Albuterol Sulfate Hmoov CAS 51022-70-9

Albuterol sulfate hmoovTxawm li cas los 51022 {{- 70-9, miscular mis formula c13h23no7s, dawb lossis yuav luag dawb ntxhiab tsw. Me ntsis yaj nyob rau hauv ethanol; Yuav luag Insoluble hauv ether. Zoo thermal stability, ib nrab-lub neej ntawm 4-6 teev. Salbutamol tau pom thiab tsim los ntawm British kws tshawb fawb nyob rau xyoo 1988, nws tau ua hauv Suav teb hauv xyoo 1985. Xyoo xyoo 1985. Xyoo 2012 Khaws rau hauv cov thawv ntim hauv lub chaw txias thiab qhuav, thiab ua kom muaj qhov cua txias lossis kev tso pa tawm hauv qhov chaw ua haujlwm. Nws yog feem ntau siv los kho Bronchospasm hauv cov neeg mob bronchial mob ntsws asthma, asthmatic mob ntsws, thiab emphysema. Cov khoom no yog rau kev kuaj siv nkaus xwb.

1. Pib los ntawm P - hydroxyacetophenone, hydroticization, hydrolysis thiab ntsev tsim, nrog rau tag nrho cov txiaj ntsig ntawm 11% ~ 13%. Ntxiv mus, qhov kev tawm tsam ntawm txoj kev no yog ua phem, "peb tus neeg muaj kuab lom" yog qhov tseem ceeb, thiab tus nqi yog qhov siab.

{{02. 4- bromoacetyl salicylalhyde thiab 4-chloroacetyl Tom qab hws, hydrolysis thiab ntsev tsim nyob rau hauv tib chav da dej, lawv tau hloov pauv mus rau hauv 5-11-dimethylethyl) amino] acetyl-2-hydroxybenzaldehyde. Tom qab ntawd, salbutamol sulfate tau npaj los ntawm kev sib koom tes ntawm cov poov tshuaj borohydride thiab zinc chloride ntawm chav tsev kub thiab ntsev tsim nrog sulfuric acid.

3. Noj cov ntsev ua kom zoo nkauj thiab tert butylamine li pib cov khoom,}}}}}}}}}}}}}}}}}}} 5 -} {[(1,1-dimethylethyl) aminocetyl}

Albuterol sulfate hmoov, raws li ib tug sawv cev tshuaj ntawm xaiv - cov tshuaj lom neeg ua pa, thiab cov kab mob plawv, thiab ntau dua bronchodilator nyhuv, thiab ntau lub zog kev tswj hwm ua haujlwm.

Pharmacological Mechanism: Molecular tus yuam sij rau txoj cai meej ntawm ₂ receptors

 

Los ntawm xaiv cov ₂ receptors ntawm bronchchial du cov leeg, thiab cov leeg ntshav du Cov phiaj xwm kev taw qhia no ua rau:
Bronchial du cov leeg nqaij so kom txaus: PKA phosphorylates myosin teeb saw kinease (myosin actin khi, thiab ncaj qha relaxing Airway du leeg; Ib txhij inhibiting influx ntawm calcium ions thiab txo cov calcium calcium concentration rau unceviate bronchospasm los ntawm ob lub tshuab sib txawv.

 

Inhibiting cov kev tso tawm ntawm cov neeg nruab nrab ntawm cov neeg mob hlwb los ntawm cov kev tawm tsam ntawm cov chaw pw
Txhim khu kev ua kom lub zog txav: Txhawb nqa cov zaus ntawm cov kab mob bronchials, nrawm nrawm txoj haujlwm ntawm cov kab mob hnoos qeev, thiab txhim kho cov hnoos qeev.
Uterine du cov nqaij
Vasodilatory nyhuv: tshuab luam ntawv los ntawm ₂ receptors, nws ua rau kev so ntawm vascular doog leeg, txo lub vascular vascular kuj, thiab txhim kho cov nqaij hauv cov nqaij ntses.

Tub Ntxhais Tub Ntxhais: Tas Nrho Cov Tsheb Tswj Kev Lag Luam Ua pa Cov Kab Mob

 

1. Mob exacerbation thiab kev tiv thaiv ntawm bronchial hawb pob
Kev Kho Mob Tawm Tsam Kev Kho Mob: Nws yog qhov kev noj tshuaj uas nyiam rau kev tawm tsam hnyav uas pom zoo los ntawm cov thoob ntiaj teb kev pib ua rau mob hawb pob (gina). Nws siv tau cov nyhuv 5-15 feeb tom qab nqus tau thiab kav ntev li 4-6 teev. Nws tuaj yeem daws cov tsos mob sai li xws li hawb pob, lub hauv siab nruj, thiab ua pa nyuaj. Rau cov neeg mob uas muaj mob hnyav rau kev qaug dab peg, kev sib xyaw ua ke nqus cov pa corticosteroids (ICS) tuaj yeem txo tus nqi hauv tsev kho mob.
Kev tiv thaiv kev qoj ib ce ua mob hawb pob (EIA): nqus tau sulbutamol sulfate 15-20 feeb ua rau kev tawm dag zog ua rau muaj kev tawm dag zog ua rau cov pa tawm tsam. Kev tshawb fawb tau pom tias nws cov nyhuv tiv thaiv yog zoo dua rau cov sodium succinate thiab qhov ncauj beta agonists.
Kev tswj lub sijhawm ntev ntev: txawm hais tias tsis ntev -}}}}} kev siv tuaj yeem txo cov pa hyperresponeness. Rau cov neeg mob uas muaj mob hawb pob, kev siv cov salbutamol sulfate ua ke nrog qis {2} ics li xav tau tuaj yeem txo cov zaus ntawm kev tawm tsam.

2. Mob exacerbation ntawm cov kab mob ntsws sib tw (CopD)
Bronchial Spasm nyem:

 

Hauv kev siv hluav taws xob ntau ntawm cov tub ceev xwm ntawm Copdamol sulramol sulfate ua ke nrog Ipratropicaergic ua ke nrog anticholicergic ua ke nrog 15% -20%) thiab luv luv lub sij hawm.
Kev tswj cov hnoos qeev ntawm cov hnoos qeev: los ntawm kev txhim kho ciliation txav thiab inhibiting mucus secition, ua pa rau los ntawm kev hnoos qeev muaj peev xwm. Rau cov neeg mob siab cov hnoos qeev cov tub luam, kev sib xyaw ua ke ntawm kev cia siab rau tshuaj (xws li Ambroxol) tuaj yeem txhim kho kev ua tau zoo.

3. Asthmatic Bronchitis thiab emphysema
Requmatic BRONCHISITISS: tuaj yeem ua kom tawv nqaij thiab cov tsos mob hnoos, tshwj xeeb yog haum rau cov neeg mob pediatric. Kev tshawb fawb qhia tau hais tias nws txoj kev ua tau zoo dua rau cov tshuaj pleev rau cov tshuaj rau sab hauv, thiab qhov tshwm sim ntawm kev phiv tsis zoo.
Mob siab rau cov neeg mob empsema: rau cov neeg mob ntsws uas tuaj yeem hloov kho cov pa roj carbon dioxide (PACO ₂) tuaj yeem tiv thaiv tau.

Daim ntawv thov rau cov neeg tshwj xeeb: kev cuam tshuam kev cuam tshuam los ntawm kev muaj teeb meem rau kev tawm tsam

 

1. Obstetrics Teb: Kev Tiv Thaiv thiab Kev Kho Mob ntawm Kev Tiv Thaiv Thaum Yug Menyuam thiab Hauv Paus Tiv Thaiv
Kev yug ntxov ntxov: Nws yog tib daim FDA pom zoo beta agonist rau thaum ntxov ntxov. Los ntawm inhibiting uterine du leeg leeg, lub sijhawm cev xeeb tub tau txuas ntxiv los ntawm 24-48 teev, yuav sijhawm rau glucocorticoids los txhawb lub pob tw fetal. Qhov kev pom zoo tau muab tshuaj yog 2.4-4.8 mg errally txhua 4-6 teev, lossis 10-20 μE txog g / min g / min enavenously.
Kev kho mob rau kev txhim kho kev loj hlob sai (i Zuag tsis muaj tsawg - dose tshuaj aspirin tuaj yeem txhawb cov nyhuv ntxiv.

Kev txiav txim siab txog menyuam yaus: Rau kev hem thawj tsis zoo los ntawm ncauj tsev menyuam yaus, thiab ua ke nrog cov ncauj tsev menyuam, thiab ua ke nrog cov ncauj lus qhuab qhia kev phais mob kom raug txhim kho kom tau zoo.

 

2. Cov Pediatric Teb: Tus mob hawb pob thiab ua pa nyuaj siab ntxhov plawv
Mob siab rau cov neeg mob hawb pob: Inhalation cov neeg sawv cev yog qhov kev noj tshuaj uas zoo tshaj plaws rau kev ua haujlwm mob hawb pob mob hawb pob. Rau cov menyuam yaus hnub nyoog qis dua 5 xyoos, nws raug nquahu kom siv cov chhalation pa hluav taws (koob tshuaj 0.15 mg / kg, siab tshaj plaws 2.5 mg); Cov menyuam yaus hnub nyoog loj dua los yog sib npaug rau 5 tuaj yeem siv cov tshuaj tua kab mob kom ntau (MDI) nrog lub caterection canister (muab 100-200 μ g / sijhawm).
Neonatal ua pa nyuaj siab (NRDs): Rau cov menyuam mos liab nrog NRDS,Albuterol sulfate hmoovtuaj yeem txhawb cov kev zais ntawm pulmonary surfdactant (PS) thiab txhim kho Lung Ua Raws. Kev sib xyaw ua ke PS hloov kev kho kev kho mob tuaj yeem txo qhov xav tau kev siv tshuab tshuab cua.
Lub sijhawm yug menyuam thaum ntxov apnea: los ua kom cov beta ₂ receptors nyob rau hauv lub coliconic tshav ua pa, qhov zaus ntawm apnoa ntu yog txo. Qhov kev pom zoo tau muab tshuaj yog 0.2 mg / kg ntawm itly txhua 6-8 teev.

Kev Siv Kho Mob Kho Siab: Synergistic Ua Tau Thiab Offsetting ntawm Kev Ruaj Ntseg

 

1. Ua ke siv nrog nqus tau corticosteroids (ICS)
Lub sij hawm ntev tswj tau mob hawb pob: ua ke daim ICS (xws li Budesonide) tuaj yeem ua tiav txoj kev hloov pauv ntaul ntawm "sai sai- lub sij hawm tswj". Kev tshawb fawb qhia tau hais tias Pawg Neeg Kho Mob txo qhov ntau ntawm kev tawm tsam kev tawm tsam los ntawm 50% thiab txhim kho lub ntsws ua haujlwm ntau dua.
Kev kho mob CopD kho: rau cov neeg mob saib xyuas cov neeg mob nquag ua ke, ua ke} Ua rau cov tshuaj tiv thaiv antichilegicergic) los ntawm 30%.
2. Ua ke siv nrog tshuaj anticholinid
Kev nqus tau pa hluav taws xob: salbutamol sulfate (2.5 mg) ua ke nrog ₂ recatropicly nqus tau ib txhij thiab thaiv m Haum rau cov neeg mob uas muaj qhov mob hawb pob thiab mob hnyav ua haujlwm ntawm Copd.

 

Pharmaciinetic Qhov zoo: Anticholiceergic tshuaj tuaj yeem txo cov tshuaj tiv thaiv kab mob edema induced los ntawm salbutamol sulfate thiab ntev nws ntev ntawm kev nqis tes ua; ₂ Agonists tuaj yeem tiv thaiv cov kev sib raug zoo xws li lub qhov ncauj qhuav los ntawm cov tshuaj antichitygilceergic.
3. Ua ke siv nrog cov tshuaj ntawm theophly
Mob siab rau kev mob hawb pob: ua ke nrog IntranTenous Txoj kev lis ntshav ntawm Aminophylline, nws tuaj yeem daws qhov sai sai BRONCHOSSPASM. Tab sis nws yog qhov tsim nyog los saib xyuas cov ntshav theophline confration (hom phiaj nrug (hom phiaj) kom tsis txhob muaj kev sib raug zoo xws li arrhythmia.
Kev tswj kom mob hlwb: salbutamol sulfate txhawb nqa {}} tso tawm cov ntsiav tshuaj ua ke ntawm} thaum hmo ntuj thiab txo cov zaus ntawm hmo ntuj awakenings.

Salbutamol sulfate, raws li cov tshuaj tseem ceeb rau kev kho mob ntawm cov pa ua pa thiab cov neeg tshwj xeeb, tau dav siv tau rau nws cov nqi kho mob. Los ntawm precisely regulating ₂ receptors, nws tsis tsuas yog ua tiav kev nkag siab sai thiab ua tau zoo, tab sis kuj ua rau pom tshwj xeeb hauv kev tiv thaiv thaum ntxov thiab hauv plab tiv thaiv.

1. Txoj Kev Lub Npe: Salbutamol Sulfate kev txiav txim siab ntawm Salbutamol Sulfate tsis muaj kev daws teeb meem

Daim Ntawv Thov: Cov qauv no siv tsis yog - queous daws cov ntsiab lus ntawm salbutamol sulfate ((c13h21no4).

Cov qauv no haum rau kev txiav txim siab ntawm Salbutamol Sulfate.

Txoj kev qhia txuj ci me me: Tom qab cov lus xeem me ntsis nrog lub ntsej muag actict acticator, thiab 1 leeg ua kom txog thaum txoj kev daws teeb meem xiav- ntsuab. Thiab cov cuab yeej ua si tau raug kho nrog kev ntsuas dawb paug. Txhua txhua 1ml ntawm perchloric acid sidrant (0.1 mol / l) yog sib npaug rau 57.67mg ntawm (c13h21no3) 2S11.

Reagent: dej (tshiab boiling mus rau chav sov), acacial anhydride qhia txog, ib qho kev ua yeeb yam siv leadic anid, l), siv cov poov tshuaj hydrogen phthalate

Cov twj thiab cov khoom siv:

Kev Npaj Qauv: 1. Crystal Cov Qauv Txhaum Cai: Noj 0.5g Crystal Violet thiab ntxiv 100ml Glacial Acetic Acid kom yajAlbuterol sulfate hmoov.

2. Perchloric acid npe (0.1mol / l):

Kev npaj: Nqa 750ml dej - paab acetic acid (70 ~ 72 ~ Cov ntsiab lus ntawm kev daws yuav tsum txiav txim siab los ntawm kev txiav txim siab noo noo, thiab tom qab ntawd kho rau 0.01% ~ 0.2% nrog dej thiab acetic anhydride.

Kev ntsuas hluav taws xob: siv sijhawm 0.16g ntawm Renchassium hydrogen phticator qhuav tas li, ntxiv 1ml ntawm frystal fircial accet activer, thiab kho lub ntsuas hluav taws xob kom muaj qhov sib tw tau. Txhua txhua 1ml ntawm perchloric acid sidrant (0.1mol / l) yog sib npaug rau 20.42mg ntawm cov poov tshuaj hydrogen phthalate. Xam cov kev ua kom haum ntawm cov kua raws li kev noj ntawm cov kua thiab qhov ntau ntawm potassium hydrogen phthalate.

3. Siv Potassium hydrogen phthalate

Cia: Muab nws tso rau hauv lub khob xim av thiab kom nws nruj nreem.

Cov kauj ruam kev ua haujlwm: Siv li 0.4g ntawm cov khoom no, qhov ntsuas yog qhov tseeb, txias rau lub ntsej muag accetic anhetly, txias} glten Txhua txhua 1ml ntawm perchloric acid sidrant (0.1 mol / l) yog sib npaug rau 57.67mg ntawm (c13h21no3) 2S11.

Cim npe nrov: Albuterol Sulfate Hmoov CAS 51022-70-9, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav, nqi, loj, rau muag