Gs -441524, ib lub peev xwm ntawm lub ntiaj teb kev sib kis, cov kws kho tsiaj txhu hauv nws cov kws kho mob lub cev (FARTH). hauv qhov no Kev tshawb nrhiav, peb yuav tshuaj xyuas qhov nqus, bioavailability, metabolism, thiab muaj peev xwm ntawmGs 441524 Hmoovlos hla cov ntshav-lub hlwb lub teeb rau nws cov txiaj ntsig zoo li cov tshuaj fip noj tshuaj.
1. General Specification (hauv Tshuag)
(1) kev txhaj tshuaj
20mg, 6ml; 30Mg, 8ml; 40mg, 10ml
(2) Ntsiav tshuaj
25/45 / 60/0mg
(3) API (hmoov ntshiab)
(4) ntsiav tshuaj xovxwm tshuab
https: // www . . com / ntsiav tshuaj-ncej
2. Kev Customization:
Peb yuav sib tham ntawm ib leeg zuj zus, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm tsuas yog .
Intern Code: BM -2-1-049
Gs -441524 CAS 1191237-69-0
Kev tsom xam: HPLC, LC-MS, HNMR
Kev txhawb thev naus laus zis: R & Dept .-4
Peb muab GS 441524 hmoov, thov saib cov vev xaib hauv qab no rau cov ncauj lus kom ntxaws thiab cov khoom lag luam {}}
Khoom:https: // www . bloomtechz. com / synthetic-inclediates / gs {}} HTML
Kev nqus thiab bioavailability ntawm gs -441524 hmoov hauv miv
Nkag siab txog kev nqus thiab bioavailability ntawm gs -441524 yog qhov tseem ceeb hauv kev kho cov xov tooj uas tus kab mob uas tus kab mob nyob rau hauv.
Cov plab zom movte nqus ntawm gs -441524
Thaum muab cov ncauj lus, gs -441524 Undergoes tau sib txawv nyob rau hauv lub plab hnyuv {2} Txawm li cas los xij, suav nrog cov khoom noj hauv plab me me, suav nrog cov khoom noj hauv plab me me, suav nrog cov khoom noj hauv plab me me, muaj cov khoom noj, thiab cov khoom noj muaj sia qhov sib txawv.
Bioavailability tshwj xeeb gs -441524 ua hauj lwm zoo
Cov xyoob ntawm gs -441524 Hais txog qhov kev coj ua uas tau pom tias muaj qhov sib luag ntawm cov khoom tsis sib xws kuj muaj siab, feem ntau yog xws li los ntawm 70-80% . cov peev xwm loj no muaj txiaj ntsig zoo li ibFip Medicalation, tso cai rau ib feem tseem ceeb ntawm cov tshuaj kom ncav cuag nws cov hom phiaj npaj .
Kev cuam tshuam ntawm kev tsim kho ntawm kev nqus
Cov qauv ntawm GS 441524 hmoov tuaj yeem cuam tshuam nws cov ntawv nqus kom nrawm dua, muaj qee qhov kev sib xyaw ua ke
Ib nrab-lub neej thiab cov metabolism: ntev npaum li cas gs -441524 Ua kom nquag ua haujlwm?
Lub sijhawm ntawm gs -441524 'to taub cov regimens thiab ntsuas nws lub neej tseem ceeb hauv kev tswj hwm lub ntsej muag thiab cov metabolism tau muab cov khoom lag luam zoo rau hauv nws cov khoom siv tshuaj kom muaj txiaj ntsig zoo {}}
Ntshav ib nrab-lub neej ntawm gs -441524
Lub Plasma ib nrab-lub neej ntawm gs -441524 Qhov tseem ceeb no kom nco ntsoov tias yog qhov ua tau zoo ib txwm muaj rau cov metabolation feem ntau yuav ntev dua, txhawb nqa antiviral cuam tshuam ntawm koob tshuaj .
Cov kev metabolic thiab tshem tawm
Gs -441524}, siv davFip Medicalation, undergoes metabolism feem ntau yog hloov dua siab tshiab rau cov kev ua haujlwm ntawm lub cev, nrog rau kev ua haujlwm me me, nrog rau kev ua haujlwm me me.}
Yam cuam tshuam rau cov metabolism thiab tshem tawm
Ntau ntau yam tuaj yeem cuam tshuam cov metabolism thiab tshem tawm ntawm gs -441524 hauv miv:
Hepatic muaj nuj nqi: miv nrog lub cev muaj nuj nqi yuav ua tau hloov kho metabolism ntawm cov tshuaj .
Lub raum muaj nuj nqi: muab cov thawj txoj kev ntawm kev tshem tawm yog los ntawm ob lub raum, lub raum tsis kam tuaj yeem cuam tshuam cov tshuaj tshem tawm kev siv tshuaj tsis haum tshuaj {}}
Hnub nyoog: Cov miv laus dua yuav tau txo cov metabolic thiab tshem tawm peev xwm, muaj peev xwm ua rau cov tshuaj sib txuam .
Concurrent tshuaj: qee cov tshuaj yuav cuam tshuam nrog gs -441524, cuam tshuam rau nws cov metabolism lossis tshem tawm.
Puas yog gs -441524} boss cov ntshav-lub hlwb thaiv kev mob siab?
Lub peev xwm ntawm gs -441524}} bbb barrier (BBB) yog qhov tshwj xeeb ntawm cov kab mob fip uas tau kis rau lub ntsej muag fip uas tau kis mus rau hauv nruab nrab lub siab lub hlwb {}}
Kev tshawb fawb tau pom tias gs -441524 Puas muaj qhov sib txawv ntawm cov fip, uas yog qhov tseem ceeb rau kev tswj hwm ntawm cov fip, uas muaj peev xwm ua rau muaj peev xwm ua haujlwm ntawm FIP, Bbb .
Kev tshawb fawb tshuaj xyuas cov kev sib tw ntawm gs -441524} Qhov tseem ceeb ntawm cov tswv yim uas tsim nyog ntawm cov tswv yim zoo thaum lub hom phiaj neurological fip .
Lub peev xwm ntawmGs 441524 HmoovTxhawm rau hla BBB muaj qhov cuam tshuam tseem ceeb rau kev kho cov fip neurological:
Cov koob tshuaj ntau dua yuav tsim nyog kom ua tiav cov kev kho kom haum hauv CNS .
Kev kho mob lossis kev xa khoom tawm tswv yim yuav raug tshawb nrhiav los txhim kho CNS nkag mus .
Saib xyuas cov tsos mob neurological thiab csf tseem ceeb heev hauv kev txheeb xyuas kev kho kom zoo {}}
Cov kws tshawb nrhiav tau tshawb xyuas ntau cov tswv yim los txhim kho BBB nkag mus rau gs -441524, suav nrog:
Nanoparticle cov qauv uas tuaj yeem yooj yim dua hla hla BBB
Cov hau kev prodrugs uas rub tawm cov neeg thauj neeg tshwj xeeb ntawm BBB
Kev cuam tshuam ib ntus ntawm BBB kom nce kev quav yeeb tshuaj
Cov hau kev no tuav cov lus cog tseg rau kev txhim kho qhov ua tau zoo ntawm gs -441524}}.
Tag
Cov Khoom Siv Hluav Taws Xob ntawm Gs -441524}} nws muaj peev xwm hla kev ua kom muaj kev tuag taus thiab cov kev xa tawm tuaj yeem ua rau kev txhim kho cov chaw muag tshuaj cov tshuaj hauv lub neej yav tom ntej .
Raws li peb txoj kev nkag siab ntawm gs -441524 '} Cov kws kho mob thiab cov kws kho mob ua kom zoo dua qub rau kev ua kom muaj cov tshuaj feline thiab kev txhim kho cov neeg muaj cov tshuaj feline cuam tshuam nrog Fip .
Rau cov tuam txhab tuam tsev lag luam, cov tsev tshawb fawb, thiab chaw kho mob kho tsiaj nrhiav cov khoom zooGs 441524 Hmoovrau cov kev kawm tshawb fawb lossis sib sau ua ke, Shaanxi Bloom Tech Co {}} Cov tswv yim zoo tshaj plaws hauv peb cov txiaj ntsig siab tshaj plaws ntawm kev ua tau zoo thiab huv si. kom paub ntau ntxiv txog peb Gs -441524 hmoov thiab lwm yam tshuaj tshwj xeeb, thov hu rau peb pab pawg muag khoom ntawmSales@bloomtechz.com. Peb cov kws tshaj lij tau npaj txhij los pab koj nrog koj cov kev daws teeb meem thiab muab cov kev daws teeb meem rau koj cov kev kuaj mob lossis cov chaw kuaj mob xav tau.
Ntawv Sawv cev
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{4. dickinson, p {}}}}}}} {} {{5} {{3} {{{{}} Phau ntawv xov xwm ntawm Veterinary Internal Tshuaj, 34 (4), 1587-1593.