Epitalon(link:https://www.bloomtechz.com/synthetic-chemical/peptide/epitalon-powder-cas-307297-39-8.html) yog ib qho yooj yim peptide uas muaj plaub amino acids (alanine, glutamine, lysine thiab aspartic acid). Cov tshuaj formula ntawm Epitalon yog C14H22N4O9, tus txheeb ze molecular hnyav yog 390.34g/mol, CAS 307297-39-8. Rau cov hmoov dawb. Epitalon muaj solubility siab hauv dej thiab tuaj yeem yaj hauv cov kua qaub thiab alkaline daws. Nws tuaj yeem yaj hauv ethanol, dimethyl sulfoxide, acetone thiab lwm cov kuab tshuaj. Txawm li cas los xij, nws muaj tsawg solubility hauv cov kuab tshuaj uas tsis yog polar xws li chloroform thiab benzene. Epitalon Peptide muaj ntau yam tshuaj lom neeg thiab cov cim keeb kwm, uas tau piav qhia hauv qab no.
Chemical Properties:
1. Cov yam ntxwv ntawm cov qauv thiab stereochemical:
Epitalon muaj plaub cov amino acids txuas nrog hauv ib qho kev txiav txim, suav nrog ob pawg amine thiab ob pawg carboxyl. Qhov no txhais tau hais tias Epitalon yog peptide molecule nrog ob amino termini thiab ob carboxyl termini. Cov qauv tseem ceeb ntawm Epitalon yog cyclic peptide nrog ob pawg amine sab hauv thiab ob pawg carboxyl sab nraud. Thaum lub sij hawm synthesis ntawm Epitalon, nws cov amino thiab carboxyl termini feem ntau tiv thaiv kom tsis txhob muaj kev phiv thaum lub sij hawm cov tshuaj tiv thaiv.
2. Thermal stability thiab lub teeb stability:
Epitalon muaj qhov zoo thermal stability thiab tsis yooj yim rau degrade ntawm qhov kub thiab txias. Txawm li cas los xij, nws muaj cov duab tsis zoo thiab muaj qhov cuam tshuam rau cov tshuaj tiv thaiv photochemical thiab inactivation.
3. pH tus nqi thiab lub xeev tus nqi:
Raws li qhov xwm txheej ntawm nws cov amino thiab carboxyl pawg, Epitalon tuaj yeem hloov nws lub xeev los ntawm kev kho cov pH. Thaum tus nqi pH tsawg dua lossis sib npaug li 2, Epitalon yuav muaj nyob hauv nws daim ntawv them nyiaj ion, thiab thaum tus nqi pH ntau dua lossis sib npaug rau 12, Epitalon yuav nyob rau hauv nruab nrab. Hauv qhov nruab nrab pH ntau, Epitalon yuav raug them, molecular, lossis ob qho tib si, nyob ntawm kev sib cuam tshuam ntawm Epitalon hauv kev daws thiab nws qhov chaw ib puag ncig.
4. Tshuaj tiv thaiv:
Cov peptide daim ntawv cog lus ntawm Epitalon tuaj yeem ua rau cov tshuaj tiv thaiv hydrolysis txhawm rau txhawm rau cov saw peptide. Tsis tas li ntawd, Epitalon tuaj yeem hloov kho los ntawm amide bond condensation thiab ester bond hydrolysis. Cov tshuaj tiv thaiv tshuaj no muab ib txoj hauv kev los hloov cov qauv thiab kev ua haujlwm ntawm Epitalon, txhim kho nws cov kev ua haujlwm lom neeg thiab kev ruaj ntseg. Piv txwv li, qee cov peptide derivatives zoo ib yam li Epitalon tau npaj, xws li Cyclo-Pro-Gly, Cyclo-Pro-Pro thiab Cyclo-Pro-Gly-Pro, thiab lwm yam.
Hauv cov ntsiab lus, Epitalon yog peptide molecule nrog zoo thermal stability thiab acid-base solubility. Nws cov qauv tshuaj yog yooj yim, nrog lub nplhaib qauv yam ntxwv. Cov amino thiab carboxyl termini ntawm Epitalon tuaj yeem hloov kho los ntawm kev tiv thaiv kev tiv thaiv. Vim nws cov khoom tshwj xeeb tshuaj, Epitalon tau kawm dav rau kev txhim kho cov tshuaj thiab cov khoom noj qab haus huv.
Epitalon yog peptide uas muaj plaub yam amino acids, uas muaj ntau yam kev kho mob zoo xws li ncua kev laus, txhim kho kev tiv thaiv thiab txhim kho kev pw tsaug zog zoo. Nws tau pom thiab siv zog kawm los ntawm Lavxias tus kws tshawb fawb Vladimir Khavinson thaum xyoo 1980s.
1. Vladimir Khavinson txoj hauj lwm thiab kev tshawb fawb keeb kwm:
Vladimir Khavinson yog ib tug paub zoo ntawm Lavxias teb sab kws tshawb fawb, yug nyob rau hauv 1946, kawm nyob rau hauv Leningrad (tam sim no St. Petersburg) Medical University, thiab tom qab ntawd tau txais ib tug kws kho mob nyob rau hauv cov tshuaj. Nws tau kawm thiab ua haujlwm ntau hauv zej zog kev tshawb fawb thiab ua haujlwm tseem ceeb rau kev tawm tsam mob qog noj ntshav hauv nws lub xyoo thaum ntxov. Nyob rau hauv nruab nrab -1980s, nws pib kawm txog molecular biological mechanism ntawm lifespan thiab pib tshawb nrhiav lub luag hauj lwm ntawm peptide cov tshuaj hormones ntawm tib neeg physiological functions.
2. Discovery ntawm Epitalon:
Thaum xyoo 1980s lig, Khavinson tau kawm txog cov neeg nyob ntev-Split cov txwj laus. Cov pab pawg no nyob hauv Split koog tsev kawm ntawv nyob rau sab qaum teb Russia, thiab lawv lub neej nyob nruab nrab yog li 20 xyoo ntev dua li cov pej xeem ntawm tib lub hnub nyoog. Khavinson tau tshawb xyuas qhov tob ntawm lub cev thiab cov yam ntxwv ntawm lub cev ntawm cov pab pawg no, thiab ua cov kev tshawb fawb hauv chav kuaj los ntawm kev kuaj ntshav los ntawm lawv. Thaum kawg nws tau pom tias cov ntshav ntawm cov neeg laus hauv Split yog nplua nuj nyob rau hauv cov tshuaj peptide, uas tuaj yeem txhawb kev tso tawm cov tshuaj hormones loj hlob hauv tib neeg lub cev, uas tuaj yeem ua lub luag haujlwm hauv ntau yam kev ua haujlwm ntawm lub cev xws li txhim kho kev tiv thaiv thiab ncua kev laus. nyhuv.
Tom qab ntawd, Khavinson tau pib kawm cov tshuaj peptide no hauv qhov tob, thiab thaum kawg tau tshawb pom Epitalon hauv 1991. Nws tau tshuaj xyuas qhov muaj pes tsawg leeg ntawm Epitalon siv cobalt txoj kev tsim los ntawm Linus Pauling, tus yeej Nobel nqi zog hauv chemistry hauv xyoo 1953, thiab lees paub tias nws yog peptide. muaj plaub amino acids. Nws kuj tau kawm ntxiv txog cov khoom siv tshuaj lom neeg, kev ua haujlwm lom neeg thiab kev kho mob ntawm Epitalon.
3. Kev kho mob ntawm Epitalon:
Khavinson txoj kev tshawb fawb ntawm Epitalon qhia tau hais tias nws tuaj yeem txhawb kev tso tawm ntawm tib neeg kev loj hlob hormone, yog li txhim kho kev pw tsaug zog, txhim kho kev tiv thaiv, ncua kev laus thiab lwm yam teebmeem. Nws kuj pom tias Epitalon tuaj yeem txhawb nqa cov metabolism hauv cell, nce lub peev xwm ntawm cov hlwb los tsim cov proteins, txo cov roj cholesterol hauv cov ntshav, thiab txo cov tsos mob ntawm cov kab mob neurodegenerative, thiab lwm yam.
Khavinson qhov kev tshawb pom tau ua rau muaj kev txhawj xeeb thoob plaws hauv zej zog kev kho mob thiab teeb tsa kev nce qib ntawm Epitalon kev tshawb fawb hauv Russia thiab lwm lub tebchaws. Tam sim no, Epitalon tau siv dav hauv kev kho mob, xws li tshuaj tiv thaiv kev laus, immunomodulator, thiab cov tshuaj adjuvant rau kev kho mob qog noj ntshav. Nws kuj yog siv los ua kev noj qab haus huv ntxiv uas tib neeg noj qhov ncauj lossis txhaj tshuaj kom noj qab haus huv.
Epitalon yog ib qho tshuaj peptide uas tsim los ntawm plaub cov amino acids, uas tuaj yeem txhawb kev tso tawm ntawm tib neeg kev loj hlob hormone, yog li pab ncua kev laus, txhim kho kev pw tsaug zog, thiab txhim kho kev tiv thaiv, thiab lwm yam. Kev tshawb pom ntawm Epitalon tau pib thaum xyoo 1980s. Nws yog Vladimir Khavinson txoj kev tshawb fawb txog cov neeg laus hauv Split. Nws nrhiav tau peptide hormone uas tuaj yeem txhawb kev tso tawm ntawm tib neeg txoj kev loj hlob hormone, thiab thaum kawg tau tshawb pom thiab txiav txim siab cov qauv tshuaj ntawm Epitalon. Epitalon txoj kev tshawb fawb tau xav tias yuav muab kev kho mob tshiab thiab kev tiv thaiv kev xaiv rau thaj chaw tshuaj thiab kev kho mob.