Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm acridine cas 260-94-6 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo acridine cas 260-94-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Acridineyog ib qho organic compound teej tug mus rau chav kawm ntawm aromatic amines. Acridine muaj cov tshuaj formula C13H9N thiab qhov hnyav molecular yog 179.22. Nws muaj lub nplhaib nruab nrab pyridine thiab ob lub nplhaib benzene, tsim ib daim duab peb sab. Cov qauv no muab Acridine tshwj xeeb lub cev thiab tshuaj lom neeg lub cev.Acridine feem ntau yog daj mus rau daj - xim av crystalline hmoov nrog lub melting point ntawm txog 106 ~ 109℃thiab lub boiling point ntawm 346℃. Nws muaj zoo solubility nyob rau hauv cov organic solvents xws li dioxane.Acridine muaj ib tug tej yam℃ntawm alkalinity, thiab nws muaj peev xwm hnov mob nrog acids los ua ntsev. Nws tuaj yeem ua rau tshuaj lom neeg nrog qee cov reagents los ntawm kev hloov pauv, ntxiv thiab oxidation.
Acridine nws tus kheej yuav tsis raug siv ncaj qha raws li cov khoom lag luam, tab sis nws yuav raug siv los ua cov khoom siv raw lossis nruab nrab hauv qee qhov tshwj xeeb lossis cov khoom lag luam. Hauv chav kuaj, Acridine tuaj yeem siv ntau yam kev tshawb fawb thiab kev sim tshuaj, suav nrog cov organic synthesis, photophysical thiab photochemical kev tshawb fawb.
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Tshuaj Formula |
C13H9N |
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Molecular Luj |
179.22 |
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Exact Mass |
179.07 |
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m/z |
179.07 (100.0%), 180.08 (14.1%) |
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Elemental Analysis |
C, 87.12; H, 5.06; N, 7.82 |
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Melting point |
106-109 degree |
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Boiling point |
346℃(lit.) |
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Qhov ntom |
1,005 g / cm3 |
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Cia tej yam kev mob |
Lub tub yees |
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Solubility |
Dioxane: 0.1 g / ml, ntshiab |
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Flash Point |
346 degree |
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Index Ntawm Refracction |
1.7270 (kwv yees) |
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Acidity Coefficient (pKa) |
5.58 (ntawm 20 degree) |
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Daim ntawv |
Crystalline hmoov |
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Xim |
Yellow rau yellow-xim av |
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Dej Solubility |
57.35 mg / L (24 ºC) |
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Kev ruaj ntseg |
ruaj khov. Hluav taws kub. Incompatible nrog muaj zog oxidizing neeg sawv cev. |
Acridine, raws li cov organic compound, muaj nws daim ntawv thov nyob rau hauv ntau lub teb. Hauv qab no yog cov chaw siv tseem ceeb ntawm Acridine:
Kev tshawb fawb tshuaj
Hauv chav kuaj, Acridine feem ntau yog siv rau hauv cov organic synthesis cov tshuaj tiv thaiv, qhov twg nws tuaj yeem siv los ua cov catalyst lossis nruab nrab rau cov tshuaj tiv thaiv vim nws cov qauv tshuaj tshwj xeeb. Tsis tas li ntawd, Acridine kuj tseem siv rau hauv kev tshawb fawb txog kev siv lub cev thiab kev tshawb fawb photochemical, qhov twg nws tuaj yeem siv los ua cov tshuaj fluorescent lossis photosensitiser rau kev kawm txog lub teeb - cov tshuaj sib cuam tshuam.
Kev tshawb fawb biochemical
Acridine thiab nws cov derivatives muaj ntau yam kev siv hauv biochemistry, tshwj xeeb tshaj yog cov fluorescent dyes rau DNA thiab RNA. Cov dyes tuaj yeem khi rau thiab fluoresce nucleic acids, yog li pab cov kws tshawb fawb kom pom cov nucleic acids hauv cov hlwb.
Piv txwv li, Acridine Txiv kab ntxwv (Acridine Orange) yog ib qho tshuaj fluorescent dye uas khi rau DNA thiab emits ntsuab fluorescence rau cell staining thiab fluorescence microscopy.
Kev saib xyuas ib puag ncig
Qee cov derivatives ntawm Acridine tuaj yeem siv los ua cov cim rau kev saib xyuas ib puag ncig kom pom cov pa phem hauv dej lossis lwm yam kev ntsuas ib puag ncig.
Dye Industry
Acridine thiab nws cov derivatives kuj tseem siv tau los ua cov khoom ua ntej lossis nruab nrab ntawm cov dyes rau kev sib txuas ntawm dyes ntawm ntau yam xim, uas yog siv dav hauv textile thiab luam ntawv industries.
Nws yuav tsum tau muab sau tseg tias txij li thaum Acridine thiab nws cov derivatives yog tshuaj lom thiab carcinogenic, nws yog ib qho tsim nyog yuav tsum tau ua raws li cov txheej txheem kev nyab xeeb thaum siv lawv, tsis txhob sib cuag nrog cov tawv nqaij, qhov muag, thiab lwm yam, thiab xyuas kom meej tias qhov chaw ua haujlwm yog qhov cua zoo. Lub caij no, thaum tuav cov kua khib nyiab lossis cov khib nyiab uas muaj Acridine, kev tiv thaiv ib puag ncig tsim nyog yuav tsum tau coj los tiv thaiv kev ua qias tuaj rau ib puag ncig.
Acridine yog ib qho kev sib xyaw ua ke nrog ntau yam keeb kwm ntawm kev tshawb fawb thiab ntau yam kev siv. Nws cov qauv tshuaj lom neeg tshwj xeeb thiab kev ua haujlwm lom neeg ua rau nws muaj txiaj ntsig zoo hauv cov tshuaj, biotechnology, thiab cov ntaub ntawv tshawb fawb. Txawm li cas los xij, kev txiav txim siab ib puag ncig thiab kev nyab xeeb cuam tshuam nrog kev siv acridine qhia txog qhov xav tau kom muaj kev ruaj khov thiab muaj lub luag haujlwm hauv nws cov ntawv thov. Kev tshawb fawb yav tom ntej ntawm acridine yuav tsum tsom mus rau kev txhim kho cov derivatives tshiab, ntsuab chemistry mus kom ze, thiab kev sib koom tes sib koom tes, paving txoj hauv kev rau cov ntawv thov tshiab thiab zoo siab ntawm qhov sib txuas zoo nkauj no.
Kev siv tshuaj lom neeg
Antimicrobial thiab Antiparasitic Agents
Acridine derivatives tau ntev tau lees paub rau lawv cov khoom siv tshuaj tua kab mob:
Proflavine (3,6-Diaminoacridine): Siv los ua tshuaj tua kab mob hauv Ntiaj Teb Tsov Rog Zaum 1, txawm hais tias nws siv tau poob qis vim muaj kev txhawj xeeb ntawm mutagenicity.
Acriflavine (Sib xyaw ntawm Proflavine thiab Euchoflavine): Siv tau zoo tiv thaiv Gram- cov kab mob zoo thiab qee cov kab mob fungi, keeb kwm ua haujlwm hauv qhov txhab tua kab mob thiab aquaculture.
Quinacrine (Mepacrine): Ib qho acridine derivative siv los kho giardiasis thiab malaria ua ntej qhov tshwm sim ntawm chloroquine.
Mechanism of Action: Acridines intercalate rau hauv DNA, cuam tshuam kev rov ua dua thiab kev hloov pauv los ntawm kev ruaj ntseg DNA-cov protein complexes thiab inducing ib leeg -strand so.
Anticancer Activity
Ntau cov acridine derivatives nthuav tawm cov teebmeem tshuaj tiv thaiv kab mob:
Amsacrine (m-AMSA): A 9-aminoacridine derivative siv los kho mob myeloid leukemia (AML) thiab tsis yog-Hodgkin lymphoma. Nws inhibits topoisomerase II, ua rau DNA ob-strand so thiab apoptosis.
Doxorubicin (Adriamycin): Txawm hais tias tsis yog ib qho ntshiab acridine, nws cov qauv anthracycline (los ntawm acridine) yog qhov tseem ceeb rau nws txoj kev ua tau zoo tiv thaiv lub mis, zes qe menyuam, thiab mob ntsws cancer.
Cov kev sib tw: Cardiotoxicity thiab tshuaj tiv thaiv tsis pub ntev tshaj - siv sijhawm, ua rau kev tshawb fawb txog nanotechnology- raws li kev xa khoom los txhim kho lub hom phiaj thiab txo cov kev mob tshwm sim.
Fluorescent Probes thiab Stains
Acridine's fluorescence ua rau nws tsis muaj nuj nqis hauv kev kuaj ntshav lom:
Acridine Txiv kab ntxwv (AO): Stains nucleic acids (DNA: ntsuab; RNA: liab) thiab yog siv nyob rau hauv flow cytometry thiab microscopy kom sib txawv hom ntawm tes thiab soj ntsuam kev vam meej.
Acridine Yellow: pH- cov xim rhiab heev rau kev taug qab lysosomal kev ua haujlwm hauv cov cell nyob.
DNA Intercalators thiab Mutagenesis
Thaum intercalation yog kho hauv kev kho mob qog noj ntshav, nws tuaj yeem ua rau muaj kev hloov pauv. Acridine derivatives zoo li 2-aminofluorene yog cov mutagens classic siv hauv Ames kuaj los ntsuas qhov muaj peev xwm carcinogenic.
Laboratory tshawb fawb
Acridine feem ntau siv nyob rau hauv lub chaw soj nstuam ntawm cov organic synthesis, photophysical thiab photochemical tshawb fawb. Vim nws cov khoom siv tshuaj lom neeg tshwj xeeb, nws tuaj yeem siv los ua ib qho catalyst rau cov tshuaj tiv thaiv organic, fluorescent probes thiab photosensitisers.
Pharmaceuticals
Txawm hais tias Acridine nws tus kheej tsis yog siv ncaj qha rau hauv kev npaj tshuaj, nws cov derivatives muaj qee yam kev siv hauv kev lag luam tshuaj. Piv txwv li, qee cov Acridine derivatives tuaj yeem siv los ua cov neeg sib tw rau cov tshuaj tiv thaiv kab mob lossis tshuaj tua kab mob.
Kev tshawb fawb biochemical
Acridine tuaj yeem siv rau hauv kev tshawb fawb biochemical, xws li staining thiab labeling ntawm DNA thiab RNA. Qee cov Acridine derivatives tuaj yeem siv los ua fluorescent probes rau kev tshawb pom ntawm nucleic acid molecules hauv hlwb.
Dye Industry
Acridine thiab nws cov derivatives kuj muaj cov ntawv thov hauv kev lag luam dyeing. Lawv tuaj yeem siv los ua cov precursors lossis intermediates hauv kev sib txuas ntawm dyes ntawm ntau yam xim.
Txawm li cas los xij, vim muaj cov tshuaj lom ntau ntawm Acridine, cov txheej txheem kev nyab xeeb yuav tsum tau ua raws li nruj me ntsis thaum siv, tsis txhob sib cuag nrog cov tawv nqaij, ob lub qhov muag, thiab lwm yam. Nyob rau tib lub sijhawm, nws yuav tsum xyuas kom meej tias qhov chaw ua haujlwm tau zoo ventilated kom tsis txhob nqus nws vapor mus ntev. Thaum khaws cia, Acridine yuav tsum khaws cia rau hauv qhov chaw qhuav, txias thiab qhov cua, tsis txhob tshav ntuj ncaj qha thiab kub siab.
Acridinefeem ntau yog synthesized nyob rau hauv ntau txoj kev.
- Txoj Kev 1: Los ntawm Acridone
Acridone yog tau los ntawm diphenylamine-2-carboxylic acid los ntawm cycling nrog sulfuric acid, thiab ces oxidising acridine los ntawm kev txo mus rau 9,10-dioxoacridine nrog pentanol thiab sodium.
Kev npaj hauv chav kuaj kuj tseem tuaj yeem ua los ntawm kev sib xyaw acridone Chemicalbook nrog zinc hmoov thiab cua sov.
Acridine sublimation generated los ntawm cov tshuaj tiv thaiv yog yaj nyob rau hauv hydrochloric acid, thiab ces alkalised nrog sodium hydroxide tov, precipitate, lim kom tau cov khoom crude.
Recrystallisation nrog methanol muab cov khoom zoo nrog lub melting point ntawm 110 degree.
- Txoj Kev 2: Raws li cov tshuaj tiv thaiv condensation ntawm aniline thiab aldehyde lossis ketone
1.Condensation ntawm aniline
ua ntej, aniline yog condensed nrog formaldehyde nyob rau hauv acidic tej yam kev mob los tsim N-methylaniline.
C6H5NH2 + CH2O → C6H5NHCH3 (N-methylaniline)
2.Bromination ntawm methylaniline
Tom ntej no, N-methylaniline reacts nrog bromine nyob rau hauv cov kev mob tsim nyog muab N-methyl-N-bromoaniline.
C6H5NHCH3 + Br2 → C6H5N(CH3)Br (N-}methyl-N-bromoaniline)
3.Coupling tshuaj tiv thaiv
Thaum kawg, ob lub N-methyl-N-bromoaniline molecules teb los ntawm kev sib txuas los ua Acridine.
2C6H5N(CH3)Br → C13H9N (Acridine) + 2 HBr + 2 CH3Br
Tsis ntev los no ua ntej thiab cov lus qhia yav tom ntej
Targeted Drug Delivery:Nanoparticles ua haujlwm nrog acridine derivatives (xws li liposomes, dendrimers) txhawm rau txhim kho cov tshuaj solubility thiab txo qis - cov txiaj ntsig hauv kev kho mob qog noj ntshav.
Organic Electronics:Acridine's electron-cov khoom thauj khoom ua rau nws yog ib tus neeg sib tw rau cov teeb pom kev organic-emitting diodes (OLEDs) thiab organic photovoltaics (OPVs).
Bioorthogonal Chemistry:Acridine-raws li kev sojntsuam tau raug tsim los rau kev nyob hauv- xovtooj ntawm tes yam tsis cuam tshuam cov txheej txheem biochemical ib txwm muaj, ua kom muaj sijhawm tiag - taug qab cov metabolites thiab proteins.
Green Synthesis:Enzymatic thiab microbial synthesis txoj kev tab tom tshawb nrhiav los tsim cov acridine derivatives nyob rau hauv ambient tej yam kev mob, txo cov tshuaj pov tseg.
Acridine tus qauv tshwj xeeb thiab kev ua haujlwm ntau yam tau txhawb nqa nws qhov cuam tshuam thoob plaws kev qhuab qhia rau ntau xyoo. Los ntawm nws qhov pib txo qis raws li cov thee tar derivative rau nws lub luag haujlwm niaj hnub hauv kev kho mob qog noj ntshav thiab kev noj qab haus huv, acridine txuas ntxiv txhawb kev tsim kho tshiab. Kev tshawb fawb yav tom ntej yuav zoo li tsom mus rau txo nws cov tshuaj lom, txhim kho nws qhov tshwj xeeb hauv kev siv tshuaj lom neeg, thiab nthuav dav nws cov txiaj ntsig hauv cov thev naus laus zis tshiab. Raws li kev sib koom tes sib koom tes loj hlob tuaj, acridine lub peev xwm los daws cov teeb meem thoob ntiaj teb hauv kev noj qab haus huv, lub zog, thiab ib puag ncig tseem loj heev thiab vam meej.
Kev xav yav tom ntej
Kev loj hlob ntawm Novel Derivatives
Txoj kev loj hlob ntawm cov tshiab acridine derivatives nrog kev txhim kho kev ua haujlwm lom neeg thiab txo cov kev mob tshwm sim yog ib qho kev tshawb fawb hauv cheeb tsam. Los ntawm kev hloov kho cov qauv ntawm acridine, cov kws tshawb fawb tuaj yeem txhim kho nws qhov tshwj xeeb rau lub hom phiaj molecules thiab txo nws cov toxicity rau cov tsis yog - lub hom phiaj hlwb. Piv txwv li, kev txhim kho ntawm acridine derivatives nrog lub hom phiaj xa khoom tuaj yeem txhim kho lawv cov txiaj ntsig hauv kev kho mob qog noj ntshav.
Green Chemistry Txoj Kev
Kev saws me nyuam ntawm ntsuab chemistry mus kom ze nyob rau hauv lub synthesis thiab siv acridine thiab nws derivatives yuav tsum tau nce nyob rau hauv lub neej yav tom ntej. Green chemistry aims kom txo cov kev cuam tshuam ib puag ncig ntawm cov txheej txheem tshuaj los ntawm kev siv cov peev txheej txuas ntxiv dua tshiab, txo cov khoom pov tseg, thiab txhim kho kev siv hluav taws xob. Txoj kev loj hlob ntawm ntsuab synthesis txoj kev rau acridine thiab nws cov derivatives tuaj yeem ua rau muaj kev lag luam tshuaj lom neeg ruaj khov.
Kev tshawb fawb ntau yam
Lub neej yav tom ntej ntawm kev tshawb fawb acridine zoo li yuav koom nrog ntau txoj hauv kev, kev sib txuas ntawm chemistry, biology, cov ntaub ntawv tshawb fawb, thiab kev tshawb fawb ib puag ncig. Los ntawm kev sib koom ua ke kev paub los ntawm ntau qhov chaw, cov kws tshawb fawb tuaj yeem nkag siab tob txog cov khoom thiab kev siv ntawm acridine thiab tsim cov kev daws teeb meem tshiab rau cov teeb meem nyuaj.
Cov lus nug nquag
Acridine ua dab tsi?
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Acridine yog polycyclic aromatic dye nrogantineoplastic, antimicrobial thiab imaging kev ua ub no. Acridine thiab nws cov derivatives intercalate nyob rau hauv DNA thiab RNA los ntawm kev tsim hydrogen- bonds thiab stacking ntawm lub hauv paus khub uas ua rau DNA crosslinks thiab strand so.
Dab tsi yog qhov hloov pauv los ntawm acridine dyes?
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Qhov no hu ua aframeshift kev hloov. Proflavin yog ib qho acridine dye uas intercalates nws tus kheej ntawm lub hauv paus khub ntawm DNA saw thiaj li ua rau poob los yog nce ntawm ib tug nucleotide. Cov noob hloov pauv hloov lub hauv paus ua ntu zus ntawm tag nrho cov kab mob caj ces los ntawm qhov kev hloov pauv hu ua frameshift mutation.
Puas yog acridine txiv kab ntxwv carcinogenic?
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Toxicity thiab carcinogenicity ntawm AO. Txij li AO yog mutagenic hauv cov kab mob (24, 25),Nws kuj tseem yuav ua tau carcinogenic hauv tib neeg.
Cim npe nrov: Acridine CAS 260-94-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom