Kab mob kab mob plague veterinary care thiab kev tshawb fawb thoob ntiaj teb. Los ntawm lub plawv larvae ntsiag to tsim nyob rau hauv canine circulatory systems mus rau me me mites burrowing nyob rau hauv daim tawv nqaij, cov creatures xav tau kev kho mob zoo. Cov kws tshawb fawb thiab kws kho tsiaj sivmilbemycin oxime hmoovlos tawm tsam cov teeb meem kab mob sib txawv no, cov cuab yeej pov thawj nrog ntau xyoo ntawm kev kuaj mob validation.
Kev nkag siab txog qhov no macrocyclic lactone molecule cuam tshuam li cas rau ntau hom kab mob parasite yog qhov tseem ceeb rau kev tswj hwm tsiaj noj qab haus huv, kev tsim kho tshuaj, thiab kev tshawb fawb parasitology. Dav -spectrum antiparasitic agents muaj txiaj ntsig zoo tiv thaiv cov kab mob hauv nruab nrog cev thiab cov kab mob arthropod sab nraud, ua kom tiav cov txheej txheem tiv thaiv.
Kev siv tshuaj kho mob, cov dej num molecular, thiab kev tshawb fawb muaj peev xwm ntawm no ntau yam molecule piav qhia vim li cas nws tseem ua rau cov kab mob tswj hwm tam sim no thoob plaws hom thiab ecosystems.
Milbemycin Oxime hmoov
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
Rau dev: 2.3mg / 5.75mg / 11.5mg / 23.0mg
Rau miv: 5.75mg / 11.5mg / 23.0mg
(3) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-1-112
Milbemycin Oxime CAS 129496-10-2
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Dab tsi yog Daim Ntawv Thov Tseem Ceeb ntawm Milbemycin Oxime Powder hauv Kev Tshawb Fawb Parasite?
Cov koom haum tshawb fawb thiab cov chaw kho tsiaj thoob ntiaj teb siv milbemycin oxime hmoov rau kev tshawb xyuas kab mob parasitology. Cov kws tshawb fawb siv cov tshuaj no rau txhua yam los ntawm kev tshawb nrhiav neurotransmission mus rau tsiaj kho mob. Nws yog qhov zoo tshaj plaws los tsim cov ntaub ntawv hauv paus hauv kev tshawb fawb tshuaj tshuaj sib piv vim nws ua haujlwm hauv txhua qhov kev tshawb nrhiav.
Kev tshawb fawb tshawb fawb txog kev cuam tshuam txog kab mob parasite lifecycle siv cov tshuaj no. Cov kws tshawb fawb kawm seb cov tshuaj cuam tshuam li cas rau cov larvae rau cov neeg laus kom paub seb cov kab mob muaj sia nyob li cas. Cov kev tshawb fawb no nthuav dav cov qauv macrocyclic lactone tsis kam thiab pab txiav txim siab lub sijhawm kho kab mob.
Cov kws kho tsiaj kws kho tsiaj cov chaw soj nstuam siv cov tshuaj no los tshuaj xyuas cov tsiaj metabolism thiab faib cov ntaub so ntswg. Cov kev tshawb fawb no tshuaj xyuas seb cov tsiaj txhu, hnub nyoog, thiab lub cev li cas cuam tshuam rau kev nqus tshuaj thiab tshem tawm.
Kev kho mob thiab cov lus pom zoo txog kev nyab xeeb yog nyob ntawm cov ntaub ntawv no.
Kev tshawb fawb tshuaj siv tshuaj nrhiav cov tshuaj tiv thaiv kab mob tshiab siv milbemycin oxime ua tus qauv. Cov kev tshawb fawb txog kev ua tau zoo sib piv piv cov tshuaj tshiab rau yav tas los ua tau zoo, tshwj xeeb tshaj yog rau cov kab mob cab thiab arthropod parasites. Qhov kev sib koom ua ke no tso cai rau kev sib piv kev kawm muaj txiaj ntsig thiab ua kom yooj yim rau kev tswj hwm kev tshem tawm.
Environmental toxicology soj ntsuam seb cov tshuaj no puas nyob hauv cov xwm txheej thiab nws qhov cuam tshuam rau cov tsis yog -cov hom phiaj. Pharmaceuticals tau ntshai tsam ua paug av thiab dej. Qhov kev tshawb fawb no pab tsim cov qauv siv tsim nyog uas sib npaug cov txiaj ntsig kho mob thiab kev tiv thaiv ib puag ncig.
Milbemycin Oxime Powder rau Nematode Control thiab Veterinary Studies
Kev tshawb nrhiav Heartworm Prevention
Nyob rau hauv veterinary tshuaj,milbemycin oxime hmoovtau kawm ntau ntxiv los tiv thaiv dirofilariasis. Ntau qhov kev tshawb fawb tau pom tias nws tuaj yeem tshem tawm Dirofilaria immitis microfilariae ua ntej lawv dhau los ua cov kab mob loj. Cov kev tshawb fawb soj ntsuam nyob rau hauv cov chaw uas muaj mob nquag qhia tias kev kho mob raws sij hawm tiv thaiv ntau dua 98% ntawm cov tib neeg, ua rau nws txoj hauv kev zoo tshaj plaws los tiv thaiv nws.
Txoj kev kho no muaj txiaj ntsig zoo thoob plaws lub caij sib kis, raws li kev tshawb nrhiav ntev ntawm cov neeg kho tsiaj. Cov kws tshawb nrhiav pom tias kev tswj hwm tshuaj txhua hli tswj cov ntshav plasma siab txaus los tiv thaiv cov menyuam yaus uas tau txais tshiab los ntawm kev nkag mus rau cov ntaub so ntswg.
Cov kev tshawb fawb no ua rau cov kws kho tsiaj pom zoo xyoo - ntsuas kev nyab xeeb nyob rau hauv siab - thaj chaw muaj kev pheej hmoo. Cov kev tshawb fawb txog kev sib piv tshuaj ntsuam xyuas cov tshuaj- kev hloov pauv ntawm caj ces, tshwj xeeb hauv kev yug tsiaj dev nrog MDR1 kev hloov pauv noob.
Kev tshawb fawb pom tau hais tias cov tshuaj kho mob ib txwm siv ntawm avermectin muab qee qhov kev txhawj xeeb txog paj hlwb piv rau cov tshuaj zoo sib xws. Qhov no tso cai rau nws siv rau cov tsiaj uas tsis tuaj yeem tau txais qee yam tshuaj tiv thaiv kab mob. Cov neeg mob uas tsis muaj kev kho mob txaus tam sim no muaj ntau dua nrog qhov kev nyab xeeb no.
Kev tshem tawm ntawm plab hnyuv nematode
Kev tshawb fawb qhia tau hais tias plab hnyuv nematodes tua ntau yam dev thiab miv cab. Kev tshawb fawb qhia tias nws tawm tsam Toxocara canis, Toxascaris leonina, Ancylostoma caninum, thiab Trichuris vulpis ntawm lub neej sib txawv. Cov kev tshawb fawb Fecal qhia tau hais tias kev kho kom txo qis qe tso tawm hauv 48-72 teev, txwv tsis pub muaj kev cuam tshuam ib puag ncig thiab rov ua dua tshiab.
Veterinary teb kev tshawb fawb qhia cov pej xeem- theem tswj ua haujlwm hauv cov chaw nyob nrog ntau tus kab mob. Txij li kev kho mob loj txo cov kab mob hauv cov tsiaj txwv tsis pub, cov tshuaj no yuav siv tau ntau dua li kev saib xyuas tus neeg mob.
Cov kev tshawb fawb no qhia txog tsiaj kev siab hlub kev saib xyuas rau ntau yam tsiaj uas muaj kev puas tsuaj.
Kev saib xyuas kev tiv thaiv kev kawm yuav ua li cas qee yam ua haujlwm nyob rau lub sijhawm thiab hauv qhov chaw sib txawv. Tsis zoo li lwm cov chav kawm anthelmintic, cov ntaub ntawv soj ntsuam qhia pom tias hom kab kab mob no tsis tau txais kev tiv thaiv siab. Raws li tshuaj-cov kab mob resistant tau nce zuj zus nyob rau hauv cov kws kho tsiaj, kev tiv thaiv kev ruaj ntseg tseem ceeb.
Kev Tshawb Nrhiav Kev Kho Mob Sib Txuas
Cov kev tshawb fawb sib xyaw ua ke qhia pom tias milbemycin oxime ua haujlwm zoo dua nrog ntau cov tshuaj tiv thaiv kab mob. Praziquantel inhibits nematodes thiab cestodes;
Yog li ntawd, nws tuaj yeem kho ntau tus kab mob nrog rau ib koob, raws li kev tshawb fawb. Cov kev tshawb fawb no kawm txog kev sib txuas hauv metabolic kom txhawb nqa kev siv tshuaj.
Cov kev tshawb fawb soj ntsuam kuaj cov khoom sib xyaw ua ke los txhim kho -kev ua raws li lub neej tiag tiag. Cov tswv tsiaj nyiam kev kho mob tsis yooj yim dua li ntau cov tshuaj, raws li kev tshawb fawb kws kho tsiaj. Txoj kev tshawb no qhia tau hais tias kev txiav txim siab tsim tshuaj yuav cuam tshuam li cas los ntawm kev txhawb kom cov neeg siv ua raws li cov lus qhia.
Ntau -Kev tshawb fawb txog kev nyab xeeb ntawm tus neeg mob qhia tias cov khoom sib xyaw ua ke muaj kev nyab xeeb rau txhua lub hnub nyoog thiab lub cev muaj zog. Combination formula kev nyab xeeb txwv tau teeb tsa los ntawm kev tshawb fawb toxicology los txo qhov tsis zoo. Cov ntaub ntawv no pab soj ntsuam kev pom zoo ntawm ntau- cov khoom lag luam spectrum.
Milbemycin Oxime Powder cuam tshuam li cas rau cov kab mob hauv lub paj hlwb?
Glutamate-Gated Chloride Channels
Invertebrate glutamate-gated chloride channels rhuav tshem cov cab nrog milbemycin oxime hmoov. Parasites hlub vertebrate paj hlwb thiab cov leeg nqaij tsis muaj cov kab no. Cov kws tshawb fawb tau tshawb pom tias cov tshuaj tiv thaiv ruaj khov rau cov kab no, hloov kho lawv cov qauv kom ntev qhib. Parasite txav thiab noj cov neurotransmission yog impaired los ntawm hyperpolarization. Patch-clamp parasite neuron recordings qhia tau hais tias cov tshuaj hloov pauv kev ua tau zoo.
Qhov no qhia txog kev sib xyaw neurophysiology.
Tus qauv molecular qhia hom - tshwj xeeb channel protein khi qhov chaw. Cov txiaj ntsig no piav qhia tias vim li cas cov kab mob cab tsis cuam tshuam los ntawm cov tshuaj ntau dua li cov tsiaj txhu GABA receptors.Kev nkag siab ntawm cov noob caj noob ces pab cov kws kho tsiaj cawm tsiaj.
Comparative pharmacology kev tshawb fawb parasite rhiab heev, piav qhia txog kev kho mob sib txawv.
Cov channel subunit sib txawv ua rau arthropods ntau nematode-sensitive. Qhov kev tshawb nrhiav xaiv cov kab mob parasite- cov tshuaj tshwj xeeb.
Paralysis thiab Death Mechanisms
Neuromuscular txoj kev tshawb fawb qhia tau hais tias ntev - lub sij hawm ua kom channel flaccidly paralyzes parasites. Lub sij hawm-lapse microscopy qhia pom cov kab mob parasite immobilization pib feeb tom qab kis tau thiab xaus rau teev tom qab, nyob ntawm theem. Kev ceev ceev ntawm kev pub mis thiab rov tsim dua yog qhov tseem ceeb rau cov kab mob muaj sia nyob.
Kev tuag tes tuag taw hloov hlwb, raws li kev tshawb fawb electron microscopy ultrastructural qhia. Cov koob tshuaj kho mob ua rau cov kab mob ua kom tsis zoo rau cov leeg nqaij fibers thiab bulging mitochondria, qhia txog kev ua tsis tiav ntawm cov metabolism.
Subcellular hloov ua ntej kev tuag, qhia tau hais tias cov tshuaj lom ntau tshaj li thaiv cov hlab ntsha.
Kev tshawb fawb ib puag ncig qhia pom tias cov kab mob tsis taus tuaj yeem rov qab los ntawm cov tswv. Milbemycin ua rau tuag tes tuag taw tom qab tshem tawm, tsis zoo li lwm yam tshuaj. Qhov no ncua kev kho mob los ntawm kev tiv thaiv cov kab mob tuag.
Ntshav-Brain Barrier Protection
Mammalian hlwb system kev tshawb fawb neurosafety qhia rau kws kho tsiaj siv.Milbemycin Oxime hmoovtej zaum yuav tsis nkag mus rau cov ntshav mammalian- hlwb teeb meem. Yog tsis muaj cov teeb meem no, nws tuaj yeem cuam tshuam cov kab mob hauv cov hlab ntsha. Kev nyab xeeb tshuaj rau cov tsiaj kho yog vim muaj kev hloov pauv permeability.
P-glycoprotein transporter kev tshawb fawb qhia pom cov txheej txheem tso tawm uas tiv thaiv CNS cov piam thaj hauv cov tsiaj ib txwm. MDR1- cov tsiaj tsis muaj peev xwm pom tau tias muaj lub hlwb ntau dua, tab sis cov tshuaj muaj kev nyab xeeb ntawm cov koob tshuaj pom zoo, tsis zoo li lwm tus.Cov ntaub ntawv txheeb xyuas no txiav txim siab txog cov koob tshuaj tshwj xeeb thiab txaus ntshai.
Cov kev tshawb fawb txog kev sib piv toxicity qhia tau tias cov tshuaj kho tau ntau dua 10 npaug siab dua rau feem ntau hom tsiaj. Kev sim kev nyab xeeb loj dua qhia pom qhov tsis sib xws ntawm cov kab mob parasite- tua thiab sab - cuam tshuam - ua rau muaj ntau ntau. Cov ntaub ntawv no txhawb kev ntseeg siab siv kev kho mob nrog ntau pab pawg neeg mob.
Milbemycin Oxime Powder hauv Kev Tshawb Fawb Txog Mites thiab Lwm Cov Ectoparasites
Sarcoptic Mange Treatment Studies
Kev tshawb fawb dermatological qhia tau hais tias nws ua haujlwm zoo heev tiv thaiv Sarcoptes scabiei mites, uas ua rau khaus khaus ntawm daim tawv nqaij. Hauv kev tshawb fawb soj ntsuam, cov txheej txheem kho mob tau coj mus rau kev kho mob ntawm qhov txhab thiab tshem tawm cov kab mob. Cov tawv nqaij scrapings pom tau tias cov mites maj mam txo. Cov kev tshawb fawb histopathological qhia tau hais tias raws li mite loads nqis, inflammatory infiltrates nqis mus, uas yog nyob rau hauv txoj kab nrog kev kho mob.
Cov kev tshawb fawb txog kev kho mob sib piv piv rau milbemycin oxime hmoov rau lwm cov tshuaj acaricides hauv cov pab pawg ntawm cov tsiaj muaj mob. Tsis tsuas yog cov kev tshawb fawb no saib xyuas seb puas muaj kab mob ntau npaum li cas kho tau, tab sis lawv kuj saib cov khoom xws li kev kho mob zoo li cas thiab zoo siab npaum li cas cov tswv nrog nws.
Cov txiaj ntsig yeej ib txwm qhia tau zoo, tshwj xeeb tshaj yog thaum piv rau cov tshuaj pleev ib ce uas yuav tsum tau siv ntau dua ib zaug ntawm kev siv yooj yim thiab kev txais tsiaj.
Kev soj ntsuam kev tiv thaiv nyob rau hauv cov kab mob mite khaws cov kev hloov pauv ntawm qhov yooj yim npaum li cas lawv kis mob thaum lub sijhawm thiab nyob rau ntau qhov chaw. Cov ntaub ntawv tsis ntev los no qhia tau tias cov tshuaj tseem ua haujlwm zoo yam tsis muaj kev tiv thaiv ntau, tab sis nws tseem ceeb heev uas yuav tsum tau saib xyuas nws. Cov txheej txheem tshawb fawb ua cov kev sim ua kom zoo sib xws kom cov kev tshawb fawb tuaj yeem muab piv rau txoj hauv kev muaj txiaj ntsig thiab kev tawm tsam tshiab tuaj yeem pom sai.
Kev tshawb nrhiav Demodex Mite
Cov kws tshawb fawb kawm txog Demodex canis kab mob tab tom saib seb cov tshuaj no tuaj yeem pab tswj cov kab mob follicle tawv li cas.
Cov kev tshawb fawb qhia tau hais tias qhov ua tau zoo sib txawv raws li qhov kev siv ntawm tus kab mob thiab lub xeev ntawm lub cev tiv thaiv kab mob. Piv txwv li, thoob plaws demodicosis xav tau kev kho mob ntev dua. Cov txheej txheem soj ntsuam saib mus rau qhov zoo tshaj plaws ntawm cov koob tshuaj thiab lub sijhawm ntev uas yuav tsum tau tshem tawm cov kab mob hauv ntau hom neeg mob.
Kev tshawb fawb txog kev tiv thaiv kab mob yog sim xyuas seb vim li cas qee tus tsiaj tau txais Demodex uas tsis tuaj yeem nres thaum lwm tus tsuas yog nqa tus kab mob tsis muaj tsos mob. Cov kev tshawb fawb uas siv kev kho mob milbemycin nrog rau kev ntsuas kev tiv thaiv kab mob qhia tau tias kev tswj cov kab mob parasites thiab kho tus tswv tsev tiv thaiv kab mob yog ob yam sib txawv heev uas cuam tshuam rau ib leeg hauv txoj hauv kev nyuaj.
Cov txiaj ntsig no pab cov thawj coj tuaj nrog cov phiaj xwm ua tiav uas cuam tshuam nrog cov kev xav hauv qab.
Kev tshawb fawb txog cov menyuam yaus hnub nyoog qis dua - pib demodicosis saib txoj hauv kev zoo tshaj plaws los kho tus mob thiab nws cuam tshuam rau tib neeg lub sijhawm. Cov kws tshawb fawb uas ua raws li cov dev kho los ntawm cov neeg laus cov ntaub ntawv daws teeb meem thiab rov ua dua. Qhov no muab cov ntaub ntawv vets lawv tuaj yeem siv los pab cov tswv txiav txim siab. Cov ntaub ntawv txuas ntxiv no pab peb kawm paub ntau ntxiv txog seb cov kab mob ua tiav li cas thiab kev kho mob cuam tshuam rau lawv li cas.
Otoacariasis Control
Cov kws tshawb fawb tau pom tias pob ntseg tuaj yeem kis tau ob tus dev thiab miv nrog Otodectes cynotis.
Systemic milbemycin kev tswj hwm thiab tshuaj pleev acaricides tau muab piv rau hauv cov kev tshawb fawb uas saib xyuas kev ua raws cai thiab kev kho tus nqi. Cov txiaj ntsig tau pom muaj txiaj ntsig zoo sib xws, nrog cov txiaj ntsig tau zoo ntawm kev xa khoom yooj yim, tshwj xeeb tshaj yog nyob rau hauv cov tsiaj uas chim siab thiab tsis xav kom lawv lub pob ntseg kov.
Ntau-Kev tshawb fawb tsiaj hauv tsev saib seb nws ua haujlwm zoo npaum li cas rau kev kho txhua tus tsiaj tib lub sijhawm, uas txwv tsis pub rov- kis kab mob uas tuaj yeem tshwm sim hauv pab pawg neeg nyob. Kev tshawb fawb ib puag ncig hauv cov tsev kho mob qhia pom tsawg dua mites pom hauv txaj thiab cov cuab yeej tu. Qhov no qhia tau hais tias kev kho mob muaj txiaj ntsig rau ib puag ncig tshaj li tsuas yog tua kab mob ntawm cov tsiaj.
Tshawb nrhiav qhov Broader Parasite Control Potential ntawm Milbemycin Oxime Powder
Flea Life Cycle Disruption
Kev tshawb fawb Entomological saib seb yam twg cuam tshuam rau fleas ntawm ntau theem ntawm txoj kev loj hlob, qhia tias kev kho tsiaj ib puag ncig tuaj yeem tua cov flea larvae thiab pupae. Cov neeg laus fleas xav tau kev kho mob sib txawv, tab sis kev sim tau pom tiasmilbemycin oxime hmoovtxwv cov dev mub los ntawm kev yug me nyuam thaum lawv pub rau cov tswv tsev kho mob. Thaum siv los ua ib feem ntawm txoj kev tswj xyuas kab tsuag sib xyaw, qhov kev cuam tshuam nrog kev loj hlob tuaj yeem pab txo qis cov pej xeem.
Raws li ib feem ntawm ntau- txoj hauv kev, kev tshawb fawb ib puag ncig siv cov khoom no los taug qab seb cov neeg dev mub hloov pauv hauv tsev li cas. Kev sib koom ua ke kev kho mob nrog kev tswj hwm ib puag ncig thiab kev tua neeg laus ua rau cov pej xeem poob qis, raws li cov ntaub ntawv.
Qhov tseeb tias cov kev sib xyaw ua ke no ua haujlwm zoo dua li ib qho qhia tau hais tias qhov sib xyaw tseem ceeb npaum li cas nyob rau hauv tag nrho cov kev tswj flea.
Emerging Parasite Targets
Cov kws tshawb fawb tab tom saib mus rau hauv kev siv tau los tiv thaiv kab mob uas mus dhau qhov kev siv li niaj zaus. Cov kws tshawb fawb tau pom cov txiaj ntsig sib xyaw thaum lawv saib seb hom zuam sib txawv ua haujlwm zoo li cas. Lawv pom tias lawv tsis muaj ntau qhov cuam tshuam ncaj qha rau cov neeg laus cov zuam uas txuas nrog, tab sis lawv yuav muaj kev cuam tshuam rau kev loj hlob thiab kev loj hlob. Cov kev tshawb fawb tshawb fawb no pom qhov tsis sib xws hauv peb txoj kev paub uas yuav tsum tau muaj kev tshawb fawb ntxiv.
Cov kab mob parasite tshawb nrhiav tshuaj tiv thaiv cov kab mob tsawg dua pom hauv cov tsiaj txawv teb chaws lossis hauv cov neeg uas muaj cov tsos mob txawv txawv.
Cov ntaub ntawv tshawb fawb pom tau tias muaj kev kho mob zoo ntawm cov kab mob uas feem ntau tsis pom hauv chaw kho mob. Qhov no nthuav dav ntau yam ntawm kev siv tshuaj kho mob. Cov ntawv ceeb toom no pab peb kawm paub ntxiv txog yam tshuaj no tuaj yeem ua li cas.
Resistance Management Strategies
Txhawm rau ua haujlwm tau zoo nyob rau lub sijhawm, cov kev tshawb fawb parasitology uas saib kev siv cov kev coj ua zoo xyuas cov kev sib hloov thiab sib xyaw ua ke. Cov qauv kev tshawb fawb kwv yees thaum qhov kev tawm tsam yuav tshwm sim hauv kev siv sib txawv. Qhov no pab ua cov lus qhia sib npaug ntawm qhov xav tau kev kho mob tam sim nrog qhov xav tau los tiv thaiv cov tshuaj rau yav tom ntej. Antiparasitic tshuaj tau pom nyob rau hauv cov kev tshawb fawb no raws li cov peev txheej tsawg uas yuav tsum tau tswj kom zoo.
Molecular surveillance cov kev pab cuam khaws lub qhov muag ntawm cov kab mob parasite rau cov cim caj ces txuas rau kev tiv thaiv. Txoj kev tshawb nrhiav ntxov sim nrhiav kev tawm tsam ua ntej nws kis mus rau ntau tus neeg mob, kom tswj tau txav mus ua ntej muaj teeb meem tshwm sim. Cov txheej txheem tshawb fawb qhia cov txheej txheem sim kom cov ntaub ntawv tuaj yeem sib koom yooj yim ntawm pawg tshawb fawb thiab ntawm ntau qhov chaw hauv ntiaj teb.
Xaus
Milbemycin Oxime hmoovmuaj ntau qhov chaw kho mob thiab kev tshawb fawb siv rau cov teeb meem kab mob sib txawv. Qhov no qhia tau hais tias nws muaj txiaj ntsig zoo li cas rau cov kws kho tsiaj thiab kev tshawb fawb parasitology. Cov tshuaj no muaj txiaj ntsig zoo rau ntau yam, los ntawm kev tiv thaiv kab mob plawv uas muaj kev phom sij heev kom tshem tawm cov teeb meem mite uas ua rau muaj kev ntxhov siab heev. Muaj pov thawj kev tshawb fawb muaj zog los txhawb qhov no. Nws cov txheej txheem xaiv tau tsom mus rau cov kab mob neurotransmission hauv cov neeg tsis muaj zog thaum tsis muaj cov kab mob mammalian. Qhov no yog qhov ua rau nws muaj kev nyab xeeb zoo uas cia cov neeg mob rhiab heev siv nws nrog kev ntseeg siab.
Peb tseem tab tom kawm ntxiv txog txoj hauv kev zoo tshaj plaws los siv cov khoom sib xyaw no, yuav ua li cas ua ke nrog lwm cov tshuaj, thiab yuav ua li cas nws tuaj yeem pab tiv thaiv kab mob tshiab. Cov kws kho tsiaj tuaj yeem ntseeg siab pom zoo cov cuab yeej tiv thaiv kab mob pov thawj no vim tias nws tau siv hauv tsev kho mob ntau xyoo thiab tseem tab tom kawm los ntawm cov kws tshawb fawb.
Ua haujlwm nrog cov kws kho mob paub txog uas paub txog cov qauv thiab cov kev cai zoo yog qhov zoo rau cov koom haum thiab cov tub ntxhais kawm tab tom nrhiav cov kws kho mob muaj txiaj ntsig zoo - cov ntaub ntawv qib rau kev tshawb fawb parasitology lossis kev siv kws kho tsiaj. Nws tseem yog ib qho tseem ceeb uas yuav tsum muaj kev nkag tau mus rau qib siab - cov khoom sib txuas zoo kom paub ntau ntxiv txog tsiaj kev noj qab haus huv thiab kev tswj kab mob cab.
FAQ
1. Dab tsi ua rau milbemycin oxime hmoov zoo tiv thaiv nematodes thiab ectoparasites?
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Qhov sib xyaw ua ke ntau qhov cuam tshuam yog vim qhov tseeb tias nws lub hom phiaj glutamate -gated chloride channels pom nyob rau hauv ntau lub paj hlwb invertebrate. Cov kab no ua haujlwm nrog ob qho tib si hauv cov kab mob nematode thiab lwm hom kab mob arthropod, yog li ib qho sib xyaw tuaj yeem tua ntau dua ib hom kab mob. Cov channel subtypes sib txawv ua rau nws tsawg dua lossis zoo dua tiv thaiv ntau hom kab mob parasites, tab sis cov tshuaj kho mob muaj zog txaus los tswj cov kab mob feem ntau hauv txoj hauv kev uas muaj txiaj ntsig zoo rau cov tshuaj.
2. Milbemycin oxime hmoov piv rau ivermectin li cas rau kev tswj cov kab mob parasite?
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Milbemycin tsis tshua muaj peev xwm ua rau neurotoxicity hauv cov tsiaj nrog MDR1 kev hloov pauv caj ces, txawm tias ob qho tib si yog macrocyclic lactones thiab ua haujlwm zoo sib xws. Raws li kev tshawb fawb, nws tseem ua haujlwm tawm tsam feem ntau ntawm cov kab mob parasites uas raug tsom, thiab nws muaj kev ruaj ntseg ntau dua hauv cov pab pawg uas muaj kev pheej hmoo ntau dua. Nws tsis yog ib txwm paub meej tias qhov twg yog qhov zoo dua vim nws nyob ntawm tus kab mob uas tau kho, tus neeg mob, thiab qhov kev tawm tsam hauv cheeb tsam.
3. Dab tsi concentration thiab purity theem yog tsim nyog rau kev tshawb fawb daim ntaub ntawv?
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Rau kev tshawb fawb- cov ntaub ntawv qib, lawv feem ntau yuav tsum muaj tsawg kawg yog 98% ntshiab, uas tuaj yeem ua pov thawj los ntawm HPLC kev tshuaj xyuas thiab tuaj nrog cov ntawv pov thawj uas qhia cov impurity profiles. Kev xav xav tau hloov pauv nyob ntawm seb qhov kev sim tau teeb tsa li cas. Pure hmoov muab kev ywj pheej tshaj plaws rau koj los ua koj tus kheej cov kev daws teeb meem, thaum ua ntej - cov ntaub ntawv ua haujlwm zoo tshaj plaws nrog cov txheej txheem txheej txheem. Thaum cov kws tshawb fawb nrhiav cov ntaub ntawv, lawv yuav tsum paub meej txog qhov lawv xav tau, suav nrog cov ntaub ntawv tshawb fawb uas lawv xav tau. Qhov no yog kom paub tseeb tias cov ntaub ntawv yuav ua haujlwm rau lawv qhov kev npaj siv.
Koom tes nrog Bloomtechz rau hwm Milbemycin Oxime Powder Supply
Yog tias koj xav tau tshuaj -qib milbemycin oxime hmoov cov khoom siv rau koj txoj kev kawm lossis kev lag luam kws kho tsiaj, Bloomtechz tuaj yeem pab. Lawv qhov zoo yog qhov tsis sib xws, thiab lawv muaj tag nrho cov ntawv pov thawj tsim nyog los thim nws. Peb 100,000-square-meter GMP-certified cov chaw tsim khoom ua tau raws li cov qauv tsim los ntawm US FDA, EU, Nyiv, thiab Tuam Tshoj. Qhov no ua kom paub tseeb tias txhua batch ua tau raws li cov kev xav tau ntawm kev cai lij choj txawv teb chaws. Peb tau ua cov kws tshaj lij hauv cov organic synthesis thiab tshuaj intermediates rau ntau tshaj 12 xyoo. Peb muab cov hmoov API ntshiab nrog rau cov qauv kev cai, xws li cov ntsiav tshuaj thiab cov ntaub ntawv qhia meej, uas yog tsim los kom haum rau koj txoj kev xav tau.
Peb peb -tier kev ruaj ntseg system- Hoobkas kuaj, kev soj ntsuam hauv QA / QC, thiab kev txheeb xyuas los ntawm peb tus neeg thib peb-tsoomfwv tog- kom ntseeg tau tias tag nrho peb cov ntaub ntawv zoo ib yam thiab dawb huv. Raws li cov neeg muab kev pom zoo rau 24 lub tuam txhab tshuaj thoob ntiaj teb, peb paub tias nws tseem ceeb npaum li cas kom muaj kev sib txuas lus meej, cov ntaub ntawv raug, thiab lub sij hawm ua cov khoom lag luam. Peb qhov ruaj khov - cov nqi sib tw ua kom paub tseeb tias koj tau txais cov nqi sib tw yam tsis muaj kev cuam tshuam zoo, txawm tias koj xav tau me me rau kev kawm lossis ntau ntau rau kev tsim khoom.
Koj tuaj yeem tham nrog peb pab pawg kws tshaj lij ntawmSales@bloomtechz.comtxog kojmilbemycin oxime hmoovxav tau, nug rau cov ntaub ntawv ntawm kev tsom xam, los yog saib mus rau hauv kev cai synthesis xaiv. Peb xav kom koj ua tiav thaum koj ua haujlwm txhawm rau txhawm rau tshawb fawb txog tsiaj noj qab haus huv thiab kab mob parasitology.
Cov ntaub ntawv
1. Campbell WC, Benz GW. "Ivermectin: Kev Tshawb Fawb Txog Kev Ua Haujlwm thiab Kev Nyab Xeeb." Phau ntawv Journal of Veterinary Pharmacology and Therapeutics, vol. 7, no. 1, 1984, pp. 1-16.
2. Prichard RK. "Macrocyclic Lactones: Hom Kev Ua Haujlwm thiab Kev Ua Haujlwm." Hauv: Vercruysse J, Rew RS, editors. Macrocyclic Lactones hauv Antiparasitic Therapy. CABI Publishing, 2002, pp. 125-140.
3. Shoop WL, et al. "Neurotransmission thiab Anthelmintic Drug Action." Parasitology Today, vol. 11, no. 10, 1995, pp. 353-357.
4. Mealey KL, Bentjen SA, Gay JM, Cantor GH. "Ivermectin Sensitivity nyob rau hauv Collies yog txuam nrog kev hloov pauv ntawm MDR1 Gene." Pharmacogenetics, vol. 11, no. 8, 2001, pp. 727-733.
5. Geary TG, Bourguinat C, Prichard RK. "Cov pov thawj rau Macrocyclic Lactone Anthelmintic Resistance hauv Dirofilaria immitis." Topics in Companion Animal Medicine, vol. 26, no. 4, 2011, pp. 186-192.
6. Plum DC. "Milbemycin Oxime." Hauv: Plumb's Veterinary Drug Handbook, 9th Edition. Wiley-Blackwell, 2018, pp. 1089-1092.