Taw qhia:
EptifibatideQhov tseeb yog cov tshuaj nquag siv hauv kev tswj hwm ntawm ntau yam mob plawv, tshwj xeeb tshaj yog thaum cov txheej txheem invasive xws li angioplasty lossis stent placement.Txawm li cas los xij, tuaj yeem muaj kev tsis sib haum xeeb uas suav nrog nws cov kev txiav txim raws li cov ntshav ntau dua, vim nws cov khoom tivthaiv ntawm kev ua haujlwm thiab nws cov feem hauv. forestalling ntshav clump kev loj hlob.
Eptifibatide muaj ib qho chaw nrog cov chav kawm ntawm cov tshuaj hu ua glycoprotein IIb / IIIa inhibitors. Cov tshuaj no ua haujlwm los ntawm kev cuam tshuam cov glycoprotein IIb / IIIa receptor nyob rau txheej txheej ntawm platelets, uas yog cov platelets me me nrog kev txhim kho clump. Thaum lub sij hawm enacted, cov receptors xav tias yog ib feem tseem ceeb ntawm platelet conglomeration, lub voj voog tseem ceeb rau kev loj hlob ntawm cov ntshav. Los ntawm thaiv cov receptors, eptifibatide tiv thaiv platelets los ntawm clumping ua ke, yog li txo qhov kev pheej hmoo ntawm thrombus tsim nyob rau hauv cov hlab ntsha.
Thaum eptifibatide ua kom paub tseeb tias qeeb ntawm cov txheej txheem thickening, nws yog ib qho tseem ceeb kom cais nws los ntawm cov ntshav thinners xws li anticoagulants. Anticoagulants, piv txwv li, warfarin lossis heparin, ua haujlwm los ntawm kev tsom mus rau ntau qhov chaw ntawm cov ntshav coagulating overflow, hauv paus los ntawm kev cuam tshuam qhov kev ua ntawm thickening variables. Lawv cuam tshuam lub voj voog coagulation los ntawm qhov kev xav dav dua, ua rau txo qis hauv cov ntshav lub peev xwm rau pawg.
Hauv qhov sib piv, eptifibatide tshwj xeeb tsom rau platelet muaj nuj nqi los ntawm inhibiting platelet aggregation, tab sis nws tsis cuam tshuam rau coagulation cascade ncaj qha. Nyob rau hauv txoj kev no, thaum eptifibatide tuaj yeem raug saib raws li cov tshuaj uas cuam tshuam cov ntshav kev loj hlob, nws tsis raug tso cai rau cov ntshav ntau dua los yog cov tshuaj tiv thaiv kab mob.
Kev nkag siab txog qhov sib txawv ntawm eptifibatide thiab cov tshuaj ntshav ib txwm muaj yog qhov tseem ceeb rau cov kws kho mob thiab cov neeg mob ib yam nkaus. Thaum ob hom tshuaj npaj rau kev tswj hwm pawg, lawv ua xws li los ntawm ntau lub tshuab thiab muaj cov cim hloov pauv, kev siv tshuaj noj, thiab yuav muaj txiaj ntsig thib ob.
Hauv kev xaus, eptifibatide ua lub luag haujlwm tseem ceeb hauv kev kho mob plawv los ntawm kev tiv thaiv platelet aggregation thiab txo qhov kev pheej hmoo ntawm kev tsim cov thrombus thaum cov txheej txheem cuam tshuam. Txawm li cas los xij, nws tsis raug cais raws li cov ntshav thinner hauv cov kev xav ib txwm muaj, vim nws tsis ncaj qha cuam tshuam rau coagulation cascade. Kev nthuav qhia qhov sib txawv no tuaj yeem pab ua kom siv tau thiab nkag siab txog cov tshuaj tseem ceeb no hauv kev kho mob.
Eptifibatide ua haujlwm li cas hauv kev kho mob plawv?
Eptifibatideyog paub tseeb tias glycoprotein IIb / IIIa inhibitor, uas yog ib qho tseem ceeb ntawm cov tshuaj siv hauv kev tswj hwm kev mob plawv mob plawv (ACS) thiab thaum lub sij hawm percutaneous coronary mediations (PCI). Nws cov ntsiab lus ntawm kev ua haujlwm suav nrog kev tsom mus rau cov platelet receptor glycoprotein IIb / IIIa.
Platelet conglomeration xav tias yog ib qho tseem ceeb hauv kev tsim cov ntshav clumps, tshwj xeeb tshaj yog hais txog cov hlab ntsha apoplexy. Glycoprotein IIb / IIIa receptors nyob rau ntawm txheej txheej ntawm platelets thiab yog qhov tseem ceeb rau kev txwv ntawm fibrinogen, uas cuam tshuam cov platelets ua ke, ua rau tag nrho thiab nws thiaj li ua rau cov ntshav txhaws.
Eptifibatideua haujlwm los ntawm kev khi rau cov glycoprotein IIb / IIIa receptors, yog li inhibiting txoj hauv kev kawg ntawm platelet aggregation. Los ntawm kev thaiv kev khi ntawm fibrinogen rau cov receptors, eptifibatide zoo tiv thaiv kev sib txuas ntawm platelets thiab tsim cov hlab ntsha loj.
Hauv kev xyaum kho mob, eptifibatide tau siv tsis tu ncua cuam tshuam nrog ibuprofen thiab heparin thaum lub sij hawm PCI cov tswv yim kom txo tau qhov kev twv txiaj ntawm ischemic tsis meej pem xws li myocardial localized necrosis lossis stent apoplexy. Tsis tas li ntawd, nws tau siv rau hauv kev tswj hwm ntawm ACS, suav nrog qhov tsis ruaj khov angina thiab tsis-ST ntu nce myocardial infarction (NSTEMI), txhawm rau txhim kho cov plaques thiab tiv thaiv cov xwm txheej thrombotic ntxiv.
Los ntawm kev nkag siab txog cov txheej txheem meej ntawm kev ua ntawm eptifibatide hauv inhibiting platelet muaj nuj nqi, cov kws kho mob tuaj yeem txiav txim siab txog nws txoj kev siv hauv ntau yam xwm txheej kho mob. Txoj kev xaiv no los daws cov kev kho mob antiplatelet tau ntxiv rau kev tsim cov txiaj ntsig ntxiv thiab txo qis ntawm cov sij hawm ischemic hauv cov neeg mob uas muaj kab mob coronary.
Puas yog Eptifibatide Zoo ib yam li cov ntshav cov tshuaj niaj hnub?
Thaum ob leegEptifibatidethiab cov tshuaj tua kab mob ib txwm muaj xws li tshuaj aspirin lossis warfarin txhawm rau tiv thaiv cov ntshav txhaws, lawv ua haujlwm los ntawm cov txheej txheem sib txawv. Cov ntshav thinners feem ntau ua raws li ntau qhov chaw ntawm coagulation overflow, prompting anticoagulant cuam tshuam uas cuam tshuam rau ob leeg hlab ntsha thiab venous apoplexy. Cov tshuaj no txwv txoj kev loj hlob ntawm fibrin, ib qho tseem ceeb hauv cov ntshav thickening, tom qab ntawd txo qis kev twv txiaj ntawm kev loj hlob ntawm cov hlab ntsha sib txawv.
Hauv qhov sib piv, Eptifibatide tsom rau ib qho tshwj xeeb ntawm kev tsim cov ntshav los ntawm inhibiting platelet aggregation. Platelets suav tias yog ib feem tseem ceeb hauv kev txhim kho cov hlab ntsha thrombi, tshwj xeeb tshaj yog nyob rau hauv cov xwm txheej xws li mob plawv mob plawv (ACS) thiab thaum lub sij hawm percutaneous coronary mediation (PCI). Los ntawm kev cuam tshuam cov glycoprotein IIb / IIIa receptor nyob rau txheej txheej ntawm platelets, Eptifibatide forestalls platelet tsub zuj zuj thiab kev loj hlob ntawm cov hlab ntsha thrombi, li no txo qis kev twv txiaj ntawm ischemic zaus xws li myocardial localized necrosis lossis stroke.
Kev nkag siab txog cov txheej txheem tshwj xeeb ntawm kev ua haujlwm ntawm Eptifibatide pab kom nws sib txawv ntawm cov ntshav nyias nyias thiab qhia txog nws lub luag haujlwm hauv kev tiv thaiv cov xwm txheej ntawm cov hlab ntsha, tshwj xeeb tshaj yog nyob rau hauv cov kev pheej hmoo siab plawv xws li ACS lossis thaum lub sijhawm PCI cov txheej txheem. Cov neeg muab kev pabcuam khomob tuaj yeem siv cov ntaub ntawv no mus nrog cov kev kawm paub txog kev txiav txim siab txog kev kho mob antithrombotic, kho kom haum rau cov kev kho mob tshwj xeeb thiab kev phom sij ntawm txhua tus neeg mob.Los ntawm kev tsom mus rau platelet aggregation,Eptifibatidemuaj txoj hauv kev tsom mus rau kev tiv thaiv cov hlab ntsha thrombosis, ua tiav cov txiaj ntsig anticoagulant dav ntawm cov tshuaj ntshav thinners hauv kev tswj cov kab mob plawv.
Dab tsi yog qhov kev txiav txim siab thiab kev mob tshwm sim ntawm kev siv Eptifibatide?
ThaumEptifibatidemuaj txiaj ntsig zoo hauv kev tiv thaiv cov teeb meem thrombotic, nws tsis yog yam tsis muaj kev xav thiab muaj peev xwm tshwm sim. Cov kev mob tshwm sim feem ntau ntawm Eptifibatide tuaj yeem muaj xws li los ntshav, tshwj xeeb tshaj yog nyob rau ntawm qhov chaw ntawm cov hlab ntsha nkag los yog thaum ua haujlwm. Cov neeg mob uas muaj keeb kwm los ntshav los yog kev phais loj tsis ntev los no yuav tsum tau ua tib zoo saib xyuas thiab hloov koob tshuaj thaum siv Eptifibatide.
Xav txog cov xwm txheej tshwj xeeb ntawm tus neeg mob, xws li lub raum ua haujlwm, cov tshuaj sib xyaw ua ke, thiab cov txheej txheem kev pheej hmoo, yog qhov tseem ceeb hauv kev nyab xeeb thiab siv tau zoo ntawm Eptifibatide. Cov kws kho mob yuav tsum ntsuas cov txiaj ntsig ntawm kev tiv thaiv thrombosis tiv thaiv cov kev pheej hmoo los ntshav thaum sau tshuaj Eptifibatide.
Hauv kev xaus, Eptifibatide yog ib qho tshuaj muaj txiaj ntsig hauv kev kho mob plawv, tshwj xeeb tshaj yog rau kev tiv thaiv cov teeb meem thrombotic thaum cov txheej txheem cuam tshuam. Nws lub hom phiaj ntawm kev nqis tes ua ntawm platelet aggregation distinguishes nws los ntawm ib txwm cov ntshav thinners, qhia txog qhov tseem ceeb ntawm kev nkag siab txog nws lub luag haujlwm thiab kev xav hauv kev kho mob.
Cov ntaub ntawv:
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2. O'Shea JC, Hafley GE, Greenberg S, et al. Platelet glycoprotein IIb / IIIa integrin blockade nrog eptifibatide hauv kev cuam tshuam ntawm coronary stent: qhov kev sim ESPRIT: kev sim randomized tswj. JAMA. 2001; 285(19):2468-2473.
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