Eriodictyol(link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/eriodictyol-powder-cas-552-58-9.html) yog ib qho flavonoid uas belongs rau teakin flavonoids. Nws cov mis molecular yog C15H14O6, thiab nws cov txheeb ze molecular hnyav yog 290.27 g / mol. Eriodictyol's molecular structure diagram thiab nws cov yam ntxwv yooj yim:
Lub molecule ntawm Eriodictyol muaj 15 carbon atoms, 14 hydrogen atoms thiab 6 oxygen atoms. Tag nrho cov qauv tuaj yeem muab faib ua peb ntu: ob qhov txuas benzene nplhaib thiab ib qho txuas anthracycline. Ntawm lawv, anthracycline ib feem yog tsim los ntawm tsib-carbon nplhaib thiab ib lub nplhaib rau-carbon. Cov qauv molecular muaj ntau yam, nrog rau benzene nplhaib, anthracene nplhaib, thiab phenonyl pawg.
Eriodictyol muaj ntau pawg ua haujlwm tseem ceeb, pawg ua haujlwm tseem ceeb suav nrog benzophenone pawg (C=O), pawg hydroxyl (OH) thiab methyl pawg (CH3). Cov pab pawg no muab Eriodictyol nws cov khoom siv tshuaj lom neeg thiab kev ua haujlwm lom neeg. Muaj ntau yam kev sib cog lus tshuaj, xws li carbon-carbon ib daim ntawv cog lus, carbon-carbon ob daim ntawv cog lus, thiab carbon-oxygen bonds. Lub xub ntiag ntawm cov ntawv cog lus no txiav txim siab qhov kev teeb tsa spatial thiab tshuaj lom neeg cov tshuaj tiv thaiv ntawm Eriodictyol molecule. Raws li chiral compound, enantiomers D- thiab L-Eriodictyol ntawm Eriodictyol muaj cov khoom siv kho qhov muag sib txawv. Qhov no txhais tau hais tias lawv muaj peev xwm tig linearly polarized lub teeb nyob rau hauv opposite lus qhia.
Cov qauv molecular ntawm Eriodictyol ua rau muaj ntau yam tshuaj lom neeg. Nws tuaj yeem npaj tau los ntawm enzymatic catalysis, cov txheej txheem tshuaj hluavtaws lossis ntuj rho tawm. Cov txheej txheem rau kev sib txuas ntawm Eriodictyols feem ntau koom nrog cov tshuaj enzymatic lossis tshuaj lom neeg ntawm cov khoom tsim nyog los tsim cov phiaj xwm sib xyaw.
Cov dej num lom neeg: Eriodictyol tau kawm ntau thiab pom tias muaj ntau yam kev ua ub no lom neeg. Nws ntseeg tau tias muaj tshuaj tua kab mob antioxidant, tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob. Cov kev ua ub no lom neeg muaj feem cuam tshuam nrog cov pab pawg ua haujlwm thiab cov khoom siv tshuaj lom neeg hauv cov qauv molecular ntawm Eriodictyol.
Pharmacological teebmeem: Vim nws muaj ntau yam kev ua ub no lom neeg, Eriodictyol tau qhia txog cov txiaj ntsig pharmacological. Cov kev tshawb fawb tau pom tias nws tuaj yeem muaj kev tiv thaiv kab mob hauv lub plawv, lub paj hlwb thiab lub cev tsis muaj zog. Tsis tas li ntawd, Eriodictyol kuj tau pom tias muaj kev cuam tshuam rau cov txheej txheem pathological xws li qog nqaij hlav, ntshav qab zib thiab kab mob hauv plab.
Eriodictyol yog ib qho chaw sib xyaw nrog ntau qhov chaw reactive, thiab nws cov khoom reactive yog cuam tshuam los ntawm nws cov qauv molecular thiab pab pawg ua haujlwm.
1. Hydrolysis cov tshuaj tiv thaiv:
Cov pab pawg benzophenone (C=O) thiab hydroxyl pawg (OH) ntawm Eriodictyol yog cov feem ntau ua rau hydrolysis. Eriodictyol tuaj yeem tawg rau hauv benzophenone thiab ntau cov hydroxyl compounds los ntawm hydrolysis cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv hydrolysis no tuaj yeem ua tiav hauv vivo nrog rau hauv chav kuaj, thiab cov kab mob alkaline feem ntau yog siv los txhawb cov tshuaj tiv thaiv.
2. Cov tshuaj tiv thaiv oxidation:
Eriodictyol muaj ntau qhov chaw electrophilic, xws li benzophenone thiab hydroxyl pawg ntawm lub nplhaib benzene. Cov chaw electrophilic no ua rau Eriodictyol raug rau cov tshuaj tiv thaiv oxidation. Cov tshuaj tiv thaiv oxidation tuaj yeem pib los ntawm cov pa oxygen, hydrogen peroxide, lossis lwm yam tshuaj oxidizing. Cov tshuaj tiv thaiv oxidation feem ntau ua rau muaj kev hloov pauv hauv Eriodictyol los tsim cov khoom sib txawv oxidation.
3. Txo cov tshuaj tiv thaiv:
Lub nplhaib benzene thiab pawg hydroxyl ntawm lub nplhaib anthracene hauv Eriodictyol yog cov chaw feem ntau ua rau txo qis kev cuam tshuam. Kev txo cov tshuaj tiv thaiv tuaj yeem pib los ntawm tus neeg sawv cev txo qis xws li hlau sodium, sodium sulfite lossis hydrogen. Kev txo cov tshuaj tiv thaiv tuaj yeem ua rau muaj kev hloov pauv ntawm Eriodictyol los tsim cov khoom sib txawv.
4. Cov tshuaj tiv thaiv Esterification:
Cov pab pawg hydroxyl hauv Eriodictyol tuaj yeem hnov mob nrog cov kua qaub anhydride lossis kua qaub kom dhau esterification cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv no feem ntau xav kom muaj cov catalyst, xws li acid catalysis lossis enzyme catalysis. Esterification tuaj yeem qhia ntau pawg acyl rau hauv cov molecule ntawm Eriodictyol, yog li hloov nws cov khoom thiab kev ua ub no.
5. Cov tshuaj tiv thaiv condensation:
Cov chaw electrophilic ntawm lub nplhaib benzene thiab anthracene nplhaib hauv Eriodictyol molecule tuaj yeem koom nrog cov tshuaj tiv thaiv condensation. Cov tshuaj tiv thaiv no suav nrog nucleophilic ntxiv, kev sib txuas ntawm alkenes thiab cov tshuaj tsw qab, thiab lwm yam. Cov tshuaj tiv thaiv condensation tuaj yeem tsim cov tshuaj polycyclic ntawm Eriodictyol, yog li ua rau nws cov complexity thiab ntau haiv neeg.
6. Methylation tshuaj tiv thaiv:
Cov pab pawg hydroxyl hauv Eriodictyol thiab hydrogen atoms ntawm lub nplhaib uas muaj ntxhiab tuaj yeem koom nrog cov tshuaj tiv thaiv methylation. Cov tshuaj tiv thaiv no feem ntau yog ua nyob rau hauv lub xub ntiag ntawm ib tug methyl pub thiab ib tug catalyst. Methylation tuaj yeem hloov pauv cov dej solubility, bioavailability thiab tshuaj metabolism ntawm Eriodictyol.
7. Lub cev qhuav dej:
Cov pab pawg hydroxyl hauv Eriodictyol tuaj yeem ua rau lub cev qhuav dej los tsim ob daim ntawv cog lus lossis cov qauv nplhaib. Cov tshuaj tiv thaiv lub cev qhuav dej feem ntau yog ua raws li cov kua qaub-catalyzed lossis thermal tej yam kev mob. Cov tshuaj tiv thaiv no tuaj yeem hloov pauv cov qauv molecular thiab cov khoom ntawm Eriodictyol.
8. Photochemical cov tshuaj tiv thaiv:
Vim tias muaj ntau lub tshuab sib txuas hauv Eriodictyol molecule, nws muaj zog teb rau lub teeb. Thaum raug ultraviolet los yog pom lub teeb, Eriodictyol tuaj yeem raug cov tshuaj tiv thaiv photochemical, xws li photosensitization, photooxidation, thiab photolysis. Cov tshuaj tiv thaiv photochemical tuaj yeem ua rau muaj kev hloov pauv hauv cov qauv molecular thiab tsim cov khoom sib txawv photodegradation.
Eriodictyol yog ib yam khoom ntuj uas nws nrhiav tau hnub rov qab mus rau lub xyoo pua 19th. Qhov kev tshawb pom ntawm Eriodictyol hnub rov qab mus rau 1829, thaum German chemist Heinrich Hlasiwetz thawj zaug cais cov khoom ntawm citrus cog (Citrus). Nws hu ua Eriodictyol, los ntawm Greek keeb kwm Eriodictyon, lub ntsiab lus "split scale," los piav qhia txog cov khoom siv crystalline.
Hauv kaum xyoo tom ntej, Eriodictyol tau txais kev nyiam ntawm lwm cov kws tshawb fawb thiab nyiam kev tshawb fawb dav dav. Xyoo 1860, Fab Kis kws tshuaj Raphaël Dubois tau kawm ntxiv txog cov tshuaj lom neeg ntawm Eriodictyol thiab ua tiav nws cov glycoside derivatives.
Nyob rau hauv thaum ntxov 20th caug xyoo, Eriodictyol pib nyiam cov kev txaus siab ntawm kws tshuaj. Raws li cov lus ceeb toom, xyoo 1925, British biochemist J. McLaren Howard tau luam tawm ib daim ntawv tshawb fawb txog cov tshuaj tua kab mob antioxidant ntawm Eriodictyol, uas yog thawj cov ntaub ntawv ntawm Eriodictyol tau muaj kev txhawj xeeb hauv kev lag luam biology.
Txij thaum ntawd los, nrog rau kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis thiab kev txhim kho ntawm txoj kev tshawb fawb, cov kws tshawb fawb tau ua qhov kev tshawb fawb ntau ntxiv ntawm kev ua haujlwm lom neeg thiab muaj peev xwm siv tau ntawm Eriodictyol. Lawv pom tias Eriodictyol muaj ntau yam tshuaj ua haujlwm, suav nrog tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, thiab lwm yam.
Nyob rau hauv xyoo tas los no, nrog rau kev txhim kho ntawm purification technology thiab cov qauv kev soj ntsuam cov txheej txheem, cov kws tshawb fawb tau ua ntau cov ncauj lus kom ntxaws kev tshawb fawb thiab characterization ntawm cov tshuaj cov qauv ntawm Eriodictyol. Siv cov tswv yim xws li nuclear magnetic resonance (NMR) thiab huab hwm coj spectrometry, cov kws tshawb fawb tau txiav txim siab cov qauv molecular, molecular hnyav thiab peb-dimensional qauv ntawm Eriodictyol.
Tsis tas li ntawd, nrog kev txhim kho ntawm cov khoom siv tshuaj lom neeg, cov kws tshawb fawb kuj tau tshawb pom cov peev txheej nplua nuj hauv Eriodictyol hauv qee cov nroj tsuag. Eriodictyol tau pom nyob rau hauv cov nroj tsuag ntawm genus Genistae, txiv hmab txiv ntoo, paj ntoos, thiab lwm yam.
Txog tam sim no, Eriodictyol, uas yog ib qho tseem ceeb ntawm cov khoom ntuj tsim, tau ua rau muaj kev txaus siab thoob plaws hauv kev lag luam tshuaj, kev lag luam zaub mov thiab tshuaj pleev ib ce. Cov kws tshawb fawb tseem tab tom tshawb nrhiav lub peev xwm ntawm Eriodictyol thiab ua haujlwm hnyav los tshawb pom thiab tsim cov ntawv thov ntau dua.