Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm apigenin hmoov cas 520-36-5 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo apigenin hmoov cas 520-36-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Apigenin hmoov, tseem hu ua vetiver, muaj ib tug molecular mis ntawm C15H10O5 , CAS 520-36-5 thiab yog ib tug dawb mus rau me ntsis daj siv lead ua los yog hmoov tshuaj nrog ib tug me ntsis iab aromatic saj. Nws cov qauv molecular muaj 2 lub nplhaib benzene thiab ib lub nplhaib uas muaj ntxhiab, thiab muaj ntau pawg hydroxyl thiab pawg ketone. Nws yog ntuj flavan compound nrog ntau yam kev ua ub no lom neeg. Nws yog ib qho khoom siv kho qhov muag nrog kev sib hloov kho qhov muag ntawm -159.9℃(c=1, ethanol). Solubility nyob rau hauv dej yog tsawg, 0.22 mg / L (25 degree), thaum solubility nyob rau hauv organic solvents xws li ethanol thiab dimethyl sulfoxide yog siab. Nyob ruaj khov nyob rau hauv lub teeb, tab sis susceptible rau deliquescence. Nyob rau hauv acidic tej yam kev mob, Apigenin muaj tsis zoo stability thiab yog yooj yim rau decompose. Nws yog ib qho tseem ceeb ntawm flavan compound, uas tuaj yeem siv rau hauv kev tsim tshuaj thiab kev tshawb fawb txog kev npaj.
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Apigenin hmoovyog ib hom flavan compound, uas muaj ntau yam kev ua ub no lom neeg thiab cov tshuaj pharmacological, yog li nws tau nyiam ntau yam hauv kev kho mob thiab kev kho mob. Txhua qhov kev siv ntawm Apigenin tau piav qhia hauv qab no.
1. Antioxidant zog
Apigenin muaj lub zog dawb radical scavenging muaj nuj nqi. Cov kev tshawb fawb tau pom tias Apigenin tuaj yeem txo cov kev ntxhov siab oxidative, txo cov synthesis ntawm lipid peroxides, thiab ua kom cov enzymes antioxidants xws li superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px). kom muaj zog antioxidant nyhuv. Tsis tas li ntawd, Apigenin kuj muaj peev xwm tiv thaiv DNA puas.
2. Anti-cov nyhuv inflammatory
Apigenin muaj cov tshuaj tiv thaiv dav dav - mob. Nws muaj peev xwm inhibit zus tau tej cov inflammatory cytokines, xws li TNF-, IL-6, IL-1, thiab lwm yam., yog li txo cov inflammatory teb. Nyob rau tib lub sijhawm, Apigenin tseem tuaj yeem tiv thaiv kev tsim cov kab mob sib kis xws li COX-2 thiab iNOS, thiab muaj kev tiv thaiv zoo hauv ntau yam qauv, xws li mob hawb pob, rheumatoid mob caj dab, thiab mob plab hnyuv.
3. Anticancer nyhuv
Apigenin muaj tshuaj tiv thaiv - mob qog noj ntshav. Nws tuaj yeem txo qhov tshwm sim thiab kev loj hlob ntawm cov qog nqaij hlav hauv ntau txoj hauv kev, xws li:
Inhibit cancer cell proliferation: Apigenin tuaj yeem cuam tshuam kev loj hlob ntawm ntau yam qog nqaij hlav cancer, xws li mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, thiab lwm yam.
Induction ntawm apoptosis: Apigenin tuaj yeem tsim cov qog cell apoptosis, yog li nws muaj peev xwm siv tau tus nqi hauv kev kho mob qog.
Anti-angiogenesis: Apigenin tuaj yeem cuam tshuam kev tsim cov hlab ntsha ntawm cov hlab ntsha, yog li tiv thaiv kev loj hlob thiab kis ntawm cov qog.
Kev tswj cov kev taw qhia txoj hauv kev: Apigenin tuaj yeem tswj ntau txoj hauv kev qhia, xws li PI3K/AKT, MAPK, NF{{1}κB, thiab lwm yam, yog li inhibiting kev loj hlob thiab kev sib kis ntawm cov qog nqaij hlav cancer.
4. Cov nyhuv neuroprotective
Apigenin muaj kev tiv thaiv ntawm lub paj hlwb. Nws tuaj yeem txo qhov kev puas tsuaj oxidative ntawm cov neurons, txo qhov kev pheej hmoo ntawm kev mob neuronal los ntawm kev tswj cov kev qhia ntawm NO, iNOS, COX-2 thiab lwm yam; Nyob rau tib lub sijhawm, Apigenin tseem tuaj yeem txo cov neuronal apoptosis, txhim kho synaptic plasticity, thiab tiv thaiv cov neurons Kev Tiv Thaiv los ntawm co toxins thiab oxidative kev nyuaj siab, nrog rau daim ntawv thov dav dav.
5. Kev tiv thaiv kab mob plawv
Apigenin muaj kev tiv thaiv zoo ntawm cov hlab plawv. Nws tuaj yeem txo qhov kev pheej hmoo ntawm vascular raug mob thiab atherosclerosis los ntawm kev txo qis oxidative kev nyuaj siab thiab inhibiting inflammatory teb. Nyob rau tib lub sijhawm, Apigenin tseem tuaj yeem tswj hwm myocardial contraction, nce coronary artery flow, txo qhov kev pheej hmoo ntawm myocardial ischemia thiab hypoxia, thiab muaj txiaj ntsig zoo rau cov hlab plawv. Kev tiv thaiv dav.
6. Kev kho mob ntshav qab zib
Raws li lub ntuj tshuaj molecule, Apigenin tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev kho mob ntshav qab zib. Apigenin tuaj yeem tswj hwm txoj kev taw qhia cov tshuaj insulin los ntawm ntau txoj hauv kev, txhawb nqa thiab siv cov piam thaj, thiab tib lub sijhawm txo cov ntshav qab zib kom tsawg, thiab tuaj yeem cuam tshuam oxidative kev ntxhov siab thiab kev mob tshwm sim hauv cov txheej txheem ntawm ntshav qab zib, yog li txhim kho cov txiaj ntsig ntawm kev kho mob ntshav qab zib.
7. Kev kho mob ntawm lub paj hlwb
Apigenin tuaj yeem siv los kho ntau yam kab mob hauv lub paj hlwb, xws li kev paub tsis meej hauv cov neeg laus, Alzheimer's disease, thiab lwm yam Nws tuaj yeem txhim kho kev muaj peev xwm ntawm cov neurons, txhawb cov synthesis thiab tso tawm ntawm cov neurons, ua kom cov plasticity ntawm synapses, thiab tib lub sij hawm inhibit inflammatory teb thiab oxidative kev nyuaj siab, li no alleviating neurological kab mob.
Nyob rau hauv xaus, raws li ib tug natural tshuaj molecule, Apigenin muaj ib tug dav daim ntawv thov kev cia siab nyob rau hauv lub teb ntawm cov tshuaj thiab kev kho mob. Nyob rau hauv lub neej yav tom ntej, nrog rau hauv - kev tshawb fawb tob thiab kev loj hlob ntawm pharmacological teebmeem ntawm Apigenin, peb ntseeg hais tias nws yuav ua si ib tug dav daim ntawv thov nqi nyob rau hauv ntau yam teb.
Apigenin yog flavan compound uas feem ntau muaj nyob rau hauv ntau yam txiv hmab txiv ntoo, zaub thiab lwm yam nroj tsuag ntuj. Nws muaj ntau yam kev ua ub no, xws li antioxidant, tiv thaiv - mob, tiv thaiv - mob qog noj ntshav, yog li nws tau nyiam ntau yam. Hauv kev siv tswv yim, txhawm rau txhim kho nws txoj kev siv tshuaj thiab txo cov nqi, ntau qhov kev tshawb fawb thiab kev tsim kho yuav tsum tau ua. Ib qho ntawm cov lus qhia tseem ceeb ntawm kev tshawb fawb yog los tsim ntau yam kev siv hluavtaws ntawmApigenin hmoov.
Extraction thiab cais ntawm Apigenin los ntawm cov khoom ntuj:
Apigenin muaj nyob rau hauv ntau yam nroj tsuag, xws li zaub txhwb qaib, celery, dos, tshuaj yej, thiab lwm yam. Cov nroj tsuag no tuaj yeem siv los ua lub ntuj tsim ntawm Apigenin, uas yog qhov tseem ceeb hauv kev siv tswv yim. Txoj hauv kev tseem ceeb rau kev rho tawm thiab cais Apigenin los ntawm cov nroj tsuag no yog:
1. Txoj kev rho tawm:
Extraction yog ib txoj hauv kev tseem ceeb rau rho tawm lub hom phiaj molecules los ntawm cov nroj tsuag los ntawm cov kuab tshuaj. Feem ntau siv cov kuab tshuaj extraction rau Apigenin suav nrog ethanol, methanol, ethyl acetate, thiab lwm yam. Feem ntau, cov nroj tsuag yog thawj zaug, tom qab ntawd ntxiv cov kuab tshuaj tsim nyog ntxiv, nplawm ntau zaus ntawm qhov kub thiab txias, thiab thaum kawg lub hom phiaj cov khoom raug muab rho tawm thiab purified los ntawm cov kauj ruam xws li kev sib cais thiab evaporation. Raws li cov ntaub ntawv qhia, qhov zoo tshaj plaws rau kev rho tawm Apigenin los ntawm celery yog siv 95% ethanol raws li cov kuab tshuaj extraction, thiab tsis tu ncua reflux ntawm 80℃rau 1 teev kom tau txais txiaj ntsig zoo extraction.
2. Chromatography:
Chromatography yog ib qho kev sib cais thiab kev ua kom huv huv, suav nrog ntau hom chromatography, xws li theem ib txwm, thim rov qab theem, thiab ion pauv. Thaum rho tawm Apigenin los ntawm tej yam ntuj tso, thim rov qab - theem siab - ua kua chromatography (RP-}HPLC) feem ntau yog siv rau kev sib cais thiab purification. Txoj kev no tuaj yeem sib cais lub hom phiaj sib xyaw los ntawm kev sib xyaw ua ke, thiab muaj qhov zoo ntawm kev ua haujlwm yooj yim thiab ua kom huv si zoo. Raws li cov ntaub ntawv qhia, thaum siv RP-HPLC txoj kev los cais cov dos extract, siab -purity Apigenin compounds tuaj yeem tau.
Synthetic Apigenin:
Txawm hais tias cov txheej txheem ntawm kev rho tawm thiab ua kom huv Apigenin los ntawm cov khoom siv ntuj yog qhov yooj yim, nws cov txiaj ntsig qis thiab tus nqi siab. Yog li ntawd, nws yog ib qho tsim nyog los tsim kom muaj kev lag luam ntau dua thiab siv dag zog siv dag zog. Tam sim no paub cov khoom siv hluavtaws ntawmApigenin hmoovfeem ntau suav nrog cov hauv qab no:
Phenolic condensation method yog ib txoj kev siv hluavtaws ntawm Apigenin. Nyob rau hauv txoj kev, phenol acetate thiab 2-hydroxybenzophenone yog thawj zaug rau condensation cov tshuaj tiv thaiv kom tau 2-(3-hydroxyl-4-methoxyphenyl) acetophenone. Tom qab ntawd nws raug rau Michael cov tshuaj tiv thaiv nrog aldehydes (xws li valeraldehyde) los tsim cov khoom lag luam Apigenin.
Txoj kev sib ntxiv carbene yog ib hom tshiab ntawm cov khoom siv hluavtaws rau Apigenin. Nyob rau hauv txoj kev, carbene intermediate yog synthesized thiab ntxiv rau 2-hydroxybenzophenone kom tau 1,2-dihydroxy-3-(2-hydroxyphenyl) propane. Tom qab ntawd lub compound yog reacted los ntawm acylation, lub cev qhuav dej thiab lwm yam kauj ruam kom tau lub hom phiaj khoom Apigenin.
Txoj kev Chaffythiol yog ib hom tshuaj heterocyclic tshuaj synthesis, uas kuj yog siv rau hauv cov khoom siv hluavtaws ntawm Apigenin. Nyob rau hauv txoj kev, thawj benzonitrile thiab sodium sulfite yog reacted kom tau benzene sulfate intermediate. Tom qab ntawd ntxiv ethyl iodide thiab 2-hydroxybenzophenone, thiab tau txais cov khoom lag luam Apigenin los ntawm kev sib txawv hauv cov txheej txheem.
Lub German Friedrich-Karr oxidation txoj kev yog ib qho kev siv substrate- tshwj xeeb oxidation cov tshuaj tiv thaiv, uas yog dav siv nyob rau hauv lub synthesis ntawm ntau yam organic tebchaw. Thaum cov khoom siv hluavtaws Apigenin, cov khoom siv xws li benzyl cawv thiab acetone tau siv thawj zaug hauv cov qauv no, thiab tom qab muaj kev cuam tshuam ntau, qhov nruab nrab 1,3-diphenyl-2-propanone tau txais. Tom qab ntawd nws reacts nrog o-phenolic formaldehyde los tsim lub hom phiaj khoom Apigenin.
Hauv kev xaus, Apigenin, uas yog ib qho tseem ceeb ntawm cov tshuaj molecule, muaj cov ntawv thov dav dav hauv kev siv tswv yim. Tam sim no, ntau hom kev sib xyaw ua ke tau tsim. Thaum xaiv ib txoj kev sib txuas tsim nyog, yam xws li cov txiaj ntsig, nqi, thiab kev tiv thaiv ib puag ncig yuav tsum tau txiav txim siab kom ua tiav cov txiaj ntsig zoo tshaj plaws.
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Tshuaj Formula |
C17H21ClN2S |
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Exact Mass |
320 |
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Molecular Luj |
321 |
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m/z |
320 (100.0%), 322 (32.0%), 321 (18.4%), 323 (5.9%), 322 (4.5%), 322 (1.6%), 324 (1.4%) |
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Elemental Analysis |
C, 63,63; H, 6,60; Cl, 11.05 Nws; N, 8,73; ib 9,99 |
Apigenin yog lub ntuj flavan nrog ntau yam kev ua ub no thiab cov tshuaj pharmacological. Yuav kom ua tiav qhov kev txheeb xyuas tseeb thiab kev txheeb xyuas ntawm Apigenin, cov kws tshawb fawb tau tsim ntau txoj hauv kev. Kab lus no yuav qhia ntau yam kev tshuaj xyuas ntawm Apigenin kom ntxaws.
1. Kev tshuaj ntsuam chromatographic
Chromatography yog ib txoj hauv kev siv ntau tshaj plaws hauv kev tshuaj xyuas ntawm Apigenin, suav nrog kev ua haujlwm siab ua kua chromatography (HPLC), roj chromatography (GC) thiab nyias txheej chromatography (TLC).
HPLC yog ib txoj kev siv dav siv chromatographic rau kev tsom xam ntawm Apigenin. HPLC tau sib cais los ntawm qhov thim rov qab - theem chromatographic kem, siv methanol- dej raws li theem ntawm lub xov tooj ntawm tes, thiab siv lub teeb ultraviolet nrog kev tshawb pom wavelength ntawm 330 nm. Txoj kev no tuaj yeem muab kev daws teeb meem siab thiab rhiab heev, yog li nws feem ntau siv rau hauv cov qauv thiab cov ntsiab lus tsom xam ntawm Apigenin.
Tsis zoo li HPLC, roj chromatography yuav tsum muaj methylation ntawm cov qauv ua ntej kev soj ntsuam roj chromatographic. Feem ntau 50% methanol / chloroform extraction yog siv los ntawm capillary gas chromatography nrog kuaj pom ntawm 220 nm lossis 254 nm. Txoj kev no tuaj yeem muab siab precision thiab rov tsim dua tshiab, yog li nws feem ntau siv rau hauv kev tshuaj xyuas ntawm Apigenin.
Nyias- txheej chromatography yog ib txoj hauv kev yooj yim thiab ceev ceev, uas yog tsim rau kev tshawb nrhiav sai thiab kev txheeb xyuas ntawm Apigenin. Silica gel nyias- txheej chromatography feem ntau yog siv, nrog methanol- dej los yog ethyl acetate-methanol raws li theem ntawm lub xov tooj ntawm tes, thiab kuaj pom ntawm lub wavelength ntawm 366 nm. Txoj kev no tsim nyog rau kev lees paub ntawm cov txiaj ntsig ua ntej, tab sis yuav tsum muaj kev lees paub ntxiv.
2. Mass Spectrometry
Mass spectrometry yog ib txoj hauv kev zoo rau kev txheeb xyuas qhov tseeb ntawm Apigenins, thiab tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau kev kuaj xyuas cov kab mob. Feem ntau siv cov qauv spectrometry xws li kua chromatography-mass chromatography (LC-MS) thiab roj chromatography-mass chromatography (GC-MS).
Ua kua chromatography-mass spectrometry (LC-MS)
LC-MS txoj kev siv thim rov qab-theem HPLC cais Apigenin, thiab tom qab ntawd kuaj pom nws los ntawm electrospray pawg spectrometry. Feem ntau methanol - dej los yog acetonitrile - dej yog siv raws li theem mobile. Txoj kev no tuaj yeem muab cov ntaub ntawv nrog kev ua haujlwm siab thiab rhiab heev, yog li nws yog qhov tshwj xeeb tshaj yog muaj txiaj ntsig zoo hauv kev tshuaj xyuas ntawm Apigenin hauv thaj chaw muag tshuaj thiab tshuaj.
GC-MS
GC txoj kev hais txog GC txoj kev, thiab cov qauv yuav tsum tau methylated ua ntej, ces sib cais los ntawm capillary gas chromatography, thiab thaum kawg kuaj tau los ntawm electron bombardment ion qhov chaw loj spectrometry. Feem ntau, methanol -chloroform lossis methanol-acetone yog siv los ua lub sijhawm txawb, thiab qhov kev tshawb pom wavelength yog 220 nm lossis 254 nm. Txoj kev no tuaj yeem muab cov ntaub ntawv tseem ceeb txog qhov hnyav molecular, fragmentation qauv thiab molecular qauv ntawm apigenin.
3. Nuclear Magnetic Resonance (NMR) Kev Ntsuam Xyuas
Nuclear magnetic resonance (NMR) yog lub cuab yeej muaj zog rau kev tshuaj xyuas cov qauv ntawm apigenin. Los ntawm NMR, 1H-NMR thiab 13C-NMR ntawm Apigenin tuaj yeem ntsuas tau, ob qho tib si tuaj yeem muab cov ntaub ntawv ntxaws ntxaws heev.
Hauv 1H-NMR ntawm Apigenin, nws tuaj yeem muab cov ntaub ntawv hais txog tus lej thiab txoj haujlwm ntawm hydrogen hauv Apigenin molecule, thiab tseem tuaj yeem siv los ntsuas qhov sib txuas tas li, thiab qhov rhiab heev. Hauv 13C-NMR ntawm Apigenin, peb tuaj yeem pom cov ntaub ntawv hais txog txoj haujlwm thiab cov pa roj carbon ntau, uas tuaj yeem siv los ntsuas cov tshuaj hloov pauv. Tsis zoo li lwm txoj kev tshuaj ntsuam xyuas, NMR tsis tas yuav muaj kev tswj hwm ntawm Apigenin, yog li tsis muaj cov tshuaj ntxiv tau qhia.
Hauv cov ntsiab lus, muaj ntau txoj hauv kev rau kev tshuaj xyuas Apigenin. Seb nws yog los ntawm chromatography, huab hwm coj spectrometry los yog NMR, siab - rhiab heev nrhiav thiab txheeb xyuas ntawmApigenin hmoovtuaj yeem ua tiav, tso lub hauv paus rau nws daim ntawv thov hauv tshuaj, kev kho mob thiab kev ua liaj ua teb.
tshuaj muaj zog
Acidity thiab alkalinity:
Apigenin ruaj khov nyob rau hauv nruab nrab lossis me ntsis acidic, tab sis yooj yim hydrolyzed nyob rau hauv acidic tej yam kev mob. Thaum Apigenin yaj nyob rau hauv cov tshuaj alkaline muaj zog, decolorization tuaj yeem tshwm sim.
Redox khoom:
Apigenin muaj cov cuab yeej redox muaj zog thiab tuaj yeem txo cov khoom sib txawv los ntawm kev txo cov neeg ua haujlwm. Nyob rau tib lub sijhawm, Apigenin tuaj yeem koom nrog cov tshuaj tiv thaiv oxidation, thiab tuaj yeem oxidized rau hauv cov khoom sib txawv hauv qee yam mob.
Hydroxylation cov tshuaj tiv thaiv:
Apigenin muaj ntau pawg hydroxyl, yog li nws yooj yim los nqa tawm cov tshuaj tiv thaiv hydroxylation. Piv txwv li, cov tshuaj tiv thaiv ntawm Apigenin thiab methyl iodide tuaj yeem tsim cov khoom methylated.
Cov tshuaj tiv thaiv Formylation:
Apigenin tuaj yeem hnov mob nrog formic acid los tsim cov khoom lag luam methylated.
Synthesis Reaction:
Tam sim no, muaj ob txoj kev hluavtaws tseem ceeb ntawm Apigenin: ib qho yog rho tawm, ntxuav thiab hloov kho los ntawm tej yam ntuj tso; Lwm qhov yog cov khoom siv hluavtaws. Hauv cov khoom siv hluavtaws, feem ntau siv txoj hauv kev suav nrog cov tshuaj tiv thaiv phenolic condensation, carbene ntxiv cov tshuaj tiv thaiv, thiab lwm yam.
Photochemical cov tshuaj tiv thaiv:
Apigenin tuaj yeem zoo siab los ntawm ultraviolet lossis pom lub teeb kom dhau los ntawm cov tshuaj tiv thaiv photochemical. Cov tshuaj tiv thaiv photochemical no tuaj yeem cuam tshuam nrog cov khoom antioxidant ntawm Apigenin, piv txwv li, Apigenin nanoparticles nrog cov khoom muaj zog antioxidant tuaj yeem npaj los ntawm kev txo cov photocatalytic.
Thermodynamic zog:
Apigenin tuaj yeem ua rau endothermic lossis exothermic cov tshuaj tiv thaiv nyob rau hauv qee yam mob, thiab nws cov thermodynamic zog yuav yog qhov tseem ceeb rau kev kawm txog cov tshuaj metabolism thiab hauv vivo tus cwj pwm.
Nyob rau hauv xaus, raws li ib tug natural compound,Apigenin hmoovmuaj ntau yam tshuaj lom neeg thiab daim ntawv thov tus nqi. Nyob rau hauv tus txheej txheem ntawm kev tshawb fawb thiab tsim kev siv ntawm Apigenin, nws yog ib qho tsim nyog yuav tsum tau ua hauv - kev soj ntsuam tob thiab kev tshawb fawb ntawm nws cov khoom siv tshuaj txhawm rau txhawm rau tshawb pom nws cov txiaj ntsig dav dua.
Cim npe nrov: apigenin hmoov cas 520-36-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom