Taw qhia
Glucagon-zoo li Peptide (GLP) tau nce mus rau qhov pom tau zoo ua tus tswj hwm tseem ceeb hauv kev sib koom ua ke ntawm metabolic thiab kev tswj hwm ntshav qab zib. Unwinding nws cov kev ua ub no yog qhov tseem ceeb rau kev tsim kom muaj kev kho mob txaus thiab kev thov. Hauv qhov kev nkag blog no, peb tawm ntawm kev mus ncig ua si rau hauv cov txheej txheem tsis meej pem zais GLP thiab nws txoj kev cuam tshuam rau kev sib txawv ntawm lub cev.
GLP-1(7-37)Cov tshuaj peptide tso tawm los ntawm kev zom zaub mov, suav tias yog ib feem tseem ceeb hauv kev ntsuas cov kab mob metabolic, tshwj xeeb tshaj yog cov uas txuas nrog cov piam thaj homeostasis. Ib qho ntawm nws lub peev xwm tseem ceeb yog ua kom cov tshuaj insulin tso tawm los ntawm cov kab mob pancreatic vim tias cov ntshav qabzib nce siab, tom qab ua haujlwm nrog cov piam thaj coj los ntawm cov hlwb thiab txo qis cov piam thaj hauv cov ntshav. Tsis tas li ntawd, GLP txo qis glucagon tawm ntawm pancreatic-cells, pab ntxiv nrog zais cov piam thaj hauv siab. Cov kev ua ub no muaj lub hom phiaj ntxiv rau kev saib xyuas glycemic tshuav hauv lub cev.
Cov dej num ntawm GLP raug cuam tshuam los ntawm Glucagon-zoo li Peptide-1 receptor (GLP-1R), G-protein-coupled receptor sib txuas lus hauv cov ntaub so ntswg sib txawv, suav nrog pancreatic -cells, kab mob plab, thiab focal sensory qhov system. Tom qab kev txwv rau GLP-1(7-37), GLP pib lub qhov dej ntawm cov kab mob hauv lub cev, ua rau kev pib ntawm cov protein kinases thiab kev tswj hwm kev sib txuas lus zoo. Qhov no thaum kawg tshwm sim hauv kev hloov kho cov tshuaj insulin, txwv tsis pub glucagon tso tawm, ncua kev zom zaub mov, thiab kev nce qib ntawm satiety.
Muab nws txoj haujlwm tseem ceeb hauv cov txheej txheem metabolic thiab qabzib homeostasis, GLP thiab nws cov receptors tau dhau los ua qhov tseem ceeb rau kev sib haum xeeb hauv kev tswj hwm ntshav qab zib thiab cov teeb meem metabolic. Cov kws kho mob tshwj xeeb hu ua GLP-1 receptor agonists tau tsim los xyaum ua cov haujlwm ntawm endogenous GLP-1, hauv txoj kev no txhim kho cov tshuaj insulin tawm thiab txhim kho glycemic tswj hauv cov neeg mob ntshav qab zib hom 2. Cov kws kho mob tshwj xeeb no muab txoj hauv kev los daws cov ntshav qab zib cov thawj coj, nrog rau qhov muaj peev xwm ntxiv lossis sim thiab hloov cov kev kho mob zoo li insulin infusions lossis tshuaj tiv thaiv kab mob hauv qhov ncauj.
Txhua yam, Glucagon-zoo li Peptide (GLP) tseem yog tus neeg koom tes tseem ceeb hauv ntau lub koom haum ntawm cov txheej txheem metabolic thiab ntshav qab zib hauv pawg thawj coj. Los ntawm nws cov dej num cuam tshuam los ntawm GLP-1 receptor, GLP siv cov txiaj ntsig tseem ceeb rau insulin emission, glucagon txwv tsis pub, thiab kev tswj hwm kev tshaib kev nqhis, yog li cuam tshuam rau cov kab mob sib txawv hauv lub cev kom ua raws li cov metabolism hauv homeostasis. Los ntawm kev nkag siab txog cov cuab yeej tseem ceeb ntawm GLP cov dej num, cov kws tshuaj ntsuam tuaj yeem txuas ntxiv tsim cov kev kho mob xav tau taw qhia rau kev txhim kho ntxiv rau cov neeg mob ntshav qab zib thiab cov teeb meem metabolic.
Glucagon-Like Peptide tswj cov ntshav qab zib li cas?
Glucagon-zoo li Peptide (GLP-1) yog ib qho tshuaj incretin tsim los ntawm lub plab zom mov hauv qhov pom ntawm kev noj tshuaj ntxiv. Ib qho ntawm nws lub peev xwm tseem ceeb yog cov txheej txheem ntawm cov piam thaj. Thaum cov zaub mov nkag mus rau hauv lub plab zom mov, GLP-1 raug xa mus rau hauv cov hlab ntsha, uas nws ua raws li pancreatic beta hlwb kom txhawb nqa cov tshuaj insulin. Qhov kev cuam tshuam insulinotropic no pab ua haujlwm nrog kev nqa cov piam thaj mus rau hauv cov hlwb, yog li ua rau cov ntshav qabzib qis. Ntxiv mus,GLP-1(7-37)represses qhov tuaj txog ntawm glucagon, ib yam tshuaj uas txhawb nqa cov piam thaj, ntxiv rau nws cov yeeb ncuab ntawm kev cuam tshuam hyperglycemic.
Txhawm rau nkag siab txog cov cuab yeej tom qab GLP-1 cov haujlwm ntawm cov lus qhia ntawm cov piam thaj, kev tshawb xyuas nws txoj kev koom tes nrog cov kab mob pancreatic yog qhov tseem ceeb. GLP-1 kev sib raug zoo rau cov receptors meej ntawm beta hlwb, teeb tsa tus ciav dej uas thaum kawg ua rau exocytosis ntawm cov hlwv uas muaj cov tshuaj insulin. Qhov kev cuam tshuam no yog cuam tshuam los ntawm cyclic adenosine monophosphate (cAMP) thiab protein kinase A (PKA) chij txoj hauv kev. Los ntawm kev txhim kho cov tshuaj insulin emissions thiab smothering glucagon tso tawm, GLP-1 pab tswj cov piam thaj hauv lub cev hauv lub cev.
Glucagon-zoo li Peptide ua haujlwm li cas hauv kev tswj hwm kev ntshaw?
Yav dhau los nws cov kev cuam tshuam ntawm cov lus qhia hauv qabzib, Glucagon-zoo li Peptide kuj tseem suav tias yog ib feem tseem ceeb hauv kev xav tswj thiab satiety. Tom qab noj mov, GLP-1 raug xa mus rau hauv cov hlab ntsha thiab ua raws li lub paj hlwb, ib cheeb tsam ntawm lub paj hlwb koom nrog tswj kev xav thiab lub zog sib npaug. GLP-1 receptors muaj ntau nyob rau hauv lub paj hlwb, qhov chaw uas lawv tweak neuronal kev txiav txim thiab cuam tshuam rau kev saib xyuas tus cwj pwm.
Cov kev tshawb fawb tau pom tias GLP-1 txo qis kev ntshaw los ntawm kev nce qib ntawm kev ua tiav thiab kev txaus siab. Nws yooj yim rov qab plab purging, ncua sij hawm nws yuav siv sij hawm rau cov zaub mov tawm hauv plab thiab nkag mus rau hauv lub plab zom mov me. Qhov no ua rau lub plab zom mov ua rau lub plab zom mov hauv qhov tuaj txog qeeb dua ntawm cov tshuaj ntxiv rau hauv cov hlab ntshav, ua rau muaj kev txhawb nqa kev xav ntawm tag nrho thiab kev noj zaub mov tsawg. Tsis tas li ntawd,GLP-1(7-37)smothers qhov kev txiav txim ntawm orexigenic neurons, uas yog lub luag hauj lwm rau invigorating kev tshaib kev nqhis, thaum tib lub sij hawm enacting anorexigenic neurons uas ua rau satiety.
Puas yuav Glucagon-zoo li Peptide siv rau cov ntshav qab zib cov thawj coj?
Muab nws cov kev cuam tshuam hnyav rau cov lus qhia hauv qabzib thiab kev tswj hwm kev xav, Glucagon-zoo li Peptide tau khwv tau nyiaj tau los ua lub hom phiaj kho mob ntshav qab zib cov thawj coj. Txij li thaum lig, GLP-1 receptor agonists tau tshwm sim raws li cov chav kawm ntawm cov tshuaj siv hauv kev kho mob ntshav qab zib hom 2. Cov tshuaj no ua rau kev ua haujlwm ntawm endogenous GLP-1, ua kom cov tshuaj insulin emissions thiab txwv glucagon tawm.
GLP-1 receptor agonists muab ob peb yam txiaj ntsig tshaj li cov tshuaj noj ntshav qab zib. Lawv tau tshwm sim los ua ntej kev poob phaus, txhim kho glycemic tswj, thiab txo qhov kev twv txiaj ntawm lub plawv dhia. Tsis tas li ntawd, nyob rau hauv qhov pom ntawm qhov tseeb tias lawv yuav tsum muaj peev xwm tsis muaj peev xwm beta ntawm tes los siv lawv cov khoom, GLP-1 receptor agonists yog qhov zoo tshaj plaws rau cov neeg mob uas muaj peev xwm tiv thaiv kab mob pancreatic. Ua li ntawd, lawv txoj kev siv yog cuam tshuam rau qee yam kev cuam tshuam, nrog rau kev ua tsis zoo ntawm plab hnyuv thiab qhov kev twv txiaj ntawm tus kab mob pancreatitis.
Txhua yam, Glucagon-zoo li Peptide suav tias yog ib feem tseem ceeb hauv cov lus qhia ntawm qib qabzib thiab tswj kev ntshaw. Nws lub luag haujlwm tseem ceeb suav nrog kev zoo siab ntawm kev tso tawm insulin, txwv tsis pub glucagon xa, thiab sib npaug ntawm kev ua haujlwm neuronal hauv lub paj hlwb. Los ntawm kev nkag siab li casGLP-1(7-37)muaj peev xwm, cov kws tshawb fawb tuaj yeem txhawb nqa kev kho mob rau cov ntshav qab zib cov thawj coj thiab kev kho mob hnyav, muab kev cia siab ntxiv txhim kho kev noj qab haus huv rau ntau tus neeg thoob ntiaj teb.
Cov ntaub ntawv:
1. Drucker DJ. Kev tshawb fawb ntawm cov tshuaj incretin. Cell Metab. 2006; 3(3):{4}}.
2. Holst JJ, Minister CF, Vilsbøll T, Krarup T, Madsbad S. Glucagon-zoo li peptide-1, glucose homeostasis thiab ntshav qab zib. Patterns Mol Tshuaj. 2008; 14(4): 161-168.
3. Nauck Mama, Meier JJ. Glucagon-zoo li peptide 1 thiab nws cov koom haum hauv kev kho mob ntshav qab zib. Regul Peb. 2005; 128(2): 135-148.
4. Pob zeb A, Raben A, Astrup A, Holst JJ. Glucagon-zoo li peptide 1 txhawb kev satiety thiab smothers zog nkag rau hauv tib neeg. J Clin Pab. 1998; 101(3): 515-520.
5. Knudsen LB, Pridal L. Glucagon-zoo li peptide-1-(9-36) amide yog ib qho tseem ceeb metabolite ntawm glucagon-zoo li peptide-1-(7-36) amide tom qab hauv vivo lub koom haum rau canines, thiab nws mus txog raws li ib tug neeg phem phem nyob rau hauv lub pancreatic receptor. Eur J Pharmacol. 1996; 318(2-3):{10}}.
6. Meier JJ, Nauck Mam. Glucagon-zoo li peptide 1 (GLP-1) hauv kev tshawb fawb thiab kab mob. Diabetes Metab Res Fire up. 2005; 21(2):{7}}.
7. Astrup A, Rossner S, Van Gaal L, thiab al. Kev cuam tshuam ntawm liraglutide hauv kev kho mob heftiness: ib qho randomized, ob npaug ntawm qhov muag tsis pom kev, kev tshawb fawb cuav. Lancet. 2009; 374(9701):1606-1616.
8. Vilsbøll T, Christensen M, Junker AE, Knop FK, Gluud LL. Kev cuam tshuam ntawm glucagon-zoo li peptide -1 receptor agonists ntawm kev txo qhov hnyav: kev tshawb fawb thiab kev tshawb xyuas meta ntawm randomized tswj ua ntej. BMJ. Xyoo 2012; 344: d7771.
9. Pories WJ, Swanson MS, MacDonald KG, et al. Leej twg yuav tau xav txog nws? Ib qho kev ua ub ua no yog qhov kev kho mob zoo tshaj plaws rau cov neeg laus pib mob ntshav qab zib mellitus. Ann Surg. 1995; 222(3):{5}}.
10. Baggio LL, Drucker DJ. Kev tshawb fawb ntawm incretins: GLP-1 thiab GIP. Gastroenterology. 2007; 132(6):{5}}.