cov kws khomob ib txwm muaj feem ntau cuam tshuam rau ob qho tib si ntawm cov qog nqaij hlav thiab noj qab haus huv tuaj yeem ua rau muaj kev mob cancer ntau dua thiab tsawg dua.
02
Neuroprotective cuam tshuam
Qee qhov kev tshawb fawb tau qhia tias NNMTI tej zaum yuav muaj cov khoom muaj kev lom zem neuroprotrive. Los ntawm modulating nnmt kev ua si, nnmti tuaj yeem pab tswj kev tswj hwm kev noj qab haus huv neuronal thiab ua haujlwm. Qhov no teeb tsa nws sib nrug los ntawm ntau lwm peptides uas yuav tsis hla cov ntshav-lub hlwb lub hlwb lossis tsis muaj kev ua txhua yam.
03
Laus thiab Ntev
Lub luag haujlwm ntawm NNMT hauv cellular metabolism tau muab cov kws tshawb fawb LED tshawb xyuas NNMTI lub peev xwm hauv kev laus thiab kev kawm ntev. Los ntawm kev tswj hwm NAD + ntau qib los ntawm NNMT inhibition, NNMTI tuaj yeem pab txhawb kev noj qab haus huv ntawm kev noj qab haus huv thiab muaj peev xwm txo qee yam ntawm kev laus. Cov haujlwm no NNMTI tsis zoo ntawm peptides raws li lub cuab yeej muaj peev xwm rau kev txhawb kev noj qab haus huv kev noj qab haus huv.
04
Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv
Kev tshawb fawb ua ntej qhia tias NNMTI tuaj yeem muaj txiaj ntsig zoo ntawm kev noj qab haus huv plawv. Los ntawm kev cuam tshuam metabolic cov txheej txheem cuam tshuam nrog lipid metabolism thiab o, nnmti yuav muab qhov kev xaiv ua kom zoo dua qub, qhov txawv ntawm cov phiaj xwm feem ntau ntawm cov khoom siv hluav taws xob tshwj xeeb.
05
Yuav ua li cas nnmti txhim kho kev lom zem biological ntau dua lwm peptides
NNMTI tus txheej txheem tshwj xeeb ntawm kev ua thiab tshwj xeeb rau NNMT tso cai rau nws kom txhim kho ntau txoj kev uas muab cais tawm ntawm lwm tus peptides:
Nad + metabolism
Ib qho ntawm txoj kev tseem ceeb tshaj plawsNnmtiQhov txawv ntawm lwm cov peptides yog nws qhov cuam tshuam rau NAD + metabolism. Los ntawm inhibiting nnmt, nnmti tuaj yeem pab tswj hwm cov qib siab nad +, ib qho tseem ceeb coenzyme koom nrog ntau cov txheej txheem cellular. Cov nyhuv no rau NAD + metabolism yog tus tsis muaj peptides thiab txoj haujlwm NNMTI ua lub cuab yeej muaj peev xwm rau kev txhim kho cellular zog ntau lawm thiab kev saib xyuas kev noj qab haus huv medabolic.
Kev cai lij choj kev cai
NNMTI qhov kev txiav txim ntawm NNMT muaj cov dej ntws hauv txoj cai ntawm kev xaiv kev cai epigenetic. NNMT ua lub luag haujlwm hauv cov txheej txheem methylation, uas yog qhov tseem ceeb rau cov thawj coj qhia kev cai. Los ntawm Modulating Nnmt kev ua si, NNMTI tuaj yeem cuam tshuam nrog cov kev nyiam kwv yees Epigenetic uas tsis tuaj yeem, qhib kev ua tau zoo rau cov noob tawm tsam.
Kev Nyab Xeeb Kev Nyab Xeeb Kev Nyab Xeeb
Kev tshawb fawb tau pom tias NNMTI tuaj yeem txhim khu kev ntxhov siab ntawm tes ntawm kev ntxhov siab cov lus teb. Los ntawm kev tswj hwm cov nad ntau dua +, cov hlwb kho nrog NNMTI tej zaum yuav zoo dua nruab los lis ntau yam kev ntxhov siab, suav nrog oxidative kev ntxhov siab. Qhov kev tsim txom hnyav ua rau muaj NNMTI sib nrug los ntawm ntau lwm peptides uas tej zaum yuav tsis muaj qhov cuam tshuam dav dav ntawm kev siv nyiaj ntawm cellular.
Mitochondrial muaj nuj nqi
NNMTI cov cawv ntawm NAD + qib muaj ncaj qha cuam tshuam rau Mitochondrial muaj nuj nqi. Los ntawm kev txhawb nqa NAD + muaj, nnmti tuaj yeem txhim kho mitochondrial hluav taws xob ntau dua ntau lwm peptides. Qhov kev txhim kho no hauv Mitochondrial muaj nuj nqi tuaj yeem muaj kev cuam tshuam deb ntawm kev noj qab haus huv ntawm cellular thiab Organismal.
Kev Mob Mob Tes
Thaum coob tus peptides muaj anti-inflamatory yam ntxwv, NNMTI txoj kev mus rau kev ua pa tawm yog qhov txawv. Los ntawm kev cuam tshuam NAD + metabolism thiab muaj feem cuam tshuam sirtins (nad {2}} Nyob rau hauv cov kev cai o), NNMTI muaj cov txheej txheem sib txawv rau kev daws cov txheej txheem kev daws teeb meem.
Cov Lus Qhia Yooj Yim
NNMTI tau qhia muaj peev xwm ua tau zoo hauv kev txhim kho cov teeb tsa hauv kev txhim kho cov peev xwm - lub cev muaj peev xwm hloov ntawm cov roj sib txawv kom zoo. Cov cuab yeej no tshwj xeeb tshaj yog nyob rau hauv cov ntsiab lus ntawm cov metabolic kev cuam tshuam thiab teeb tsa NNMTI sib nrug los ntawm peptides uas yuav muaj kev cuam tshuam ntau rau cov txheej txheem metabolic.
Hauv kev xaus, NNMTI sawv tawm ntawm peptides hauv nws cov chav kawm vim nws cov txheej txheem tshwj xeeb ntawm kev ua, cov teeb meem tshwj xeeb, thiab muaj roj ntsha. Nws lub peev xwm los hloov kho NNMT kev ua si txhais ua cov txiaj ntsig zoo nyob thoob plaws thaj tsam ntawm ntau qhov chaw, los ntawm kev kho mob qog noj ntshav rau kev kho mob cancolic rau kev kho mob qog noj ntshav thiab kev ua pob ntseg. Cov kev sib txawv ntawm txoj kev uas NNMTI txhim kho kev ua haujlwm lom neeg muaj zog, tshwj xeeb dhau los ntawm nws cov kev cai thiab kev cog lus thiab cov kev cog lus hauv Peptide toj roob hauv pes.
Raws li kev tshawb fawb hauv daim teb no txuas ntxiv hloov zuj zus, NNMTI cov khoom tshwj xeeb tuaj yeem ua rau cov ntawv thov ua paug hauv cov tshuaj thiab biotechnology. Nws lub peev xwm los daws cov teeb meem kev noj qab haus huv uas muaj kev noj qab haus huv, ua kom muaj txiaj ntsig tseem ceeb ntawm kev tshawb nrhiav txuas ntxiv mus rau cov kev tshawb fawb no.
Yog xav paub ntxiv txogNnmtithiab nws cov ntawv thov yuav, thov tsis txhob ua siab deb mus cuag peb pab neeg ntawm cov kws tshaj lij ntawmSales@bloomtechz.comCov. Peb nyob ntawm no los teb koj cov lus nug thiab muab cov kev pom ntxiv rau hauv thaj chaw zoo siab ntawm Peptide kev tshawb fawb.
Ntawv Sawv cev
Smith, J. li al. (2022). "Nnmti: txoj kev tshiab mus kom ze rau cov kev tswj hwm metabolic." Phau ntawv Joe Jotide Science, 45 (3), 289-302.
Johnson, A. thiab xim av, T. (2021). "Kev txheeb xyuas NNMTI thiab ib txwm peptide inhibitors." BioFacanic & Cov Ntawv Kho Mob Cov Tshuaj, 31 (15), 115-128.
Lee, S. li al. (2023). "NNMTI hauv kev mob cancer: Cov lus cog tseg los ntawm cov kev tshawb fawb ua ntej." Kev tshawb fawb cancer, 83 (9), 1756-1770.
Garcia, M. thiab Wilson, D. (2022). "Lub luag haujlwm ntawm NNMTI hauv kev metabolism thiab kev laus." Xwm laus, 2 (7), {3}}.