Langerhans pancreatic islets 'alpha cells tso tawmglucagon, ib peptide. Nws lub peev xwm tseem ceeb yog txhawm rau nce cov ntshav qabzib los ntawm kev pib glycogenolysis thiab gluconeogenesis thaum lub sijhawm hypoglycemia thiab yoo mov. Glucagon khaws cov piam thaj homeostasis ntawm ib qib.
Glucagon txhawb nqa glycogenolysis li cas?
Glucagon, ib qho hluavtaws ua los ntawm cov txiav, cia siab tias yog ib feem tseem ceeb hauv kev tswj cov piam thaj los ntawm kev nce qib glycogenolysis, kev tawg ntawm glycogen tso tseg hauv daim siab thiab cov leeg pob txha. Lub voj voog no yog kho los ntawm kev txav ntawm muddled sub-nuclear moj khaum:
Glucagon Receptor Limiting thiab Hailing:
Glucagon khi rau unequivocal glucagon receptors teem rau sab nraud txheej ntawm hepatocytes, lub siab hlwb lub luag hauj lwm rau glycogen txwv thiab conveyance.
Qhov kev sib khi no pib ua G-protein signaling cascade, cov saw hlau ntawm kev sib cuam tshuam molecular uas nqa cov teeb liab thoob plaws hauv lub cell.
CAMP ntau lawm thiab ua kom cov Protein Kinase:
Lub incited G-protein txhawb nqa adenylate cyclase, ib qho chaw uas hloov ATP rau hauv cyclic adenosine monophosphate (cAMP).
cAMP mus tej zaum yog ib qho kev xa tawm, nce lub teeb liab glucagon hauv xov tooj.
Protein kinase A (PKA), ib qho tshuaj kinase uas phosphorylates ntau lub hom phiaj protein, yog qhib los ntawm qib cAMP.
Glycogen Phosphorylase activation thiab phosphorylation:
PKA phosphorylates glycogen phosphorylase, ib qho chaw muaj kev pheej hmoo rau cais glycogen rau hauv qabzib{0}}phosphate.
Kev rhuav tshem cov piam thaj thiab tso tawm cov piam thaj:
Phosphorylation yog kev sib cuam tshuam los ntawm glycogen phosphorylase hloov mus rau hauv nws cov qauv dynamic, glycogen phosphorylase a.
Dynamic glycogen phosphorylase sai cais glycogen, ib qho carb staggering muab tso rau hauv daim siab thiab pob txha pob txha, mus rau hauv qabzib -1-phosphate.
Glucose-1-phosphate yog qhov sib txawv rau hauv qabzib-6-phosphate, uas yog ntxiv rau kom tawm cov piam thaj dawb.
Cov piam thaj no tau xa mus rau lub siab lub hlwb thiab mus rau hauv cov txheej txheem circulatory, txuas ntxiv cov piam thaj.
Glycogen phosphorylase txav yog nrawm raws li qhov tshwm sim ntawmglucagon's waning ciav, ua rau muaj kev puas tsuaj sai dua ntawm glycogen thiab kev ua tiav cov piam thaj los ntawm cov khw muag khoom cell mus rau hauv cov hlab ntsha. Lub voj voog no yog qhov yooj yim hauv kev paub txog cov piam thaj homeostasis thiab ua kom muaj kev ntseeg siab ntawm lub zog rau lub cev lub xov tooj.
Glucagon txhim kho gluconeogenesis li cas?
Yav dhau los glycogenolysis, chav kawm ntawm glycogen debasement, Glucagon ntxiv rau siv cov txiaj ntsig ntawm glucagonogenesis, ib zaug ntxiv ntawm Glucose los ntawm cov khoom tsis yog qab zib. Hauv txhua qhov xwm txheej, thaum cov khw muag khoom noj cov hmoov txhuv nplej siab tau ntws tawm, cov txheej txheem ntau yam no tuaj yeem lav qhov ruaj khov ntawm cov piam thaj mus rau hauv lub cev.
Transcriptional Incitation ntawm Cov Ntsiab Lus Mixtures:
Phosphoenolpyruvate carboxykinase (PEPC) thiab qabzib -6-phosphatase (G6Pase) yog ob qho tseem ceeb tsim kev siv zog uas tau txhawb nqa los ntawm glucagonogenesis. Glucagon ntxiv rau cov npe ntawm cov kev siv tseem ceeb no.
Kev txwv cov piam thaj los ntawm cov tsis-carb substrates nce vim qhov kev nce qib ntawm cov protein.
Qhia Pathway Motion thiab Accessibility:
Los ntawm kev teeb tsa lipolysis (kev tawg ntawm cov rog) thiab proteolysis (kev tawg ntawm cov proteins),glucagonenergizes lub activation ntawm glucagonogenic substrates zoo li amino acids thiab glycerol.
Qhov no ua kom ntseeg tau tias lub tsev thaiv kev sib xyaw ua ke tau npaj.
Tsis tas li ntawd, Glucagon tswj glycolysis, Glucagon-siv lub voj voog, hloov pauv pyruvate, ib qho tseem ceeb hauv metabolic Moderate, ntawm Glucagonogenesis.
Kev nce qib zoo dua los ntawm Glucagonotropic Pathway:
Glucagon ua haujlwm ntawm kev tsim cov khoom sib xyaw ua ke nrog Glucagonogenic txoj hauv kev, tshwj xeeb tshaj yog nyob rau hauv liter, qhov chaw tseem ceeb ntawm Glucose creation.
Txoj hauv kev zoo zuj zus ntawm cov metabolites yog ua haujlwm nrog los ntawm qhov nthuav dav catalyst txav, amplifying qabzib yield.
Raws li qhov tshwm sim ntawm cov kev hloov pauv no, glucagon txhawb kev tsim cov piam thaj los ntawm lactate, amino acids, thiab glycerol, tso cov piam thaj ntxiv rau hauv cov hlab ntsha. Kev khaws cov piam thaj hauv homeostasis yuav tsum muaj kev sib cuam tshuam, tshwj xeeb tshaj yog thaum ncua kev yoo mov lossis thaum nkag mus rau carb tsawg.
Dab tsi yog tag nrho cov txiaj ntsig ntawm cov kev ua glucagon no?
Vim tias nws lub peev xwm los txhawb nqa ob qho tib si glycogen tawg thiab tsim cov piam thaj, glucagon muaj txoj haujlwm nyuaj ntawm kev khaws cov piam thaj homeostasis, qhov tsis sib haum xeeb ntawm cov piam thaj hauv qib nruj. Cov xwm txheej ua raws li lub ntsiab lus ntawm nws cov kev tawm dag zog:
Kev tiv thaiv hypoglycemia:
Glucagon tiv thaiv hypoglycemia, qhov txaus ntshai cov piam thaj tsawg.
Thaum lub sijhawm cov piam thaj poob qis, glucagon raug xa tawm, uas ua rau lub peev xwm glycogen hauv lub siab xa cov piam thaj (glycogenolysis) thiab cov khoom tsis yog hmoov txhuv nplej siab los tsim cov piam thaj tshiab (gluconeogenesis).
Vim tias cov tshuaj tiv thaiv sai no, cov kab mob hauv lub cev tau txais cov khoom lag luam zoo sib xws ntawm cov piam thaj, tiv thaiv hypoglycemia thiab cuam tshuam txog kev cuam tshuam ntawm av qeeg, kev tsis sib haum xeeb, thiab qaug dab peg.
Txhawb nqa qib Glucose thaum yoo mov:
Glucagoncia siab tias muaj ib feem loj hauv thwarting perilously qis cov piam thaj thaum lub sij hawm yoo mov, thaum cov hmoov txhuv nplej siab raug kaw.
Los ntawm kev ua kom sai ntawm gluconeogenesis, glucagon ua kom muaj cov piam thaj zoo ib yam los ntawm cov khoom tsis muaj carbohydrate xws li amino acids thiab glycerol. Qhov no tiv thaiv cov qib qabzib.
Restoring Action Related Glucose Levels:
Tom qab kev tawm dag zog hnyav, cov khw muag khoom ntawm cov nqaij glycogen yog depleted, tej zaum yuav ua rau cov piam thaj poob qis.
Los ntawm stimulating glycogenolysis thiab gluconeogenesis, glucagon tiv thaiv qhov no, ntxiv cov piam thaj reserves thiab rov ua kom cov ntshav qab zib ib txwm muaj.
Xyuas kom cov piam thaj thauj mus rau cov ntaub so ntswg yooj yim:
Glucagon cov kev tawm dag zog kom ntseeg tau tias muaj cov piam thaj txaus rau lub hlwb thiab lwm cov ntaub so ntswg uas muaj qabzib, tsis hais, thaum lub khw muag khoom glycogen tsawg.
Qhov no yog qhov tseem ceeb rau kev txuag lub peev xwm cerebrum zoo tib yam thiab ua kom deb ntawm cov teeb meem neurologic txais tos los ntawm hypoglycemia.
Kev tswj hwm cov tshuaj insulin:
Glucagon ua rau muaj kev tawm tsam rau insulin, qhov sib xyaw uas ua rau cov piam thaj nce ntxiv thiab txwv.
Qhov kev sib raug zoo no ua rau muaj kev tswj hwm cov piam thaj nruj, tiv thaiv hypoglycemia thiab hyperglycemia.
Hauv ncej,glucagonLub peev xwm metabolic tseem ceeb yog tua cov piam thaj poob qis los ntawm kev ua kom cov piam thaj tso tseg thiab sib xyaw cov piam thaj tshiab. Cov kab ke sib txawv no cuam tshuam cov ntshav qab zib mellitus, nyob twj ywm paub txog cov piam thaj homeostasis thaum lub sijhawm yoo mov thiab kev tawm dag zog, thiab ua kom cov piam thaj tuaj yeem ua rau cov ntaub so ntswg tseem ceeb, qhia txog nws txoj haujlwm tseem ceeb hauv kev paub txog tag nrho cov metabolism hauv kev sib raug zoo.
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Cov ntaub ntawv
1. Quesada I, Tudurí E, Ripoll C, Nadal A. Physiology ntawm pancreatic alpha-cell thiab glucagon secretion: lub luag haujlwm hauv qabzib homeostasis thiab ntshav qab zib. J Endocrinol. 2008; 199(1):{5}}.
2. Jiang G, Zhang BB. Glucagon thiab tswj cov piam thaj metabolism. Am J Physiol Endocrinol Metab. 2003; 284(4):E671-E678.
3. Cryer PE. Glucagon thiab hypoglycemia. Endotext. Hloov kho Lub Xya Hli 15, 2021. Nkag mus rau Lub Ib Hlis 30, 2023.
4. Ramnanan CJ, Edgerton DS, Cherrington AD. Cov ntsiab lus tam sim no ntawm kev tswj hwm lub cev ntawm cov piam thaj hauv siab. Mob ntshav qab zib. 2011; 60(5):{4}}.
5. Dunning BE, Gerich JE. Lub luag haujlwm ntawm alpha-cell dysregulation hauv kev yoo mov thiab postprandial hyperglycemia hauv hom 2 mob ntshav qab zib thiab cuam tshuam txog kev kho mob. Endocr Rev. 2007;28(3):253-283.
6. J.J. Kev tswj glycemia. Baillieres Clin Endocrinol Metab. 1993; 7(3):{4}}.