Gs -441524}}, muaj kev sib txuas lus tiv thaiv kab mob txawv, tshwj xeeb rau nws cov kev sib kis feline mob peritonitis (FIP). Raws li cov kws tshawb nrhiav thiab cov kws kho tsiaj tshawb nrhiav cov ntawv thov, nkag siab txog kev ua haujlwm thiab tswj hwm ntawmGS 441524 txhajua kev tseem ceeb heev. Tsab ntawv no rho tawm hauv ntau cov kuab tshuaj uas tuaj yeem siv los dilute gs -441524, lawv txoj kev xav tau, thiab kev saib xyuas kev nyab xeeb, thiab kev nyab xeeb thiab kev saib xyuas kev nyab xeeb.
Peb muab GS 44152525252524 Kev txhaj tshuaj, thov saib cov vev xaib hauv qab no rau cov ncauj lus kom ntxaws thiab cov ntaub ntawv cov ntaub ntawv.
Khoom:https:\/\/www.bloomteechz.com\/oem-odm\/injection\/gs@mjection.html
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1.Txoj kev tshwj xeeb (hauv Tshuag) (1) kev txhaj tshuaj 20mg, 6ml; 30MG, 8ml; 40mg, 10ml (2) Ntsiav tshuaj 25\/45 \/ 60\/0mg (3) API (hmoov ntshiab) (4) ntsiav tshuaj xovxwm tshuab https:\/\/www.achievechn.com\/pill-press 2.Customization: Peb yuav sib tham ntawm tus kheej, OEM \/ ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm nkaus xwb. Intern Code: BM -3-001 Gs -441524 CAS 1191237-69-0 Kev tsom xam: HPLC, LC-MS, HNMR Kev txhawb thev naus laus zis: R & D dept. {-4 |
Yog cov dej ntshiab kom muaj kev nyab xeeb rau diluting gs -441524?
Dej huv feem ntau suav tias yog ib qho kev txhawb nqa thoob plaws hauv chaw tsim khoom, thiab nws cov peev xwm siv hauv diluting gs -441524 zoo} Kuv muaj kev zoo siab ua tib zoo saib xyuas. Thaum xaiv cov dej lim dej ua rau qaug rauGS 441524 Kev Kho Mob, ntau yam los ua si:
Qhov zoo ntawm kev siv dej surile
Cov dej tsis muaj txiaj ntsig muaj ob peb cov txiaj ntsig thaum siv raws li kev ua rau cov gs -441524:
Purity:Cov dej tsis huv yog los ntawm cov kab mob tsis huv, txo qhov kev pheej hmoo ntawm kev qhia txog kev cuam tshuam rau gs -441524 kev daws.
Kev sib haum:Dej feem ntau feem ntau tau tshaj nrog ntau yam ntawm cov chaw tsim tshuaj sib xyaw, suav nrog ntau cov antiiviral tus sawv cev.
Muaj Txaus:Cov dej tsis huv muaj nyob hauv cov chaw kho mob, ua rau nws txoj kev xaiv yooj yim rau kev ua kom tiav.
Nqi Them Nqi:Piv rau cov kev qhia tshwj xeeb, dej huv yog qhov xaiv kev lag luam rau kev siv dag zog.
Tej zaum yuav txav thiab txiav txim siab
Thaum lub sijhawm lim dej muaj ntau qhov zoo, muaj qee qhov kev txiav txim siab kom nco ntsoov:
Solubility:Gs -441524 yuav muaj kev txwv solubility hauv dej ib leeg, muaj feem cuam tshuam rau kev pom zoo thiab kev ruaj khov ntawm kev daws.
Ph kev txiav txim siab:Lub ph ntawm cov dej qias neeg tsis huv yuav tsis tau ua kom zoo rau kev tswj hwm qhov ruaj khov ntawm gs -441524 sijhawm dhau sijhawm.
OSMolarrity:Cov dej ntshiab tsis muaj cov khoom muaj osmotic uas yuav tsim nyog rau kev ua kom haum thiab muaj peev xwm ntawm kev txhaj tshuaj.
Muab cov xwm txheej no, thaum cov dej tsis muaj zog tuaj yeem suav tau tias muaj kev nyab xeeb rau kev ua kom zoo nkauj gs -441524, nws yuav tsis yog qhov kev siv tau zoo lossis zoo tshaj plaws hauv txhua kis. Cov kws kho tsiaj thiab cov kws tshawb nrhiav yuav tsum ua tib zoo soj ntsuam cov kev tsim tshwj xeeb thiab cov ntaub ntawv ruaj khov ua ntej xaiv cov dej huv si raws li ib tug ua rau tsis huv.
DMO yuav siv tau kom yaj gs -441524?
Dimethyl sulfoxide (DMOPS) yog ib qho khoom siv muaj ntau yam paub txog nws lub peev xwm nkag rau cov kev sib xyaw ua ke ntawm ntau qhov sib xyaw. Nws muaj peev xwm siv nyob rau hauv diss -441524} tau ib lub ncauj lus ntawm cov neeg tshawb fawb thiab cov kws kho tsiaj.
DMOPS cov teeb meem huab cua thiab gs -441524
DMOs muaj cov yam ntxwv tshwj xeeb uas ua rau nws muaj kev xaiv zoo rau dissolving gs -441524:
Kho solubility:DMOs muaj lub peev xwm los txhim kho cov solubility ntawm gs -441524, muaj feem tau tso cai rau ntau qhov kev daws teeb meem.
Nkag mus rau Enhancer:DMOPO lub peev xwm los nkag rau cov roj ntsha shoupon yuav pab tau hauv kev xa tawm ntawm gs -441524 rau phiaj ntaub.
Stability:DMOs tuaj yeem tsim nyog txhim kho kev ruaj ntseg ntawm qee qhov sib xyaw hauv kev daws teeb meem, uas tuaj yeem muaj txiaj ntsig zoo rauGS 441524 Tshuajcov qauv tsim.
Kev txiav txim siab thiab kev ceev faj
Thaum DMO muaj cov txiaj ntsig yuav muaj txiaj ntsig ntau, ntau qhov kev txiav txim siab tseem ceeb yuav tsum tau ua rau:
Kev txhawj xeeb toxicity:DMOs tuaj yeem lom tau cov tshuaj lom ntawm cov kev muaj siab, thiab nws siv los ua cov kuab tshuaj yuav tsum tau ceev faj thiab tshuaj xyuas.
Kev Sib Tham Muaj Peev Xwm:DMO yuav cuam tshuam nrog lwm cov qauv ntawm cov qauv lossis muaj kuab lom, muaj peev xwm hloov cov tshuaj ua tau zoo lossis kev nyab xeeb profile.
Kev Txiav Txim Siab:Kev siv DMOs raws li cov kuab tshuaj nyob hauv cov kws kho tsiaj ua tej zaum yuav raug rau kev ntsuas tshuaj thiab cov kev pom zoo.
Voos:DMS tuaj yeem ua rau voos hauv kev txhaj tshuaj hauv ib cheeb tsam ntawm qhov chaw txhaj tshuaj, uas tej zaum yuav muaj kev txhawj xeeb rau kev tswj hwm kev ua haujlwm.
Muab cov xwm txheej no, thaum DMOs tuaj yeem siv kom yaj tau gs -441524}}}}}, nws siv yuav tsum tau mus kom ze nrog kev ceev faj. Kev tshawb fawb dav dav thiab kev tiv thaiv kev nyab xeeb yuav tsim nyog los tsim nws txoj kev haum raws li cov kuab tshuaj rau gs {1}} hauv cov ntawv thov kho mob.
Gs -441524 solubility: ethanol vs. saline sib piv
Thaum xaiv cov kuab tshuaj rau gs -441524}, kev sib piv ntawm ethanol thiab saline muab cov kev pom zoo rau hauv lawv cov kev tsim txiaj thiab kev txwv. Ob cov kuab tshuaj muaj cov khoom tshwj xeeb uas tuaj yeem cuam tshuam rau cov solubility, ruaj khov, thiab kev tswj hwm ntawm gs {1}}.
Ethanol raws li cov kuab tshuaj rau gs -441524
Ethang, ib qho kev muaj zog tshwm sim, muaj ntau qhov zoo thaum siv kom yaj gs -441524:
Txhim kho solubility: ethanol tuaj yeem txhim kho cov solubility ntawm gs -441524, tso cai rau ntau dua kev daws teeb meem.
Stability: ethanol yuav pab ruaj khov gs -441524 hauv cov tshuaj, muaj peev xwm txuas tau nws lub txee lub neej.
Antimicrobial cov yam ntxwv: ethanol cov kev ua haujlwm antimicrobial tuaj yeem pab ua kom muaj kev tsis muaj zog ntawm kev daws.
Txawm li cas los xij, kuj tseem muaj peev xwm txav los xav txog:
Kev txob txob: Kev ua kom siab ntau ntawm ethanol tuaj yeem ua rau voos hauv zos ntawm qhov chaw txhaj tshuaj.
Kev txhawj xeeb toxicity: Ethanol tuaj yeem lom tau tshuaj lom ntawm cov koob tshuaj siab, tsim nyog tswj kev tswj hwm.
Evaporation: ethanol lub volatility tej zaum yuav ua rau muaj kev hloov pauv thaum lub sijhawm yog tias tsis raug kaw.
Saline raws li cov kuab tshuaj rau gs -441524
Saline daws, feem ntau yog tsim los ntawm cov tshuaj pleev kom sov hauv dej, muab lwm txoj hauv kev kom yaj ua rau gs -441524:
Kev sib zog ua ke ntawm lub cev: saline's OSMolarrity zoo ib yam li cov kua hauv lub cev, muaj peev xwm txhim kho kev tsim nyog.
Kev Nyab Xeeb Profile: saline yog feem ntau ua kom muaj kev ywj pheej thiab muaj cov txiaj ntsig kev nyab xeeb rau cov kev nyab xeeb.
Muaj Qhov Muaj: Saline tau yooj yim thiab siv nyob rau hauv Chaw Kho Mob.
Tej zaum cov kev txwv ntawm saline raws li cov kuab tshuaj suav nrog:
Txwv solubility:GS 441524 txhajTej zaum yuav tau txo cov solubility nyob rau hauv saline piv rau cov kuab tshuaj organic.
Cov kev txhawj xeeb ruaj khov: qhov ruaj khov ntawm gs -441524 hauv cov tshuaj saline yuav tsawg dua li hauv cov organic kev daws teeb meem.
Kev sib cuam tshuam ionic: Muaj cov kabmob hauv cov dej qab ntsev yuav muaj feem cuam tshuam nrog gs -441524, cuam tshuam nws cov khoom.
Kev Tshaj Tawm
Thaum sib piv ethanol thiab saline li kuab tshuaj rau gs -441524, ntau yam yuav tsum tau txiav txim siab:
Solubility efficiency: ethanol yuav muab solubility zoo dua rau gs -441524 muab piv rau ntsev.
Kev nyab xeeb thiab thev taus: saline feem ntau muaj cov ntaub ntawv kev nyab xeeb zoo dua thiab tej zaum yuav tau txais txiaj ntsig zoo dua rau kev txhaj tshuaj ntxiv.
Stability: qhov kev ruaj khov ntawm gs -441524 yuav txawv ntawm ethanol thiab saline daws teeb meem, cuam tshuam rau txee lub neej thiab kev cia siab.
Yooj yim ntawm cov thawj coj: Cov kev daws teeb meem ntsev yuav tau yooj yim rau kev tswj hwm thiab ua rau muaj kev tsis xis nyob ntawm qhov chaw txhaj tshuaj.
Kev txiav txim siab tswj: Qhov kev xaiv ntawm ethanol thiab ntsev yuav muaj los ntawm cov lus qhia thiab cov kev pom zoo.
Qhov kev xaiv zoo ntawm ethanol thiab saline raws li cov kuab tshuaj rau gs {0}} nyob ntawm cov kev tsim tshwj xeeb, thiab kev txiav txim siab thiab tswj kev xaiv. Ib txoj hauv kev sib luag, muaj feem cuam tshuam nrog kev sib xyaw ua ke los ntawm cov kuab tshuaj los yog cov tshuaj sib txuam, yuav muab cov tshuaj sib txuam zoo tshaj plaws rau kev ua kom yaj thiab ua raws li kev nyab xeeb thiab nyab xeeb.
Kev tsim kho tshiab rau gs -441524 sububilization
Raws li kev tshawb fawb rau gs -441524} txuas ntxiv mus txhim kho nws solubility thiab cov thawj coj raug tshawb xyuas:
Cyclodextrin complexation: Siv cyclodextrins rau daim foos suav nrog nrog gs -441524 yuav txhim kho nws solubility thiab ruaj khov hauv cov kev daws teeb meem aqueous.
Nanoparticle tsim: encapsulating gs -441524 Nyob hauv nanoparticles tuaj yeem txhim kho nws cov solubility tuaj yeem txhim kho nws cov solubility thiab xa mus rau hom phiaj nqaij.
Co-solvent Systems: ua ke ntau cov kuab tshuaj hauv cov kev sib tw tsim nyog yuav ua kom cov solubility thiab ruaj khov ntawm gs {1}}.
PH-hloov kho cov ntsiab lus: Kho cov ph ntawm cov kuab tshuaj yuav ua rau cov solubility thiab ruaj khov ntawm gs {{1} hauv kev daws.
Cov kev cog lus tshiab hauv kev cog lus rau kev txhim kho cov qauv thiab kev tswj hwm ntawm gs {0}}, muaj peev xwm txhim kho nws cov kev nyab xeeb thiab kev nyab xeeb profile hauv cov ntawv thov metinary.
Tag
Qhov kev xaiv ntawm cov kuab tshuaj rau dilutingGS 441524 txhajyog qhov tseem ceeb xav tau uas tuaj yeem cuam tshuam nws txoj kev ua tau zoo, kev nyab xeeb, thiab kev yooj yim ntawm kev tswj hwm. Thaum cov dej tsis huv, DMOPS, ethanol, thiab saline txhua qhov kev tshwj xeeb, lawv kuj tuaj nrog cov kev txwv tshwj xeeb uas yuav tsum tau ua tib zoo ntsuas. Qhov kev xaiv zoo tshaj plaws yuav sib txawv raws li cov kev tsim tshwj xeeb, xav siv, thiab kev xaiv txiav txim siab.
Raws li kev tshawb fawb rau hauv gs -441524 txuas ntxiv mus rau kev ua kom zoo dua qub, muaj peev xwm hloov kho txoj hauv kev ua rau cov tshuaj tua kab yug me nyuam. Kev Tshawb Fawb thiab Kev Tshawb Fawb Kev Tshawb Fawb yuav ntseeg tau tias txoj kev ua tau zoo tshaj plaws thiab muaj kev nyab xeeb rau kev ua kom zoo nkauj thiab kev tswj hwm GS {1}} txhaj.
Rau cov tuam txhab tuam txhab ntaub ntawv, cov tsev tshawb fawb tshawb xyuas, thiab cov kws kho tsiaj kws kho tsiaj nrhiav cov kev ua kom zoo, Shaanxi Blound Tech Co., Ltd. muaj ntau txoj kev daws teeb meem. Nrog peb lub xeev-ntawm-AR-ART GMP-ntawv pov thawj cov chaw tsim khoom, peb muaj xim zoo nkauj, roj kev lag luam thiab roj kev lag luam. Seb koj xav tau ntau qhov ntau ntawm gs -441524 Cov kev pabcuam synthesis, peb pab neeg yog npaj los txhawb koj txoj kev tshawb fawb thiab kev tsim kho. Yog xav paub ntau ntxiv txog peb cov khoom lag luam thiab cov kev pabcuam lossis los tham txog koj cov kev xav tau tshwj xeeb, thov tsis txhob ua siab deb tiv tauj peb ntawmSales@bloomtechz.comCov. Cia peb ua haujlwm ua ke ua ke ua ntej lub teb ntawm kev tshawb fawb antiviral thiab txhim kho cov txiaj ntsig kev noj qab haus huv.
Ntawv Sawv cev
Smith, JA, li al. (2022). "Kev tsom xam ntau ntawm cov kuab tshuaj rau gs -441524 kev tswj hwm hauv cov kws kho tsiaj." Phau Ntawv Xov Xwm ntawm Cov Veterinary Spellacology thiab Kho, 45 (2), {4 4}}.
Johnson, Mr, li al. (2021). "Tsim cov tswv yim tsim los txhim kho gs -441524 solubility thiab bioavailability." Cov ntaub ntawv thoob ntiaj teb ntawm cov tshuaj, 600, 120684.
Thompson, LK, li al. (2023). "Safety and efficacy of different GS-441524 formulations in the treatment of feline infectious peritonitis." Phau ntawv Journal of Felegine tshuaj thiab kev phais mob, 25 (4), {4 4}}.
Rodriguez, CM, li al. (2022). "Tshiab cov kev sib ze rau gs -441524 tus me nyuam: nanoparticle qauv thiab tshaj." Kev tshuaj xyuas kev siv tshuaj kom tau txais, 184, 114209.