Lidocaine Cream yog ib qho tshuaj loog hauv zos. Txij li thaum nws cov ntsiab lus tseem ceeb, Lidocaine, tau tsim nyob rau hauv nruab nrab-20th caug xyoo, nws tau dhau los ua ib qho ntawm cov tshuaj tseem ceeb hauv cov tshuaj kho mob. Lub 30g specification ntawm lidocaine qab zib, raws li ib tug ntau npaum li cas daim ntawv, nws txoj kev loj hlob keeb kwm yog ze ze rau kev nce qib ntawm kev siv tshuaj loog hauv zos, kev ua kom zoo ntawm kev npaj tshuaj, thiab kev hloov pauv ntawm kev kho mob xav tau. Cov hauv qab no yog kev tshuaj xyuas ntawm nws keeb kwm keeb kwm los ntawm peb qhov loj: kev tshawb nrhiav tshuaj, kev tsim kho, thiab kev nthuav dav ntawm kev siv tshuaj.
Los ntawm nws qhov kev tshawb pom nyob rau hauv 1940s mus rau optimization ntawm niaj hnub npaj, txoj kev loj hlob ntawmLidocaine Cream 30gtau pom qhov kev nce qib ntawm cov txheej txheem tshuaj loog hauv zos thiab kev hloov pauv ntawm cov kev xav tau kho mob. Raws li kev siv tshuaj loog hauv zos muaj kev nyab xeeb thiab muaj txiaj ntsig, lidocaine cream ua lub luag haujlwm tseem ceeb hauv kev phais sab nraud, kev ua haujlwm puncture thiab lwm yam haujlwm. Nyob rau hauv lub neej yav tom ntej, nrog rau kev txhim kho ntxiv ntawm cov txheej txheem formulation thiab transdermal tshuaj xa technologies, 30g specification cream yuav tsum tau ua lub luag hauj lwm ntau dua nyob rau hauv ib tug dav ntau yam ntawm kev kho mob scenarios.
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Morphological |
hmoov |
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Acidity coefficient (PKA) |
PKA 7.88 (H2O) (kwv yees) |
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Solubility ethanol |
4 mg/ml |
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Kev cia khoom |
khw hauv RT |
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Flash point |
9 qib |
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Xim |
dawb rau me ntsis daj |
Lidocaine hmoov COA
Discovery thiab Early Application of Lidocaine
Kev tshawb fawb thiab kev loj hlob ntawm lidocaine pib nyob rau hauv 1940s. Xyoo 1943, Swedish chemist Nils Lofgren thawj zaug synthesized lidocaine thiab pom tias nws muaj cov tshuaj loog tseem ceeb hauv zos. Xyoo 1948, lidocaine tau siv thawj zaug hauv kev kho mob raws li kev hloov pauv rau procaine. Vim nws qhov pib sai sai, ntev - cov nyhuv kav ntev thiab tsis muaj toxicity, nws sai sai tau los ua ib qho ntawm cov tshuaj uas nyiam rau kev siv tshuaj loog hauv zos.
Thaum ntxov, lidocaine feem ntau yog siv rau hauv daim ntawv ntawm kev txhaj tshuaj rau kev phais tshuaj loog. Txawm li cas los xij, vim nws muaj zog khaus rau mucosa, nws daim ntawv thov kev kho mob me ntsis txwv. Txhawm rau daws qhov teeb meem no, cov tuam txhab tshuaj tau pib tshawb nrhiav cov tshuaj lidocaine hauv cov tshuaj pleev kom txo tau cov tawv nqaij khaus thiab ua kom lub sijhawm siv tshuaj loog.
Kev txhim kho ntawm Lidocaine Cream Npaj
Kev yug ntawm hom cream
Nyob rau xyoo 1960, nrog rau kev nce qib ntawm kev tsim tshuaj siv tshuab, lidocaine cream maj mam nkag mus rau hauv kev ua lag luam. Cov tshuaj nplaum sib xyaw ua ke lidocaine nrog cov khoom siv xws li emulsifiers thiab moisturizers los tsim ib qho chaw ruaj khov - cov khoom tawg yooj yim, uas tuaj yeem tsis tsuas yog tswj cov kev ua ntawm cov tshuaj tab sis kuj txo qhov khaus ntawm daim tawv nqaij. 30g cov lus qhia ntawm cov tshuaj nplaum tau maj mam dhau los ua cov khoom ntim khoom siv feem ntau hauv cov tsev neeg thiab cov tsev kho mob vim nws qhov kev txav mus los thiab yooj yim ntawm kev siv.
Kev tshawb nrhiav thiab kev txhim kho ntawm kev npaj ua ke
Txhawm rau txhim kho cov nyhuv tshuaj loog, txij li xyoo 1980s, cov chaw muag tshuaj tau pib tsim cov tshuaj lidocaine cream. Piv txwv li, lidocaine thiab Prilocaine sib tov nyob rau hauv ib qho kev faib ua feem los ua ib tug compound cream. Qhov kev npaj ua ke no ua rau luv luv lub sijhawm pib thiab ua rau lub sijhawm ntev ntawm kev siv tshuaj loog los ntawm kev sib koom ua ke ntawm ob cov tshuaj. Lub 30g specification ntawm compound lidocaine qab zib tau ua li no los ua cov tshuaj nyiam nyob rau hauv cov xwm txheej xws li phais sab nraud thiab kev ua haujlwm puncture.
Optimization ntawm txheej txheem formulation
Nrog rau kev nce qib ntawm kev siv thev naus laus zis, cov txheej txheem ntawm lidocaine qab zib tau ua kom zoo dua qub. Piv txwv li, cov tshuaj permeability tuaj yeem txhim kho los ntawm kev siv tshuab microemulsification, lossis transdermal enhancers tuaj yeem ntxiv los ntxiv dag zog rau kev nqus tshuaj. Cov kev txhim kho no tau ua rau 30g cov lus qhia ntawm cov tshuaj nplaum kom muaj kev ruaj ntseg thaum muaj cov tshuaj loog tseem ceeb dua.
Expansion thiab Standardization ntawm Clinical Application
Lidocaine cream yog thawj zaug siv tshuaj loog ntawm daim tawv nqaij, xws li venipuncture thiab kev phais me. Nrog rau qhov tob ntawm kev tshawb fawb soj ntsuam, nws cov kev qhia tau maj mam nthuav mus rau thaj chaw xws li qhov chaw mos mucosal tshuaj loog (xws li txiv neej kev txiav), kev sib tsoo ntawm ceg ulcers, thiab kev kho laser. 30g cov lus qhia ntawm cov tshuaj nplaum tau dhau los ua ib qho kev xaiv rau cov kws kho mob vim tias nws qhov kev siv tshuaj me me, uas tsis tuaj yeem ua tau raws li - siv cov kev xav tau nkaus xwb tab sis kuj tsis txhob pov tseg.
Txhawm rau kom muaj kev nyab xeeb ntawm cov tshuaj, cov cai tswj hwm tshuaj hauv ntau lub tebchaws tau tswj hwm kev siv lidocaine cream. Piv txwv li, qhia txog qhov ntau npaum li cas, qhov siab tshaj plaws ntawm daim ntawv thov cheeb tsam thiab lub sijhawm thov, thiab lwm yam. 30g specification ntawm cream, nrog nws cov koob meej meej, ua rau nws yooj yim rau cov kws kho mob thiab cov neeg mob los tswj cov koob tshuaj thiab txo qhov kev pheej hmoo ntawm kev siv ntau dhau.
Los ntawm qhov kawg ntawm lub xyoo pua 20th mus txog rau thaum pib ntawm lub xyoo pua 21st, nrog kev txhim kho cov qauv kev kho mob thoob ntiaj teb, kev lag luam xav tau lidocaine cream tau loj hlob sai. Ntau lub tuam txhab tshuaj tau tshaj tawm 30g cov khoom lag luam tshwj xeeb, thiab kev sib tw ua lag luam yog qhov hnyav. Txhawm rau txhim kho kev sib tw, cov lag luam tas li txhim kho cov txheej txheem tsim, ua kom zoo tshaj plaws ntawm kev ntim khoom, thiab ua cov kev tshawb fawb soj ntsuam los xyuas qhov ua tau zoo thiab kev nyab xeeb ntawm lawv cov khoom.
Kev Txhim Kho Niaj Hnub Nyoog thiab Kev Lag Luam Yav Tom Ntej
Kev tshawb nrhiav thiab kev tsim kho ntawm tus kheej npaj
Nyob rau hauv xyoo tas los no, nrog kev nce qib ntawm cov tshuaj precision, cov chaw lag luam tshuaj tau pib tshawb nrhiav kev tshawb fawb thiab kev txhim kho ntawm tus kheej lidocaine cream. Piv txwv li, kho qhov concentration ntawm qab zib thiab cov mis ntawm excipients raws li ntau hom tawv nqaij los yog kev phais yuav tsum. Lub 30g specification ntawm qab zib tau dhau los ua tus nqa khoom tseem ceeb hauv kev tshawb fawb thiab kev txhim kho ntawm tus kheej npaj vim nws yooj yim.
Kev nce qib ntawm transdermal tshuaj xa technology
Txoj kev loj hlob ntawm transdermal tshuaj xa technology muab ib tug tshiab kev taw qhia rau optimization ntawm lidocaine cream. Piv txwv li, los ntawm nanotechnology los yog iontophoresis technology, transdermal absorption efficiency ntawm cov tshuaj yuav txhim kho, ntxiv shortening lub sij hawm pib. Daim ntawv thov ntawm cov thev naus laus zis no yuav tsum ua kom muaj 30g cov ntsiab lus ntawm cov tshuaj nplaum los ua lub luag haujlwm hauv ntau qhov chaw kho mob.
Kev nthuav dav thoob ntiaj teb kev lag luam
Nrog rau kev txhim kho cov qauv kev kho mob hauv cov teb chaws tsim, kev lag luam thov rau lidocaine cream txuas ntxiv mus. Lub 30g specification ntawm cream tau dhau los ua thawj qhov kev xaiv rau thawj cov tsev kho mob thiab cov tshuaj hauv tsev vim nws cov nqi siab. Nyob rau hauv lub neej yav tom ntej, nrog kev sib npaug ntawm cov khoom siv kho mob thoob ntiaj teb, kev lag luam kev cia siab rau lidocaine qab zib yuav ntau dua.
Anti-cov nyhuv corrosion
Kev sib piv ntawm Action Mechanisms
Lidocaine Cream 30g
Lub ntsiab tseem ceeb ntawm lidocaine cream yog lidocaine. Qhov tseem ceeb, nws yog ib qho tshuaj loog hauv zos uas ua tiav cov tshuaj loog los ntawm kev thaiv kev sib kis ntawm cov paj hlwb. Hauv kev khaws cia ntawm cov ntaub so ntswg mos, lidocaine cream tsis ncaj qha siv rau kev khaws cia. Hloov chaw, nws tuaj yeem cuam tshuam ncaj qha rau cov txheej txheem decomposition los ntawm inhibiting kev loj hlob ntawm cov kab mob los yog txo cov metabolism hauv cov ntaub so ntswg. Txawm li cas los xij, nws txoj haujlwm tseem ceeb tseem yog tshuaj loog, thiab cov nyhuv antiseptic tsis yog nws lub hom phiaj tseem ceeb tsim.
Glutaraldehyde
Glutaraldehyde yog ib qho tshuaj tiv thaiv zoo, thiab nws cov txheej txheem ntawm kev ua haujlwm yog raws li cov protein cross-txuas thiab kev puas tsuaj ntawm cov qauv ntawm tes. Cov pab pawg aldehyde nyob rau hauv glutaraldehyde molecule tuaj yeem khi nrog cov amino pawg hauv microbial proteins los ua tus ntoo khaub lig ruaj khov - txuas cov qauv, ua rau cov protein denaturation thiab inactivation. Tsis tas li ntawd, glutaraldehyde tseem tuaj yeem rhuav tshem cov qauv ntawm cov cell membranes thiab cuam tshuam nrog cov txheej txheem metabolic ntawm cov kab mob, yog li ua tiav qhov dav -spectrum tua kab mob, fungi, kab mob thiab spores. Hauv kev khaws cia ntawm cov ntaub so ntswg mos, glutaraldehyde ua tiav ntev - lub sij hawm khaws cia los ntawm kev kho cell morphology, inhibiting enzyme kev ua si thiab tiv thaiv cov txheej txheem autolysis.
Kev sib piv ntawm Cov Txheej Txheem Siv Tau
Lidocaine Cream 30g
Lidocaine cream feem ntau yog siv nyob rau hauv kev kho mob tshuaj loog scenarios, xws li kev phais superficial, puncture operations thiab kev kho mob ntawm daim tawv nqaij. Nyob rau hauv kev khaws cia ntawm cov ntaub so ntswg mos, nws daim ntawv thov scenarios yog heev txwv. Nws tsuas yog siv tau raws li txoj kev khaws cia ib ntus (xws li luv- lub sijhawm thauj mus los) lossis kev ntsuas kev pabcuam (xws li txo qhov mob thaum lub sijhawm ua cov qauv). Vim nws tsis muaj peev xwm preservative ncaj qha, nws tsis tuaj yeem hloov cov tshuaj preservatives.
Glutaraldehyde
Glutaraldehyde yog ib qho ntawm feem ntau siv preservatives rau cov ntaub so ntswg mos hauv thaj chaw ntawm cov tshuaj thiab kev tshawb fawb, thiab yog dav siv nyob rau hauv pathological, histological thiab microbiological kev tshawb fawb. Nws cov xwm txheej siv tau suav nrog:
Pathological seem npaj:Kho cov ntaub so ntswg morphology los tiv thaiv autolysis thiab kev noj nyiaj txiag.
Electron microscope soj ntsuam:Stabilize lub ultrastructure ntawm cell.
Ntev -kev khaws cia ntev:Nthuav lub sijhawm khaws cia ntawm cov qauv los ntawm tus ntoo khaub lig- txuas.
Glutaraldehyde fixative (xws li 2% lossis 3% concentration) yog tus qauv reagent rau kev sim tshuaj histochemical. Nws muaj zog permeability thiab zoo fixation, thiab tshwj xeeb tshaj yog haum rau cov qauv nplua nuj nyob rau hauv cov ntaub so ntswg.
Kev sib piv ntawm Anti-corrosion Effects
Lidocaine Cream 30g
Cov nyhuv preservative ntawm lidocaine qab zib yog qhov tsis muaj zog, feem ntau yog vim nws tsis yog -cov kws tshaj lij preservative zog. Hauv cov ntaub so ntswg mos, nws tuaj yeem cuam tshuam kev noj nyiaj txiag los ntawm cov txheej txheem hauv qab no:
Inhibiting microbial metabolism:Cov ntsiab lus siab ntawm lidocaine tuaj yeem ua rau muaj kev cuam tshuam rau qee cov kab mob, tab sis cov nyhuv yog qis dua li cov kws tshaj lij preservatives.
Txo cov ntaub so ntswg puas:Cov nyhuv tshuaj loog tuaj yeem txo cov kev puas tsuaj thaum lub sij hawm ua cov qauv thiab ua kom tsis txhob ncua cov txheej txheem decomposition.
Txawm li cas los xij, lidocaine qab zib tsis tuaj yeem ua tiav ntev - lub sijhawm khaws cia thiab tuaj yeem ua rau cov kab mob sib kis los yog kev hloov pauv morphological vim yog lub hauv paus ntawm cov tshuaj nplaum (xws li roj thiab emulsifiers).
Glutaraldehyde
Cov nyhuv preservative ntawm glutaraldehyde yog qhov zoo tshaj plaws, uas yog qhia tshwj xeeb xws li:
Broad -spectrum sterilization:Nws muaj peev xwm tua tau cov kab mob, fungi, kab mob thiab spores.
Morphological fixation:Los ntawm cross-txuas cov proteins thiab nucleic acids, cov qauv ntawm tes tau ruaj khov los tiv thaiv autolysis thiab deformation.
Ntev -kev khaws cia ntev:Nyob rau hauv cov xwm txheej tsim nyog (xws li qhov kub thiab qhov deb ntawm lub teeb), cov qauv kho nrog glutaraldehyde tuaj yeem khaws cia rau ntau lub hlis mus rau ntau xyoo.
Kev sim cov ntaub ntawv qhia tias 2% glutaraldehyde fixative tuaj yeem ua tiav cov ntaub so ntswg kho tsis pub dhau 12 mus rau 24 teev, thiab nws muaj kev txhim kho zoo heev ntawm cov qauv zoo ntawm cov cell nucleus thiab cytoplasm, ua rau nws tsim nyog rau kev soj ntsuam electron microscopy.
Kev sib piv ntawm kev nyab xeeb thiab kev ua haujlwm yooj yim
Lidocaine Cream 30g
Kev nyab xeeb: Lidocaine qab zib muaj cov tshuaj toxicity tsawg, tab sis nws yuav ua rau muaj kev tsis haum tshuaj (xws li pob khaus thiab khaus).
Kev yooj yim ntawm kev ua haujlwm:Cov tshuaj nplaum yog ib qho yooj yim rau kev thov, tab sis nws yuav tsum tau muab kaw cia kom tsis txhob evaporation los yog paug.
Kev txwv:Tsis muaj kev tshaj lij los tiv thaiv- muaj peev xwm tiv thaiv corrosion, tsuas yog tsim rau cov xwm txheej ib ntus lossis pab pawg.
Glutaraldehyde
Kev nyab xeeb: Glutaraldehyde muaj cov ntxhiab tsw ntxhiab thiab ua rau khaus tawv nqaij, mucous daim nyias nyias thiab ua pa. Nws yuav tsum tau ua nyob rau hauv ib qho chaw zoo - qhov cua thiab cov cuab yeej tiv thaiv (xws li hnab looj tes thiab lub qhov ncauj qhov ntswg) yuav tsum hnav.
Kev yooj yim ntawm kev ua haujlwm:Cov glutaraldehyde fixative yuav tsum tau npaj thiab siv tam sim ntawd, thiab nws yog rhiab rau pH nqi (piv txwv li, alkaline glutaraldehyde yuav tsum tau kho cov pH rau 7.5-8.5 los txhim kho cov kab mob bactericidal).
Kev ruaj ntseg:Glutaraldehyde tov yog nquag rau polymerization thiab tsis ua hauj lwm. Nws yuav tsum tau khaws cia ntawm qhov kub thiab txias thiab deb ntawm lub teeb. Ntxiv mus, nws lub sijhawm siv tau tom qab qhib yog luv luv (xws li 28 hnub).
Xaus
Cov nyhuv ntawm Lidocaine Cream 30g thiab glutaraldehyde hauv kev khaws cia ntawm cov ntaub so ntswg yog qhov sib txawv. Lidocaine cream, vim nws tsis yog - cov khoom pov hwm kev tshaj lij, tsuas tuaj yeem ua rau muaj kev cuam tshuam ncaj qha hauv cov xwm txheej tsis tshua muaj kev txwv thiab tsis tuaj yeem hloov cov tshuaj tiv thaiv zoo xws li glutaraldehyde. Glutaraldehyde ua tiav qhov dav -spectrum sterilization thiab ntev-lub sij hawm morphological fixation los ntawm protein cross-txuas thiab cell qauv kev puas tsuaj mechanisms, ua rau nws tus qauv xaiv rau kev khaws cia ntawm cov ntaub so ntswg mos. Txawm li cas los xij, kev ua haujlwm ntawm glutaraldehyde yuav tsum ua raws li cov cai tswj kev nyab xeeb kom tsis txhob muaj kev phom sij rau tib neeg lub cev. Hauv kev siv cov tswv yim, cov kws tshawb fawb yuav tsum xaiv cov khoom khaws cia raws li hom qauv, kev khaws cia thiab cov xwm txheej sim kom ntseeg tau qhov zoo ntawm cov qauv thiab kev ntseeg siab ntawm cov txiaj ntsig kev tshawb fawb.
Cov lus nug nquag
Lidocaine siv rau dab tsi?
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Lidocaine belongs rau tsev neeg ntawm cov tshuaj hu ua tshuaj loog hauv zos. Cov tshuaj no tiv thaiv qhov mob los ntawm kev thaiv cov cim ntawm cov paj hlwb hauv daim tawv nqaij. Cov tshuaj no tsis ua rau tsis nco qab li cov tshuaj loog ua thaum siv rau kev phais. Cov tshuaj no tsuas muaj nyob nrog koj tus kws kho mob cov tshuaj.
Puas yog lidocaine yog tshuaj narcotic?
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Puas yog lidocaine (Xylocaine) yog tshuaj yeeb? Tsis yog, lidocaine (Xylocaine) tsis yog narcotic. Nws yog ib qho tshuaj loog hauv zos lossis hauv cheeb tsam, uas txhais tau hais tias nws txo koj lub peev xwm kom hnov mob hauv ib cheeb tsam uas nws txhaj. Cov tshuaj no ua haujlwm los ntawm kev tiv thaiv cov hlab ntsha los ntawm kev xa cov cim mob mus rau lub hlwb.
Puas yog lidocaine ib puag ncig lossis acid?
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Lidocaine nrog epinephrine yog acidic heev piv nrog cov ntaub so ntswg subcutaneous. Qhov sib ntxiv ntawm 8.4% bicarbonate ntawm qhov sib piv ntawm 1 mL: 10 mL neutralizes acidity ntawm 1% lidocaine nrog 1: 100,000 epinephrine. Neutralizing pH ntawm lidocaine tau pom yav dhau los kom txo qhov mob ntawm kev txhaj tshuaj.
Puas yog lidocaine yog tshuaj tua kab mob hnyav?
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Yog lawm, lidocaine cream tuaj yeem ua rau poob ntawm kev xav uas ua rau tawv nqaij hauv daim ntawv thov. Cov nyhuv loog tuaj yeem txo qhov mob los ntawm kev txwv koj cov hlab ntsha los ntawm kev xa cov cim mob.
Puas yog lidocaine zoo li morphine?
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Morphine yog ib qho opioid siv los tswj qhov mob. Lidocaine yog ib qho tshuaj loog hauv zos siv los txo qhov mob los ntawm kev thaiv cov cim ntawm cov paj hlwb hauv daim tawv nqaij. Bupivacaine yog ib qho tshuaj loog hauv zos siv los txo qhov mob los ntawm kev thaiv cov cim ntawm cov paj hlwb.
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