GABAhmoov ntshiab, tshuaj lub npe 4-aminobutyric acid, yog ib tug compound nrog cov tshuaj formula C4H9NO2, alias 4-aminobutyric acid (- Aminobutyric acid yog ib qho amino acid, uas dav muaj nyob rau hauv vertebrates, nroj tsuag, thiab kab mob. - Gamma-aminobutyric acid yog ib qho tseem ceeb neurotransmitter nyob rau hauv lub hauv paus paj hlwb, nrog dej zoo thiab thermal stability. Tsawg molecular hnyav yog ib qho kev nyab xeeb amino acid thiab tuaj yeem siv rau hauv dej haus thiab lwm yam khoom noj. Cov kev tshawb fawb tau pom tias muaj qee yam uas ua rau kev pw tsaug zog zoo hauv tib neeg lub cev thiab txo cov ntshav siab.
Lub neej nrawm nrawm ua rau ntau tus neeg niaj hnub raug kev txom nyem los ntawm kev pw tsaug zog thiab kev ntxhov siab hauv lub neej niaj hnub no. Raws li 2020 daim ntawv qhia txog kev pw tsaug zog, ntau dua 300 lab tus tib neeg hauv Suav teb muaj teeb meem pw tsaug zog. Kev tshawb fawb txog kev kho mob niaj hnub no tau lees paub tias qhov kev siv zog ntau dhau ntawm cov ntaub ntawv neural kis tau tus mob (overexcitation ntawm lub paj hlwb) yog ib qho laj thawj tseem ceeb rau ntau tus neeg niaj hnub cov tsos mob ntawm lub cev thiab lub hlwb. Raws li cov kws tshawb fawb 'kev tshawb fawb mus sij hawm ntev ntawm nws, nws pom tau hais tias raws li ib tug neurotransmitter inhibitor, nws muaj nyob rau hauv tib neeg lub hlwb thiab lwm yam paj hlwb thiab koom tes nyob rau hauv regulating ntau yam physiological kev ua ub no. Txog tam sim no, ntau cov kev tshawb fawb tau pom tias nws yog ib qho kev nyab xeeb thiab kev thaj yeeb nyab xeeb hauv lub hlwb. Nws lub xub ntiag nyob rau hauv tib neeg lub cev yuav txo tau los yog inhibit kev txaus siab heev thiab mob siab rau cov paj hlwb teeb liab.
Nws ua ke nrog cov sib txuas ion channel receptor los ua kom qhib cov tshuaj chloride ion channel, ua kom cov tshuaj chloride ion influx thiab hyperpolarization ntawm cov cell membrane, inhibit qhov tshwm sim ntawm qhov ua tau zoo, inhibit paj hlwb, thiab tiv thaiv overheating ntawm neurons, ua rau tib neeg ruaj khov. thiab calm down. Yog li ntawd, nws tuaj yeem txhim kho kev pw tsaug zog, txo qhov qaug zog, txo qhov siab, thiab txhawb lub hlwb tseem ceeb.
Ntawm qhov tsis sib xws, yog tias qhov concentration ntawm qhov tsis txaus, nws yuav ua rau muaj kev ntxhov siab, ntxhov siab, qaug zog, ntxhov siab, thiab lwm yam kev xav. Txawm li cas los xij, nrog lub hnub nyoog nce ntxiv, cov ntsiab lus hauv tib neeg lub cev yuav qhia txog kev poob qis. Nws tau tshaj tawm tias GABA cov ntsiab lus ntawm tib neeg lub cev txo qis li 5 feem pua txhua xyoo 10 xyoo, thiab cov poj niam txo qis dua. Qhov poob ntawm cov ntsiab lus twg yog qhov ua rau txo qis tib neeg kev txawj ntse thiab lub hlwb laus. Tsis tas li ntawd, nws tuaj yeem cuam tshuam kev ua haujlwm neuronal thiab txhim kho daim tawv nqaij mob (Huaxi lom GABA anti-aging efficacy test). Nrog nws cov txiaj ntsig zoo tiv thaiv kev laus, nws yog siv cov kauj ruam los ntawm kauj ruam hauv cov tshuaj pleev qhov muag, lub ntsej muag lub ntsej muag, ntsej muag cream, thiab lwm yam tshuaj pleev ib ce.
Raws li ib tug bioactive tshuaj, nws dav muaj nyob rau hauv lub paj hlwb ntawm cov tsiaj thiab nroj tsuag, uas muaj txiaj ntsig zoo rau tib neeg lub neej. Yog li ntawd, peb muaj peev xwm nco ntsoov ntxiv cov tshuaj no thiab noj ib co zaub mov uas nplua nuj nyob rau hauv cov tshuaj no nyob rau hauv lub neej. Xws li txiv lws suav, qos yaj ywm, txiv hmab txiv ntoo, taub dag, thiab tshuaj yej. fermented zaub mov xws li pickles thiab germinated brown mov kuj nplua nuj nyob rau hauv lawv.
Muaj ntau txoj hauv kev tshuaj rau hluavtaws GABA: Ua ntej, poov tshuaj yog siv los ua raw khoom rau phthaloylimine thiab ionogenic -chloroprene lossis butyrolactone. Cov khoom kawg tau txais tom qab kev qhia meej thiab cov tshuaj tiv thaiv hydrolysis yog qhov thib ob feem ntau siv pyrrolidone ua cov khoom siv saum npoo av. Thaum nws nres qhib, nws hnov mob nrog calcium hydroxide thiab carbohydrate ammonia - lub nplhaib kom tau txais nws. Qhov thib peb yog siv butyric acid thiab ammonia ua raw khoom rau GABA; Txoj kev plaub yog los ua ke nrog propylamine thiab formic acid los ntawm glow paug; Qhov thib tsib yog siv methyl bromoacetate thiab ethylene ua raw khoom los npaj nws. Methyl 4-bromobutyrate yog tau los ntawm polymerization. Thaum kawg, cov khoom tom qab ammonolysis thiab hydrolysis yog GABA. Cov txheej txheem tshuaj synthesis uas muaj qhov tsis zoo ntawm kev tswj cov tshuaj tiv thaiv nyuaj thiab tus nqi siab.
Lub luag haujlwm ntawm lub cev ntawm lub cev uas: kev qhia thiab kev ua haujlwm ntawm cov nroj tsuag GAD thaum kis kab mob - Kev hloov pauv ntau ntawm hydroxybutyric acid yuav nce, nce nws. Qhov rhiab heev ntawm kev haus luam yeeb nrog qib siab GABA synthesis rau Agrobacterium tumefaciens C58 tus kab mob txo qis. Nws tuaj yeem ntxias cov kab mob Agrobacterium attklm operon, txo qhov concentration ntawm N - (3- oxooctyl) homoserine lactone, thiab txo qis quorum-sensing teeb liab (los yog hormone), uas cuam tshuam rau nws toxicity rau cov nroj tsuag.it kuj plays lub luag hauj lwm. nyob rau hauv lub teeb liab kev sib txuas lus ntawm cov nroj tsuag thiab cov kab mob.GABAmuaj peev xwm inhibit qhov kev qhia ntawm HrpL noob hauv cov kab mob (cov protein encoded los ntawm HrpL noob sensitizes cov nroj tsuag los yog ua rau lawv cov ntaub so ntswg kab mob) thiab inhibit lub ntsej muag ntawm HRP noob nyob rau hauv cov nroj tsuag los tiv thaiv cov nroj tsuag los ntawm kev tsis haum tshuaj (HRP: tswj lub pathogenic muaj peev xwm ntawm cov nroj tsuag kab mob thiab ua rau muaj kev tsis haum tshuaj).