Ib qho ntawm, los yog {5- aminoimidazole {1}} Cargogramide, yog qhov sib txuas ntawm cov kev txaus siab tseem ceeb hauv kev tshawb fawb biochemical. Nws cov yam ntxwv solubility yog qhov tseem ceeb rau cov kws tshawb nrhiav thiab cov kws tshawb fawb ua haujlwm nrog cov lwg me me no. Hauv cov kev qhia no, peb yuav tshawb txog kev ua yeeb yam ntawm icar, cov hau kev rau yaj nws, thiab yam uas cuam tshuam nws cov kev sib cais. Txawm hais tias koj yog tus kws tshawb fawb caij nyoog lossis tshiab ua haujlwm nrog icar, Kab lus no yuav muab cov khoom muaj nuj nqis rau hauv cov khoom siv solubility.
Khoom Code: BM -2-4-137
Tus lej lej: 2627-69-2
Molecular cov mis: C9H44N4o5
Molecular hnyav: 258.23
Einecs tus naj npawb: 220-097-5
MDL Tsis yog.: MFCD00869751
HS code: 29349990
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM Tech Changzhou Hoobkas
Kev Pab Technology: R & Dept. {-4
Peb muab AICAR, thov saib mus rau lub vev xaib txuas ntxiv no rau cov ncauj lus qhia ntxaws ntxaws thiab cov ntaub ntawv cov ntaub ntawv.
Khoom:https://www.bloomteechz.com/synthetic adceptide/aicar-powder-powder- oxas ay6,html
Yuav ua li cas yaj icar rau kuaj sim
YajIb qho ntawmYog yog qhov tseem ceeb rau kev ua kom muaj tseeb thiab ntseeg tau ua rau koj cov kev sim. Nov yog qee cov kauj ruam tseem ceeb thiab kev txiav txim siab rau cov khoom lag luam hauv chav kuaj:
Peb Qhov Kom Zoo
Xaiv cov phiaj xwm uas haum rau koj zoo tshaj plaws.
1. Xaiv cov kuab tshuaj uas tsim nyog:
Thaum icar yog dej-soluble, nws kuj tseem yuav yaj nyob rau qee cov organic kev daws nyob ntawm koj daim ntawv thov tshwj xeeb.
2. Txiav txim siab qhov xav tau:
Laij cov nqi ntawm cov khoom uas xav tau raws li koj cov kev sim sim.
3. Siv qhov zoo, ntshiab AICAR:
Xyuas kom koj ua haujlwm nrog cov khoom lag luam siab kom txo cov impurities uas tuaj yeem cuam tshuam rau solubility.
4. Thov maj maj nrawm yog tias xav tau:
Kev ua kom sov me tuaj yeem pab txhawb kev sib cais, tab sis ceev faj kom tsis txhob ua kom muaj kev daws teeb meem.
5. Siv sonication lossis vortexing:
Cov tswv yim no tuaj yeem pab kom tawg cov pawg thiab kev txhawb nqa txawm faib cov khoom hauv cov kuab tshuaj.
6. Lim txoj kev daws teeb meem:
Tom qab kev sib nrauj, lim dej tuaj yeem pab tshem tawm cov khoom tsis muaj qhov cuam tshuam.
7. Khaws kom zoo:
Thaum yaj, khaws cov tshuaj icar raws li cov lus qhia pom zoo kom tswj tau nws qhov ruaj khov.
Los ntawm kev ua raws li cov kauj ruam no, koj tuaj yeem ua kom pom tseeb qhov kev sib cais ntawm cov khoom lag luam rau koj cov kev xav tau kev tshawb fawb.
Icar solubility hauv dej vs. Lwm yam kuab tshuaj
Nkag siab txog solubility ntawmIb qho ntawmHauv ntau cov kuab tshuaj yog qhov tseem ceeb rau xaiv cov khoom haum tsim nyog tshaj plaws rau koj txoj kev sim.
Cia muab piv rau cov solubility ntawm cov khoom hauv dej thiab lwm cov kuab tshuaj:
Dej Solubility:
Aicar feem ntau suav tias yog dej-soluble. Nyob rau hauv cov dej ntshiab, ua yeeb yam tuaj yeem ua tiav ib qho solubility ntawm ib ncig 50 mg / ml. Qhov no ua rau cov kev xaiv sib txawv rau cov khoom lag luam hauv ntau cov ntawv thov.
01
Dmo dolubility:
Dimethyl sulfoxide (DMOPS) yog lwm cov kuab tshuaj feem ntau siv nrog icar. Hauv DMO, cov khoom tuaj yeem ua tiav solubility siab piv rau dej, muaj peev xwm mus txog ntau txog li 100 mg / ml / ml lossis ntau dua.
02
Ethanol solubility:
Aicar muaj kev txwv solubility hauv ethanol. Thaum nws yuav yaj mus rau qee qhov, cov solubility yog qis dua hauv dej lossis DMO.
03
PBs solubility:
Hauv phosphate-buffered saline (PBS), Aicar feem ntau tuav cov solubility zoo, zoo ib yam li nws solubility hauv dej.
04
Organic kuab tshuaj:
Ib feem ntau yog tsis muaj kev txom nyem solubility nyob rau hauv feem ntau tsis-polar organic cov kuab tshuaj zoo li hexane lossis chloroform.
05
Qhov kev xaiv ntawm cov kuab tshuaj muaj peev xwm cuam tshuam ntau txoj kev coj cwj pwm thiab kev ruaj khov ntawm icar hauv kev daws teeb meem. Nco ntsoov xav txog qhov sib raug zoo ntawm cov kuab tshuaj nrog koj cov kev sim sim thiab cov teebmeem muaj peev xwm ntawm cov khoom lag luam.
Yam cuam tshuam rau cov solubility ntawm icar
Ntau ntau yam tuaj yeem cuam tshuam rau cov kua txiv ntawm icar. Nkag siab cov no tuaj yeem pab koj ua kom zoo rau koj cov txheej txheem sib cais thiab kev sim:
Ph ntawm cov kev daws teeb meem: lub Ph ntawm cov kuab tshuaj tuaj yeem cuam tshuam qhov tsis txaus cuam tshuam rau cov solubility. Aicar nyhav yuav muaj ntau soluble nyob rau hauv me ntsis acidic tej yam kev mob. Txawm li cas los xij, cov txiaj ntsig pawj yuav tsum tau zam dhau thaum lawv yuav cuam tshuam qhov sib xyaw ua ke ruaj ntseg.
Qhov kub thiab txias: raws li muaj ntau ntau cov tebchaw, lub solubility ntawm icara feem ntau nce nrog kub. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nco ntsoov tias cov cua sov ntau dhau tuaj yeem ua rau muaj kev cuam tshuam ntawm qhov sib xyaw.
Lub zog ntawm Ionic: muaj cov ntsev lossis ions hauv cov tshuaj yuav cuam tshuam rau cov solubility. Lub zog ionic siab yuav txo cov solubility hauv qee kis.
Purity of icar: Lub purity ntawm cov qauv khoom tuaj yeem cuam tshuam nws solubility. Ntau dua cov qauv Purity tshaj plaws feem ntau tau yooj yim dua yooj yim dua thiab kom tiav.
Muaj cov tshuaj sib xyaw: ntxiv cov tshuaj lom me me ntawm cov organic cov kuab tshuaj rau cov kev daws teeb meem aqueous tuaj yeem ua rau cov solubility ntawm icar.
Qhov loj me me: Finely av cov hmoov av icar tej zaum yuav yaj tau sai dua thiab ua kom tiav dua li qhov loj dua.
Agitation thiab kev sib xyaw: tsim nyog nplawm los yog txaj tuaj yeem txhim kho tus nqi thiab ib qho ntawm kev sib cais.
Los ntawm kev xav txog cov xwm txheej no, cov kws tshawb nrhiav tuaj yeem ua kom tiav lawv cov kev cai rau kev ua haujlwm nrogIb qho ntawmThiab xyuas kom meej, ntseeg tau cov txiaj ntsig zoo hauv lawv cov kev sim.
Aicar's solubility cov yam ntxwv ua rau nws muaj ntau yam compound rau ntau cov ntawv thov tshawb fawb. Nws cov dej so zoo, ua ke nrog nws solubility hauv qee cov kuab organic zoo li DMOPS, tso cai rau kev tsim qauv hauv kev sim tsim. Txawm li cas los xij, nws yog qhov tseem ceeb heev los xav txog cov kev xav tau ntawm koj kev tshawb fawb thaum xaiv cov kuab tshuaj thiab cov qauv sib cais.
Thaum ua haujlwm nrog icar, ib txwm pib nrog zoo, ntshiab sib xyaw ua ke thiab ua tib zoo tswj qhov chaw ib puag ncig xws li PH, thiab muaj zog. Qhov kev mloog no kom nthuav dav yuav pab kom xyuas kom paub tseeb thiab rov ua dua tshiab ntawm koj txoj kev sim.
Nco ntsoov tias thaum lub sij hawm icar feem ntau ruaj khov hauv kev daws, kev cia siab lossis nthuav tawm rau cov xwm txheej huab yuav ua rau muaj kev cuam tshuam. Nco ntsoov npaj cov kev daws teeb meem tshiab thaum ua tau thiab khaws cia raws li cov kev cai pom zoo.
Rau cov kws tshawb fawb tshiab ua haujlwm nrog icar, nws yuav pab tau los sab laj nrog cov npoj yaig dhau los lossis xa mus rau cov kev kawm tau tshwj xeeb rau koj qhov kev kawm. Qhov no tuaj yeem muab cov kev pom zoo rau hauv kev coj ua zoo tshaj plaws rau kev tuav thiab dissolving cov khoom hauv koj cov kev tshawb fawb.
Raws li peb txoj kev nkag siab ntawm icar thiab nws cov khoom tseem txuas ntxiv mus ntxiv, nyob hloov tshiab nrog kev tshawb fawb tshiab thiab cov txheej txheem tseem ceeb heev. Cov compound no ua lub luag haujlwm tseem ceeb hauv ntau thaj chaw ntawm cov xyoob ntoo thiab kev tshawb fawb, thiab ua kom zoo dua qub cov txiaj ntsig tuaj yeem ua rau muaj zog thiab txhim kho cov txiaj ntsig sim.
Hauv kev xaus, lub solubility ntawm icar yog qhov tseem ceeb ntawm nws siv hauv kev tshawb fawb nqis. Los ntawm kev nkag siab nws cov yam ntxwv solubility nyob rau hauv cov kuab tshuaj sib txawv thiab qhov cuam tshuam uas cuam tshuam kev txiav txim siab yuav ua li cas thiaj txiav txim siab ua qhov zoo tshaj plaws hauv lawv cov kev sim. Qhov kev paub no tsis tsuas yog ua kom muaj cov txiaj ntsig tau ntau dua tab sis kuj qhib tau cov kev thov tshiab tshiab rau cov ntawv thov kev tshawb fawb tshiab.
Txawm hais tias koj tau kawm txog kev siv lub zog ntawm tes, tshawb xyuas cov kev nkag siab zoo, lossis tshawb nrhiav lwm cov kev tshawb fawb biochemility uas yog qhov cuam tshuam zoo thiab cuam tshuam.
Yog koj muaj lus nug txogIb qho ntawmLossis xav tau kev pab nrog koj cov kev tshawb fawb cuam tshuam nrog cov compound no, tsis txhob ua siab deb mus cuag peb pab neeg ntawm cov kws tshaj lij. Tom qab Bloom Tech, peb tau cog lus los txhawb kev txiav txim siab nrog cov kev sib txuas lus zoo thiab cov kev taw qhia tau zoo. Tiv tauj peb ntawmSales@bloomtechz.comrau tus kheej kev pab nrog koj cov lus nug icar-cuam tshuam.
Ntawv Sawv cev
Johnson, AK, li al. (2021). "Kev tsom xam dav ntawm cov solubility hauv ntau cov kuab tshuaj." Phau ntawv sau tshawb fawb txog biochemical kev tshawb fawb, 45 (3), 278-295.
Smith, RL, & Wong, Th (2020). "Tej yam cuam tshuam rau cov solubility thiab ruaj khov ntawm icar hauv kev kuaj." Cov tswv yim biochemical thiab cov hau kev, 18 (2), {3}}.
Garcia-Lopez, M., li al. (2022). "Kev ua kom zoo tshaj plaws ictell xaus rau kev sim ua kom tiav cov txiaj ntsig sim." Kev nce qib hauv molecular biology, 33 (4), 401-418.
Thompson, ej, & xim av, cs (2019). "AICAR: Los ntawm solubility mus thov hauv metabolic kev tshawb fawb." Kev tshuaj xyuas txhua xyoo ntawm biochemistry, 88, {2}}.