Paeoniflorin, tseem hu ua Peoniflorin, yog monoterpene glycoside muab rho tawm los ntawm cov hauv paus hniav ntawm cov nroj tsuag Paeonia lactiflora, ib hom ntawm tsev neeg Ranunculaceae. Cov tshuaj no tau txais kev saib xyuas tseem ceeb hauv cov tshuaj suav tshuaj (TCM) vim nws muaj ntau yam kev ua haujlwm tshuaj thiab muaj peev xwm kho tau. Kab lus no delves rau hauv kev tshawb fawb ib puag ncig paeoniflorin, tshawb txog nws cov peev txheej, cov khoom siv tshuaj, cov txheej txheem ntawm kev ua, thiab kev siv tshuaj kho mob.
Peb muab Paeoniflorin CAS 23180-57-6, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Khoom siv:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/paeoniflorin-cas-23180-57-6.html
Qhov chaw ntawm Paeoniflorin
Paeoniflorin feem ntau pom muaj nyob hauv cov hauv paus hniav ntawm Paeonia lactiflora, nrog rau lwm yam tsiaj xws li Paeonia suffruticosa thiab Paeonia officinalis. Cov nroj tsuag no ib txwm siv hauv Suav tshuaj rau lawv cov khoom kho mob. Kev rho tawm thiab ua kom huv ntawm paeoniflorin koom nrog ntau yam txuj ci, suav nrog kev tshem tawm cov kuab tshuaj, adsorption resin refinement, chromatography, thiab lwm yam. Cov kws tshawb fawb tau tshawb nrhiav tsis tu ncua los txhim kho cov txheej txheem no txhawm rau txhim kho cov txiaj ntsig thiab purity ntawm paeoniflorin.
Hauv TCM, paeoniflorin muaj npe nrov rau nws cov txiaj ntsig kho mob ntau yam. Nws muaj antioxidant zog, muaj peev xwm tiv thaiv oxidative kev nyuaj siab puas tsuaj rau cov ntaub so ntswg hlwb. Tsis tas li ntawd, nws inhibits kev ua haujlwm ntawm astrocytes thiab txhim kho cov teebmeem neuroprotective, qhia qhov tseem ceeb antagonism tiv thaiv kev puas tsuaj rau dopaminergic neurons hauv striatum thiab substantia nigra. Cov khoom no ua rau nws siv los kho cov kab mob neurological xws li Alzheimer's disease, Parkinson's disease, thiab qaug dab peg.
Tshaj li kev siv paj hlwb, paeoniflorin qhia txog kev ua haujlwm ntawm cov qog nqaij hlav thiab muaj txiaj ntsig zoo hauv cov kab mob autoimmune xws li mob caj dab rheumatoid thiab ankylosing spondylitis. Cov kev tshawb fawb tsiaj kuj tau pom tias nws txo qis cov ntshav qab zib thiab tiv thaiv cov hlwb cardiopulmonary. Clinically, nws yog siv los kho cov kab mob hauv lub plawv thiab ua ib qho kev pab cuam hauv kev tswj cov kab mob ua pa ntev hauv cov neeg laus, txhim kho kev tiv thaiv kab mob thiab muab cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab expectorant.
Hauv cov ntsiab lus, paeoniflorin, nrog nws cov kev kho mob sib txawv thiab kev siv tshuaj kho mob dav dav, yog ib qho pov thawj rau kev txawj ntse hauv cov tshuaj suav tshuaj. Nws lub peev xwm los daws ntau yam kev txhawj xeeb txog kev noj qab haus huv, los ntawm cov kab mob hauv lub paj hlwb mus rau cov kab mob autoimmune, qhia txog nws qhov tseem ceeb hauv cov tshuaj niaj hnub sib xyaw.
Pharmacological Properties ntawm Paeoniflorin
Paeoniflorin muaj ntau yam khoom siv tshuaj uas pab txhawb rau nws cov txiaj ntsig kho mob. Cov no suav nrog cov tshuaj tua kab mob antioxidant, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob sib kis, vasodilatory, thiab cov haujlwm tiv thaiv neuroprotective.
Antioxidant Kev Ua Haujlwm
Paeoniflorin nthuav tawm cov khoom antioxidant los ntawm kev tshem tawm cov dawb radicals thiab txhim kho cov haujlwm ntawm cov enzymes antioxidant xws li superoxide dismutase (SOD), glutathione (GSH), thiab catalase (CAT). Qhov kev ua no pab tiv thaiv cov hlwb los ntawm oxidative kev nyuaj siab vim kev puas tsuaj.
01
Anti-inflammatory kev ua
Paeoniflorin tau pom tias inhibit zus tau tej cov inflammatory cytokines thiab nitric oxide (NO), yog li txo qhov mob. Qhov no ua rau nws muaj peev xwm sib tw rau kev kho cov kab mob inflammatory.
02
Antiplatelet Aggregatory Activity
Paeoniflorin nthuav tawm cov nyhuv antiplatelet aggregatory, uas tuaj yeem pab tiv thaiv kev tsim cov ntshav txhaws. Cov cuab yeej no tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm cov kab mob plawv.
03
Vasodilatory kev ua
Paeoniflorin tau pom los ua kom cov hlab ntsha so, ua rau txo cov ntshav siab thiab txhim kho cov ntshav ncig.
04
Kev Ua Haujlwm Neuroprotective
Kev tshawb fawb tsis ntev los no tau qhia txog cov teebmeem neuroprotective ntawm paeoniflorin. Nws tuaj yeem tiv thaiv cov neurons los ntawm oxidative kev nyuaj siab, inhibit neuronal apoptosis, thiab txhawb nqa neurogenesis. Cov khoom no qhia tias nws muaj peev xwm siv tau los kho cov kab mob neurodegenerative.
05
Mechanisms ntawm Action
Cov kev ua ub no muaj ntau yam tshuaj ntawm paeoniflorin yog kho los ntawm ntau yam kev ua haujlwm.
Txoj cai ntawm Oxidative Stress
Paeoniflorin txhim khu kev ua haujlwm ntawm antioxidant enzymes thiab scavenges reactive oxygen hom (ROS), yog li txo oxidative kev nyuaj siab. Qhov no pab tiv thaiv cov hlwb los ntawm kev puas tsuaj los ntawm oxidative kev nyuaj siab.
01
Modulation of Inflammatory Pathways
Paeoniflorin inhibits zus tau tej cov inflammatory cytokines thiab TSIS los ntawm kev tswj cov kev ua ntawm inflammatory signaling txoj kev xws li NF-κB thiab MAPK. Qhov no pab txo qhov mob thiab cov ntaub so ntswg puas.
02
Inhibition ntawm Platelet Aggregation
Paeoniflorin inhibits kev sib sau ntawm cov platelets los ntawm inhibiting cov haujlwm ntawm ADP thiab thromboxane A2 receptors, yog li tiv thaiv kev tsim cov ntshav txhaws.
03
Vasodilation
Paeoniflorin txo cov hlab ntsha los ntawm inhibiting kev ua ntawm vasoconstrictor tshuaj xws li angiotensin II thiab endothelin-1. Qhov no ua rau txo cov ntshav siab thiab txhim kho cov ntshav ncig.
04
Neuroprotection
Paeoniflorin tiv thaiv cov neurons los ntawm oxidative kev nyuaj siab, inhibits neuronal apoptosis, thiab txhawb neurogenesis los ntawm ntau yam mechanisms, nrog rau kev ua kom cov adenosine A1 receptors, kev cai ntawm MAPK, PI3K / Akt, thiab Nrf2 / ARE teeb liab txoj kev.
05
Muaj peev xwm siv tshuaj kho mob
Raws li nws cov tshuaj pharmacological thiab cov txheej txheem ntawm kev ua, paeoniflorin tau pom cov lus cog tseg hauv kev kho mob ntawm ntau yam kab mob.
Cov Kab Mob Neurodegenerative
Cov teebmeem neuroprotective ntawm paeoniflorin qhia tias nws muaj peev xwm siv tau los kho cov kab mob neurodegenerative xws li Alzheimer's disease, Parkinson's disease, thiab cerebral ischemia.
Cov kab mob plawv
Cov tshuaj antiplatelet aggregatory thiab vasodilatory kev ua ub no ntawm paeoniflorin ua rau nws muaj peev xwm sib tw rau kev kho cov kab mob plawv xws li kub siab, atherosclerosis, thiab myocardial infarction.
Kab mob o
Cov tshuaj tiv thaiv kab mob ntawm paeoniflorin tuaj yeem muaj txiaj ntsig zoo hauv kev kho mob inflammatory kab mob xws li mob caj dab rheumatoid, kab mob plab hnyuv, thiab psoriasis.
Mob qog noj ntshav
Cov kev tshawb fawb ua ntej tau pom tias paeoniflorin nthuav tawm cov haujlwm antitumor los ntawm inhibiting kev loj hlob thiab tsiv teb tsaws ntawm cov qog nqaij hlav cancer. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau kom paub meej tias nws cov txiaj ntsig zoo hauv kev kho mob qog noj ntshav.
Cov kev sib tw thiab cov kev taw qhia yav tom ntej
Txawm hais tias muaj kev vam meej kev tshawb fawb nyob ib puag ncig paeoniflorin, ntau qhov kev sib tw tseem nyob. Kev rho tawm thiab ua kom huv ntawm paeoniflorin los ntawm cov khoom siv ntuj yog siv zog thiab siv sijhawm. Tsis tas li ntawd, kev sib cais ntawm paeoniflorin los ntawm lwm cov tshuaj sib xws xws li albiflorin tseem yog ib qho kev sib tw. Tsis tas li ntawd, kev soj ntsuam kev ua tau zoo thiab kev nyab xeeb ntawm paeoniflorin yuav tsum tau soj ntsuam ntxiv hauv kev sim tshuaj loj.
Kev tshawb fawb yav tom ntej yuav tsum tsom mus rau kev txhim kho cov kev rho tawm thiab kev ua kom huv ntawm paeoniflorin, tshawb nrhiav nws cov txiaj ntsig muaj txiaj ntsig nrog lwm cov tshuaj sib xyaw, thiab ua cov kev sim tshuaj nruj dua kom siv tau nws cov txiaj ntsig kho. Tsis tas li ntawd, cov txheej txheem ntawm kev txiav txim ntawm paeoniflorin nyob rau hauv ntau yam kab mob yuav tsum tau ntxiv elucidated los pab txhawb txoj kev loj hlob ntawm ntau hom kev kho mob.
Xaus
Paeoniflorin, monoterpene glycoside muab rho tawm los ntawm cov hauv paus hniav ntawm Paeonia lactiflora, nthuav tawm ntau yam tshuaj muaj txiaj ntsig uas ua rau nws muaj txiaj ntsig zoo rau kev kho mob ntawm ntau yam kab mob. Nws cov tshuaj tiv thaiv kab mob antioxidant, tiv thaiv kab mob, tshuaj tiv thaiv kab mob, vasodilatory, thiab neuroprotective kev ua ub no pab txhawb rau nws cov txiaj ntsig kho mob. Txawm li cas los xij, ntau qhov kev sib tw tseem nyob ua ntej paeoniflorin tuaj yeem siv dav hauv kev kho mob. Kev tshawb fawb yav tom ntej yuav tsum tsom mus rau kev txhim kho kev rho tawm thiab kev ua kom huv huv, tshawb nrhiav cov txiaj ntsig zoo sib xws, thiab ua cov kev sim tshuaj ntsuam xyuas kom paub tseeb tias nws cov txiaj ntsig kho tau zoo. Nrog kev tshawb fawb txuas ntxiv thiab kev txhim kho, paeoniflorin tuaj yeem dhau los ua cov cuab yeej tseem ceeb hauv kev kho mob ntawm ntau yam kab mob, pab txhawb rau kev hloov kho tshiab thiab thoob ntiaj teb ntawm cov tshuaj suav tshuaj.