Thawj antiandrogen tau tshawb pom thaum ntxov li xyoo 1960. Antiandrogens yog qhov tseem ceeb rau cov neeg mob uas muaj teeb meem hormonal xws li benign prostatic hyperplasia, pob txuv, hirsutism, txiv neej alopecia, mob qog noj ntshav prostate, thiab hypersexuality. Ntau yam ntawm antiandrogens tau pom, tab sis tsuas yog ib feem ntawm cov tshuaj antiandrogens tau siv hauv tsev kho mob. Antiandrogens ua raws li kev khi cov tshuaj tiv thaiv rau androgen receptors hauv cov ntaub so ntswg reactive los thaiv lossis txo cov teebmeem ntawm lub cev ntawm testosterone thiab dihydrotestosterone (DHT). Hauv lwm lo lus, lawv inhibit lossis thaiv kev ua haujlwm ntawm testosterone thiab DHT.ua 58841hmoov(los yog ru-58841) yog ib hom antiandrogen complex. Ru58841 tau siv los ua kev kho mob sab nraud rau txiv neej alopecia, pob txuv thiab hirsutism.
Lub physiological muaj nuj nqi ntawm uas yog contraindications rau dutasteride thiab finasteride tebchaw. Nws tsis tiv thaiv DHT ntau lawm tab sis tsuas yog cuam tshuam nrog androgen receptors. Androgen receptors qhia nyob rau hauv ntau cov ntaub so ntswg hauv lub cev. Lawv kuj muaj nyob rau hauv cov tawv taub hau thiab cov hauv paus hniav. Muaj ntau androgen receptors nyob rau hauv cov plaub hau poob follicles tshaj nyob rau hauv cov plaub hau tsis follicles. Cia peb saib qhov kev sib raug zoo ntawm kev ua haujlwm ntawm androgen receptor thiab ru58841 ntawm androgen alopecia. Xav txog tias lub oval saum toj no yog koj cov plaub hau follicle lossis tawv nqaij ntawm tes. Feem ntau, testosterone yuav nkag mus rau hauv lub cell, thiab yog tias muaj 5, tus Reductase hloov mus rau DHT. Tom ntej no, ob qho tib si txuas rau androgen receptors. Tom qab ntawd, androgen receptor khiav mus rau lub nucleus, ua ntau yam txheej txheem. Dab tsi ru58841 ua yog: ru58841 khi nws tus kheej rau cov androgen receptor thiab tom qab ntawd ua rau ob androgens (DHT ntxiv rau testosterone) tsis ua haujlwm. Yog tias koj saib, nws tsis yog qhov xav tsis thoob tias cov neeg yug los nrog androgen receptor deficiency yuav tsis muaj teeb meem ntawm txiv neej alopecia vim tias tsis muaj androgen receptor thiab androgen tsis muaj txiaj ntsig.
Ru58841 yog tsim los ua antiandrogen hauv zos. Ru58841 yog siv los ua antiandrogen hauv zos. Kuv xav paub tias thaiv kev ua haujlwm ntawm androgen receptors hauv tag nrho lub cev tsis yog kev xaiv ntse. Tseem, nws tsuas tuaj yeem nres cov androgen receptors hauv tawv taub hau thiab cov hauv paus hniav. Vim hais tias ib nrab-lub neej ntawm ru58841 yog luv heev, tsuas yog 1 teev, nws yog heev haum rau aga. Nws tsuas yog ua haujlwm ntawm tawv taub hau lossis tawv nqaij. Lwm qhov zoo dua yog tias cov qauv ntawm cov complex no txawv ntawm txhua yam-natural steroids hauv lub cev. Qhov no yog non-steroidal antiandrogen / tshuaj qauv thiab tsis cuam tshuam nrog hormonal concentration. Feem ntau lub teb chaws tsis tau lees paub ru58841. Nws tsuas yog siv tau los ua tshuaj tshawb fawb, tsuas yog cov kws tshawb fawb tuaj yeem yuav nws rau kev tshawb fawb.
Ru58841 hmoov phiv tshuaj ru58841 siv rau ntawm tawv taub hau thiab yog absorbed los ntawm cov hauv paus plaub hau. Hauv txoj kev xav, nws tuaj yeem nkag mus rau cov ntshav thiab cuam tshuam rau lwm yam hauv lub cev. Txawm li cas los xij, tsis muaj kev phiv tshwm sim hauv kev tshawb fawb ntawm kev siv hauv zos hauv cov liab. Txawm li cas los xij, qee cov neeg uas simru58841 uathov tias lawv tau ntsib qee qhov kev mob tshwm sim los ntawm kev siv Ru, suav nrog kev khaus khaus ntawm daim tawv nqaij, txo libido, kev ua haujlwm tsis zoo, xeev siab, qhov muag liab, kiv taub hau thiab mob taub hau.