Phenylbutazone, feem ntau hu ua "bute," yog cov tshuaj uas tsis yog tshuaj steroidal mitigating (NSAID) feem ntau siv hauv cov tshuaj kho tsiaj, tshwj xeeb tshaj yog rau cov ponies. Cov tshuaj no yog nto moo rau nws cov haib mitigating thiab mob relieving zog, ua rau nws ib tug tseem ceeb kev kho mob rau txawv cov leeg nqaij mob. Hauv qhov kev nkag blog no, peb yuav tshawb xyuas lub hom phiaj ntawm phenylbutazone, zeroing ntawm nws cov ntawv thov hauv cov tshuaj kho tsiaj thiab nws qhov tseeb siv rau tib neeg cov tshuaj.
Yuav Siv Phenylbutazone li cas hauv Veterinary Medicine?
Phenylbutazone yog siv dav hauv cov tshuaj kho tsiaj los tswj qhov mob thiab mob hauv cov tsiaj, tshwj xeeb yog nees. Yuav ua li cas yog phenylbutazone siv nyob rau hauv veterinary tshuaj?
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Ib lub hom phiaj tseem ceeb ntawm phenylbutazone nyob rau hauv cov tshuaj veterinary yog kev tswj hwm ntawm cov leeg nqaij sab nrauv hauv ponies. Cov xwm txheej zoo li mob pob qij txha, laminitis, thiab tendonitis ua rau muaj kev tsim txom thiab khaus khaus, cuam tshuam tus pony txoj kev txav mus los thiab kev vam meej. Phenylbutazone txo qis cov kev mob tshwm sim no, tso cai rau tus pony txav tau yooj yim dua thiab rov kho dua txhua qhov ntau tiag tiag.
Phenylbutazone feem ntau tswj hwm rau ponies nthuav tawm cov txheej txheem kho mob ntawm kev saib xyuas kev tsim txom thiab kev khaus. Kev phais, txawm tias txuas nrog lub qhov txhab lossis lwm yam mob, tuaj yeem ua rau muaj kev ntxhov siab loj. Los ntawm kev muab kev pab cuam nrog kev tsis xis nyob, phenylbutazone txhawb kev rov qab zoo dua thiab txo qhov siab thiab tsis xis nyob cuam tshuam nrog kev ua haujlwm tom qab kev nyuaj siab.
Nees koom nrog kev sib tw kis las lossis kev ua haujlwm hnyav yog qhov raug mob hnyav, xws li pob txha, mob, thiab nqaij tawv. Phenylbutazone feem ntau yog siv los kho cov kev raug mob no los ntawm kev txo qhov mob thiab muab kev kho mob, ua kom tus nees rov zoo dua thiab rov qab mus rau nws cov dej num.
Kev ntsuas thiab lub koom haum ntawmCov tshuaj phenylbutazonenyob rau hauv ponies yog mob siab rau tswj kom lav kev ruaj ntseg thiab txaus. Cov tshuaj yog ib txwm tswj qhov ncauj los yog intravenously, nrog rau kev ntsuas raws li tus pony qhov hnyav, qhov hnyav ntawm tus mob, thiab tus kws kho tsiaj cov lus pom zoo. Nws yog ib qho tseem ceeb uas yuav tau ua raws li cov kev ntsuas pom zoo kom nyob deb ntawm qhov muaj feem cuam tshuam thiab muaj tshuaj lom.
Thaum phenylbutazone siv tau, nws tsis yog yam tsis muaj kev pheej hmoo. Cov kev mob tshwm sim feem ntau suav nrog cov teeb meem hauv plab hnyuv, xws li mob plab thiab colic, nrog rau lub raum thiab lub siab puas tsuaj nrog kev siv ntev. Kev saib xyuas tsis tu ncua los ntawm tus kws kho tsiaj yog qhov tseem ceeb txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau), kev saib xyuas los ntawm kws kho tsiaj yog qhov tseem ceeb rau kev saib xyuas cov tshuaj muaj txiaj ntsig zoo.
Phenylbutazone puas tuaj yeem siv rau tib neeg?
Phenylbutazone ib zaug tau siv dav hauv tib neeg cov tshuaj, tab sis nws txoj kev siv tau poob qis vim muaj kev txhawj xeeb txog kev nyab xeeb. phenylbutazone puas tuaj yeem siv rau tib neeg?
Keeb Kwm Siv Hauv Tib Neeg Tshuaj
Phenylbutazone tau pib qhia rau tib neeg siv xyoo 1950 los kho cov mob xws li mob caj dab rheumatoid, gout, thiab ankylosing spondylitis. Nws muaj zog tiv thaiv kab mob thiab tshuaj tua kab mob ua rau nws muaj kev xaiv nrov rau kev tswj qhov mob hnyav thiab mob txuam nrog cov mob no.
Cov teebmeem tsis zoo
Txawm hais tias nws txaus,Cov tshuaj phenylbutazonetau pom tias muaj kev cuam tshuam tsis zoo rau tib neeg, ua rau nws tshem tawm ntawm kev siv tsis tas. Cov teeb meem tsis txaus ntseeg feem ntau suav nrog cov teeb meem plab hnyuv loj, xws li mob plab thiab tuag, nrog rau lub raum thiab lub siab mob. Tsis tas li ntawd, ob peb tus neeg mob tau ntsib kev cuam tshuam loj ntawm hematological, piv txwv li, aplastic paleness, ib qho mob uas cov pob txha tsis saib xyuas los tsim cov platelets txaus.
Cov xwm txheej tam sim no
Vim tias cov kev cuam tshuam loj heev no, kev siv phenylbutazone hauv tib neeg tau mus rau qhov zoo heev. Muaj kev nyab xeeb dua lwm txoj kev xaiv, piv txwv li, cov NSAIDs sib txawv thiab mob hloov cov tshuaj tiv thaiv kab mob (DMARDs), tau hloov phenylbutazone hauv kev kho cov xwm txheej provocative. Txawm li cas los xij, kev nkag siab txog nws qhov kev siv qhov tseeb tau muab cov kev paub tseem ceeb rau hauv kev tig ntawm cov xwm txheej thiab kev nce qib ntawm cov ntawv sau tshuaj.
Off-Label thiab kev sim siv
Qee qhov xwm txheej tsis tshua muaj, phenylbutazone tseem yuav raug siv tawm ntawm daim ntawv lo lossis hauv kev sim tshuaj raws li kev saib xyuas nruj. Cov xwm txheej no tau tswj hwm tau zoo, thiab cov kev pheej hmoo thiab cov txiaj ntsig tau ua tib zoo ntsuas kom ntseeg tau tias tus neeg mob muaj kev nyab xeeb.
Dab tsi yog qhov txaus ntshai thiab ceev faj cuam tshuam nrog Phenylbutazone?
Phenylbutazone, zoo li txhua yam tshuaj, los nrog nws cov kev pheej hmoo thiab kev ceev faj. Dab tsi yog qhov txaus ntshai thiab kev ceev faj cuam tshuam nrog phenylbutazone?
Ib qho kev phom sij tseem ceeb cuam tshuam nrogCov tshuaj phenylbutazoneyog kev tsis meej pem hauv plab. Cov tshuaj tuaj yeem ua rau mob plab, tuag, thiab qhov, tshwj xeeb tshaj yog nrog kev siv qeeb. Cov kev tsis sib haum xeeb no tshwm sim los ntawm kev cuam tshuam ntawm COX-1, tshuaj uas tiv thaiv lub plab hauv ob sab phlu. Txhawm rau txo cov kev phom sij no, ua raws li kev ntsuas pom zoo thiab ncua kev kho mob yog qhov tseem ceeb.
Phenylbutazone yog metabolized nyob rau hauv daim siab thiab tawm los ntawm ob lub raum. Kev siv ntev ntev tuaj yeem ua rau lub raum thiab lub siab puas tsuaj, ua rau muaj cov tsos mob xws li jaundice, tso zis tsaus, thiab o ntawm cov ceg. Kev saib xyuas lub siab thiab lub raum ua haujlwm tsis tu ncua yog qhov tseem ceeb rau cov neeg mob tau txais kev kho mob mus sij hawm ntev txhawm rau txheeb xyuas cov tsos mob ntxov ntawm kev puas tsuaj.
Ib qho tsis tshua muaj tab sis mob hnyav ntawm phenylbutazone yog cov pob txha pob txha, ua rau muaj mob xws li aplastic anemia. Tus mob no txo qis kev tsim cov qe ntshav, ua rau cov tsos mob xws li qaug zog, ua rau kis kab mob, thiab los ntshav txawv txav. Cov neeg mob ntawm phenylbutazone yuav tsum tau kuaj ntshav tsis tu ncua los saib xyuas lawv cov qib cellular.
Phenylbutazone tuaj yeem koom tes nrog cov tshuaj sib txawv, nthuav dav kev twv txiaj ntawm cov kev cuam tshuam antagonistic. Piv txwv li, kev siv ib txhij nrog cov NSAIDs sib txawv tuaj yeem txhawb nqa kev twv txiaj ntawm kev tsis meej pem hauv plab, thaum kev sib txuas lus nrog cov tshuaj tiv thaiv coagulants tuaj yeem ua rau muaj kev phom sij ntxiv. Nws yog ib qho tseem ceeb los qhia tus kws kho mob txog txhua yam tshuaj uas yuav tsum tau nyob deb ntawm kev sib txuas lus xav tau.
Hauv cov kws kho tsiaj, muaj kev ceev faj zoo sib xws. Nees tau txais phenylbutazone yuav tsum tau saib xyuas cov tsos mob ntawm kev mob plab hnyuv, lub raum ua haujlwm, thiab kev noj qab haus huv tag nrho. Ua raws li cov tshuaj tau sau tseg thiab zam kev siv mus sij hawm ntev tshwj tsis yog tias tsim nyog kiag li tuaj yeem pab txo qhov kev pheej hmoo.
Xaus
Phenylbutazone, feem ntau hu ua "bute," yog NSAID muaj zog nrog keeb kwm nyuaj hauv ob qho tib si tsiaj thiab tib neeg cov tshuaj. Thaum nws nyob twj ywm ib qho tseem ceeb rau kev saib xyuas kev mob thiab khaus khaus hauv ponies, nws txoj kev siv hauv tib neeg tau poob qis vim muaj kev cuam tshuam loj heev. Kev txheeb xyuas lub hom phiaj, kev phom sij, thiab kev pov hwm cuam tshuam nrog phenylbutazone yog qhov tseem ceeb rau kev daws cov lus xaus txog nws daim ntawv thov. Kev kuaj xyuas ib txwm muaj thiab ua raws li kev ntsuas pom zoo yog qhov ceev kom lav kev ruaj ntseg thiab txaus.
Cov ntaub ntawv
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