Methylergometrine(txuas:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/methylergonovine-powder-cas-113-42-8.html) yog quaternary ammonium alkaloid nrog cov qauv tshuaj ntawm C15H23NO2 thiab CAS 113-42-8. Nws muaj kev ua haujlwm kho qhov muag, thiab ob leeg sab laug thiab sab tes xis lub cev muaj kev ua haujlwm lom neeg, nrog rau sab laug lub cev muaj zog ua haujlwm. Feem ntau tam sim no nyob rau hauv ergot nroj tsuag xws li rye, barley, nplej, nrog rau lwm yam cereal qoob loo thiab nyom. Hauv ryegrass, cov ntsiab lus ntawm methylergometrine yog qhov siab, tab sis nws cov ntsiab lus tshwj xeeb txawv nyob ntawm seb hom nroj tsuag, kev loj hlob, thiab kev ua haujlwm. Nws muaj ntau yam kev ua si lom neeg. Nws tuaj yeem cuam tshuam kev loj hlob thiab kev sib kis ntawm cov qog hlwb thiab tuaj yeem siv rau kev kho mob thiab tiv thaiv qog noj ntshav. Tsis tas li ntawd, methylergometrine kuj muaj cov tshuaj tiv thaiv kab mob, tiv thaiv kab mob, thiab tshuaj tua kab mob antioxidant, uas tuaj yeem siv los kho cov kab mob inflammatory, kab mob autoimmune, thiab cov kab mob oxidative kev nyuab siab. Hauv kev kho mob, nws yog siv los kho cov tsos mob xws li mob migraine, mob khaub thuas, thiab dysmenorrhea, nrog rau kev txhim kho cov tsos mob ntawm cov kab mob inflammatory, kab mob autoimmune, thiab oxidative kev nyuaj siab ntsig txog kab mob. Nws kuj tuaj yeem siv los kho cov qog, ua ke nrog lwm cov tshuaj tiv thaiv qog, txhawm rau txhim kho kev kho mob thiab ua kom muaj sia nyob ntev.
Txoj kev lom neeg fermentation ntawm methyl ergosteine feem ntau siv ergic acid ua raw khoom thiab tsim methyl ergosteine los ntawm microbial fermentation.
Fermentation txoj kev los tsim ergic acid:
C6H12O6 + 2H2O + O2→ 2 CH2OHCHOHCOOH + zog
Kev npaj ntawm methyl ergosterine los ntawm cov tshuaj tiv thaiv methylation:
CH2OHCHOHCOOH + CH3Ib → CH3(CHOH) COV + CH3OH + HI
Fermentation ntawm ergot acid:
1. Siv cov nplej thiab lwm cov nplej nplej ua cov khoom siv tseem ceeb, wort tau txais tom qab kev kho mob ua ntej xws li crushing, liquefaction, thiab saccharification.
2. Ntxiv cov kab mob ergot kab mob rau hauv wort thiab ferment raws li qhov tsim nyog xws li kub thiab pH tus nqi.
3. Tom qab fermentation, cov kab mob hauv lub cev yog lim tawm kom tau txais fermentation broth uas muaj lysergic acid.
Kev npaj ntawm methyl ergometrine:
1. Ntxiv cov kuab tshuaj uas tsim nyog xws li ethanol lossis isopropanol rau fermentation broth kom yaj lysergic acid, thiab ntxiv cov kua qaub uas tsim nyog xws li sulfuric acid lossis sodium hydroxide hydrochloride los kho pH tus nqi rau acidity.
2. Ntxiv rau qhov tsim nyog ntawm sodium nitrite rau cov kua qaub thiab ua rau lub zog ntawm qhov kub thiab txias rau qee lub sijhawm ua rau cov tshuaj diazotization ntawm lysergic acid thiab sodium nitrite, tsim cov ntsev diazonium.
3. Kho cov ntsev diazonium nrog rau qhov tsim nyog ntawm sodium hydroxide tov, kho tus nqi pH mus rau nruab nrab, thiab tau txais ergometrine.
4. Nyob rau hauv alkaline tej yam kev mob, ib tug tsim nyog tus nqi ntawm methylation reagent (xws li dimethyl sulfate los yog iodomethane) yog ntxiv rau ergometrine ua rau ib tug methylation cov tshuaj tiv thaiv ntawm ergometrine, tsim methyl ergometrine.
Cov txheej txheem semi hluavtaws ntawm methyl ergometrine yog npaj methyl ergometrine los ntawm cov tshuaj aspirin los ntawm hydrolysis, etherification, txo, thiab lwm yam kev cuam tshuam.
Aspirin hydrolysis:
C9H8O4 + 2H2O → C7H6O2 + C3H4O2
Kev npaj ntawm aspirin methyl ether:
C7H6O2+ CH3OH → C7H7O2CH3 + H2O
Kev npaj ntawm methyl ergometrine:
C7H7O2CH3+ HHO + H2 → C8H9TSIS MUAJ2+ CH3OH
Hydrolysis ntawm aspirin:
1. Ntxiv cov dej uas tsim nyog thiab dilute hydrochloric acid sulfuric acid rau hauv lub lauj kaub cov tshuaj tiv thaiv, do thiab ntxiv cov tshuaj aspirin, thiab cua sov rau qee qhov kub;
2. Ntxiv qhov tsim nyog ntawm sodium hydroxide tov dropwise kom tag nrho hydrolyze aspirin;
3. Txias rau hauv chav tsev kub, lim tawm cov khib nyiab, ntxuav nrog dej kom txog thaum nruab nrab, thiab tau txais cov khoom siv hydrolysis.
Kev npaj ntawm aspirin methyl ether:
1. Ntxiv qhov tsim nyog ntawm ethanol thiab concentrated sulfuric acid rau lub lauj kaub cov tshuaj tiv thaiv, do thiab ntxiv cov khoom siv hydrolysis;
2. Thaum tshav kub kub thiab reflux rau ib lub sij hawm ntawm lub sij hawm kom tiav cov tshuaj tiv thaiv ntawm hydrolysis khoom thiab ethanol;
3. Distilled thiab rov qab ethanol, ntxuav nrog dej kom txog thaum nruab nrab, thiab tau txais cov khoom nyoos;
4. Distilled nyob rau hauv ib tug ntauwd distillation kom tau refined aspirin methyl ether.
Kev npaj ntawm methyl ergometrine:
1. Ntxiv cov dej uas tsim nyog, hydrogen gas, thiab catalyst rau lub lauj kaub tshuaj tiv thaiv;
2. Ntxiv cov tshuaj aspirin methyl ether thiab cua sov rau qee qhov kub;
3. Ntxiv qhov tsim nyog ntawm cov tshuaj formaldehyde dropwise kom txo qis cov tshuaj tiv thaiv ntawm aspirin methyl ether thiab formaldehyde;
4. Lim thiab ntxuav nrog dej kom txog thaum nruab nrab kom tau methyl ergot alkaloid crude;
5. Distilled nyob rau hauv lub distillation ntauwd kom tau high-purity methyl ergometrine.
Tag nrho cov txheej txheem synthesis ntawm methyl ergometrine feem ntau yog siv acetophenone raws li cov khoom siv raw thiab dhau los ua cov tshuaj tiv thaiv kom tau methyl ergometrine.
Acetophenone sulfonation:
C6H5COCH3 + H2YOG4 → C6H5CH2YOG3H + H2O
Kev npaj ntawm methyl ergometrine:
C6H5CH2YOG3H + HCHO + NaOH → C8H9TSIS MUAJ2+NWS4 + H2O
Sulfonation ntawm acetophenone:
1. Ntxiv rau qhov tsim nyog ntawm acetophenone thiab concentrated sulfuric acid rau lub lauj kaub cov tshuaj tiv thaiv thiab cua sov rau qee qhov kub;
2. Ntxiv qhov tsim nyog ntawm cov dej dropwise kom tiav cov tshuaj sulfonation ntawm acetophenone;
3. Txias rau hauv chav sov, lim tawm cov dej nag, ntxuav nrog dej kom txog thaum nruab nrab, thiab tau txais 2-acetophenone sulfonic acid.
Kev npaj ntawm methyl ergometrine:
1. Ntxiv cov dej uas tsim nyog, 2-acetophenone sulfonic acid, formaldehyde, thiab catalyst rau cov tshuaj tiv thaiv lauj kaub;
2. Thaum tshav kub kub thiab reflux rau ib lub sij hawm ntawm lub sij hawm ua rau cov tshuaj tiv thaiv ntawm 2-phenylethyl ketone sulfonic acid thiab formaldehyde;
3. Ntxiv cov tshuaj alkaline uas tsim nyog los ua kom cov tshuaj tiv thaiv tsis zoo thiab lim tawm cov dej nag;
4. Ntxuav lub precipitate nrog dej, ces recrystallize nrog ethanol kom tau cov khoom crude ntawm methyl ergometrine;
5. Distilled nyob rau hauv lub distillation ntauwd kom tau high-purity methyl ergometrine.
Nws yuav tsum tau muab sau tseg tias cov reagents thiab cov cuab yeej siv nyob rau hauv txoj kev no yog feem ntau siv cov cuab yeej kuaj thiab reagents, thiab cov txheej txheem ua haujlwm yog qhov yooj yim. methyl ergometrine tau los ntawm txoj kev no yog cov khoom siv raw uas yuav tsum tau ua ntxiv xws li crystallization thiab sib cais kom tau txais cov khoom purity siab dua. Nyob rau tib lub sijhawm, kev sim nruj thiab tswj cov tshuaj reagents thiab cov cuab yeej siv kuj tseem yuav tsum tau ua kom cov khoom zoo thiab kev nyab xeeb.