GLP-1(link:https://www.bloomtechz.com/synthetic-chemical/peptide/glp-1-peptide-cas-87805-34-3.html) muaj ob txoj kab sib txuas polypeptide: cov saw peptide nrog 21 amino acid residues ntawm N-terminus (GLP-1[7-27]), thiab peptide saw nrog 30 amino acid residues ntawm C- terminus (GLP-1 [28-58]), muaj ib tug condensation choj ntawm cov chains. Cov tshuaj formula ntawm GLP-1 yog C165H264N50O55S2, molar mass yog li 3.8 kDa, thiab CAS 87805-34-3. Lub xeev them nqi ntawm GLP-1 hloov nrog pH. Thaum pH qis dua qhov isoelectric point ntawm GLP-1, GLP{19}} raug them zoo; thaum pH ntau dua qhov taw tes isoelectric, GLP-1 raug nqi tsis zoo. Raws li lub cev muaj zog, GLP-1 feem ntau raug them tsis zoo. Nws muaj zog redox rhiab heev thiab protease rhiab heev. Raws li lub cev muaj zog, GLP-1 feem ntau yog hydrolyzed sai sai los ntawm proteases xws li trypsin, yog li poob nws cov khoom lom. Tsis tas li ntawd, thermal zog, pH, hlau ions thiab lwm yam tseem yuav cuam tshuam rau kev ruaj ntseg ntawm GLP-1. Txhawm rau txhim kho qhov ruaj khov ntawm GLP-1, cov kws tshawb fawb feem ntau siv ntau txoj hauv kev los txhim kho nws, xws li kev hloov kho tshuaj lom neeg thiab hloov cov qauv molecular.
GLP-1 yog glucagon-zoo li polypeptide, uas feem ntau yog synthesized thiab secreted los ntawm txoj hnyuv L hlwb. Nws muaj cov haujlwm tseem ceeb hauv kev tswj cov ntshav qab zib, qab los noj mov, lub cev hnyav, thiab lwm yam. Nws yog ib qho tseem ceeb rau kev kho mob ntshav qab zib hom 2 thiab rog. Tsis tas li ntawd, GLP-1 kuj tau siv dav hauv lwm qhov chaw, xws li kab mob plawv, kab mob siab, kab mob paj hlwb thiab qog.
1. Kev kho mob ntshav qab zib hom 2:
Daim ntawv thov ntxov tshaj plaws ntawm GLP-1 yog los kho mob ntshav qab zib hom 2. GLP-1 cov tshuaj tuaj yeem tsim cov tshuaj insulin secretion thiab inhibit kev tsim cov piam thaj, yog li txo cov ntshav qab zib. Piv nrog rau lwm cov tshuaj hypoglycemic, GLP-1 cov tshuaj muaj qhov zoo ntawm kev txo qis hauv lub cev thiab txo cov xwm txheej hypoglycemic. Feem ntau siv GLP-1 tshuaj suav nrog exexagliptin, liraglutide, exenatide, dapagliflozin, thiab lwm yam.
2. Kev kho mob rog:
Ntxiv nrog rau kev kho mob ntshav qab zib, GLP-1 cov tshuaj kuj tau siv dav hauv kev kho mob rog. Qhov no yog vim muaj txiaj ntsig zoo ntawm GLP-1 cov tshuaj hauv kev ua kom satiety thiab txo qis qab los noj mov. Tam sim no muaj GLP-1 cov tshuaj muaj xws li exenatide, liraglutide, thiab canagliflozin.
3. Kab mob plawv:
GLP-1 tshuaj kuj muaj qee yam kev tiv thaiv kab mob plawv. Ntau qhov kev sim tshuaj tau pom tias GLP-1 cov tshuaj tuaj yeem txo tus nqi ntawm cov kab mob plawv, xws li mob plawv tsis ua rau mob plawv, mob stroke thiab plawv tsis ua haujlwm. Tib lub sijhawm, GLP-1 cov tshuaj kuj tuaj yeem txhim kho cov haujlwm endothelial thiab arteriosclerosis. Kev ua haujlwm ntev liraglutide, exenatide, thiab dapagliflozin tau pom zoo nyob rau hauv cov kab mob plawv.
4. Kab mob siab:
Cov kev tshawb fawb tsis ntev los no tau pom tias GLP-1 cov tshuaj kuj muaj cov txiaj ntsig zoo hauv kev kho mob siab. GLP-1 cov tshuaj tuaj yeem txo cov rog hauv daim siab thiab cov lus teb inflammatory, yog li txhim kho cov tsos mob ntawm daim siab rog, thiab tseem muaj qee yam kev tiv thaiv ntawm daim siab mob siab thiab lwm yam kab mob. GLP-1 tshuaj xws li exenatide thiab liraglutide ua haujlwm ntev tau txais kev saib xyuas ntau hauv kev tshawb fawb hauv xyoo tas los no.
5. Cov kab mob hauv paj hlwb:
Ntxiv rau thaj chaw saum toj no, GLP-1 cov tshuaj kuj tau siv dav hauv kev kho cov kab mob hauv lub paj hlwb, xws li Alzheimer's disease, Parkinson's disease thiab mob stroke. GLP-1 cov tshuaj tuaj yeem tiv thaiv cov neurons los ntawm ntau lub tswv yim, xws li txo cov lus teb inflammatory, txo oxidative kev nyuaj siab, thiab txhim kho cov metabolism hauv neuronal. Tam sim no cov kev sim tshuaj tsis tu ncua tau pom tias GLP-1 cov tshuaj muaj cov txiaj ntsig zoo thiab muaj kev phiv tsawg.
6. Tumor:
Cov kev tshawb fawb tshiab qhia tau hais tias GLP-1 cov tshuaj kuj tseem tuaj yeem ua lub luag haujlwm hauv kev kho mob qog noj ntshav. Qee qhov kev tshawb fawb hauv chaw kuaj mob tau pom tias GLP-1 cov tshuaj tuaj yeem tiv thaiv qog nqaij hlav los ntawm inhibiting qog cell proliferation thiab txhawb apoptosis. Tsis tas li ntawd, GLP-1 receptor kuj tau nthuav dav hauv cov ntaub so ntswg. Kev tshawb fawb soj ntsuam ntawm GLP-1 tshuaj nyob rau hauv kev kho mob qog nqaij hlav.
Hauv kev xaus, GLP-1 yog ib qho kev ua haujlwm ntau ntawm bioactive peptide, uas muaj ntau yam kev ua haujlwm ntawm lub cev xws li tswj cov ntshav qab zib, qab los noj mov, thiab lub cev hnyav. GLP-1 cov tshuaj tau siv dav hauv kev kho mob ntshav qab zib hom 2, rog rog, kab mob plawv, kab mob siab, kab mob hauv lub paj hlwb thiab qog nqaij hlav. Nrog rau kev tshawb fawb tob txog cov txheej txheem ntawm GLP-1, nws ntseeg tau tias GLP-1 cov tshuaj yuav raug siv tas li thiab tsim kho hauv ntau qhov chaw.