Cov Pim Acriflavine HmoovPuas yog cov organic sib xyaw nrog cov tshuaj noj tshuaj c14h1414Caiv3 thiab CAS 8048- 52-0. Nws zoo li xim av liab lossis txiv kab ntxwv liab crystalline hmoov nrog lub ntsiab lus melted ntawm 179-181 degree. Nws yog yooj yim soluble hauv dej thiab ethanol, tab sis yuav luag Insoluble hauv chloroform, ether, thiab roj. Qhov kev daws yog txiv kab ntxwv liab hauv cov xim thiab muaj fluorescence tom qab dhuav. Cov tshuaj no tau cais ua pawg 3 carcinogen los ntawm lub chaw ua haujlwm thoob ntiaj teb rau cov mob kheesxaws lub koomhaum hauv ntiaj teb (tseem tsis tau ua rau tib neeg). Nws yog cov tshuaj tawm dav-spectrum feem ntau yog siv los kho kab mob hauv cov tsiaj. Nws tuaj yeem ua kom zoo nyob rau hauv kev loj hlob thiab kev luam me me ntawm ntau cov kab mob, suav nrog cov kab mob zoo, thiab cov kab mob anaerobic. Nws cov ntawv thov suav nrog qhov chaw muag khoom ntawm Biology Kev sim, nrog rau cov tshuaj tua kab mob, tab sis nws cov tshuaj tsw qab, tab sis nws cov yam ntxwv tsis muaj txiaj ntsig vim nws cov yam ntxwv. Cov khoom tiv thaiv tiv thaiv thaum siv, zam kev sib cuag nrog tawv nqaij lossis qhov muag, yaug tam sim ntawd thiab nrhiav kev kho mob tom qab kev sib cuag. Qhov no compound muaj siab toxicity rau dej yug tsiaj thiab tej zaum yuav ua kom dej ua qias tuaj. Cov khib nyiab yuav tsum tau muab pov tseg raws li cov kev phom sij khoom.
Peb Cov Khoom
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
| Khoom npe | Daim paj lug Khwv | Cov Pim Acriflavine Hmoov | Cov Tshuaj Ua Si Acriflavine |
| Khoom Yam | Kua | Hmoov | Ntsiav tshuaj |
| Khoom Siv Purity | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% |
| Cov Khoom Qhia Khoom Khoom | Tau sib kho | Tau sib kho | Tau sib kho |
| Khoom Pob | Tau sib kho | Tau sib kho | Tau sib kho |
Peb Cov Khoom
Acriflavine +. coa
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Daim Ntawv Pov Thawj Kev Ntsuam Xyuas |
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Compound npe |
Tsa li acriflavine | |
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Cas Tsis tau. |
590-63-6 | |
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Teem nqi |
Kws Tshuaj Ntsuam Xyuas | |
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Qho ntau |
Me nyuam | |
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Ntim txheem ntim |
Me nyuam | |
| Tus tsim | Shaanxi Bloom Tech Co., Ltd. | |
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Lauj tsis tau. |
20250109001 |
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Mfg |
Jan 12th 2025 |
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Tus txeeb |
Jan 8th 2029 |
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Lub tsev |
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| Kuaj Tus Qauv | GB / T24768-2009 kev lag luam. Stnndard | |
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Yam |
Kev Lag Luam Kev Lag Luam |
Kev tsom xam tau |
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Kev tshwm sim |
Dawb lossis yuav luag dawb hmoov |
Hloov |
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Dej Cov Ntsiab Lus |
Tsawg dua los yog sib npaug rau 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua los yog sib npaug rau 1.0% |
0.15% |
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Cov hlau hnyav |
PB tsawg dua lossis sib npaug rau 0.5ppm |
N.D. |
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Tsawg tsawg dua li lossis sib npaug rau 0.5ppm |
N.D. | |
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Hg tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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CD tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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Purity (hplc) |
Ntau dua los yog sib npaug rau 99.0% |
99.5% |
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Ib Leeg Cav |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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TAG NRHO LICBIAL COUNT |
Tsawg dua li lossis sib npaug rau 750cfu / g |
80 |
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E. coli |
Tsawg dua los yog sib npaug rau 2mpn / g |
N.D. |
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Tus ntses siav |
N.D. | N.D. |
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Ethanol (los ntawm gc) |
Tsawg dua los yog sib npaug rau 5000ppm |
400ppm |
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Chaw ntim khoom |
Khaws rau hauv ib qho chaw sib khi, qhov chaw tsaus thiab qhuav ntawm-20 degrees |
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Cov Pim Acriflavine Hmoov, raws li qhov sib txuas nrog cov kev ua haujlwm tseem ceeb, ib txwm tau ua rau muaj kev saib xyuas hauv thaj chaw tshawb fawb txog nws cov xwm txheej zoo nkauj. Tam sim no, tus synthesis ntawm acriflavine yog tsuas yog ua tiav los ntawm kev hloov kho chemical ntawm cov duab sau nyiaj. Cov hauv qab no yuav muab cov lus qhia ntxaws ntxaws rau ntau txoj kev sib zog hluav taws xob.
Txoj Kev 1: Chemial Modence Kev Hloov Synthesis raws li Cov Khoom
(1) Cov ntsiab cai synthesis
Cov Compondine Cov Qauv muaj cov qauv npaj ua atoms, thiab cov nitrogen atoms thiab cov molomic ntiv nplhaib hauv lawv cov lwg me me muab cov chaw nquag ua haujlwm rau kev hloov kho tsis zoo. Los ntawm kev qhia tshwj xeeb ntawm cov chaw sib txawv ntawm lub nplhaib Acidne, Acridne Derivatives nrog cov khoom sib txawv thiab cov haujlwm tuaj yeem ua ke. Cov yeeb yaj kiab daj feem ntau yog npaj los ntawm cov khoom siv acidne nrog cov pab pawg muaj zog xws li pawg amino lossis halogen.
(2) Cov ntsiab lus saptthesis tshwj xeeb
Cov ris tsho: Ua cov khoom pib, nws txoj kev coj dawb huv thiab kev xav tau kom txo qis kev cuam tshuam rau kev cuam tshuam rau kev siv neeg rau kev siv hluav taws xob ntxiv. Cov ntaub ntawv npog pov tseg tau npaj tau los ntawm cov av sib cais lossis cov tswv yim organic synthesis.
Chloroacetyl chloride los yog bromoacetyl bromide: raws li reagents rau kev qhia chaw nyob, lawv muaj cov kev pheej hmoo siab, lawv tuaj yeem yauv hloov chaw nrog cov ntaub ntawv.
Dissolve nyob rau hauv ib qho cov organic tsim nyog, xws li Dichloromethane lossis Clocoacetyl vomide lossis Bromoacetyl Bromide Dauv Kev tswj nruj yog qhov yuav tsum tau ua nrawm rau thaum lub sij hawm raction kom tsis txhob muaj tshwm sim ntawm sab kev sib tw los ntawm kev xav hauv lub nroog.
Tom qab lub sijhawm ntawm raction, nce qhov ntsuas kub ntawm raction system to chav kub thiab txuas ntxiv nplawm cov kev rov ntsuas kub thiab txuas ntxiv mus ua kom tiav. Tom qab raction tiav, cov kev sib xyaw sib xyaw yog raug xa mus rau kev rho tawm, ntxuav, thiab lwm cov kauj ruam kom tau txais acetyl chloride lossis acetyl bromide derivatives ntawm dos.
Dissolve cov ris tsho acetyl chloride lossis acetyl bromide derivatives hauv ib organic huab cua thiab ntxiv cov diethylamine lossis lwmyine componds. Lub raction yog nqa tawm ntawm chav tsev kub lossis raws li cov cua sov, thiab lub sijhawm raction nyob ntawm qhov teeb meem tshwj xeeb.
Thaum lub sij hawm raction txheej txheem, acetyl chloride lossis acetyl bromide indergoes unection nrog amine componds los ua kom muaj kev sib tw ntawm cov ris tsho. Tom qab raction tiav, tshaj tawm {{{{{{} Kev kho mob, ntxuav, ntxuav, kom tau txais siab}}} txoj cai tswj hwm kev ntseeg tau.
Ua Cycloize RECTION rau hauv Intermediate Amide nyob rau hauv acidic tej yam kev mob los tsim cov acidne daj. Cov acidic catalaltstions muaj xws li muaj cov sulfuric acid, etc. Qhov ntsuas kub thiab lub sijhawm yuav tsum tau ua kom zoo raws li cov kev rov ua haujlwm tshwj xeeb.
Thaum lub caij Cyclounte Raction, Intermediate amide to taub inclorolecular cyclization, sib sau tus qauv ntawm daj daj. Tom qab cov raction tiav, cov khoom kawg ntawm cov ris ntev yog tau los ntawm cov kauj ruam xws li kev ne ce, rho tawm, ntxuav, thiab recrystallization.
Txoj kev 2: synthesis raws li 3,6-diaminoacridine
(1) Cov ntsiab cai synthesis
3,6-diaminoacridine yog qhov tseem ceeb hauv nruab nrab rau cov synthesis ntawmCov Pim Acriflavine HmoovCov. Los ntawm kev kho cov amino pab pawg ntawm 3,6-diaminoacridine, cov chaw hloov tshwj xeeb tuaj yeem qhia tau zoo rau cov ncej daj. Txoj kev siv no siv lub nucleophilicity ntawm cov amino pab pawg, tso cai rau lawv hnov mob nrog ntau yam hluav taws xob tawm tsam.
(2) Cov ntsiab lus saptthesis tshwj xeeb
3,6-diaminoacridine tuaj yeem suav nrog cov kauj ruam xws li nitration thiab txo cov acrogne. Firstly, acridne raug rau kev tiv thaiv nitration hauv cov pa roj acid, thiab cov pab pawg Nitro
Tom qab ntawd, 3,6-dinitroacridine yog raug rau kev txo tus neeg sawv cev nrog tus neeg saib xyuas cov hlau (xws li lwm pawg rau cov pab pawg amino, ua rau muaj 3,6-diaminoacridine.
Dissolve 3,6-diaminoacridine hauv cov kuab organic zoo thiab ntxiv cov me me methyl chloroformate lossis lwm yam tshuaj txhuam hniav hauv acyl chloride. Kev ntsuas yog nqa tawm hauv qab qhov kub tsawg (0-5 Degree) thiab nplawm cov kev mob. Tom qab ib lub sijhawm, qhov kub tau tsa mus rau chav sov kom txuas ntxiv kev sib txuas.
Cov pab pawg AMEEs tau yov nucleophilic hloov cov kev siv cov kab mob ans Tom qab raction tiav, cov kev sib xyaw sib xyaw yog raug kho los ntawm kev rho tawm, ntxuav, thiab lwm cov kauj ruam kom tau txais kev txhawb nqa kev lom zem.
Lub nplhaib kaw kev rov ntsuas ntawm kev sib cav sib ceg hauv cov kab mob hauv qab Alkaline cov xwm txheej los tsim cov acridne daj. Cov khoom siv alkaline alkaline suav nrog sodium hydroxide, etc. Lub raction baschlization kev rov qhia los ua tus qauv ntawm cov qauv acridne.
Tom qab reacton tiav lawm, cov khoom kawg ntawm daj yog tau los ntawm cov kauj ruam xws li acidification, extraction, ntxuav, thiab recrystallization.
Txoj Kev 3: Cov qauv hluavtaws raws li Acridone
(1) Cov ntsiab cai synthesis
Acridone muaj cov pab pawg carbonyl, uas tuaj yeem tsim nrog cov khoom siv amine rau daim ntawv imine intralediates, thiab tom qab ntawd synthesized mus rau hauv lub pov haum daj los ntawm kev txo qis thiab lwm cov kauj ruam. Cov qauv no siv cov kev pheej hmoo ntawm cov pab pawg carbonyl los tsim cov qauv ntawm daj daj los ntawm kev tiv thaiv tsis zoo.
(2) Cov ntsiab lus saptthesis tshwj xeeb
Synthesis ntawm acridone
Cov Pim Acriflavine Hmoovtuaj yeem suav nrog cov oxidation raction ntawm cov ntaub ntawv. Dissolve acridne nyob rau hauv ib qho kev tsim nyog muaj kuab, tshuaj pleev roj rau oxidation ib tug neeg kub thiab cov pa roj carbon monoxide thiab cov pa roj carbon monoxide
Cov tshuaj tiv thaiv hws
Dissolve acridone hauv cov organic huab cua thiab ntxiv cov diethylamine ntxiv lossis lwm yam khoom siv Amine. Kev ntsuas yog nqa tawm hauv qab cov cua kub, thiab cov ketone carbon, thiab cov ketone carbonsl ntawm acridone undergoes undergoes condensation kev sib tw nrog cov khoom siv amine los ua cov lus imine intermediates.
Thaum lub sij hawm Reacton cov txheej txheem, nws yog ib qho tsim nyog los tswj cov kev siv ntsuas kub thiab sijhawm kom ntseeg tau tias qhov kev kawm du ntawm cov reacton. Tom qab reacton ua tiav, kev sib xyaw kev sib xyaw muaj kev sib xyaw tau raug rau kev rho tawm, ntxuav, thiab lwm cov kauj ruam kom tau txais lub tswv yim nruab nrab.
Txo cov tshuaj tiv thaiv
Nyob rau hauv qhov kev txiav txim ntawm kev txo cov neeg sawv cev xws li Sodium borohydride thiab lithine fromining lub tswv yim rau cov amino pab pawg, ua rau muaj kev tsim cov acros daj. Cov reacton yog nqa tawm hauv qis kub (0-5 degree) thiab nplawm cov kev mob. Tom qab reactin tiav lawm, cov khoom kawg ntawm daj yog tau los ntawm cov kauj ruam xws li acidification, rho, kom qhuav, thiab recrystallization.
(3) Qhov zoo thiab qhov tsis zoo ntawm txoj kev
Qhov Zoo: Cov qauv no siv cov kev siv dag zog ntawm daim acridone, thiab cov txheej txheem hluavtaws muaj qee cov tswv yim tshiab rau cov cuab yeej tshiab rau cov hluavtaws daj.
Qhov tsis zoo: Cov oxidation reactin tej yam kev mob ntawm acridone yog nruj me ntsis kev tswj hwm ntawm cov oxidant thiab reactio cov xwm txheej kom tsis txhob muaj oxidation ntau dhau los yog lwm yam kev hloov pauv mus; Tus neeg sawv cev txo cov neeg sawv cev siv hauv qhov txo cov tshuaj tiv thaiv reactio yog kim thiab muaj qee qhov kev phom sij, xav tau kev ua haujlwm nruj.
Txoj kev 4: Kev tshawb nrhiav ntawm cov qauv xov xwm ntsuab
(1) microwave pab stsy
Lub hauv paus ntsiab lus:
Microwave pab hluav taws xob hluav taws xob yog kev siv lub microwave zog los ua kom muaj kev tawm tsam kev tawm tsam. Microwaves tuaj yeem pab cov tshuaj tua kab mob kom nqus tau kom yooj yim, ua kom muaj qhov kub thiab txias dua thiab ua kom muaj kev siv sijhawm ntev.
Daim Ntawv Thov:
Nyob rau hauv synthesis ntawm acriflavine, microwave - Gradthesis tuaj yeem siv rau cov kauj ruam xws li cov kev xaiv hloov chaw thiab kev sib tw. Piv txwv li, hauv kev hloov pauv ntawm cov ntaub ntawv ntawm chloroacetyl thiab coj cov kev siv microwave muaj hwj chim thiab kev xaiv tsa tau txhim kho tus nqi RECTION thiab tawm los.
(2) ionic kua catalyzed synthesis
Lub hauv paus ntsiab lus:
Ionic kua yog ib hom ionic compacter uas muaj nyob rau hauv lub xeev ua kua nyob rau hauv lossis ze rau chav sov, nrog rau solubility zoo, thiab kev xaiv. Ionic kua muaj peev xwm ua cov catalysts los yog cov kuab tshuaj, koom nrog rau kev xaiv chemial, thiab txhim kho kev xaiv thiab tawm los ntawm cov raction.
Daim Ntawv Thov:
Nyob rau hauv synthesis ntawm acriflavine, kua txiv ionic tuaj yeem siv rau kev hloov chaw lossis cov kev faib tawm tshiab, thiab lwm cov kauj ruam. Piv txwv li, hauv qhov hloov chaw ntawm 3,6-diaminoacridine, siv ionyl chloroformate, siv cov kuab tshuaj thiab cov tshuaj catalysts tuaj yeem nce kev siv nyiaj thiab tawm los txo cov tshuaj organic.
Qhov zoo thiab qhov tsis zoo:
Cov txiaj ntsig zoo: Cov kua roj tau rov ua dua tshiab thiab rov ua dua, uas tuaj yeem txo cov pa phem ib puag ncig; Cov xwm txheej daws teeb meem me me thiab kev xaiv tau zoo.
Qhov tsis zoo: Tus nqi hluav taws xob ntawm cov kua hluav taws xob ionic yog cov kua muaj mob siab, thiab cov kua ionic yuav muaj qee yam tshuaj lom, xav tau kev ntsuas kev nyab xeeb.
Cim npe nrov: Cov Nplej Zog Hmoov, Tuam Tshoj Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas, Lag Luam Wholesale, Yuav, Nqe, Hlua, Rau Muag