Acriflavine HCL, Azizihuang hydrochloride yog ib qho chaw nrog ntau yam ntxwv thiab siv. Los ntawm kev xav tshuaj, nws feem ntau tshwm sim raws li cov xim liab los yog txiv kab ntxwv liab crystalline hmoov, tsis muaj ntxhiab, thiab muaj kua qaub saj. Cov tshuaj formula C27H25ClN6 · 3 (HCl) yuav txawv nyob ntawm seb cov kev tshawb fawb sib txawv los yog cov khoom, nrog rau qhov hnyav molecular li ntawm 500 mus rau 580. Nws yog yooj yim soluble hauv dej thiab ethanol, tab sis nyuaj rau yaj hauv chloroform, ether, thiab roj. Cov yam ntxwv solubility no muab nws qee yam yam ntxwv hauv kev npaj daws teeb meem thiab kev sim siv. Hauv daim ntawv thov teb, nws tuaj yeem siv rau kev tshawb fawb thiab kev txhim kho ntawm cov tshuaj tiv thaiv- qog, tshuaj tua kab mob, thiab tshuaj tua kab mob hauv tshuaj; Nws tuaj yeem siv los ua tus neeg sawv cev ntawm tes staining thiab taw qhia txoj hauv kev tshawb fawb cov cuab yeej hauv kev tshawb fawb tshawb fawb; Nws tuaj yeem siv los ua ib qho ntxiv hauv kev pub noj, tab sis kev tshawb fawb ntxiv yog xav tau ntawm nws cov txheej txheem ntawm kev ua thiab kev nyab xeeb.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Acriflavine Cream | Acriflavine hmoov | Acriflavine ntsiav tshuaj | Acriflavine Hcl |
| Yam khoom | Cream | Hmoov | Cov ntsiav tshuaj | Hmoov |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable | Customizable |
Peb Cov Khoom
Acriflavine Hcl +. COA
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Certificate of Analysis |
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Compound npe |
Acriflavine Hcl | |
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CAS Nr. |
8063-24-9 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib qho impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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(1) Kab mob ntawm daim tawv nqaij
Kab mob kis kab mob ntawm daim tawv nqaij
Ua rau thiab cov tsos mob: Cov kab mob kis kab mob xws li folliculitis, furuncle, pustule, thiab lwm yam yog tshwm sim los ntawm cov kab mob xws li Staphylococcus aureus thiab Streptococcus. Cov tsos mob muaj xws li liab, o, mob, thiab suppuration ntawm daim tawv nqaij.
Mechanism ntawm kev ua thiab kev ua tau zoo: Acrflavine inhibits cov kab mob loj hlob thiab kev tsim tawm, txo cov tawv nqaij o, thiab txhawb qhov txhab kho los ntawm nws cov khoom siv tshuaj tua kab mob. Nws tuaj yeem cuam tshuam nrog cov kab mob DNA replication, protein synthsis, thiab matrix membrane muaj nuj nqi, yog li ua tiav cov kab mob bactericidal.
Cov kab mob fungal kab mob ntawm daim tawv nqaij
Ua rau thiab cov tsos mob: Cov kab mob fungal kis kab mob xws li tinea corporis, tinea pedis, tinea pedis, thiab lwm yam yog tshwm sim los ntawm fungi xws li dermatophytes. Cov tsos mob muaj xws li khaus, flaking, thiab liab ntawm daim tawv nqaij.
Mechanism of action and therapeutic effect: Txawm hais tias muaj kev tshawb fawb ncaj qha me ntsis ntawm cov nyhuv antifungal, raws li nws cov tshuaj tua kab mob, nws tau kwv yees tias nws kuj yuav muaj qee yam inhibitory nyhuv ntawm fungi. Nws tuaj yeem cuam tshuam kev loj hlob thiab kev tsim tawm ntawm cov fungi los ntawm kev cuam tshuam nrog lawv cov qauv ntawm tes thiab kev ua haujlwm. Txawm li cas los xij, kev tshawb fawb soj ntsuam ntxiv yog xav tau los txheeb xyuas nws cov nyhuv antifungal.
(3) Cov kab mob qog nqaij hlav ntawm daim tawv nqaij
Daim tawv nqaij precancerous lesions
Etiology thiab Cov tsos mob: Ua ntej mob qog noj ntshav ntawm daim tawv nqaij xws li keratosis tshwm sim los ntawm tshav ntuj yog cov theem pib ntawm daim tawv nqaij mob cancer, tus cwj pwm los ntawm liab, nplai, thiab wart zoo li loj hlob ntawm daim tawv nqaij.
Mechanism ntawm kev ua thiab kev ua tau zoo: Cov tshuaj tiv thaiv -tumr nyhuv ntawm Acrflavine tuaj yeem pab cuam tshuam kev loj hlob ntawm cov kab mob precancerous hauv daim tawv nqaij. Nws tuaj yeem inhibit DNA replication thiab induce apoptosis ntawm tumr matrixs, tiv thaiv kev hloov pauv ntawm qhov txhab rau hauv daim tawv nqaij.
Mob qog noj ntshav ntawm daim tawv nqaij
Ua rau thiab cov tsos mob: mob qog noj ntshav ntawm daim tawv nqaij xws li basal matrix carcinoma, squamous matrix carcinoma, thiab lwm yam., cov tsos mob thaum ntxov muaj xws li nodules, ulcers, thiab lwm yam ntawm daim tawv nqaij.
Mechanism ntawm kev nqis tes ua thiab kev ua tau zoo: Lub peev xwm kho photodynamic ntawm Acrflavine tuaj yeem muab kev xaiv tshiab rau kev kho mob qog noj ntshav ntawm daim tawv nqaij. Nyob rau hauv lub teeb lub teeb irradiation tshwj xeeb, nws tuaj yeem tsim cov pa oxygen reactive xws li singlet oxygen, uas muaj kev xaiv tua cov teebmeem ntawm tumr matrixs thiab txo kev puas tsuaj rau cov ntaub so ntswg.
(4) Lwm yam kab mob ntawm daim tawv nqaij
Eczema
Ua rau thiab Cov tsos mob: Eczema yog ib hom kab mob ntawm daim tawv nqaij uas muaj ntau yam ua rau muaj feem cuam tshuam nrog caj ces, ib puag ncig, tiv thaiv kab mob, thiab lwm yam. Cov tsos mob muaj xws li khaus, erythema, papules, hlwv, thiab lwm yam.
Mechanism ntawm kev ua thiab kev ua tau zoo: Cov tshuaj tiv thaiv - mob thiab tshuaj tua kab mob ntawm Acrflavine tuaj yeem pab txo cov tsos mob ntawm eczema. Nws tuaj yeem cuam tshuam kev tsim khoom thiab tso tawm cov txheej txheem inflammatory, txo cov tawv nqaij o, thiab inhibit cov kab mob loj hlob los tiv thaiv cov kab mob thib ob.
Psoriasis vulgaris
Etiology thiab Cov tsos mob: Psoriasis yog ib hom kab mob ntawm daim tawv nqaij mob uas muaj qhov tsis meej etiology, uas tej zaum yuav cuam tshuam nrog caj ces, tiv thaiv kab mob, ib puag ncig, thiab lwm yam. Cov tsos mob muaj xws li cov tsos ntawm thaj ua rau thaj liab ntawm daim tawv nqaij npog nrog cov nplai dawb dawb.
Mechanism ntawm kev ua thiab kev ua tau zoo: Acrflavine yuav muaj qee yam kev kho mob ntawm psoriasis los ntawm kev tswj lub cev tiv thaiv kab mob thiab inhibiting zus tau tej cov inflammatory yam. Txawm li cas los xij, kev tshawb fawb soj ntsuam ntxiv yog xav tau kom paub meej tias nws cov txiaj ntsig tshwj xeeb.
Kev tshawb nrhiav thiab kev txhim kho ntawm cov tshuaj tiv thaiv -cov tshuaj qog nqaij hlav
Vim nws muaj peev xwm ua HIF-1 inhibitor, nws muaj qee yam kev cia siab rau hauv kev txhim kho cov tshuaj tiv thaiv-tumr. Cov kws tshawb fawb tuaj yeem tshawb xyuas ntxiv txog qhov kev ua haujlwm ntawd, txhim kho cov qauv tshuaj los txhim kho nws cov txiaj ntsig thiab kev nyab xeeb, thiab txhim kho cov tshuaj tiv thaiv qog noj ntshav zoo dua. Piv txwv li, los ntawm kev hloov kho cov qauv, cov tshuaj pharmacokinetic ntawm acridin hydrochloride tuaj yeem txhim kho, txhim kho nws txoj kev ruaj ntseg thiab lub hom phiaj hauv vivo.
Antibacterial thiab antiparasitic tshuaj
Nws tuaj yeem siv los npaj cov tshuaj tua kab mob thiab tshuaj tua kab mob thiab kho cov kab mob sib kis. Hauv kev siv tshuaj kho mob, nws yog ib qho tsim nyog yuav tsum xaiv cov tshuaj tsim nyog thiab kev tswj hwm raws li hom kab mob tshwj xeeb thiab kab mob. Piv txwv li, rau cov kab mob ntawm daim tawv nqaij thiab mucosal, cov tshuaj pleev tuaj yeem npaj tau; Rau tsiaj kab mob parasitic, kev npaj ntawm qhov ncauj los yog txhaj tshuaj tuaj yeem npaj rau tsiaj siv.
(2) Kev tshawb fawb teb
Cell Biology Experiments
Hauv kev sim matrix biology, nws tuaj yeem siv los ua tus neeg sawv cev staining rau matrix staining. Nws cov xim liab los yog xim txiv kab ntxwv xim liab ua rau nws pom meej meej cov qauv matrix, ua rau nws yooj yim rau kev soj ntsuam thiab kawm. Piv txwv li, thaum soj ntsuam cov morphology, kev faib tawm, thiab kev txav ntawm matrixs nyob rau hauv lub tshuab tsom iav, acridin hydrochloride tuaj yeem ua rau cov matrixs pom meej dua.
Txoj kev tshawb nrhiav teeb liab
Raws li ib qho inhibitor ntawm HIF-1, nws tuaj yeem siv los kawm txog txoj kev taw qhia kev sib kho los ntawm HIF-1 . Los ntawm kev cuam tshuam nrog kev ua haujlwm ntawm HIF-1, kev hloov pauv ntawm cov noob caj noob ces tuaj yeem pom, muab kev nkag siab tob txog kev tswj hwm cov txheej txheem ntawm kev taw qhia txoj hauv kev thiab cov cuab yeej sim tseem ceeb rau kev kawm txog cov kab mob ntsig txog.
Nws tau hais tias nws tuaj yeem siv los ua khoom noj khoom haus fortifier lossis pub additive hmoov. Ntxiv acridin hydrochloride rau pub tuaj yeem pab txhim kho tsiaj kev noj qab haus huv thiab tiv thaiv kev tshwm sim ntawm qee yam kab mob. Txawm li cas los xij, nws cov txheej txheem tshwj xeeb ntawm kev nqis tes ua thiab kev nyab xeeb tseem xav tau kev tshawb fawb ntxiv thiab pov thawj hauv cov ntawv thov pub. Piv txwv li, nws yog ib qho tsim nyog los txiav txim siab qhov tsim nyog npaum li cas ntawm cov tshuaj ntxiv kom ntseeg tau tias lawv tuaj yeem muaj txiaj ntsig zoo yam tsis ua rau muaj kev phom sij rau tsiaj.
Biological kev ua si thiab mechanism ntawm kev ua
(1) HIF-1 inhibitors
Mechanism ntawm Action
Azizihuang hydrochloride yog ib qho zoo inhibitor ntawm HIF-1 (hypoxia inducible factor-1). Nws ua haujlwm los ntawm kev tsom mus rau txoj kev sib kho los ntawm HIF-1, txo cov qib PGK1 (phosphoglycerate kinase 1), VEGF (vascular endothelial txoj kev loj hlob), thiab HIF-1 hauv vitro thiab hauv vivo. HIF-1 plays lub luag haujlwm tseem ceeb hauv qhov tshwm sim, kev loj hlob, thiab metastasis ntawm cov qog, vim nws tuaj yeem tswj cov metabolism, angiogenesis, ntxeem tau, thiab metastasis ntawm tumr matrixs. Azizihuang hydrochloride inhibits qhov kev ua ntawm HIF-1, uas tuaj yeem thaiv nws cov dimerization nrog HIF-1 subunit, yog li inhibiting cov kev ua haujlwm ntawm HIF-1, txo cov kev qhia ntawm cov noob caj noob ces, thiab inhibiting tumr angiogenesis thiab kev loj hlob, inducing tumr matrix apoptosis.
Tshawb nrhiav qhov tseem ceeb thiab kev cia siab rau kev siv
Qhov kev ua haujlwm no muab cov tswv yim tshiab thiab lub hom phiaj rau kev kho mob qog noj ntshav. Los ntawm inhibiting qhov kev ua ntawm HIF-1, nws tuaj yeem cuam tshuam nrog kev muaj sia nyob thiab kev loj hlob ib puag ncig ntawm tumr matrixs, uas xav tias yuav tsim cov tshuaj tiv thaiv qog noj ntshav zoo dua. Tam sim no, kev tshawb fawb ntawm inhibitors ntawm HIF-1 yog ib qho ntawm cov hotspots hauv kev kho mob qog noj ntshav, thiab aziridine hydrochloride, uas yog ib qho ntawm lawv, muaj peev xwm rau kev tshawb fawb thiab kev loj hlob ntxiv.
Mechanism ntawm Action
Nws muaj cov kab mob tua kab mob, thiab nws cov tshuaj tiv thaiv kab mob yuav cuam tshuam nrog kev nkag mus rau hauv cov kab mob DNA ob npaug, cuam tshuam cov qauv DNA ntawm helical, thiab cuam tshuam nrog DNA replication thiab transcription txheej txheem. Hauv cov txheej txheem ntawm cov kab mob loj hlob, DNA replication thiab transcription yog cov kauj ruam tseem ceeb. Cov nyhuv embedding ntawm acridin hydrochloride tiv thaiv DNA polymerase thiab RNA polymerase los ntawm kev khi kom zoo, ua rau replication thiab transcription yuam kev los yog txiav, yog li inhibiting kab mob loj hlob thiab kev loj hlob. Tsis tas li ntawd, nws kuj tseem tuaj yeem khi rau cov kab mob ribosomes, cuam tshuam nrog cov txheej txheem protein synthsis, thiab cuam tshuam rau cov metabolism thiab ua haujlwm ntawm cov kab mob.
Daim ntawv thov Scope
Nws tuaj yeem siv los kho qee yam kab mob ntawm daim tawv nqaij thiab mucosal thiab lwm yam kab mob, tab sis nws daim ntawv thov raug txwv vim nws cov yam ntxwv staining. Piv txwv li, cov ntaub so ntswg hauv zos yuav tshwm sim thaum siv, cuam tshuam rau kev zoo nkauj thiab kev lees paub ntawm tus neeg mob.
(3) Antiparasitic nyhuv
Mechanism thiab Effect of Action
Nws muaj kev cuam tshuam rau cov kab mob pear, ntshav liab matrix lub cev, nees Babesia, dwarf Babesia, bovine Babesia, bovine Babesia, yaj Babesia, thiab lwm yam, tab sis nws tsis zoo rau Taylor worms thiab plasma dawb lub cev. Nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam nrog cov txheej txheem metabolic ntawm cov cab lossis cuam tshuam lawv cov qauv cellular. Cov kab mob muaj cov kab mob metabolic tshwj xeeb thiab cov qauv ntawm tes, thiab acridin hydrochloride tuaj yeem cuam tshuam nrog biomolecules hauv cov kab mob cab kom cuam tshuam rau nws cov kev ua haujlwm ntawm lub cev, yog li ua tiav lub hom phiaj ntawm inhibiting parasite kev loj hlob thiab kev yug me nyuam.
Daim ntawv thov nyob rau hauv lub teb ntawm veterinary tshuaj
Hauv kev lag luam kws kho tsiaj, acridin yellow hydrochloride tuaj yeem siv los kho cov kab mob cab hauv tsiaj thiab ua kom lawv noj qab haus huv. Txawm li cas los xij, vim muaj kev txwv ntawm nws cov spectrum ntawm kev ua, nws yog ib qho tsim nyog los xaiv raws li cov kab mob tshwj xeeb thaum siv nws.
txheej txheem hluavtaws
(1) Synthesis txoj kev siv aniline ua raw khoom
Cov txheej txheem thev naus laus zis
Pib los ntawm aniline, nws dhau los ua cov tshuaj tiv thaiv condensation nrog formaldehyde. Hauv cov tshuaj tiv thaiv no, pawg amino ntawm aniline tau txais cov tshuaj tiv thaiv nucleophilic ntxiv nrog rau pawg carbonyl ntawm formaldehyde, tsim cov methylene txuas nrog nruab nrab. Tom qab ntawd, cov tshuaj tiv thaiv nitration yog nqa tawm, uas cov pab pawg nitro tau nkag mus rau lub nplhaib benzene nyob rau hauv qhov kev txiav txim ntawm tus neeg sawv cev nitration. Tom ntej no, kev txo cov tshuaj tiv thaiv yog ua los txo cov nitro pawg rau cov amino pawg. Tom qab ntawd, kaw - lub voj voog cov tshuaj tiv thaiv yog ua los tsim ib lub nplhaib acridin nyob rau hauv lub molecule. Thaum kawg, ntsev los nag cov tshuaj tiv thaiv yog ua los tsim cov ntsev nrog hydrochloric acid kom tau acridin daj hydrochloride.
Qhov zoo thiab qhov tsis zoo tsom xam
Qhov zoo ntawm txoj kev no yog nws cov txiaj ntsig nitrification siab. Txawm li cas los xij, kuj tseem muaj qee qhov tsis zoo, xws li nyuaj rau kev sib cais isomers, uas ua rau muaj kev nyuaj thiab nqi ntawm kev ua kom huv tom qab. Tsis tas li ntawd, kev txo qis cov tshuaj tiv thaiv yuav tsis ua tiav, ua rau txo qis tag nrho cov txiaj ntsig thiab cuam tshuam rau kev tsim khoom thiab cov txiaj ntsig kev lag luam.
(2) Synthesis txoj kev siv benzene ua raw khoom
Cov txheej txheem thev naus laus zis
Pib los ntawm benzene, nitrobenzene yog tau los ntawm nitration cov tshuaj tiv thaiv. Nitrification cov tshuaj tiv thaiv yuav tsum tau ua raws li qhov kub thiab txias thiab tus neeg sawv cev nitration kom ntseeg tau qhov kev xaiv thiab tawm los ntawm cov tshuaj tiv thaiv. Tom qab ntawd nitrobenzene txo qis rau aniline, thiab txo cov tshuaj tiv thaiv feem ntau siv cov tshuaj txo qis xws li hlau hmoov. Tom qab ntawd, cov tshuaj tiv thaiv acylation yog nqa tawm, thiab aniline reacts nrog acylation reagent los tsim cov khoom acylation. Cov tshuaj tiv thaiv condensation ntxiv yog ua los ua rau cov molecules mus rau condensation thiab tsim cov intermediates tshwj xeeb. Tom qab ntawd, kaw - lub voj voog cov tshuaj tiv thaiv yog ua los tsim lub nplhaib acridin. Thaum kawg, ntsev los nag cov tshuaj tiv thaiv yog ua los tsim cov ntsev nrog hydrochloric acid kom tau acridine.Acriflavine HCL.
Qhov zoo thiab qhov tsis zoo tsom xam
Cov txiaj ntsig nitration ntawm txoj kev no zoo ib yam li ntawm txoj kev siv aniline li raw khoom, tab sis kev sib cais ntawm para isomers kuj yooj yim, uas ua rau cov txheej txheem purification tom ntej kuj yooj yim dua thiab txhim kho purity ntawm cov khoom. Yog li ntawd, txoj kev no yog qhov ua tau zoo dua hauv kev tsim khoom tiag. Txawm li cas los xij, tag nrho cov txheej txheem synthsis tseem yog qhov nyuaj, suav nrog ntau cov kauj ruam thiab xav tau kev tswj hwm nruj ntawm cov tshuaj tiv thaiv kom ntseeg tau tias qhov kev vam meej ntawm txhua kauj ruam thiab cov khoom zoo.
Cov lus nug nquag
Puas yog acriflavine muaj kev nyab xeeb siv?
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Acriflavine (INN: acriflavinium chloride) yog tshuaj tua kab mob. Nws muaj daim ntawv ntawm cov txiv kab ntxwv los yog xim av hmoov.Tej zaum nws yuav ua mob rau qhov muag lossis yog nqus tau. Nws yog dyeing thiab stains ntawm daim tawv nqaij thiab tej zaum yuav irritate.
Dab tsi kho qhov txhab qhib sai sai?
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Txhawm rau kho qhov txhab qhib sai dua, ua kom lawv huv si, noo noo (nrog hnav khaub ncaws tsim nyog), thiab tiv thaiv kev kis kab mob, tsom rau kev noj zaub mov zoo (cov protein, Vitamins A & C), tswj cov mob hauv qab, thiab siv cov tshuaj pleev los yog zib ntab; rau qhov mob hnyav, mus ntsib kws kho mob tas li.
Yuav siv acriflavine li cas?
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Xa mus rau Txoj Cai rau Kev Tswj Kab Mob:Acriflavine hauv glycerin daws tuaj yeem siv rau hauv qhov txhab ua lwm txoj hauv kev yog tias tsis muaj dej tsis zoo., vim hais tias nws txhawb nqa qhov txhab dej qnd muaj hygroscopic nkaus uas yuav txo tau qhov o hauv zos thaum siv nrog zoo - ntaub qhwv ntaub.
Dab tsi yog qhov zoo tshaj plaws antiseptic rau qhib qhov txhab?
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Thawj kauj ruam zoo tshaj plaws rau qhov qhib qhov txhab yog maj mam ntxuav nrog ntsev los yog xab npum thiab dej; rau cov tshuaj tua kab mob, povidone-iodine (Betadine) thiab chlorhexidine yog cov kev xaiv muaj zog rau kev tiv thaiv kab mob, tab sis siv me me raws li lawv tuaj yeem ua mob rau cov ntaub so ntswg, thaum BZK cov ntaub so yog cawv zoo- cov kev xaiv pub dawb, thiab tshwj xeeb sodium hypochlorite (xws li Dakin's) yog qhov zoo tshaj plaws rau cov qhov txhab ntxaum, tab sis ib txwm saib xyuas qhov mob sib sib zog nqus los yog mob hnyav.
Cim npe nrov: acriflavine hcl, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom