Miv thoob lub ntiaj teb muaj kev phom sij rau cov neeg tuag muaj kev mob phem hu ua felineitis (FIP). Feline sib kis tus kab mob peritonitis yog ib tug mutant coronavirus uas tau ntev tau xav ua kom tuag. Cov tshuaj tua kab mob tshiab, txawm li cas los xij, tau muab ob qho tib si miv thiab vets vim li cas muaj kev cia siab. Ib lub nucleoside analog nrog impressive anti - fipv thiab anti {{pob khoom,Gs 441524 Hmoovyog ib qho kev kho mob uas muaj peev xwm. Nyob rau hauv daim ntawv no, peb yuav delve rau hauv cov txheej txheem los ntawm tus txheej txheem uas FIPV ua rau o, anti {{{{{
1.Txoj kev tshwj xeeb (hauv Tshuag)
(1) kev txhaj tshuaj
20mg, 6mL; 30Mg, 8ml; 40mg, 10ml
(2) Ntsiav tshuaj
25/45 / 60/0mg
(3) API (hmoov ntshiab)
(4) ntsiav tshuaj xovxwm tshuab
https://www.achievechn.com/pillsés22 rov hais
2.Customization:
Peb yuav sib tham ntawm tus kheej, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm nkaus xwb.
Sab hauv Txoj Cai: BM-2-1-049
GS-441524 CAS 1191237-69-0
Kev tsom xam: HPLC, LC - ms, hnmr
Kev Txhawb Nqa Tshuab: R & Dept.-4
Peb muab GS 441524 hmoov, thov saib cov vev xaib hauv qab no rau cov ncauj lus kom ntxaws thiab cov ntaub ntawv cov ntaub ntawv.
Kev siv tshuab ntawm fipv -} Tsis txhob
Kom nkag siab li casGs 441524 HmoovUa haujlwm, nws yog qhov tseem ceeb rau thawj delve mus rau hauv cov txheej txheem kev cuam tshuam nyuaj los ntawm FIPV tus kab mob. Tus kab mob lub peev xwm los ntxias kev kub ntxhov yog qhov tseem ceeb hauv kev txhim kho thiab kev nce qib ntawm FIP.
Fipv tus kab mob ua rau muaj kev txhoj puab heev thiab dysregulated implation tus cwj pwm los ntawm kev tso tawm ntau dhau los ntawm kev tso tawm ntau dhau los ntawm cov cua daj Cytokine ntau zaus. This uncontrolled immune activation overwhelms the body's regulatory mechanisms, leading to extensive tissue inflammation, cellular damage, and multi-organ dysfunction. Cytokines xws li qog nqaij necrosis perp {}}}}} ({}) Lawv nce qib siab pab tsis tsuas yog rau kev mob nkeeg tab sis kuj tseem ua rau muaj kev puas tsuaj rau cov kabmob uas muaj kev sib kis tau zoo (FIP) thiab ua rau cov kev kho mob.
Macrophage kev ua kom zoo thiab tsim qauv
Fipv qhia txog kev sib txawv ntawm tropism rau macrophages, ua rau nws pheej mob siab thiab rov qab tsis pub muaj lub plab tsis zoo. Thaum muaj kab mob, macrophages los ua hyperactivated thiab tso ib qho array ntawm pro- Cov neeg tiv thaiv kab mob tiv thaiv kab mob ntxiv rau lub xaib ntawm kab mob. Lub sijhawm dhau los, kev txuam nrog cov macrophuage no ua rau kev tsim cov granulomas- Cov pawg ntawm lub hlwb puag ncig ntawm fibrotic ntaub so ntswg. Kev cuam tshuam cov chaw nyob ua kom zoo dua qub, tshwj xeeb hauv cov kabmob uas zoo li daim siab, raum, thiab nruab nrab ntawm cov paj hlwb, pab txhawb kom FIP aughology.
Lub Innate lub cev tiv thaiv kab mob rau FIPV suav nrog kev ua kom zoo dua ntawm cov txheej txheem ua tiav, uas ua lub luag haujlwm tseem ceeb hauv Pathogen kev lees paub thiab tshem tawm. Txawm li cas los xij, ntau dhau kev ua haujlwm tuaj yeem muaj kev cuam tshuam cuam tshuam, tshwj xeeb ntawm vascular kev ncaj ncees. Kev ua kom ua kom lub kaw lus no ua rau qhov kev tso tawm ntawm pro-}} Txoj kev tsim ntawm membrane tawm tsam cov nyom ntawm tes. Qhov no nce ntxiv txoj kev sib zog ua kom muaj protein}}}} Cov kab noj hniav nplua nuj, ua rau muaj effusion txuam ...}} ib tug lawb ntawm cov fip ntub. Kev sib xyaw ntawm kev tiv thaiv - Kev siv tshuaj kho mob thiab cov kua tsim ua kom muaj qhov tsis xis nyob thiab tuaj yeem kho tau sai sai ib tus mob miv yog tias tsis nyob.
Anti - inflammatory kev txiav txim ntawm GS-441524
Gs 441524 Hmoovtau tshwm sim los ua cov tshuaj tiv thaiv kab mob antiviral nrog cov khoom tseem ceeb anti {{pob khoom. Nws cov tshuab kev txiav txim feem ntau hom phiaj kev sib deev, tab sis muab cov compound kuj tau ua rau muaj kev cuam tshuam los ntawm kev ua qauv tiv thaiv kab mob hauv tsev.
Inhibition ntawm kis mob replication
Thawj hom kev ua ntawm gs - 441524 yog ua rau Insibit viral RNA synthesis. Los ntawm cuam tshuam nrog tus kab mob RNA-desent RNA Polymerase, GS-441524 tau txais txiaj ntsig rau FIPV replication. Cov tshuaj tiv thaiv kab mob antiviral coj ncaj qha ua rau muaj kev txo qis hauv cov kis phom, uas nyob rau hauv lem diminishes cov stimulus rau o.
Hloov ntawm cytokine ntau lawm
Studies have shown that GS-441524 can modulate the production of pro-inflammatory cytokines in FIPV-infected cells. Los ntawm kev txo cov qib tnf-, IL-1, thiab IL-6, lub compound cytokine cuam tshuam nrog tus FIP neeg mob hnyav.
Attenuation ntawm macrophage ua kom
GS-441524 Lub peev xwm los txo tus kab mob kis tsis pub dhau lub tshuab macrophuage ua rau lawv qhov kev ua kom tsawg dua thiab cov khoom teb ntxiv. Cov nyhuv no pab txo cov kev tsim kho granuloma thiab cuam tshuam cov nqaij mos.
Cov kev ua tau zoo hauv kev txo cov tsos mob fip fip
Daim ntawv thov ntawmFip MedicalationGs - 441524 Hauv cov chaw kuaj mob tau pom cov txiaj ntsig zoo ntawm kev kho cov miv nrog FIP. Nws cov teebmeem tshwm sim, txuas nrog nws cov kev ua kom muaj zog tiv thaiv, tau ua rau muaj kev txhim kho tseem ceeb hauv kev ua kom tau tshwm sim hauv kev soj ntsuam cov txiaj ntsig.
Hauv miv nrog Effst Fip, kho nrog GS-441524 tau raug pom kom yooj yim txo cov kua hauv lub cev tej kab kab noj hniav. Cov nyhuv no zoo li yog vim muaj kev txo qis hauv kev sib kis hauv kev thauj khoom thiab cov kev ua tiav ntawm cov lus teb tau yooj yim uas ua rau muaj kev sib tw ua ke.
Miv kho nrog GS-441524 feem ntau qhia kev txhim kho sai sai hauv chaw kho mob cuam tshuam nrog FIP. Cov kev txhim kho no suav nrog qab los noj mov, nce phaus, kev daws teeb meem ntawm kev kub taub hau, thiab ua kom zoo zuag qhia tag nrho. Qhov txo qis hauv cov txha caj qaum ua lub luag haujlwm tseem ceeb hauv kev txhim kho kev soj ntsuam no.
Tej zaum qhov kev cuam tshuam tshaj plaws ntawm gs - 441524 Kev kho mob yog nws lub peev xwm los ntxias tau ntev ntev}} thip kev zam txim hauv miv nrog FIP. Cov kev tshawb fawb tau tshaj tawm cov nqi siab rau siab, nrog ntau tus miv tseem tshuav kab mob {{pub dawb rau ncua sij hawm tom qab kev kho mob chav kawm. Qhov tshwm sim no yog feem ntau yog tus ntaus nqi rau cov compound lub dual kev txiav txim raws li cov antiiral thiab anti-inflammatory tus neeg saib xyuas.
Gs - 441524 tau pom tias muaj kev ua tau zoo txawm tias nyob rau rooj plaub ntawm neurological nyuaj. Los ntawm kev hla cov ntshav -} bi ri hlwb tuaj yeem ua rau nws cov tshuaj tiv thaiv kev tiv thaiv, ua rau txhim kho cov tsos mob neurological.
Tag
Thaum kawg, qhov cuam tshuam ntawm gs - 441524 hmoov rau qhov induction ntawm fipv yog complex thiab nyob deb- mus txog. Ib txoj kev ua kom zoo rau kev kho cov fip yog muab los ntawm gs- 441524, uas tsis ncaj ncees rau cov neeg nyob hauv Inflammaratory. Qhov no ib zaug {- beatal mob tam sim no muaj ntau dua primnosis rau cov miv vim tias nws anti daws, thiab tshuaj ntsuam xyuas-txhim kho cov khoom.
Cov kab mob ntxiv rau lwm tus thiab mob siab yuav muaj peev xwm kho nrog gs- 441524 yav tom ntej, nyob ntawm cov txiaj ntsig ntawm kev tshawb fawb txuas ntxiv. Cov chaw ua lag luam thiab cov koom haum tshawb fawb yuav tsum muaj kev nkag tau zooGs 441524 HmoovTxhawm rau tshawb xyuas lub peev xwm ntawm cov tshuaj no xav tau.
Peb ntawm Shaanxi Bloom Tech Co., Ltd. yog cov kws tshaj lij hauv kev ua cov tshuaj sib txuas nrog qib siab ntawm kev siv roj carity rau siv hauv Photutical R & D. Cov khoom lag luam rau koj cov kev tshawb fawb yog tau lees tias yog qhov zoo tshaj plaws los ntawm peb lub xeev {4 4}}} {}}}} Txawm hais tias koj yog cov chaw tshawb fawb tshawb xyuas cov kev kho mob uas xav tau los yog cov khoom siv hluav taws xob nrhiav kev cog lus, peb tuaj yeem txaus siab rau koj cov kev xav tau.
Kom paub ntau ntxiv txog peb GS-441524 hmoov thiab lwm yam khoom siv tshuaj lom, lossis los tham txog koj cov kev xav tau tshwj xeeb, thov tsis txhob ua siab deb tiv tauj peb ntawmSales@bloomtechz.comCov. Peb pab neeg cov kws tshaj lij tau npaj los txhawb koj cov kev tshawb fawb thiab kev tsim kho hauv kev sib ntaus sib tua tiv thaiv kab mob kis thiab dhau mus.
Ntawv Sawv cev
1. Murphy, BG, li al. (2020). "Tus nucleoside analog GS-441524 tau muaj zog feline rau cov kab mob peritonitis (FIP) hauv cov kev mob tus kab mob thiab sim cov miv cov kev cog lus." ERETERINER MEDIAN MERVIOGY, 219: 108-116.
2. Pedersen, NC, li al. (2019). "Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog GS-441524 rau kev kho mob ntawm cov miv uas muaj kev kis felitonitis." Phau ntawv Journal of Felegine tshuaj thiab kev phais mob, 21 (4): 271-281.
3. Kim, Y., li al. (2020). "Kev thim rov qab ntawm kev ua kom muaj zog ntawm cov neeg tuag taus hauv cov miv los ntawm qhov dav - spectrum coronavirus prote inhibitor." PLOS Pathogogen, 16 (3): E1008457.
4. Dickinson, PJ, li al. (2020). "Kev kho mob tiv thaiv siv adenosine nucleoside analogue gs-441524 hauv miv nrog kuaj xyuas cov neeg neurboritis mob." Phau ntawv Journary ntawm Veterinary Internal Tshuaj, 34 (4): 1587-1593.